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COMU 296 Regenerative Medicine (3 Credit Course)

Department of Medicine, University of Vermont Larner College of Medicine


July 17 - 21 and July 28 at UVM MedEd300; July 24 - July 27 Stem Cell Conference;
July 28 - August 11 Individualized Learning
Primary Classroom Location: Larner Medical Education Center Room 300

Program Directors & Lead Faculty:

Daniel J. Weiss MD PhD Jeff Spees PhD

Other Featured Faculty, Instructors, & Presenters:

Jason Bates PhD


Josh Bongard PhD
Tobey Clark MS
Todd Clason MS
Alicia Ebert PhD
Corine Farewell DVM, MBA
Patrick Lee PhD
Prema Menon MD
Erik Monsen PhD
Robert Pouliot PhD
Kerry Swift MS
Doug Taatjes PhD
Juan Uriarte PhD

Course Prerequisites

Enrollment limited to 50 participants

Undergraduate, masters, post-baccalaureate, or post-doctoral students in biological


sciences, biomedical sciences, or bioengineering

Required previous coursework


Basic or introductory biology or cell biology, basic or introductory chemistry or
biochemistry

Recommended previous coursework


Advanced/upper level biology, cell biology or biochemistry; basic/advanced
mathematics, organic and/or physical chemistry, physics
Course Description

This course covers the rapidly moving and exciting field of Regenerative Medicine. The
course is geared towards undergraduate, graduate, post-baccalaureate, and post-
doctoral students seeking to immerse themselves in the range of disciplines that
encompasses Regenerative Medicine. The breadth of topics to be covered will include
stem cell biology, cell therapy, gene editing, bioengineering, robotics, and advanced
microscopy/imaging such as multi-photon and atomic force microscopy. Other features
include the consideration of hurdles when bringing new therapies to the level of human
clinical trials, issues of commercialization and marketing, and patient risk (e.g. stem cell
medical tourism).

Leading UVM experts in each of these fields, including faculty from the Colleges of Arts
and Sciences, Grossman School of Business, Engineering and Mathematical Sciences,
and Medicine will present didactic, interactive sessions. In addition, the classroom
experience will be complemented by hands-on experience and exposure to the UVM
Stem Cell Core Laboratory and the microscopy laboratories. Students will work
individually and in groups to read through relevant literature and develop presentations
for group discussion.

Importantly, the second week of the course will involve participation in an actual
Regenerative Medicine conference, Stem Cells, Cell Therapies, and Bioengineering in
Lung Biology and Diseases, held every other summer at UVM. This is the leading
conference in the world in Lung Regenerative Medicine and offers a unique opportunity
to participate in cutting edge presentations and networking with the leading national
and international investigators in this area. Students will also have the opportunity to
participate in a hands-on training session for various techniques used in lung
Regenerative Medicine that is conducted as part of the conference.

Course Learning Goals

This course is intended to be a unique experience for students to develop a broad


understanding and foundation of up-to-date scientific knowledge in the complex,
exciting, and rapidly evolving areas of Regenerative Medicine. Specific learning
objectives include:
1. Understand the biology and potential applications of the range of different stem
and progenitor cell populations
2. Explore gene editing and other techniques of cell modification
3. Understand current concepts of cell-based therapies including applications in
clinical trials and potential abuses (e.g. stem cell medical tourism)
4. Explore the potential application of biomedical engineering, including robotics,
to regenerative medicine
5. Gain exposure to concepts of commercialization and entrepreneurship for
creating new therapeutics for regenerative medicine
Course Topics

Overview of Regenerative Medicine (Weiss)


Overview of Stem Cell Science (Spees)
Overview of Bioengineering (Bates)
3D Bioprinting (Pouliot)
Molecular and Cellular Techniques (Spees)
Animal Models (Ebert/Weiss)
Stem Cell Core Lab (Spees)
Basic and Advanced Imaging (Taatjes/Clason/Uriarte)
Robotics (Bongard)
Instrumentation and Modeling Facility (Clark/Lee)
Commercialization (Farewell/Swift)
Entrepreneurship (Monsen)
Industry (TBA)
Clinical Trials (Menon)
Stem Cell Medical Tourism (Weiss)

Performance Goals
1. Participation: students will be expected to engage in lectures, hands-on
activities, stem cell conference, and final presentations.

2. Final Presentation: Participants will prepare a 15 minute power point or other


multimedia presentation on a topic of their choice derived from the course. This
can be done as an individual or group effort.

