.....................................................

2
Tyramine...........................................................15
Sympathomimetic Amines ....16
Adrenergic agonist .........................17
Baroreceptor ............................20
phenylephrine Histamine .................21
catecholamines 15 ,....22
...........................................23
...........................................................................26

p.1~6

p.7~10

p.11~15

1
 PeripheralAutonomicSystem
:
1

(1)

A.
a.

B.
a.
b.
C. ACh Nicotinic
receptor E(85%) NE15%
(2)
2



Ach NE() recepto
Nicotinic r
receptor(Ng Ach
) muscarinic
receptor
Dopamine
D1
receptor
ACh muscarinic
receptor
2
(1)!!

3
(2)










3
(1)Catecholamine

OH 4 NH-
OH R
 A. 3,4 -OH
Catecholamine
(2)Catecholamine

A. Catecholamine Catechol -amine

B. Catecholamine NE E

C. EXENEisoproterenol
D.
E.
a. 3,4 -OH (BBB)

b. COMT MAO

(3)Noncatecholamine

5
 A. 3,4-OH
Noncatecholamine
B. EXphenylephrine ephedrine
Amphetamine
C.
a. -OH
BBB
b. COMTMAO
4 Catecholamine

6
5

7
 (1)

(2)
A. 1
a.
b.
c.
d.
B. 2
a. NE

8
 b.
C. 1
a.
b.
c. renin()
D. 2
a.
b.
c.
E. 3
a.
6 Catecholamines

(1)Catecholamines MAO

9
 COMT
(2) Metanephrine VMA E NE

7 Epinephrine

(1)(adrenal medulla) 85%

(epinephrine)
(112)

10
8
(1) 3,4-OH
A. CatecholaminesNE, E, Dopamine, Isoproterenol
B. Non-Catecholaminesephedrine, phenylephrine
(2) A. Direc-acting drugs
NE, E,
phenylephrine,methoxamine B. Indirect-acting drugs
NE NE
tyramine, amphetamine C. Dual-acting drugs
E9
(3)
()

A. Ca2+
B. Ca2+ NE
C. NE receptor
D. NETNE transporter
E.

11
 ()
Amphetamine NE NE

A. NE NET reversed transport

NE NE
B. NE NE
Cocaine()
Cocaine NE
A. Cocaine

NE
N ET
NE

12
(4)

Pretreatment

epinephrine tyramine
denervation
E NE
E
NE

reserpine E Reserpine
NE NE
NE
NE tyramine
NE

NE
cocaine E Cocaine NE
NE E
NE NE NE NE

13
A. tyramine NE
B. epinephrine

C. NE

14
 Tyramine

1. Tyramine

1. Tyramine tyrosine
2. Tyramine MAO (monoamine oxidase) DBH (dopamine
beta hydroxylase)
3. Tyramine NE DBH
octopamine NE NE
2. Tyramine

MAOI
MAO
(monoamine oxidase inhibitor)

1. tyramine NE 3. No tyramine NE
4. tyramine
2. tyramine NE
octopamine octopamine NE
NE

15


3 Tyramine MAOI

Sympathomimetic Amines

16
 1. isoproterenol
2. 3,4 C -OH
3. -CH4 MAO
4. -OH
Adrenergic agonist

1. Adrenergic agonist ()

1
1.
1>2>>>>> 2. (
Phenylephrine Selective 1 )
Methoaxone agonist
( 1 )
Alpha 3.
agonists

2
2>1>>>>> 1.
Clonidine
Selective 2
Methylnorepinep
agonist 2.
hrine
( 2 ) 3.

Mixed Norepinephrine 1=21>>2 1.
and
agonists
2. 2()


17
 ( no,
2)

Epinephrine 1=21=2

1
1>2>>>>>

Selective 1
Dobutamine
agonist

( 1 )

Beta
Isoproterenol 1=2>>>>
agonists
Terbutaline
2>1>>>>> 2
Metaproterenol
Selective 2
Albuterol
agonist
(
Ritodrine ( 2 )
)()
Dopamine
D1()D2
Dopamine Dopamine D1=D2>>>> 1
agonists
1
Fenoldopam D1>>D2

