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NORTH EAST INDIA RESEARCH
FORUM
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1. THE FORUM 5
2. SCIENCE NEWS 9
3. NORTH EAST INDIANS MADE US PROUD 14
4. MEMBERS IN NEWS, AWARDS /FELLOWSHIP 15
5. ARTICLES SECTION
a) POLYSACCHARIDE BASED NEW & ADVANCED MATERIALS 16
by Dr. Kamalesh Prasad
e) LET’S LAUGH 39
By Dr. Manab Sarma
4. Corruption = 18%
North East India Research Forum was 5. Apathy from Central Govt. = 4%
th
created on 13 November 2004.
• Which area of science is going to dominate
by creating a great impact on society in next
1. How we are growing.
decade?
Every forum has to pass through difficult phases
1. Nanoscience & nanotechnology =
at the time of birth. NE India Research Forum is
22%
also no exception. At the very beginning, it was
2. Biotechnology = 11%
a march hardly with few members (from
3. Nanobiotechnology = 38%
chemistry only) and today the forum comprised
4. Chemical Engineering = 0%
of a force of 350 elite members. Now we are in a
5. Medicine = 11%
position such that people voluntarily come and
6. Others = 16%
join the group irrespective of disciplines.
7. None = 0%
Mars' entire surface was shaped by water Six New Planets Discovered
Signs of liquid water had Six diverse new planets
been seen on southern from 'shrunken-Saturns' to
Mars, but the latest 'bloated hot Jupiters', as
findings reveal similar well a rare brown dwarf
signals in craters in the with 60 times the mass of
north of the Red Planet. Jupiter has been
The team of France- and US-based scientists discovered by an
led by John Carter, of the University of Paris international team, including Oxford
made their discovery by examining data University scientists.
from instruments on board Europe's Mars The CoRoT (Convection, Rotation and
Express and Nasa's Mars Reconnaissance Transits) space telescope is operated by the
Orbiter. “We're seeing signals of what were French space agency CNES. It discovers
once river beds, small seas and lakes”, John planets outside our solar system --
Carter University of Paris "Now, with the exoplanets -- when they 'transit', that is pass,
Esa and Nasa probes, we have been able to in front of their stars. Once CoRoT detects a
get a mixture of images and spectral transit, additional observations are made
information about the composition of the from the ground, using a number of
rock." He explained that these instruments telescopes all over the world. Although
had revealed clay-type minerals called astronomers cannot see the planets directly,
phyllosilicates - "the stuff you would find in they use the space- and ground-based data to
mud and in river beds." "It's not the species measure the sizes, masses, and orbits of
of mineral itself that's important," said Dr these new planets precisely. This is why,
Carter, "it's more the fact that the minerals among all known exoplanets, those with
contain water. "This enhances the picture of transits yield the most complete information
liquid water on Mars." about planet formation and evolution. "Each
The new findings suggest that at least part of of these planets is interesting in its own
the wet period on Mars, that could have right, but what is really fascinating is how
been favourable to life, extended into the diverse they are," said co-investigator Dr.
time between that giant impact and when Suzanne Aigrain from Oxford University's
volcanic and other rocks formed an Department of Physics. "Planets are
overlying mantle. This indicates that, 4.2 intrinsically complex objects, and we have
billion years ago, the planet was probably much to learn about them yet."
altered by liquid water on a global scale. But The six new planets are:
Dr Carter said that the findings did not paint CoRoT-8b: the smallest in this batch: At
a picture of huge Martian oceans. "It was about 70% of the size and mass of Saturn,
probably a very dry place," he said. "But CoRoT-8b is moderately small among the
we're seeing signals of what were once river previously known transiting exoplanets. Its
beds, small seas and lakes." internal structure should be similar to that of
Source: Science news ice giants, like Uranus and Neptune, in the
Solar System. It is the smallest planet
discovered by the CoRoT team so far after
CoRoT-7b, the first transiting Super-Earth.
