Stability Trial

temp zero 1St 2nd
30C -0.9897 -0.991 0.9921

40C -0.99597 -0.9985 0.9984
50C -0.9971 -0.9965 0.9785
-0.9942566667 -0.995333 0.9896666667
1 1-
995 0.995
Calculation of K constant
AS First order
AT 30C
r= -0.990966
Slope -0.001281
intercept 2.0031
Slope=-k/2.303
K =-(slopX2.303
K30C 0.002950143
AS First order
AT 40C
Slope -0.007104
intercept 2.015807
r= -0.998548
Slope=-k/2.303
K =-(slopX2.303
K30C 0.016360512
AS First order
AT 50C
r= -0.996497
Slope -0.073075
intercept 2.0566
Slope=-k/2.303
K =-(slopX2.303
K30C 0.168291725
Arrehenius Equation for Calculation of the Degradation rate K at room temperature 25C
TEMPC Absolute Temp 1/T Degradation rate constan
25 298 0.0033557
30 303 0.00330033 0.002950143
40 313 0.00319489 0.016360512
50 323 0.00309598 0.168291725
table between 1/T&log K

no X Y x-X
1 0.00330033 -2.53015693 0.0001032656
2 0.0031948882 -1.78620311 -5.1118210862623E-006
3 0.0030959752 -0.77393724 -0.0001040248
Sum 0.0095911934 -5.09029728 -0.000005871
AVG 0.0031970645 -1.69676576
0.0032 -1.69676576
0.0032 -1.69676576
0.0032 -1.69676576
r pearson
sum(x-X)(y-Y r=
root(sumx-x2)(sumy-y2)
Slope
intercept
LOgC90%=-KT +logC0
2.303
-3.72E+03
90
Time
logCo=LogC+KT/2.303
KT/2.303=logCo-LogC
KT=logCo-LogC*2.303
T=logCo-LogC*2.303
K
0
0.003 0.0032 0.0034
-0.5
-1 f(x) = - 8577.07231026
R = 0.9887169596
-1.5
-2
-2.5
-3
K at room temperature 25C
Log K
-2.5301569
-1.7862031
-0.7739372
y-Y x-X2 y-Y2 (x-X)(y-Y)

-0.8333912 1.066377E-008 0.6945408463 -8.60606E-005
-0.0894373 2.613071E-011 0.0079990394 4.571877E-007
0.92282852 1.082115E-008 0.851612481 -0.000095997
2.916E-010 2.151106E-008 1.5541523667 -0.0001816004
corelation coeffecient
-0.9932057107
-8577.1 equal equal8577.1

25.725 -8.58E+03 1.98E+04
-4.30E+00
+logC0
-3.72E+03 Err:502
log90 log100%
1.95424251 2
week days
0.04575749 0.1053795008 120.2605399781 841.82377985
0
0.003 0.0032 0.0034
-0.5
-1 f(x) = - 8577.0723102634x + 25.7246874774

R = 0.9887169596 Column C
-1.5
Linear (Column C)
-2
-2.5
-3
3.34314604349645E-008
1.98E+04
-2.96E-01
year
2.3063665201
0.0001828427
1.00E+04
30C 40C 50C
No Time(week concentrati No Time(week) concentrat No Time(week concentration%

1 0 100 1 initial 100 1 initial 100
2 4 100 2 4 98 2 4 95
3 8 98 3 8 90 3 8 80
4 12 97 4 12 85 4 12 70
5 16 96 5 16 80 5 16 60
6 20 95 6 20 75 6 20 50
7 24 94 7 24 70 7 24 40
calculation corelation coeffecient to determine Degradation order
Zero order
N x Y x-X y-Y x-X2 y-Y2 (x-X)(y-Y)

