Creative Biolabs Announces MHC Tetramer Product Collections

Creative Biolabs, a professional biotech company specialized in recombinant antibody

(rAb) discovery and manufacturing, announces a large number of MHC Tetramer
products.

With the common efforts of researchers, Creative Biolabs has developed a large
number of peptide MHC tetramer product collections for research on cancer,
virus-related, bacteria-related, and other fields.

MHC molecules fuction is to bind peptide fragments that are derived from pathogens
and display them on the cell surface for recognition by the appropriate T cells. The
results are almost always deleterious to the pathogenvirus-infected cells are killed,
macrophages are activated to kill bacteria living in their intracellular vesicles, and B
cells are activated to produce antibodies that eliminate or neutralize extracellular
pathogens.

MHC Tetramers are a type of MHC molecules. They have emerged as an important
tool for characterization of the specificity and phenotype of T cell immune response,
and are useful in a large variety of disease and vaccine studies. Peptide-MHC
multimers display an antigenic peptide in the MHC binding groove, functioning as a
surrogate for recognition events that occur as part of the T cell interaction with
antigen-presenting cell.

MHC tetramer is a promising tool for research in immunology. The most prevalent
form of multimer in use today consists of biotin-labeled pMHC displayed on
streptavidin molecules, forming tetravalent complexes. MHC tetramers are quite
useful in quantitation of antigen-specific T cell response. When coupled with methods
that predict peptide binding to MHC molecules, tetramer analysis can be extremely
useful for identifying T cell epitopes.

Apart from MHC tetramer products, Creative Biolabs also provides different class of
MHC tetramer custom services.

MHC tetramers may have great effects on cancer immunotherapy. They allow for ex
vivo selection and proliferation of T-cells specific to tumor-related antigens, which
can then be reintroduced to augment the immune system.

MHC tetramers may also influence vaccine development. Recently, ex vivo

enrichment protocols based on the use of MHC class I tetramers that allow the
detection and characterization of rare antigen-specific CD8+ T-cell populations as
well as an estimation of their frequency have been reported.

In addition to cancer immunotherapy and vaccine development, MHC tetramer

products provided by Creative Biolabs can also be applied in bacteriology-related
research and other relevant research fields.

About Creative Biolabs

Creative Biolabs is a professional biotech products and services provider located in

New York. Its products range from biosimilar cell lines, antibody-drug conjugates
(ADCs) to engineered antibodies such as therapeutic antibodies, single-domain
antibodies, bispecific antibodies, ntrabodies, etc.

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