CoRoT-10b: the eccentric giant: The orbit Scientists Grow New Lungs Using
of CoRoT-10b is so elongated that the planet 'Skeletons' of Old Ones
passes both very close to and very far away For incurable lung
from its star. The amount of radiation it disorder patients, such
receives from the star varies tenfold in as cystic fibrosis or
intensity, and scientists estimate that its chronic obstructive
surface temperature may increase from 250 pulmonary disease, a
to 600°C, all in the space of 13 Earth-days lung transplant may be
(the length of the year on CoRoT-10b). the only chance for survival. Unfortunately,
CoRoT-11b: the planet whose star does the it's often not a very good chance. Matching
twist: CoRoT-11, the host star of CoRoT- donor lungs are rare, and many would-be
11b, rotates around its axis in 40 hours. For recipients die waiting for the transplants that
comparison, the Sun's rotation period is 26 could save their lives. Such deaths could be
days. It is particularly difficult to confirm prevented if it were possible to use stem
planets around rapidly rotating stars, so this cells to grow new lungs or lung tissue.
detection is a significant achievement for the Specialists in the emerging field of tissue
CoRoT team. engineering have been hard at work on this
CoRoT-12b, 13b and 14b: a trio of giants: for years. But they've been frustrated by the
These three planets all orbit close to their problem of coaxing undifferentiated stem
host star but have very different properties. cells to develop into the specific cell types
Although CoRoT-13b is smaller than that populate different locations in the lung.
Jupiter, it is twice as dense. This suggests Now, researchers from the University of
the presence of a massive rocky core inside Texas Medical Branch at Galveston have
the planet. With a radius 50% large than demonstrated a potentially revolutionary
Jupiter's (or 16 times larger than the Earth's), solution to this problem. As they describe in
CoRoT-12b belongs to the family of an article published electronically ahead of
`bloated hot Jupiters', whose anomalously print by the journal Tissue Engineering
large sizes are due to the intense stellar Part A, they seeded mouse embryonic stem
radiation they receive. On the other hand, cells into "acellular" rat lungs -- organs
CoRoT-14b, which is even closer to its whose original cells had been destroyed by
parent star, has a size similar to Jupiter's. It repeated cycles of freezing and thawing and
is also massive, 7.5 times the mass of exposure to detergent.
Jupiter, which may explain why it is less The result: empty lung-shaped scaffolds of
puffed up. Such very massive and very hot structural proteins on which the mouse stem
planets are rare, CoRoT-14b is only the cells thrived and differentiated into new
second one discovered so far. cells appropriate to their specific locations.
CoRoT-15b: the brown dwarf: CoRoT- "In terms of different cell types, the lung is
15b's mass is about 60 times that of Jupiter. probably the most complex of all organs --
This makes it incredibly dense, about 40 the cells near the entrance are very different
times more so than Jupiter. For that reason, from those deep in the lung," said Dr.
it is classified as a brown dwarf, Joaquin Cortiella, one of the article's lead
intermediate in nature between planets and authors. "Our natural matrix generated the
stars. Brown dwarfs are much rarer than same pattern, with tracheal cells only in the
planets, which makes this discovery all the trachea, alveoli-like cells in the alveoli,
more exciting. pneumocytes only in the distal lung, and
definite transition zones between the bronchi an inexpensive device that is powerful
and the alveoli." enough to let doctors easily distinguish
Such "site-specific" cell development has cancerous cells from healthy cells simply by
never been seen before in a natural matrix, viewing the LCD monitor on the back of the
said professor Joan Nichols, another of the camera. The results of the first tests of the
paper's lead authors. The complexity gives camera were published online in the open-
the researchers hope that the concept could access journal PLoS ONE.
be scaled up to produce replacement tissues "Consumer-grade cameras can serve as
for humans -- or used to create models to powerful platforms for diagnostic imaging,"
test therapies and diagnostic techniques for a said Rice's Rebecca Richards-Kortum, the
variety of lung diseases. study's lead author. "Based on portability,
"If we can make a good lung for people, we performance and cost, you could make a
can also make a good model for injury," case for using them both to lower health care
Nichols said. "We can create a fibrotic lung, costs in developed countries and to provide
or an emphysematous lung, and evaluate services that simply aren't available in
what's happening with those, what the cells resource-poor countries."