1 1 95 -2.5 29.166666667 6.25 850.6944 -72.91667
2 2 80 -1.5 14.166667 2.25 200.6945 -21.25
3 3 70 -0.5 4.166667 0.25 17.36111 -2.083334
4 4 60 0.5 -5.833333 0.25 34.02777 -2.916667
5 5 50 1.5 -15.833333 2.25 250.6944 -23.75
6 6 40 2.5 -25.833333 6.25 667.3611 -64.58333
6 21 395 0 1.66667E-006 17.5 2020.833 -187.5 35364.58
AV 3.5 65.833333
3.5 65.833333
3.5 65.833333
3.5 65.833333
3.5 65.833333 100
3.5 65.833333
80 f(x) = - 10.7142857143
3.5 65.833333 R = 0.9941089838
3.5 65.833333 60
40
20
0
0 1 2 3 4
80 f(x) = - 10.7142857143
R = 0.9941089838
60
40
20
r pearson corelation coeffecient
0
sum(x-X)(y-Y r= -0.997050141
0 1 2 3 4
Slope -10.714
intercept 103.33
the graph is between concentration &time Zero order
Ist order
relation between log Concentration &time
lnA=-KT+c
1 1 1.9777236 -2.5 0.1768747922 6.25 0.031285 -0.442187
2 2 1.90309 -1.5 0.102241187 2.25 0.010453 -0.153362
3 3 1.845098 -0.5 0.04424924 0.25 0.001958 -0.022125
4 4 1.7781513 0.5 -0.02269755 0.25 0.000515 -0.011349
5 5 1.69897 1.5 -0.101878796 2.25 0.010379 -0.152818
6 6 1.60206 2.5 -0.198788809 6.25 0.039517 -0.496972
6 21 10.805093 0 6.52856E-008 17.5 0.094107 -1.278812 1.64688
AV 3.5 1.8008488
3.5 1.8008488
3.5 1.8008488 2.5
3.5 1.8008488
3.5 1.8008488 2
3.5 1.8008488 f(x) = - 0.0730749945x + 2.05661129
3.5 1.8008488 1.5 R = 0.993005852
Column
3.5 1.8008488
1 Linear (
0.5
r pearson corelation coeffecient 0
sum(x-X)(y-Y r= -0.996496789 0 1 2 3 4 5 6 7
Slope -0.0731
intercept 2.0566
the graph is between logconcentration &time Zero order
2nd order
relation between 1/ Concentration &time

1 1 0.0105263 -2.5 -0.005970134 6.25 3.6E-005 0.014925
2 2 0.0125 -1.5 -0.0039964 2.25 1.6E-005 0.005995
3 3 0.0142857 -0.5 -0.002210686 0.25 4.9E-006 0.001105
4 4 0.0166667 0.5 0.0001702667 0.25 2.9E-008 8.5E-005
5 5 0.02 1.5 0.0035036 2.25 1.2E-005 0.005255
6 6 0.025 2.5 0.0085036 6.25 7.2E-005 0.021259
6 21 0.0989787 0 2.47285E-007 17.5 0.000141 0.048625 0.00247
AV 3.5 0.0164964
3.5 0.0164964
3.5 0.0164964 0.03
3.5 0.0164964
3.5 0.0164964
0.025
3.5 0.0164964 0.02 f(x) = 0.0027785535x + 0.00677151
3.5 0.0164964 R = 0.9574152764 Column
3.5 0.0164964
0.015
0.01 Linear (
0.005
r pearson corelation coeffecient 0
sum(x-X)(y-Y r= 0.9784764375 0 1 2 3 4 5 6 7
Slope 0.0028
intercept 0.0068
the graph is between logconcentration &time Zero order
Ist order
concentration%
sum(x-X)(y-Y
188.0547
00
80 f(x) = - 10.7142857143x + 103.3333333333
R = 0.9941089838
60 Column C
40 Linear (Column C)
20
0
0 1 2 3 4 5 6 7
80 f(x) = - 10.7142857143x + 103.3333333333
R = 0.9941089838
60 Column C
20
0
0 1 2 3 4 5 6 7
on &time Zero order
sum(x-X)(y-Y
1.283308
0730749945x + 2.0566112938
3005852
Column C
Linear (Column C)
4 5 6 7
ration &time Zero order
sum(x-X)(y-Y
0.049694
0027785535x + 0.0067715121
9574152764 Column C
Linear (Column C)
4 5 6 7
ration &time Zero order

30C 40C 50C
No Time(week concentrat No Time(week) concentrat No Time(week concentration%

1 0 100 1 initial 100 1 initial 100
2 4 100 2 4 98 2 4 95
3 8 98 3 8 90 3 8 80
4 12 97 4 12 85 4 12 70
5 16 96 5 16 80 5 16 60
6 20 95 6 20 75 6 20 50
7 24 94 7 24 70 7 24 40
Zero order
120
100
f(x) = - 1.3571428571x + 102
80 R = 0.9917582418
60
40
20
0
0 5 10 15 20 25

