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DOXYVA technology is a fast, reliable and effective approach for boosting

circulation and promoting wellness for patients with diabetes and varicose
veins. An interview with key opinion leader Dr. Ito Puruhito.

Effective O2 and nutrient distribution from our lungs and guts to intended to improve micro-circulation and found DOXYVA
our organ tissues depends on micro-circulation. Micro-circulation technology to be the most efficient medical device.
is where the vascular system allows the intravascular volume to
interact with the extravascular space to deliver O2 and nutrients Prof. Puruhito stated: The
and in exchange pick up metabolic waste. When these physical DOXYVA technology caught
processes are interrupted, our body becomes stressed. my attention because of its
remarkable ability to deliver such
Physiologic stress is useful and essential for our survival. For a high concentration of CO2
example, when we are sick it plays a crucial role in recruiting the directly to the bloodstream. He
immune cell protagonists to help us overcome infections and also said: The ability to interact
sickness. But when the stress transforms from a transitory state to directly with dermal capillary and
a permanent state, our body loses the capacity to self-heal and cellular receptors near the skin
achieves homeostasis over time. DOXYVA technology and its gives it the ability to produce the
revolutionary CO2 transdermal delivery allow our body to regain desired systemic effects, which is
proper micro-circulation blood flow to our organs. critical for improving micro-
circulation and wound healing.
One of the most common public health problems related with poor
microcirculation is diabetic foot ulcers. Diabetic foot ulcers are a Prof. Puruhito is part of the DOXYVA independent researcher
healthcare problem that affects more than 6.5 million patients in team. He has been studying DOXYVAs positive impact on his
the USA alone. It is expected that 15% of this population are at patients and has documented a remarkable success rate with
risk of developing diabetic ulcers. Further epidemiological studies difficult-to-treat wounds and diabetic ulcers. Also, his preliminary
have identified that almost 25% of diabetic patients are at risk of findings indicate clear improvements in health care indicators
lower extremity amputation and foot ulcers preceded 85% of all such as peripheral O2 concentration and perfusion indexes among
amputations. his patients (scientific article pending for publication). Shortly
after he recognized DOXYVAs healthcare benefits for general
Diabetic patients with concomitant foot ulcers represent a per- body health, he started to use DOXYVA on a daily basis and
patient annual health-care cost that ranges between $12,000 and said: As a researcher, it is one thing to observe results in your
$17,000. Nationally the USA spends $13 billion in healthcare patients, but another to experience them in your body. With
management of diabetic foot ulcers complication in addition to DOXYVAs transdermal technology, I had both!
the expenses associated with diabetes itself.
DOXYVAs consistent positive impact in improving micro-
To help our community to better understand the disease and the circulation and health quality is leading to new treatment options
new proposed technology for improving diabetic patients quality for other pathologies such as varicose veins and cellulite, among
of life, we interviewed Prof. Ito Puruhito, a world renowned others. We are confident that DOXYVA technology and
cardio-thoracic surgeon based in Indonesia who has shared his effective transdermal delivery of CO2 will continue to prove its
knowledge at several top universities including Harvard. Prof. capacity to help the body improve its micro-circulation and its
Puruhito has focused his research and efforts on better capacity to self-heal and achieve homeostasis.
understanding micro-circulation, particularly in the wound
healing process.
Bibliography
In our interview, Prof. Puruhito pointed out the importance of Chandan K. Sen, P. G. (2003, NovDec). Human Skin Wounds: A Major
micro-circulation health literacy among diabetic patients. He and Snowballing Threat to Public Health and the Economy.
stated: The better the circulation, the better the body can function Wound Repair Regen., 17(6), 763771.
Doupis, K. A. (2012). Management of Diabetic foot ulcer . Diabetes Ther.
in general. Micro-circulation delivers blood and oxygen directly McCall, B. (2014, march 13). Medscape. Retrieved from Medscape/News
to tissue, and when it is impaired, virtually every bodily function & Perspective .
suffers. Improving micro-circulationespecially in ulcers
developed in diabetic patientsleads to improved treatment
response, shorter healing time, and ulcer prevention. In other
words, it will improve patient quality of life and may prevent
extremity amputation. Prof. Puruhito has dedicated the last 50
years to researching how to improve microcirculation in his
patients. During this time he tested several strategies and products
Special thanks to Prof. Puruhito for allowing us to perform the interview at the International Wound Care and Biotherapy Conference in Kuala Lumpur (2015).
Dr. Ito Puruhito is a cardiothoracic surgeon with more than 50 years of experience and Professor of Surgery at Airlangga University Medical School in Surabaya,
Indonesia.
This article was published thanks to: Circularity Healthcare - DOXYVA, interviewer: Dr. Paul Kirkitelos.

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