are doing, how well stem cell or other The team captured images of cells with a
therapy works. We can see what happens in small bundle of fiber-optic cables attached
pneumonia, or what happens when you've to a $400 Olympus E-330 camera. When
got a hemorrhagic fever, or tuberculosis, or imaging tissues, Richards-Kortum's team
hantavirus -- all the agents that target the applied a common fluorescent dye that
lung and cause damage in the lung." caused cell nuclei in the samples to glow
The researchers have already begun work on brightly when lighted with the tip of the
large-scale experiments, "decellularizing" fiber-optic bundle. Three tissue types were
pig lungs with an eye toward using them to tested: cancer cell cultures that were grown
produce larger samples of lung tissue that in a lab, tissue samples from newly resected
could lead to applications in humans. tumors and healthy tissue viewed in the
They're also taking on the challenge of mouths of patients.
vascularization -- stimulating the growth of Because the nuclei of cancerous and
blood vessels that will enable the engineered precancerous cells are notably distorted
tissues to survive outside the special from those of healthy cells, Richards-
bioreactors that the researchers now use to Kortum said, abnormal cells were easily
keep them alive by bathing them in a life- identifiable, even on the camera's small
sustaining cocktail of nutrients and oxygen. LCD screen.
Source: "The dyes and visual techniques that we
http://www.sciencedaily.com/releases/2010/ used are the same sort that pathologists have
06/100624092522.htm used for many years to distinguish healthy
Consumer-Grade Camera Detects Cancer cells from cancerous cells in biopsied
Cells in Real Time tissue," said study co-author Mark Pierce,
A stunning news was Rice faculty fellow in bioengineering. "But
revealed by biomedical the tip of the imaging cable is small and
engineers of Rice rests lightly against the inside the cheek, so
University and researchers the procedure is considerably less painful
from the University of than a biopsy and the results are available in
Texas M.D. By using an off-the-shelf digital seconds instead of days."
camera, Anderson Cancer Center has created
This research was conducted in M119 and Gallein are not known drugs; they
collaboration with Alan Smrcka, Ph.D., are compounds that act as dyes, or stains,
professor in the Department of and were previously not known to have any
Pharmacology & Physiology at the Medical therapeutic activity.
Center whose laboratory discovered This research addresses a health problem
compounds that could block GRK2 that affects nearly 6 million Americans. The
regulation by G proteins. Smrcka's research result of underlying problems like coronary
team conducted extensive screening and artery disease, high blood pressure or heart
testing to identify these experimental attack damage, heart failure is the gradual
compounds. Two such compounds, M119 loss of the heart's ability to pump with
and Gallein, were identified and put to the enough force to meet the body's need for
test. blood. Half of patients will not live five
"In this study we took an entirely new years past the day they are diagnosed. The
pharmacological approach by altering best treatment for a severe heart failure
signaling pathways after the beta adrenergic patient is a transplant, but with just over
receptor rather than altering the receptor 2,000 transplants done each year and more
itself. In this way the actions of adrenalin than 3,000 people on the waiting list at any
are modified rather than blocked as with given time, research like this is needed to
other therapies, such as beta blockers," said find new options for patients.
Smrcka. "This novel approach is applicable The current research was funded by the
in heart failure and may be useful in other National Heart, Lung and Blood Institute
conditions as well." (NHLBI) and the Institute for General
Blaxall's team found that Gallein not only Medicine at the National Institutes of Health
slowed, but halted heart failure progression and the University of Rochester Medical
when delivered to mice with pre-existing Center. Blaxall's lab recently received
heart failure. Similarly, M119 reduced two additional funding from the NHLBI to
characteristics of the disease -- strain-related compare the newly identified compounds to
thickening of muscle tissue (hypertrophy) current standard therapies for heart failure in
and scar tissue formation (fibrosis). Both human-like mouse models. Blaxall, Smrcka
compounds partially normalized the force of and their team are seeking partnerships to
heart muscle contraction by making sure the further develop these compounds.
beta adrenergic receptors became and http://www.sciencedaily.com/releases/2010/
remained responsive to adrenalin. This was 06/100624183021.htm
done by both decreasing overall levels of
GRK2 in the heart and by limiting its
effectiveness.