18
2. 3 catecholamine Norepinephrine,
epinephrine, isoproterenol
R

I>E>NE
I>E>NE
(1)
E NE I

(2)
potency(
) I>E>NE I

NE
(1)

19
 Baroreceptor
:




(
)

baroreceptor
,
,

(),
,
,


baroreceptor ,,
,,,,

20
 phenylephrine Histamine
:

21


catecholamines 15 ,

22
#

23


()
:
1 :
PhenylephrineMethoxaminemetaraminolmepherter
mine
i. Phenylephrine catecholamine ,
COMT
ii. ,(nasal decongestant)
(hypotension)
iii. (mydriatic)
2 :
i. Clonidine
1.
2. (
Catecholamine, 1,1 ,
2 norepinephrine ,
clonidine NE
24
 )
3. (2 )
4. Apraclonidine & brimonidine
,,
5. autoreceptor, NE
ii. Methyldopa

iii. 1 adrenergic agonist

1. :Isoproterenol and dopamine
Isoproterenol
,
Dopamine( D1 receptor
, 1
receptor 1
)
2. :dobutamine & prenalterol
25
 dobutamine:,

iv. 2 adrenergic agonist

26

:
103
6.?
(A)Dopamine
(B)Histamine
(C)Acetylcholine
(D)Norepinephrine
(C)Acetylcholine
Acetylcholine

13. 2-Adrenergic receptor

(A)
(B)
(C)
(D)
(C)
2-Adrenergic receptor NE

14.?
(A)Muscarinic Receptor
(B) 2-Adrenergic receptor
(C) 1-Adrenergic receptor
(D) 1-Adrenergic receptor
(D) 1-Adrenergic receptor
1

27
15. Norepinephrine
(A)Muscarinic Receptor
(B) 2-Adrenergic receptor
(C) 1-Adrenergic receptor
(D) 1-Adrenergic receptor
(B) 2-Adrenergic receptor
2-Adrenergic receptor NE

16. Renin
(A) 2-Adrenergic receptor
(B) 2-Adrenergic receptor
(C) 1-Adrenergic receptor
(D) 1-Adrenergic receptor
(C) 1-Adrenergic receptor
renin 1

17.
(A) 2-Adrenergic receptor
(B) 2-Adrenergic receptor
(C) 1-Adrenergic receptor
(D) 1-Adrenergic receptor
(A) 2-Adrenergic receptor
2 ( p8 )

18. -Antagonist

(A)Atenolol
(B)Propranolol
(C)Labetalol

28
(D)Timolol
(A)
2 ,2
2 12 2>>>1 A

19. 1
(A)
(B) Renin
(C)
(D)
(C)
2

20.
(A)Phenylephrine
(B)Morphine
(C)Neostigmine
(D)Succinylcholine
(A)

(A)Phenylephrine ,,
(B)Morphine
(C)Neostigmine (
)
(D)Succinylcholine

21. 2 Agonist
(A)Isoproterenol
(B)Timolol

29
(C)Metoprolol
(D)Terbutaline
(D)
Ritodrine Terbutaline
(A)Isoproterenol: Adams-stokes
(B)Timolol:
(C)Metoprolol:
(D)Terbutaline:
used as a "reliever" inhaler in the management of asthma
symptoms and as a tocolytic (anti-contraction medication) to
delay preterm labor for up to 48 hours ---------------Wikipedia
In the U.S., terbutaline (Brethine) is one of the most frequently
used drugs in the treatment of preterm labor

22. Propranolol
(A)
(B)
(C)
(D)
(C)
Propranolol 2

23.
(A)Dopamine
(B) Phenylephrine
(C) Isoproterenol
(D)Clonidine
(B)

30
()

24.
(A)Reserpine
(B)Amphetamine
(C)Ephedrine
(D)Isoprenaline
(A)
Reserpine

101
20.Ephedrine
(A)
(B)
(C)
(D)
(A)
2-adrenergic receptor

21.
(A)Phenylephrine
(B)Amphetamine
(C)Metaraminol
(D)Ephedrine
(A)
()

22.

31
(A)Epinephrine
(B)Isoproterenol
(C)Norepinephrine
(D)Propanolol
: (A)

(A)(B)(C) Epinephrine
(D)Propanolol

23.

