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HIGH GRADE B CELL NON HODGKIN LYMPHOMA (small type) of

BRAIN with CHRONIC MYELOGENOUS LEUKIMIA : A RARE CASE

M. Fikri Hafidhi*, Dody Priambada**

*General Surgery Residence Faculty Medicine of Diponegoro University / Dr. Kariadi General
Hospital Center, Semarang Indonesia

** Staff of Sub Division of Neuro Surgery Departement Faculty Medicine of Diponegoro University /
Dr. Kariadi General Hospital Center, Semarang Indonesia

ABSTRACT
BACKGROUND
High grade B cell non hodgkin lymphoma (small type) of brain with chronic myelogenous
leukimia is a rare without evidence of a systemic primary tumor. Chronic myeloid leukemia is a
clonal expansion of hematopoietic progenitor cells characterized by exaggerated proliferation of
granulocytic lineage, with chronic phase, accelerated phase and blast crisis. Accelerated phase
and blast crisis may be associated with extramedulary disease Extramedullary transformation of
CML can be determined both in nodal and extranodal sites. Non-Hodgkin lymphoma is rare in
chronic myeloid leukemia and may be misdiagnosed as an extramedullary.
METHOD
Report on one case of patient with high grade B cell non hodgkin lymphoma (small type) of
brain with chronic myelogenous leukimia
DISCUSSION
We report the case of a 52-year-old woman high grade B cell non hodgkin lymphoma (small
type) of brain with chronic myelogenous leukimia. who presented with headache, nausea,
vomiting, dizziness, for five months. There who developed signs and symptoms of increased
intracranial pressure. Imaging revealed the presence of a non communican hydrocephalus.
First, the patient underwent emergencies peritoneal ventriculostomy shunt. Few days later, by
complete tumor resection via a posterior fossa craniotomy. Postoperative histopathology
revealed the lesion to be malignant small round tumor non hodgkin lymphoma. The
immunohistochemical findings revealed the lession to be high grade B cell non hodgkin
lymphoma (small type). The patient was treated with Deangelis chemotherapy regiment.
Magnetic resonance image suggested multiple inhomogen lessions at right cerebellum, relaps
of the tumor.
CONCLUSION
Management of high grade B cell non hodgkin lymphoma (small type) of brain with
chronic myelogenous leukimia must be adequate to avoid relaps. Further studies are required
to clarify the pathogenetic relationship between chronic myeloid leukemia and non-Hodgkin
lymphomas
KEY WORDS: high grade B cell non hodgkin lymphoma, chronic myelogenous leukimia