BY: PITH LAOHAVIROJANA 02

CHEMISTRY
PROJECT:
PARACETAMOL
 [1]
PHYSICAL
PROPERTIES
Paracetamol can be in form of liquid(for
children)and solid (medicine pills for adult)
Paracetamol has a bitter taste.
The pH value is approximately 5.5 -6.5
with the property of a saturated aqueous solu-
tion. It sill is an acid but almost neutral.
The boiling point: less than 500 celsius
Solubility: less than 22.7 ug/mL
Paracetamol is a white crystal-
line solid, odorless and color-
less.
The melting point: less than
336-342 F (168.89 c -172.22 c)
Water at 25 celsius solubil-
ity: 14000 mg/L.
It is also fully soluble in al-
cohol such as methanol and etha-
nol.
 Paracetamol will not be able to solute in petroleum ether.

Paracetamol will not be able to solute in petroleum ether.

Paracetamols density is about 1.3 g/cm3 at 70F. However, the

density of it can be varied by temperature.

The dissociated constant or pKa value is 9.38.

 [1][2]

CHEMICAL
PROPERTIES
Paracetamol has a CUPAC name is N-Acetyl-4-aminophenol. Paracetamol is a common
name.

The molecular weight of Paracetamol is 151.165 g/mol.

Paracetamol has equal number of hydrogen bond donor and acceptor which is 2 .

Paracetamol has no isotope number.

Paracetamol has no formal charge. It is the stable compound.

Paracetamol has the property of antioxidant.

6
 [2]

APPLICATION &
PURPOSE
Paracetamol common used pharmacy Paracetamol is well known for temporary
especially household remedy. fever reduction () and pain reliever.

Paracetamol helps improve blood Paracetamol can protect heart and used
glucose control to prevent hear disease or called Cardiopro-
tective.

Paracetamol helps improve the

structure and the function of elder Paracetamol can prevent the loss number
people or aged people. of neuron and maintain the neuron struc-
ture. This is called Neuroprotective.
 There are three functional groups in paracetamol.
1. Alcohol It has -OH.One benzene ring made a single bond with hy-
droxyl group became Phenol.

2. Aromatic The bond of paracetamol is switched between single bond

and double bond. This can determine than it has one benzene ring.

3. Amides It contains double bond between carbon and oxygen and

also carbon atom single bond with nitrogen that bond with hydrogen.
3
 REFERENCES
[1] National Center for Biotechnology Information.Acetaminophen. (n.d.). Retrieved May
25, 2017, from https://pubchem.ncbi.nlm.nih.gov/compound/acetaminophen

[2] Blough, E. R., & Wu, M. (2011). Acetaminophen: Beyond Pain and Fever-Relieving.
Frontiers in Pharmacology, 2, 1-6.