(A)Adrenaline
(B)Noradrenaline
(C)Dopamine
(D)Phenylephrine
(C)
D1 ()D2,
1 , 1,

24. Norepinephrine
(A)Tyramine
(B)Imipramine

32
(C)Pargyline
(D)Ritodrine
(A)Tyramine
Tyramine NE DBH
octopamine NE NE
25. 1-receptor
(A)
(B)
(C) Renin
(D)
(B)

28.
(A)
(B)
(C)
(D)
(D)

:
1.
1.Phenoxybenzamine 2.Prazosin 3.Propanolol 4.Phentolamine
(A) 1+2+3+4
(B) 2+3+4
(C) 2+3
(D) 1+2+3
(A)
Phenoxybenzamine -Adrenergic receptor antagonists

33
 pheochromocytoma-induced hypertension

34
2. Sympathomimetic drugs
1. Anaphylactic shock 2. Decongestant 3. Hypotension
4. Local Anesthetics
(A) 1+2+3
(B)2+3+4
(C)1+3+4
(D)1+2+3+4
(D)
Sympathomimetic drugs

3.
(A) Epinephrine
(B) Pro()
(C) Isoproterenol
(D) Phenoxybenzamine
(D)
Phenoxybenzamine -Adrenergic receptor antagonists
postural hypotension and reflex tachycardia
pheochromocytoma-induced hypertension

4. -adrenergic antagonist ?
1.(arrhythmia) 2. (glaucoma) 3.(angina
pectoris) 4.(asthma)
(A)1+2+3+4
(B)2+3+4
(C)1+3+4
(D)1+2+3

35
(D)
5. 1 -adrenergic receptor?
(A)Propranolol
(B) Yohimbine
(C)
(D) Phentolamine
(C)
propranolol 1=2yohimbine
2>1phentolamine 1=2 C

6. phenylephrine (??)?
1. Reflex tachycardia() 2.
hypertension 3.irreversibility block -adrenergic receptor4.
.!
(A)1+2+3+4
(B)2+3+4
(C)1+3+4
(D)1+2+3
(C)
phenylephrine

7. 1-adrenergic receptor ?
1.Propranolol 2.Acebutolol 3.Ate( Atenolol)
4.Penbutolol
(A)1+2+3+4 (B)2+3+4 (C)1+3+4 (D)1+2+3

Propranolol 12
Acebutolol 1
Atenolol 1

36
Penbutolol 12

8. Epinephrine
Precursor
(A)Tyrosine
(B)Dopamine
(C)Norepinephrine
(D)Tryptophan
(D)

9. Norepinephrine
ATyrosine
BDopaminebeta-hydroxylase
CTryptophan
DaromaticL-amino acid decarboxylase
(C)

10.

AEpinephrine
BNorepinephrine
CAcetylcholine
DSerotonin
(B)

11. adrenoceptor adenylyl cyclase

A1
B2

37
C1
D2
(B)

12. norepinephrine
A
B
C
D
(D)

13. catecholamines
(A) Reserpine
(B)Dopamine
(C)Methyltyrosine
(D)Cocaine
(D)

14. 2-adrenergic agonists

ARitodrine
BAlbuterol
CTerbutaline
DMetaproterenol
(A)
2
Ritodrine 2
1

38
15. IVintravenous Phenylephrine

A
B
C
D
(C)
Phenylephrine 1 receptor 1
1B

16. Norepinephrine
ACocaine
BTricyclic antidepressants
CAmphetamine
DGuanethidine
(C)

(A)(B) CocaineTricyclic antidepressants NET NE

NE
Camphetamine NE NET NE
NET NE vesicle NE
DGuanethidine vesicle NE

17. Adenylyl cyclase

ADobutamine
BClonidine
CRitodrine
DPhenylephrine
(B)

39
2 Adenylyl cyclase
ADobutamine 1
BClonidine 2
CRitodrine 2
DPhenylephrine 1

18. Intravenous infusionnorepinephrine

epinephrine
1. Norepinephrine cardiac output
2. Epinephrine
3. Epinephrine heart rate
4. Norepinephrine
A1+2+3+4
B2+3+4
C1+3+4
D1+2+3
(A)

(1)NE 12121
1
baroreceptor cardiac output
(2)(3)Epi 1=21=22
1 1
baroreceptor
(4)NEEpi BBB