M119 and Gallein have been used in a
similar way in the past to target the receptor
desensitization process that occurs in other
conditions, such as chronic pain. For
example, Smrcka and his collaborator Jean
Bidlack, Ph.D., professor of Pharmacology
and Physiology at the Medical Center, have
shown M119 can reverse the desensitization
of opiate receptors, which in turn increases
the efficacy of painkillers such as morphine.
1. Dr. Sasanka Deka has joined Chemistry Organic Chemicals”. He carried out his
Dept. of Delhi University as Assistant research at the department of synthetic
professor. Before joining this position he organic chemistry, NEIST-Jorhat under the
was pursuing post doctoral research in supervision of Dr. Dilip Konwer.
Italy. He did his Ph.D from National
Chemical Laboratory, Pune. 5. Madan Gopal Borthakur has joined in
Biotech Park, Guwahati. The Biotech Park
2. Dr. Bhaskar Jyoti Sarmah has got Post will provide research infrastructure for R&D
Doc offer from Technion, Israel Institute work to explore the huge bio resource of the
of Technology. At this moment he is region. The department of biotechnology,
working as post doctoral researcher in
under the Union ministry of science and
Gauhati University. He completed his
technology, has sanctioned Rs 24 crore for
PhD from NEIST (CSIR) Jorhat in June
setting up this state-of-the- art Biotech Park
2009 under the supervision of Dr. Dipak
for Assam which will help carry out high-
Kumar Dutta.
end research in the field of biotechnology.
3. Archana Devi, a PhD student of
Department of Chemistry, Dibrugarh ----
University has got INSPIRE fellowship.
Ayurvedic Herbal Remedies: This is one of the
(Innovation in Science Pursuit for
most ancient medicinal system in India, in
Inspired Research) from DST. Selection Sanskrit, the word ayurveda consists of the
of INSPIRE Fellows is based on the words āyus, meaning "longevity", and veda,
screening of applications for eligible meaning "related to knowledge" or "science". In
candidates, 25% of total fellowship from ancient time the Ayurvedic system was divided
national level tests such as NET, GATE into 8 branches - Kaya chikitsa : Internal
etc and 75% of total fellowship from 1st medicine; Baala : Pediatrics; Graha :
Rank Holders of post-graduate programs Treatment of diseases arising from possession
of any recognized university in science by pathogens, evil spirits, etc. Mainly diseases of
stream & undergraduate/post-graduation a mental nature; Urdhvanga : Dealing with the
course in engineering / technology / eyes, ear, nose, throat and dentistry; Salya :
Surgery including plastic surgery; Danstra :
agriculture / pharmacy/applied science
Insect bites, poisons (Toxicology); Rasayana :
streams at recognized universities and Diseases of advancing age; Prasuti :
academic institutions. Gynecology and obstetrics. During those days
all the medicines were derived from plants.
4. Saikat Dassharma was awarded PhD Interestingly, of the top 150 proprietary drugs
degree by Dibrugarh University for his used in the USA in 1993, found that 57% of all
research in the area of chemical sciences prescriptions contained at least one major active
on the topic “Studies on New Synthetic compound currently or once derived from (or
Strategies for Biologically Significant patterned after) compounds derived from
biological diversity.
