Professional Documents
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WOUND INFECTION
Wound infection appears as a result of the infection of scratches, fissures,
ruptures of the neck, mucous tunic of the vagina and vulva, wounds after excision of the
perineum, anterior abdominal wall after cesarean section.
Inflammatory reaction is characterized by such general clinical manifestations:
local inflammatory reaction: pain, hyperemia, edema, local temperature rise,
malfunction of the injured wound;
generalized reaction of the organism: hyperthermia, intoxication signs
(general weakness, tachycardia, ABP decrease, tachypnoe).
Diagnostics takes into account the following data:
clinical: examination of the injured surface, assessment of the clinical
presentation, complaints, anamnesis;
laboratory: common blood analysis (leucogram), common urine analysis,
bacteriological investigation of the exudate, immuno-grara;
instrumental: US.
Clinical signs of wound infection development in the wounds healing by primary
intention:
a) complaints:
of intensive, often throbbing pain in the region of the wound;
of body temperature rise subfebrile or to 3839 C;
b) local changes:
hyperemia around the wound without positive dynamics;
appearance of tissue edema, which gradually increases;
palpation detects tissue infiltration, which often increases; appearance of
deep infiltrates is possible (necrotizing fasciitis, which may spread to the buttocks,
anterior abdominal wall often a fatal complication);
serous exudate often changes to pus.
Clinical signs of wound infection development in the wounds healing by
secondary intention:
progressing edema and infiltration of the tissue around the wound;
appearance of dense painful infiltrates without clear contours;
signs of lymphangitis and lymphadenitis;
wound surface is covered with continuous fibrinopurulent incrustation;
deceleration or cessation of epithelization;
granulations become pail or cyanotic, their hemorrhagic diathesis sharply
decreases;
exudate quantity increases, its character depends on the agent:
staphylococcus conditions the appearance of thick yellowish pus, and some
strains cause the development of local putrid infection with the formation of the foci of
tissue necrosis and grayish pus with sharp smell;
streptococcus is characterized by the appearance of liquid pus of yellow-green
color, ichor;
colibacillary and enterococcal infections condition the appearance of brown
pus with characteristic smell;
blue pus bacillus, Pseudomonas aeruginosa, leads to the appearance of green
pus with specific smell.
The type of the agent also defines the clinical course of wound infection:
staphylococcosis is characterized by the fulminant development of the local
process with evident manifestations of purulo-resorptive fever;
streptoroccosis has a tendency to diffuse spread in the form of phlegmon, with
low-grade local symptoms;
blue pus bacillus is characterized by the flaccid, protracted course of the local
process after acute onset with evident manifestations of general intoxication.
Bacteriological investigation of exudate is conducted with the purpose of
detecting the agent and its sensitivity to antibiotics. Material sampling is to be
performed before the beginning of antibiotic therapy. Material for the investigation may
be the exudate, pieces of tissue, lavage from the wound. Material is taken with sterile
instruments and placed in sterile tubes or vials with standard medium. Material is to be
inoculated in the course of 2 h after sampling. Simultaneously with material sampling
for bacteriological investigation one should perform not less than two Gram-stained
smears for express-diagnostics.
There may be used accelerated methods of identifying the wound infection agent
with the help of multimicrotest systems, lasting 4 6h.
In the absence of microbal growth in the clinical material one should exclude
such reasons:
presence of high concentrations of local or systemic antibacterial preparations
in the material;
violation of the regimen of specimen storage and transportation;
procedural mistakes in the bacteriological laboratory; effective control over
the infectious wound process with antibacterial preparations.
You will find the US technique in the chapter Fetal Condition Imaging and
Assessment except for fact that the sensor is placed on the lesion area in order to image
the infiltration process.
Treatment: in most cases local treatment is sufficient. The treatment includes
surgical, pharmacological, and physiotherapeutic methods.
Surgical wound treatment The initial handling of the wound is performed by
primary indications. Repeated initial handling is performed if the first surgical
intervention was not radical for some reason and repeated intervention was necessary
before the development of i nfectious complications in the wound.
Surgical treatment of wound consists in:
removal of dead tissue -- primary necrosis substrate from the wound;
removal of hematomas (especially deep ones), foreign bodies;
final arrest of bleeding;
restoration of damaged tissues.
Secondary treatment of the wound is carried out by secondary indications, as a
rule, in connection with pyoinflammatory complications of the wound. Repeated
secondary treatment of the wound at severe forms of wound infection may be conducted
iteratively. In most cases secondary surgical treatment of wound includes:
removal of the focus of infectious-inflammatory alteration; wide opening of
recesses, leakages;
full-blown drainage providing exudate outflow.
The pharmacological method is antibiotic prophylaxis and antibiotic therapy.