19. epinephrine precursor

1.tryptophan 2.dopamine 3. 4.Methyldopa

40
A1+2+3
B2+3+4
C1+2
D2+3
(D)
Epinephrine Tyrosine Dopa dopamine
norepinephrine epinephrine

20. epinephrine
1. 2. 3. 4. -
adrenergic receptor
A1+2+3+4
B1+2+3
C1+2
D1+2+4
(A) (D)
epinephrine 112 1
1 /2

21. renin
A1-
B2-
C1-
D2-
(C) 1 /

22. reserpine

Acocaine

41
Btyramine
Cguanethidine
Disoproterenol
(C)
Cocaine NE
tyramine NE
Guanethidine SNAPs NE
Isoproterenol -adrenergic receptor
guanethidine C
23. 1-
A
B
C
D
(B)

24. Catecholamines
(A) Metyrosine
(B) ?
(C) Carbidopa
(D) Tyramine Metyrosine

( B)

Metyrosine tyrosine Dopa

tyrosine hydroxylase
Carbidopa
Tyramine NE NE
receptor

42
 A, C, D B
B Cocaine Tricyclic antidepressants

25.
(A)
(B)
(C)
(D)
(B) or (D)

(1)
(2) fight or flight

26. norepinephrine ?
(A) Carbidopa
(B) Reserpine
(C) Cocaine
(D) Bretylium
(E) Tyramine
(E)

(1) E
Tyramine NE
Tyramine amphetamine NE NE
receptor
(2) Carbidopa

43
Levodopa dopamine dopamine
dopamine
decarboxylase carbidopa
benserazide levodopa decarboxylation
levodopa levodopa
decarboxylase levodopa
Carbidopa
levodopa 70-75% levodopa
dopamine homovanillic acid
dopamine dopamine
Benserazide hydrochloride carbidopa Pyridoxine
hydrochloridevitamin B6
levodopa carbidopa pyridoxine
(3) Reserpine NE
(4) Cocaine NE reuptake
Bretylium

27. 15 IV infusion norepinephrine

epinephrine ? 1norepinephrine
2norepinephrine 3epinephrine
4epinephrine
(A) 1+2+3+4
(B) 1+2+3
(C) 1+3+4
(D) 2+3
(E) 2+4
(D)

44
1NE 12121
1
baroreceptor cardiac output
23Epi 1=21=22
1 1
baroreceptor
4NEEpi BBB

45
28. epinephrine ?
1 glucose 2 lactic acid 3triglyceride 4free fatty
acid
(A) 1+2+4
(B) 1+2+3
(C) 1+3+4
(D) 2+3+4
(E) 2+4
(A)
epinephrine beta-receptor
glucoselactic acidfree fatty acid

29. insulin?
(A) 3-
(B) 2-
(C) 1-
(D) 2-
(E) 1-
(D)

30. norepinephrine precursor?

(A) phenylalanine
(B) Tyramine
(C) Glutamate
(D) Tyrosine
(E) Tryptophan
(D)
Tyrosine Dopa Dopamine Norepinephrine Epinephrine

46
31. norepinephrine ?
A MAO
B
C
D
E
(C)
norepinephrine

32. IV histamine ?
(A)
(B)
(C)
(D)
(E)
(B)
histamine

33.
1 2 renin secretion34

(A)1+4
(B)2+3
(C)1+3+4
(D)1+2+3+4
(A)
Fight or Flight
renin
secretion

47
34. 3adrenergic receptor
(A) renin
(B)
(C)
(D)
(E)
(B)
3

35. catecholamines
(A) Methyltyrosine
(B) Amphetamine
(C) Carbidopa
(D) cocaine
(E) reserpine
(D)
Cocaine NE NET NE

36. 1adrenergic receptor

(A) phenylephrine
(B) Tyramine
(C) Dobutamine
(D) Cocaine
(E) reserpine
(C)
1adrenergic agonist Dobutamine Prenalterol
Dobutamine

48
37. sympathomimetic drugs

(A) amino group alkyl substituents

receptor
(B) carbon atom hydroxy group
(C) aromatic nuclei 3 4 hydroxy group
receptorreceptor
(D) carbon atom
(E)
(D)
MAO

49