$602.

3M
THE PATENT TRAIN
See when patents are slated to expire on these
local drugs, ranked at right by their 2016 sales,
showing the dollar figures at stake. Many of 404.6
them are already entrenched in a legal battle.

372.2 REMODULIN: EXPIRES 2028

R Creator: United Therapeutics Corp.
ORENITRAM: EXPIRES 2024-2031 Treats: Pulmonary hypertension Under litigation: Yes
R Creator: United Therapeutics Corp.
Lawsuit: Settled with Sandoz, Teva and Par in 2015 (see
Treats: Pulmonary hypertension Under litigation: Yes case study below)
Lawsuit: Against Actavis to protect patent rights
210.1 210.1
TYVASO: EXPIRES 2018
AMITIZA: EXPIRES 2027 R Creator: United Therapeutics Corp.
R Creator: Sucampo Pharmaceuticals Inc. Treats: Pulmonary hypertension Under litigation: Yes
Treats: IBS, constipation Under litigation: Previously Lawsuit: Against Watson Labs to protect patent rights

ADCIRCA: EXPIRES NOV. 2017

ARGUS: EXPIRES 2017 - 2032 R Creator: United Therapeutics Corp.
R Creator: OpGen 157.2 Treats: Pulmonary hypertension Under litigation: No
Treats: Genome mapping system Under litigation: No

OXTELLAR XR: EXPIRES 2027

AURIX: EXPIRES 2019 R Creator: Supernus Pharmaceuticals Inc.
R Creator: Nuo Therapeutics Inc. Under litigation: No Treats: Epilepsy Under litigation: Yes
Treats: Separates blood for platelet-based therapy Lawsuit: Against Actavis, TWi, others to protect patents

13.2
TSS4 TO GTREEBNT*: EXPIRES 2028 TROKENDI XR: EXPIRES 2027
R Creator: RegenerX Inc. Under litigation: No 3.5 R Creator: Supernus Pharmaceuticals Inc.
Treats: Alopecia, congestive heart failure Treats: Epilepsy Under litigation: Yes
1.3
*For use in Korea 45,000 Lawsuit: Against Zydus Pharmaceuticals

WASHINGTONS INVENTOR CENTERS

These are the regions top biotechs by patents granted in 2011-2015 and, because we know youre curious, a recent example of science the company filed to protect.

Proteins and nucleic acids from meningitis/sepsis-associated E. coli, which a Gaithersburg scientist named Herve Tettelin
GlaxoSmithKline 40
helped to invent

Molecules with extended half-lives, including compositions and uses, discovered by two Montgomery County scientists,
MedImmune 37
Leslie Johnson and William DallAcqua

Methods and systems for microfluidic DNA sample preparation, which was invented by three Maryland scientists named
Canon Biomedical 36
Weidong Cao, Hiroshi Inoue and Kevin Louder

Antibodies reactive with B7-H3 and their uses, which three Maryland scientists helped invent Leslie Johnson, Ling
MacroGenics 30
Huang and Paul Moore

Viloxazine compositions, discovered by four Montgomery County scientists, named Likan Liang, Padmanabh Bhatt,
Supernus 27
Aleksandr Pechenov and Alexei Tchesnokov

Intrexon 26 Endoplasmic reticulum localization signals, invented by Arlington scientist Thomas Reed

Reaction mixtures for forming cDNA from an RNA template, which two Montgomery County scientists helped invent.
Qiagen 24
Their names are Subrahmanyam Yerramilli and Martin Kreutz.

Sucampo 24 Method of treating asthenopia, invented by Montgomery County scientist and Sucampo co-founder Ryuji Ueno

Stem cell mobilization and tissue repair and regeneration, brought about by three Montgomery County scientists, Irena
Wellstat Therapeutics 22
Tsyrlova, Fawn Petty and Reid von Borstel

Treatment of circadian rhythm disorders, invented by four Montgomery County scientists named Marlene Dressman, John
Vanda Pharmaceuticals 17
Feeney, Louis Licamele and Mihael Polymeropoulos