-------
N. E. Quest; Volume 4, Issue 1, April 2010. 15
Newsletter of North East India Research Forum
POLYSACCHARIDE BASED
NEW & ADVANCED glycosidic bonds and are the oldest
MATERIALS biopolymer present on the earth. Natural
polysaccharides provide two important
functions. They act as an energy source and
Dr. Kamalesh Prasad as a structural material [1]. The basic
function of polysaccharides in living system
INTRODUCTION is as energy stores and in plants and
seaweeds. Apart from energy storage it
What is a polysaccharide ? provides structural stability. The structure of
polysaccharides is often linear, but may
Polysaccharides are polymeric carbohydrate contain various degrees of branching. Most
structures, formed of repeating units (either of the polysaccharides with some exceptions
mono- or di-saccharides) joined together by are soluble in water. The most common
polysaccharides and their source are shown
in Table 1.
Name Structure
Cellulose OH HOH2 C The structural component of plants.
HO
O
O
O Wood is largely cellulose and lignin,
O HO
HOH 2C while paper and cotton are nearly pure
OH cellulose. Cellulose is a polymer made
n with repeated glucose units bonded
together by beta-linkages. It is insoluble
in water but soluble in LiCl/N,N-
Dimethyl acetamide.
Starch HOH 2C Starch or amylum is a polysaccharide
O
O carbohydrate consisting of a large
HO HOH 2C number of glucose units joined together
OH O
O by glycosidic bonds but linkage is
HO
OH
different from that of cellulose. Starch
O contains both amylose with a linear
n structure and amylopectin with a
branched structure with α-(1 → 6)-
linked branching points. It is the most
important carbohydrate in the human
diet and is contained in such staple
foods as potatoes, wheat, maize (corn),
rice, and cassava.
O
κ-Carrageenan Carrageenan is a water soluble
OH
CH 2OH phycocolloid extracted from red algae
O
O O and is used mostly as stabilizers and
O
OH structure providers in food and ice-
n
OH cream industries. It consists of
alternating 1,3-linked α-D-
galactopyranose and 1,4-linked β-(3,6-
anhydro-) D-galactopyranose.
Chitin HOH 2C O Chitin is structurally similar to cellulose,
but it is an amino polysaccharide having
O
acetamide groups at the C-2 positions in
HO NH
n place of hydroxy groups in cellulose.
O C
CH3
The main source of chitin is Shrimp,
crab and Squid.
Chitosan HOH 2C O Chitosan is a linear polysaccharide
composed of randomly distributed β-(1-
O
4)-linked D-glucosamine (deacetylated
HO NH 2
n
unit) and N-acetyl-D-glucosamine
(acetylated unit). It is generally obtained
by the de- acetylation of chitin.
Apart from the polysaccharides listed above, materials prepared out of polysaccharides,
other important polysaccharides are the nano-composites as well as the other
alginates, Pullulan, some bacterial modified products are drawing attentions in
polysaccharides. recent days.
After many years of oblivion, the area of
polysaccharide chemistry is presently What is polymer nanocomposite (PNC)?
receiving renewed attention. This is due to
the increase in the understanding of the role Polymer nanocomposites are defined as the
of biopolymers in various biological polymers obtained by introducing nano
processes. Active research on the structured materials in the polymer matrices.
modification of the basic polysaccharides PNC are obtained by reinforcing with small
are under way in various labs to explore the quantities (less than 5% by weight) of nano-
possibilities of applications in newer fields sized particles [9]. The synthesis of polymer
such as in physicochemical, biochemical, nanocomposite is an integral part of polymer
biomedical and industrial applications [2-8]. nanotechnology. Generally nanosized
The main advantages of using (typically 1-100 nm) inorganic materials are
polysaccharides are it is cheap, obtained inserted in certain polymer backbones in
from renewable resources, biodegradable as order to change their properties as well as
well as biocompatible, it is a multifunctional functionalities. The nanocomposites
material, easy to process and the extraction obtained have always improved properties
is also less difficult. The biological over the parent polymer. The nano materials
functions of polysaccharides as glyco- introduced in to the polymer matrices must
proteins and as structural material inspired have very good compatibility with polymer
the carbohydrate chemist to contribute to the as well as must have very good dispersibility
biomaterial engineering. Among the various in the medium used for the preparation of
Scheme 1 : A schematic out lay for the formation of different types of polymer nanocomposites
Figure 1: Schematic diagram for the formation of electro active nanocomposite based on
carrageenan and polymerized ionic liquids
CH2CH(CN)
Ether derivatives of polysaccharides are increasing DS. Methyl and ethyl derivatives
soluble in water. Many of the cellulose of starches are prepared the same way of
derivatives like DEAE cellulose, prepared their cellulose counterpart, except first
by reaction of diethylaminoethyl cellulose starch granules are heated with mineral acid
with N,N-diethyl aminoethyl chloride, are at 100OC, then alkali and methyl chloride is
used as cation exchange resin. Hydroxyl added. Another type of ether substitution,
alkyl derivatives of starch and cellulose can carboxymethyl is substituted successfully in
be prepared by reacting starch and cellulose number of polysaccharides, and
with epoxides and alkylene oxides. carboxymethyl cellulose is one of the most
Hydroxyethyl starches are used primarily as important commercially important
binders for pigmented coatings and surface derivatives.