Antibiotic prophylaxis is systemic administration of an antimicrobial preparation
till the moment of microbial contamination of the wound or development of
postoperative wound infection, and also if there are signs of contamination, on the
condition that primary treatment is surgical
Antibacterial prophylaxis principles:
predominately a single dose of an antimicrobial preparation, in case of long-
term anhydrous period and other risk factors of infectious complications development
one should resort to full-blown prophylactic doses;
at noncomplicated cesarean section the first dose of antibiotic is introduced
after clipping the umbilical cord and then twice more with an interval of 6 h;
the same preparation may be used for antibiotic therapy in case of
complications arising during surgery or infectious process signs detected;
prolongation of antibiotic introduction after 24 h from the moment of surgery
termination does not lead to any increase of the efficiency of wound infection
prophylaxis;
preterm prophylactic administration of antibiotics before surgical intervention
is not expedient.
Antibiotic therapy is the usage of antibiotics for long-term treatment in case of
infectious process onset. Antibiotic therapy may be:
empirical based on the usage of broad spectrum preparations, active
relative to potential agents;
object-orientated preparations are used according to the results of
microbiological diagnostics.
Local application of antiseptics is very important. For wound cleansing one can
use 10 % solution of sodium chloride, 3 % hydrogen peroxide, 1:5,000 furacilinum
solution, 0.02 % chlorhexidme solution, etc. For quicker healing one may use liners
with levomecol, levosin, synthomycin or solcoseryl ointment, etc.
Physiotherapeutic procedures in the period of reconvalescence include UHF-
inductotherapy, ultraviolet irradiation, electrophoresis with medicamental preparations.
Prophylaxis of wound infection consists in rational management of labor and
puerperal period, observance of aseptics and antiseptics.
POSTNATAL ENDOMETRITIS
Postnatal endometritis is inflammation of the superficial layer of endometrium.
Endomyoinetritis (metroendometritis) is the spread of inflammation from the basal
layer of endometrium to mvometrium. Perimetritis is the spread of inflammation from
the endometrium and myometrium to the serous uterine layer.
The initial stage of postnatal infectious process may have different intensity
and polymorphous presentation. One should differentiate classical, obliterated and
abortive forms of endomyometritis, endornyometritis after cesarean section. The
classical form usually develops on the 3rd ~5th day after delivery. This form is
characterized .by fever, intoxication, psyche alteration, evident leucocytosis with
leucogram shift to the left, pathological discharge from the uterus. At. the obliterated
form of endomyometritis disease usually develops on the 8 th-9th day after delivery,
temperature is subfebrile, local rnanifestations are low-grade. The abortive form has a
course similar to the classical form, but is quickly arrested at a high level of
immunologic;il protection. Endomyometritis after cesarean section is often complicated
with pelviperitonitis, peritonitis, which may develop during the : 1st2nd day after the
surgery.
Diagnostics is based on:
clinical data: complaints, anamnesis, clinical examination. Vaginal
examination shows the moderately sensitive uterus, subinvolution of the uterus,
purulent discharge;
laboratory data: common blood count (leucogram), common urine analysis,
bacteriological and bacterioscopic investigation of the cervical and uterine discharge
(urine and blood if it is necessary), immunogram, blood biochemistry;
instrument data: US.
Treatment: in most cases the treatment is pharmacological, but surgical is also
possible.
Complex treatment of postnatal endomyometritis includes not only systemic
antibacterial, infusion, detosication therapy, but also local treatment. Antibiotic therapy
may be empirical and object-orientated (see above). Preference is given to object-
orientated antibiotic therapy, which is possible by using accelerated methods of agent
identification (using multimicrotest system). If fever lasts during 4872 h after
treatment beginning, one should suspect resistance of the agent to the applied
antibiotics. Treatment with intravenous antibiotics is to last for 48 h after disappearance
of hyperthennia and other symptoms. Tableted antibiotics are to be administered for 5
more days. Antibiotics get into the maternal milk in small doses. In most cases it does
not lead to clinically significant consequences. Nevertheless, the immature ferment
system of the newborn may not manage the complete excretion of antibiotics, which
may cause a cumulative effect.
Local endomyometntis therapy consists in aspiration-washing drainage of the
uterine cavity with the application of a dual-lumen catheter, through which the uterine
walls are irrigated with solutions of antiseptics, antibiotics. There are used cooled to +4
C solutions of 0.02 % furacilinum, 0.02 % chlorhexine, 0.9 % isotonic solution with the
speed of 10 ml/min. Contraindications to aspiration-washing drainage of the uterine
cavity are: inconsistency of sutures on the uterus after cesarean section, infection spread
beyond the uterus, up to 34 days of puerperal period. If it is not possible to wash the
pathological inclusions in the uterine cavity by means of drainage, they are to be
removed by vacuum aspiration or careful curettage against the background of the
conducted antibacterial therapy and normal temperature if it is possible. Correct
treatment of postnatal endomyo-metritis makes the basis of the prevention of
widespread forms of infectious diseases in parturient women and their localization at
the first stage.
Surgical treatment consists in laparotomy and extirpation of the uterus without the
appendages or extirpation of the uterus with, the uterine tubes, or with the appendages,
depending on the spread of the inflammatory process. Surgical treatment is resorted to
in case of conservative treatment inefficiency and presence of negative dynamics during
the first 2448 h of treatment, development of systemic inflammatory response
symptom (SIRS).