3. Final Essay: Participants will prepare a 3 page essay on a topic of their choice
derived from the course.

Grading
We will use the following tentative grading scheme:
Participation 50%
Final Presentation and Final Essay 50%

Academic honesty: You are expected to maintain a high standard of academic honesty.
Please read about UVMs Academic Honesty Policy at
http://www.uvm.edu/policies/student/acadintegrity.pdf
Be particularly careful to avoid plagiarism when working on presentations.

Religious holidays: You have the right to practice the religion of your choice. Each
semester, you should submit in writing to your instructors by the end of the second full
week of classes your documented religious holiday schedule for the semester. Faculty
must permit students who miss work for the purpose of religious observances to make
up this work.
Tentative Schedule
Monday, July 17, 2017
Schedule Session Title/Topic Learning Objective/Activities/Assessments Instructor/Presenter

8:30-9:00am Welcome & Orientation Daniel Weiss, M.D., Ph.D.


Jeffrey Spees, Ph.D.
9:00-10:30am Overview of Regenerative Medicine Daniel Weiss, M.D., Ph.D.
10:30-10:45am Break
10:45am-12:00pm Overview of Stem Cell Science Jeffrey Spees, Ph.D.
12:00-1:30pm Lunch
1:30-3:00pm Overview of Bioengineering Jason Bates, Ph.D.
3:00-4:00pm 3D Bioprinting Robert Pouliot Ph.D.

Tuesday, July 18, 2017


Schedule Session Title/Topic Learning Objective/Activities/Assessments Instructor/Presenter

9:00-10:30am Molecular and Cellular Techniques Jeffrey Spees, Ph.D.


10:30-10:45am Break
10:45am-12:00pm Animal Models: Zebrafish and Beyond Daniel Weiss, M.D., Ph.D.
Alicia Ebert, Ph.D.
12:00-1:30pm Lunch
1:30-3:00pm Lab Visit and Stem Cell Core Jeffrey Spees, Ph.D.
3:00-4:00pm Stem Cell Core Lab I Jeffrey Spees, Ph.D.

Wednesday, July 19, 2017


Schedule Session Title/Topic Learning Objective/Activities/Assessments Instructor/Presenter

9:00-10:30am Basic and Advanced Imaging Douglas Taatjes, Ph.D.


Todd Clason, M.S.
Juan Uriarte Ph.D.
10:30-10:45am Break
10:45am-12:00pm Imaging Technique Demos Douglas Taatjes, Ph.D.
Todd Clason, M.S.
Juan Uriarte Ph.D.
12:00-1:30pm Lunch
1:30-3:00pm Robotics Josh Bongard, Ph.D.
3:00-4:00pm Instrumentation and Modeling Tobey Clark, M.S.
Facility: Building the tools

Thursday, July 20, 2017


Schedule Session Title/Topic Learning Objective/Activities/Assessments Instructor/Presenter

9:00-10:30am Commercialization Corine Farewell, DVM, MBA


Kerry Swift, M.S.
10:30-10:45am Break
10:45am-12:00pm Entrepreneurship Erik Monsen, Ph.D.
12:00-1:30pm Lunch
1:30-3:00pm The Real World: Industry Panel Speakers from Industry (TBA)
3:00-4:00pm Stem Cell Core Lab II Jeffrey Spees, Ph.D.

Friday, July 21, 2017


Schedule Session Title/Topic Learning Objective/Activities/Assessments Instructor/Presenter

9:00-10:30am Clinical Trials Prema Menon, M.D.


10:30-10:45am Break
10:45am-12:00pm Stem Cell Medical Toursim Daniel Weiss, M.D., Ph.D.
12:00-1:30pm Picnic at Sandbar State Park Lunch
1:30-4:00pm Open Research Discussion & Q&A
Focus on Careers

Pre-Conference Workshop
Monday, July 24, 2017 Stem Cell Conference Hands-On Daniel Weiss, M.D., Ph.D.
9:00am-4:00pm Workshop & Demo at the Weiss Lab

Lung Stem Cell Conference


Monday, July 24, 2017 Lung Stem Cell Conference Opening
7:00pm-10:00pm Session
Tuesday, July 25, 2017 Lung Stem Cell Conference
8:00am-6:00pm
Wednesday, July 26, 2017 Lung Stem Cell Conference
8:00am-6:00pm
Thursday, July 27, 2017 Lung Stem Cell Conference
8:00am-6:00pm

Friday, July 28, 2017


Schedule Session Title/Topic Presenters
9:00am-12:00pm Mini-Research Symposium Student Daniel Weiss, M.D., Ph.D.
Presentations Jeffrey Spees, Ph.D.
12:00-1:00pm Lunch
1:00-3:00pm Mini-Research Symposium Student Daniel Weiss, M.D., Ph.D.
Presentations Jeffrey Spees, Ph.D.