sizing agents in paper industry.
Hydroxypropyl starches are of importance in Hydroxyalkyl substituted gums represent the
food applications, where they are used as an largest group of polysaccharide ether
edible, water-soluble film coating. derivatives; they are often prepared by the
Formation of hydroxyalkyl derivatives for attack of poly-anion on an oxirane ring to
cellulose increases its water solubility. produce the corresponding hydroxyalkyl
Hydroxypropyl derivatives of starch prevent derivative. The route of reaction is shown
retro gradation of starch chains. Better water below.
solubility of cellulose can be obtained by
O
H
PS-O O + PS-O-CH2-CH2OH
CH2 CH2R
Na
Preparation of guar gum based heat- prevent strong chain interactions among the
shapeable film materials. mannose units which is essential for double
helix formations. Attempts have been made
Guar gum (GG) or guaran is a to substitute the galacatopyranose unit with
galactomannan extracted from the seed of some block substituents, which can cause
the leguminous shrub Cyamopsis interactions among the mannose units and
tetragonoloba, and consists of (1→4)-linked hence lead to the formation of junction
β-D-mannopyranose main chain with zones. We have observed that, guar gum can
branching at the 6-positions with a α-D- give formation of gel and thin film in certain
galactopyranose. It is a hydrocolloid and ionic liquids and the films thus obtained can
does not form gel in aqueous media due to be given a desired shape upon application of
the presence of branching units, which heat [14] as depicted in Figure 3 below.
use of fluid stream cleaning. In current between the fluid and the pipe makes a
market, various manufacturers offer lot of energy to spend to pump the fluid.
scale inhibitors with fascinating Friction reducers reduce the friction to a
properties like controlled release, high very low level, thus saving a lot of
environmental acceptability, high energy in pumping activities.
temperature – high pH performance etc. Friction reducers are generally polymers
including high molecular weight
Pour point depressants: polyelectrolytes. They are used in a
very low dosage. They can reduce both
This class of specialty chemicals is used the friction between the pipe and the
commonly and widely in the mid and fluid and between different layers of the
downstream oil industries. They can fluid. This reduces the turbulence of
reduce the freezing point of crude oil by flow and hence costs lesser energy.
several degrees centigrade at a very low
dosage without affecting the oil Surfactants:
properties. This makes it possible to
transport the crude even in low This widely known class of chemical is
temperature regions and during the used for various purposes:
cold. They are also used in refined fuels Emulsification, De-emulsification,
in cold places to keep them flowable all wetting of surfaces for better
the time. penetration of fluid into a matrix etc.
