Histology of the digestive system

Part 4
Anik Harkai
 Liver
Lobus sinister Sublobular v.
Ligamentum falciforme hepatis

Arteria hepatica propria

Vena cava inferior
Vena portae

Portal triad
Hepatic
Central v.
Lobus dexter lobule
Interlobular a.
Interlobular bile
Portal triad duct
Interlobular v.
Liver acinus

sinusoid
Central v.
Kupffer cell
v. centralis
Hepatocyte Canal of
Hering hepatocyta
sinusok
Sinusoidal lumen
Space of Disse
Bile capillary Hering-
Kupffer cell
Hepatocyte
csatorna

Interlobular
a.

Interlobular
Interlobular bile Stellate cell Endothelial Dendritic cell
v.
duct cell with
fenestrae
 Hepatic lobule
central vein

sinusoid

Plates of hepatocyte

interlobular v.

interlobular a.
portal triad

interlobular bile
perilobular v. duct

perilobular a.

Rhlich: Szvettan
 Hepatic lobule

> is demarcated with septa

> looks hexagonal in section
> at the angles, there are the portal triads:
sublobular v.
> interlobular a.
> perilobular a.
> interlobular v.
> perilobular v.
bile capillary
> interlobular bile duct
> canal of Hering
canal of
> in the center, is the central v. Hering

> receives mixed blood from sinus

hepatic duct
> drained by the sublobular v.
hepatic portal v.
Dr. Endre Dob hepatic a. proper
 Hepatic lobule portal lobule hepatic acinus

Hepatic lobule - draining area of the central vein; anatomical and morphological
unit
Portal lobule draining area of the bile duct; exocrine gland unit
Hepatic acinus - supply region of the perilobular vessels; biochemical and
pathological unit
 Hepatocyte and the space of Disse
Disses space

lipid mitochondria

rER bile capillary

lysosomes
hepatocyte
Golgi Golgi
sER occluding junction

rER
glycogen microvilli

Disses space
endothel

reticular fibers
46. Liver (HE)

central vein

Portal triads

Portal triads

septum
46. Liver (HE) 5x
Portal triad

central vein

Portal triad

Portal triad
46. Liver(HE) 10x
Interlobular
bile duct

Interlobular v. Interlobular
bile duct
Interlobular a.

Interlobular a.
 46. Liver (HE) 40x hepatocytes

Interlobular v.

Interlobular a.

Interlobular bile duct

 46. Liver (HE) 50x
hepatocytes

sinusoids

Nucleus of the hepatocyte

Liver (Silver impregnation) Reticular fibers

sinusoids
Liver Kupffer cells (HE & trypan-blue)

Kupffer cells
 49. Gallbladder (HE)
Histological layer of gallbladder:

1) Tunica mucosa
- Lamina epithelialis is simple columnar
epithelium with microvilli.
- Lamina propria consists of loose connective
tissue. Small tubulo-alveolar mucous
glands are present near the neck of
gallbladder.
/Mucous membrane is thrown into many folds,
which subdivide into other small folds./

2) Tunica muscularis
Its an irregular network smooth muscle fibers,
which are traversed by elastic fibers as
well as connective tissue septa.

3) Tunica serosa/adventitia
tunica serosa simple squamous epithelium
(mesothelium) and thin connective tissue
sublayer (lamina propria serosae).
tunica adventitia this region is not enveloped
by peritoneum, the outermost layer is
loose connective tissue.
 49. Gallbladder (HE) 5x

Tunica mucosa

Tunica adventitia

Tunica
muscularis Lumen

Mucosal fold
 49. Gallbladder (HE) 10x

Simple columnar
Tunica mucosa epithelium

Tunica
serosa
Mucosal
fold

Lamina
Tunica propria
muscularis
49. Gallbladder (HE) 40x

Lamina propria

Simple columnar epithelium

Lamina propria

Simple columnar epithelium

Lamina propria
50. Pancreas (HE) 2x

Adipocytes

Blood vessels
in the septum

Islet of
Langerhans

septum Adipocytes

Interlobular
duct

Intralobular Islets of
duct Langerhans
50. Pancreas (HE) 10x
Serous
Adipocytes glandular
Peripheral nerve cells

Intralobular
duct Islets of
septum Langerhans

Blood vessels
Serous
glandular
cells
Intralobular
duct

Interlobular duct

Intralobular
duct Islets of
Langerhans
50. Pancreas (HE) 40x

Capillaries

Serous glandular
cells
Intercalated duct
50. Pancreas (HE)
Exocrin gland

Acinus Centroacinar cells

Centroacinar cells
50. Pancreas (HE) Islet of Langerhans
Endocrin gland

Islets of Langerhans

Islets of Langerhans