MATERIAL BIO

3 sks/TL141403
Rabo 10.00 - 12.30

Amaliya Rasyida
amaliya@mat-eng.its.ac.id /amaliyarasyida@gmail.com
Office: MT219 / Innovative Materials Lab.

+6281331659791

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

FTI - ITS
 BIOMATERIAL:
POLYMERIC IMPLANT
MATERIALS

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 HISTORY OF POLYMER

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 DEFINISI

Polydispersity Index (PDI)

= Mw/Mn

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 KLASIFIKASI

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Polymerization
1. Kondensasi
2. Adisi

By controlling
Reaction temperature
Pressure
Time
Presence of catalyst
The degree to which repeating unit are put together into chains can be manipulated

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Kondensasi = step reaction polymerization
Small molecule such as water will be condensed out
Kekurangan pada proses ini : rantai cenderung berhenti bereaksi sebelum
tumbuh dengan panjang yang cukup. WHY??
Natural polimer seperti Polisakarida dan protein terbuat melalui proses ini

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Adisi = Free radical polymerization
Rearrange ikatan pada masing masing monomer

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Properties
1. Effect of molecular weight
IMPORTANT : All chain should be in equal length

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Effect of Increasing T on PMMA

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

SELECTION PARAMETERS FOR BIOMEDICAL
POLYMERS:
BIOCOMPATIBILITY
BIOFUNCTIONALITY
TOXICOLOGY
APPROPRIATE DESIGN &
MANUFACTURABILITY
MECHANICAL PROPERTIES OF BIOMEDICAL
POLYMERS

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Source of Biomedical polymers

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Natural Polymer

Natural Polymers are a great of interest in the biomaterials Field

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

PROPERTIES OF NATURAL POLYMERS:
BIODEGRADABLE
GOOD BIOCOMPATIBILITY NON TOXIC
MECHANICALLY SIMILAR TO THE TISSUE TO BE REPLACED
HIGH POROUS
EASY AND CHEAP TO MANUFACTURE
CAPABLE OF ATTACHMENT WITH OTHER MOLECULES
etc

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Natural polymer for TE and
Regenerative Medicine
Chitosan
Alginate
Collagen
Gellatin
Starch
etc

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Chitin-Chitosan

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

biopolymer composed of N-acetyl-
glucosamine and N-glucosamine
monomers.

These units can be either randomly or block

distributed throughout the biopolymer
chain. Depending on the N-acetyl-
glucosamine to N-glucosamine ratio

Chitin (number of N-acetyl- glucosamine

units
>50%, poly(N-acetyl- D- glucosamine))

Chitosan (number of N-glucosamine

units >50%, poly(N-acetyl- D-glucosamine-
co-D-glucosamine))

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT
Unique characteristic:
- Biocompatible
- Biodegradable
- Non toxic
- Remarkable affinity of protein
- Renewable
- Abundant
- Antimicrobial main property used mechanism??

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Alginate

The material properties and functionality of alginates are greatly influenced by

the ratio between mannuronate and guluronate and block configuration

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Alginate - chitosan composite 3-D porous
scaffolds have been demonstrated as
suitable for stem- cell based tissue
engineering to treat cartilage lesions

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT
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Collagen
widely applied for
in vitro and in vivo tissue engineering
applications

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Collagen is one of the long, fibrous structural proteins
whose functions are quite different
Tough bundles of collagen called collagen fibers are a
major component of the extracellular matrix that supports
most tissues and gives cells structure from the outside
Collagen is the main component of fascia, cartilage,
ligaments, tendons, bone and teeth.
Along with soft keratin, it is responsible for skin strength
and elasticity, and its degradation leads to wrinkles that
accompany aging.
It plays a role in tissue development.
It is present in the cornea and lens of the eye in
crystalline form.

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Collagen treatment

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Synthetic Polymer
Highly useful in biomedical field since their properties
1. Porosity, degradation time, and mechanical characteristics)
can be tailored for specific applications.
2. Often cheaper than biologic scaffolds; it can be produced in
large uniform quantities and have a long shelf time.
3. Many commercially available synthetic polymers show
physicochemical and mechanical properties comparable to
those of biological tissues.
4. Represent the largest group of biodegradable polymers,
and they can be produced under controlled conditions.
5. Exhibit, in general, predictable and reproducible
mechanical and physical properties such as tensile strength,
elastic modulus, and degradation rate.
MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT
Biodegradation is
the process by
which organic
substances are
broken down by
living organisms

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Synthetic Biodegradable Polymer
Poly lactic acid (PLA), poly glycolic acid (PGA)
Natural Biodegradable Polymer
Proteins, polysaccharides.

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Advantages of Biodegradable Product
To the environment
In Biomedical application

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Synthetic biodegradable polymer
Aliphatic polyesters, such as poly(lactic acid)
(PLA), poly(glycolic acid), poly(-caprolactone)
(PCL) and their copolymers.
Polycarbonate
Poly(amino-acids)
Polyphospoester
Polyanhydride
Polyurethane
etc

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

Polymeric Implant Material
I. Poly(hydroxybutylate)
II. Poly(hydroxyvaleric acid)
III. Sodium alginate
IV. Poly(lactic acid)
V. Poly(glycol acid)
VI. Poly(-caprolactone)
VII. Polyanhydrides
VIII.Polyorthoester
IX. Polycarbonate
X. Polyamides
XI. Poly(methyl methacrylate)
XII. Ultrahigh molecular weight polyethylene

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

 Non Biodegradable Polymer
Thermoplastic Polymers Thermosetting
LDPE Polymers
HDPE Poly HEMA
UHMWPE resin
PTFE Silicone rubber
Polyamide
PMMA
PAN

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT

MATERIALS AND METALLURGICAL ENGINEERING DEPARTMENT