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Abstract

Background: Hyperlipidemia is a lipid metabolism disorder which characterized by the


increasing of cholesterol or triglycerides serum above normal range and decreasing level of tulis
kepanjangannya (HDL) serum in blood. Utilization of Persea americana and Moringa oleifera
leaves can be used as non-pharmacological therapies for increasing nah yg ini tanpa ada
kepanjangannya juga gapapa HDL level. Increased of HDL level can reduce the risk of coronary
heart. Moringa leaves contain flavonoid and compounds such as Cu and Zn. Flavonoid prevents
LDL oxidation through donate H+ and inhibite 3-hydroxy-3-methylglutaryl-coenzyme reductase
(HMG-CoA reductase) activities. Meanwhile, Cu and Zn compound increase the kepanjangannya
(SOD) activation. Moringa leaves contain flavonoid which prevents increasing of O2, and cut off
lipid and vitamin C peroxidation to increase Lecithin Cholesterol Acyl Transfarase (LCAT)
activities. This research aims to determine the steeping combination of Moringa and Avocado
leaves effect to gainst HDL level for hyperlipidemia rat model.

Method: The study design which used is true experimental design by using pre-test and post-
test with control group design on 36 white rats. Rats were divided into 6 groups. Rats were
divided into negative control (A), single dose of Avocado leaves steeping treatment (B), single
dose of Moringa leaves steeping treatment (E), combination treatment 1 (C), combination
treatment 2 (D), group of simvastatin (F). Data were analyzed by Shapiro Wilk test, ANOVA
hypotesis test, and Duncan post-hoc.

Results: ANOVA tests showed significant finding on post-test measurement (p = 0.008), which
means Ha is accepted. Data group analysis of the moringa and avocado leaves steeping
combination treatment showed no significant difference between D, F, and C group. This result
showed that neither avocado and moringa leaves steeping combination dose nor simvastatin dose
are equally srong to increase HDL levels on hyperlipidemia rat model.

Conclusion: The steeping combination of Moringa and Avocado leaves has an effect to
increasing HDL level. The suggested stepping combination is 18 mg / 200gramWeight avocade
leaf and 27 mg / 200gramWeight moringa leaf.

Keywords: Avocado leaf, moringa leaf, simvastatin, HDL

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