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3. In the eye
a. Alpha adrenoceptors cause contraction of the circular papillary muscle - dilation
b. Cyclospasm is a feature of organophosphate poisoning <= ciliary muscle contraction, opening the
trabecular meshwork so useful in glaucoma (echothiophate, OGP, long duration of action)
c. Beta agonist will reduce intraocular pressure b blocker
d. Antipsychotic agents such as chlorpromazine have no effect on the eye
e. Diuretics have no use in glaucoma
5. Regarding beta-receptor antagonist drugs the following has no local anaesthetic action:
a. Labetalol
b. Atenolol <= hydrophillic b1 selective, renally excreted unchanged
c. Metoprolol
d. Propranolol
e. Pindolol
6. regarding isoprenaline
a. it is a potent bronchodilator <=
b. it is a selective beta1 agonist b1=b2
c. it can be used in tachyarrythmias to decrease AV conduction
d. it has negative inotropic effects
e. it causes peripheral vasoconstriction
7. regarding beta blockers
a. inhibits renin release via beta2 receptors b1 increases, a2 decreases
b. metoprolol has intrinsic sympathomimetic effects
c. all are well absorbed esmolol IV only
d. beta1 selective antagonists dont cause bronchoconstriction none are elective enough
e. can treat ventricular tachycardias <=
8. IV drug that causes tachycardia, decreases diastolic BP, dilates pupil, doesnt affect ejaculation,
decreases sweating:
a. Beta agonist
b. Alpha antagonist
c. Muscarinic antagonist <=
d. Nicotinic antagonist
e. Nicotinic agonist
11. A young patient is given a normal dose of a drug in the emergency department. He develops
tachycardia, increased BP and dilated pupils. The drug is most likely to be:
a. Adrenaline <=
b. Atropine - ?
c. ?
d. ?
e. ?
12. dobutamine
a. results in ATPAMP
b. can decrease systemic vascular resistance/afterload <= b1>b2>>>a, but complex. Is basically an
inotrope with mixed a effects due to raemic mixture having opposing effects on alpha receptors.
c. ?
d. ?
e. ?
13. regarding propranolol
a. is a highly selective beta receptor antagonist non-selective prototypical
b. is poorly lipid soluble highly, poor = atenolol
c. has sodium channel blocking activity <= correct
d. ?
e. ?
14. A young man presents with dilated pupils, confusion and hyperpyrexia. Which of the following
could not account for these effects
a. Atropine
b. Datura
c. Morphine <= would constrict
d. ?
e. ?
16. A patient comes in staggering, agitated and hyperthermic with dilated pupils. Which is LEAST
likely to be the cause?
a. Atropine overdose
b. Amphetamines
c. Angels trumpet
d. Tricyclic overdose anticholinergic effects
e. Aspirin overdose <=
20. dopamine
a. has less alpha agonist effect than dobutamine dobutamine is b1>b2>>>a,, dopamine
D1=D2>>b>>a (at high doses mimicks adrenaline)
b. dilates the renal vascular bed by its action of beta 1 receptors D1
c. causes a profound rise in peripheral vascular resistance
d. is inactivated by sodium bicarbonate <=
e. causes vasoconstriction at all doses
21. propranolol
a. has no central effects
b. can be used safely in type I respiratory failure because of its reliable beta 1 selectivity
c. in overdose may be effectively treated by administering glucagons <=
d. needs to be given in relatively large oral doses because of its poor absorption
e. does not produce withdrawal symptoms on abrupt cessation because beta receptors do not up
regulate
22. hyoscine
a. may potentiate the anticholinergic effects of phenothiazines additive effects?
b. is well absorbed from the gastrointestinal tract <= true, delayed effect via transdermal patch
c. readily crosses the blood brain barrier - ?
d. has its main effect at nicotinic receptors
e. produces pronounced tachycardia in therapeutic doses
24. atropine
a. causes ureter and bladder wall contraction
b. acts by blocking adrenoceptors
c. is an example of a surmountable blockade <=
d. results in miosis
e. causes bradycardia in a moderate to high therapeutic dose brady then tachy
25. noradrenaline
a. is more potent than salbutamol at beta 1 receptors
b. is less potent than isoprenaline at alpha receptors isopren is b1=b2>>>a
c. antagonizes the effects of dopamine
d. has similar potency to adrenaline at beta 1 receptors <=
e. is less potent than adrenaline at alpha receptors
28. milrinone
a. has a short half life because of rapid reuptake and breakdown intravascularly by COMT
b. is extensively metabolized by the liver 12%
c. is in the same class of drugs as dobutamine it is a phosphodiesterase inhibtior
d. is a competitive inhibitor of phosphodiesterase <= increasing cAMP, Ca2+ and therefore
contractility , also vasodilation
e. is one of the most commonly used inotropes in the intensive care setting
32. Which of the following drugs does not cause the same effect?
a. Muscarine
b. Acetylchoine
c. Hyoscine <=
d. Carbachol
e. Methacholine
33. A young man is injected with an IV drug. He shows a resultant tachycardia, midriasis, normal
blood pressure and reduced sweating. The most likely drug is
a. Nicotinic antagonist
b. Muscarinic antagonist <=
c. Cholinomimetic
d. Adrenergic agonist
e. Adrenergic antagonist
35. propranolol
a. is a highly selective beta receptor antagonist
b. is poorly lipid soluble
c. has sodium channel blocking action <=
d. has intrinsic sympathomimetic activity
e. has an oral bioavailability of >50%