1 4 98 -10 15 100 225 -150
2 8 90 -6 7 36 49 -42
3 12 85 -2 2 4 4 -4
4 16 80 2 -3 4 9 -6
5 20 75 6 -8 36 64 -48
6 24 70 10 -13 100 169 -130
6 84 498 0 0 280 520 -380 145600
AV 14 83 90
14 83 85
14 83 80
14 83 75
14 83 70
14 83
14 83
14 83
sum(x-X)(y-Y r= -0.995870595
Slope -1.3571
intercept 102
the graph is between concentration &time Zero order
Ist order
lnA=-KT+c

1 4 1.991226 -10 0.0748699422 100 0.0056055082 -0.748699
2 8 1.954243 -6 0.0378865094 36 0.0014353876 -0.227319
3 12 1.929419 -2 0.0130629257 4 0.00017064 -0.026126
4 16 1.90309 2 -0.013266013 4 0.0001759871 -0.026532
5 20 1.875061 6 -0.041294737 36 0.0017052553 -0.247768
6 24 1.845098 10 -0.07125796 100 0.0050776969 -0.71258
6 84 11.49814 0 6.67703E-007 280 0.0141704751 -1.989024 3.967733
AV 14 1.916356
14 1.916356
14 1.916356
14 1.916356
14 1.916356
14 1.916356
14 1.916356
14 1.916356

sum(x-X)(y-Y r= -0.998547857
Slope -0.0071
intercept 2.0158
2.05
2
f(x) = - 0.0071036633x + 2.0158074191
1.95 R = 0.9970977551
Column C
1.9 Linear (Column C)
1.85
1.8
1.75
0 5 10 15 20 25 30
f(x) = - 0.0071036633x + 2.0158074191
1.95 R = 0.9970977551
Column C
1.85
1.8
1.75
0 5 10 15 20 25 30
2ndorder
relation between1/concentration&time
lnA=-KT+c

1 4 0.010204 -10 -0.001995743 100 0.000003983 0.019957
2 8 0.011111 -6 -0.001088889 36 1.18568E-006 0.006533
3 12 0.011765 -2 -0.000435294 4 1.89481E-007 0.000871
4 16 0.0125 2 0.0003 4 0.00000009 0.0006
5 20 0.013333 6 0.0011333333 36 1.28444E-006 0.0068
6 24 0.014286 10 0.0020857143 100 4.35020E-006 0.020857
6 84 0.073199 0 -8.7813E-007 280 1.10828E-005 0.055618 0.003103
AV 14 0.0122
14 0.0122
14 0.0122
14 0.0122
14 0.0122
14 0.0122
14 0.0122
14 0.0122
sum(x-X)(y-Y r= 0.9984251028
Slope 2.00E-04
intercept 0.0094
0.016
0.014
f(x) = 0.0001986437x + 0.009418812
0.012 R = 0.9968526029
0.01
0.008 Column C
0.004
0.002
0
0 5 10 15 20 25 30
0.008 Column C
0.004
0.002
0
0 5 10 15 20 25 30
concentration%
= - 1.3571428571x + 102
= 0.9917582418
Column F
Linear (Column F)
10 15 20 25 30
sum(x-X)(y-Y
381.5757
&time Zero order
sum(x-X)(y-Y
1.991917
sum(x-X)(y-Y
0.055706
30C 40C 50C
No Time(week concentrat No Time(week) concentrat No

1 0 100 1 initial 100 1
2 4 100 2 4 98 2
3 8 98 3 8 90 3
4 12 97 4 12 85 4
5 16 96 5 16 80 5
6 20 95 6 20 75 6
7 24 94 7 24 70 7
Zero order
101
100
99 f(x) = - 0.2857142857x + 100.6666666667
98 R = 0.9795918367
97
96
Column C
94
93
92
91
0 5 10 15 20 25 30
N x Y x-X y-Y x-X2 y-Y2
1 4 100 -10 3.3333333333 100 11.11111
2 8 98 -6 1.3333 36 1.777689
3 12 97 -2 0.3333 4 0.111089
4 16 96 2 -0.6667 4 0.444489
5 20 95 6 -1.6667 36 2.777889
6 24 94 10 -2.6667 100 7.111289
6 84 580 0 -0.0001666667 280 23.33356
AV 14 96.66667
14 96.6667
14 96.6667
14 96.6667
14 96.6667
14 96.6667
14 96.6667
14 96.6667

sum(x-X)(y-Y r= -0.9897427294
Slope -0.2857
intercept 100.67
the graph is between concentration &
Ist order
lnA=-KT+c

1 4 2 -10 0.0148132497 100 0.000219
2 8 1.991226 -6 0.0060390757 36 3.6E-005
3 12 1.986772 -2 0.0015847343 4 2.5E-006
4 16 1.982271 2 -0.002915767 4 8.5E-006
5 20 1.977724 6 -0.0074633947 36 5.6E-005
6 24 1.973128 10 -0.0120591464 100 0.000145
6 84 11.91112 0 -1.24842762150301E-006 280 0.000468
AV 14 1.985187
14 1.985187
14 1.985187
14 1.985187
14 1.985187
14 1.985187
14 1.985187
14 1.985187

sum(x-X)(y-Y r= -0.9909654388
Slope -0.0013
intercept 2.0031
2.005
2
1.995 f(x) = - 0.0012812046x + 2.0031236148
1.99 R = 0.9820143524
1.985 Column C
1.975
1.97
1.965
1.96
1.955
0 5 10 15 20 25 30
2ndorder
relation between1/concentration&time
lnA=-KT+c

1 4 0.01 -10 -0.0003491067 100 1.2E-007
2 8 0.010204 -6 -0.0001449184 36 2.1E-008
3 12 0.010309 -2 -3.97216494845368E-005 4 1.6E-009
4 16 0.010417 2 6.76666666666655E-005 4 4.6E-009
5 20 0.010526 6 0.0001773158 36 3.1E-008
6 24 0.010638 10 0.0002892979 100 8.4E-008
6 84 0.062095 0 5.33593041080263E-007 280 2.6E-007
AV 14 0.010349
14 0.010349
14 0.010349
14 0.010349
14 0.010349
14 0.010349
14 0.010349
14 0.010349
sum(x-X)(y-Y r= 0.9920730682
Slope 3.00E-05
intercept 0.0099
0.0108
0.0106 f(x) = 3.04684296308228E-005x + 0.0099225487

R = 0.9842406158
0.0104
0.0102 Column C
Linear (Column C)
0.01
0.0098
0.0096
0 5 10 15 20 25 30
Time(week concentration%
initial 100
4 95
8 80
12 70
16 60
20 50
24 40
(x-X)(y-Y) sum(x-X)(y-Y
-33.33333
-7.9998
-0.6666
-1.3334
-10.0002
-26.667 root(sumx-x2)(sumy-y2)
-80.00033 6533.396 80.82942
is between concentration &time Zero order
-0.148132
-0.036234
-0.003169
-0.005832
-0.04478
-0.120591 root(sumx-x2)(sumy-y2)
-0.35874 0.131052 0.36201
olumn C
near (Column C)
30
0.003491
0.00087
7.9E-005
0.000135
0.001064
0.002893 root(sumx-x2)(sumy-y2)
0.008532 7.4E-005 0.0086
05x + 0.0099225487
Column C
Linear (Column C)
20 25 30

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temp zero 1St 2nd

30C -0.9897 -0.991 0.9921

table between 1/T&log K

y-Y x-X2 y-Y2 (x-X)(y-Y)

-8577.1 equal equal8577.1

-1 f(x) = - 8577.0723102634x + 25.7246874774

No Time(week concentrati No Time(week) concentrat No Time(week concentration%

calculation corelation coeffecient to determine Degradation order

N x Y x-X y-Y x-X2 y-Y2 (x-X)(y-Y)

N x Y x-X y-Y x-X2 y-Y2 (x-X)(y-Y)

on &time Zero order

ration &time Zero order

ration &time Zero order

No Time(week concentrat No Time(week) concentrat No Time(week concentration%

calculation corelation coeffecient to determine Degradation order

N x Y x-X y-Y x-X2 y-Y2 (x-X)(y-Y)

N x Y x-X y-Y x-X2 y-Y2 (x-X)(y-Y)

r pearson corelation coeffecient

N x Y x-X y-Y x-X2 y-Y2 (x-X)(y-Y)

No Time(week concentrat No Time(week) concentrat No

calculation corelation coeffecient to determine Degradation order

r pearson corelation coeffecient

N x Y x-X y-Y x-X2 y-Y2

r pearson corelation coeffecient

N x Y x-X y-Y x-X2 y-Y2

0.0106 f(x) = 3.04684296308228E-005x + 0.0099225487

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