The mechanism of action of the pour Emulsifiers may be anionic, cationic,
point depressants is not fully non-ionic and amphoteric. The two
understood. Many times they prevent important parameters determining an
the formation of crystals by wax, thus emulsifier’s performance are the critical
keeping the oil flowable. Therefore, micellar concentration (cmc) and the
sometimes they are synonymously hydrophilic lipophilic balance (hlb).
called as wax inhibitors as well. Most of the chemistry students are
Generally they are oil soluble polymers familiar with cmc, though not with hlb.
having long side chains. The general mechanism of action of
Polyalkylmethacrylate is one of the emulsifiers is a well known one and
widely used classes of polymers for this hence not explained here. The
application. challenges in today’s emulsifier
Friction reducers: research are to design environmental
While pumping a fluid through a pipe friendly, yet high performing
several hundred meters, the friction emulsifiers even for high temperature
² Medical ² Engineering
Reference:
C. Liang, Z. Li, S. Dai, Reviews:
Mesoporous Carbon Materials:
Synthesis and Modification, Angew.
The wide application in every day’s Chem. Int. Ed. 47 (2008) 3696 – 3717.
life and availability of these ordered
mesoporous materials lead great ---
opportunities for the synthesis as well as The first X-ray
extraction from natural sources of other
highly ordered mesoporous materials.
The success of the hard template
synthesis lies in its simplicity in
replicating the structures of templates. The hand of Mrs.
However, this method is Wilhelm Roentgen: the
thermodynamically not driven. Few first X-ray image, 1895
chemical interactions between hard
templates and carbon precursors occur
during the replication process.
Accordingly, the hard-template synthesis The announcement of Roentgen’s discovery,
suffers from its intrinsic limitations in illustrated with an X-ray photograph of his
the sacrificial use of hard templates, wife’s hand, was hailed as one of mankind’s
insufficient stabilities of replicated greatest technological accomplishments, an
invention that would revolutionize every aspect
mesostructures, and difficulties of of human existence
synthesis of large film and monolithic
-----
N. E. Quest; Volume 4, Issue 1, April 2010. 38
Newsletter of North East India Research Forum
----
Facts behind Mona Lisa’s smile
HO
2
Scheme 1
Robinson developed the first domino It is noteworthy that even the normal
reaction of a natural product when he Mannich reaction combining an
synthesized bicyclic tropinone (6) by aldehyde (generally formaldehyde), a
putting together a mixture of ketone, and a secondary amine is a
succindialdehyde (3), methylamine (4), domino reaction and most probably the
and acetonedicarboxylic acid (5) first domino reaction described in
(Scheme 2).4 The key step in this literature.
synthesis is a double Mannich reaction.
Me
CO2H N
CHO
+ MeNH2 + O
O
CHO
CO2H
6
3 4 5
Scheme 2
Some important points to be noted: domino; all the others follow without
• A substrate with several changing the conditions. The domino
functionalities which undergo a processes are time-resolved
transformation individually in the transformations as like as domino stones,
same pot is not a domino where one stone tips over the next,
reaction. which tips the next, and the
• The preliminary formation of a next………such that they all fall down
reactive intermediate such as a in turn.
carbocation or carbanion is not Advantage of domino reaction:
counted as a reaction step. The complex organic molecules are
• In a domino reaction, the generally synthesized by the stepwise
substrates used must have more formation of the individual bonds.
than two functionalities of However, it would be much more
comparable reactivity. They can efficient if several bonds can be
be situated in one or two constructed in one sequence without
molecules, or, as in the case of isolating the intermediates, changing the
multicomponent domino reaction conditions, or adding new
reactions, in at least three reagents. Obviously, this type of
different molecules. In a domino reaction will generate less amount of
reaction, the functionalities react waste as compared to stepwise reactions
in a fixed chronological order to since the amount of solvents, reagents,
allow the formation of defined energy and the labor would be
molecules. dramatically reduced. Consequently, this
Why the name Domino was chosen? would furnish an ecological and
The name domino comes from the economical production of the target
game where one puts up several domino molecule.
pieces in one row and in agreement with The usefulness of domino reaction can
the time-resolved succession of be correlated to:
reactions, if one knocks over the first
X _ X +
+
+
Nu
_ H+
or
or
_
+ Nu
Scheme 3
Diepoxide (7) undergoes acid catalyzed cyclization to bistetrahydrofuran (8) via cationic
domino reaction (Scheme 4).8
OBz O
O
H+
O
O
O
OMe H
DEIPS
BnO OPMB
7
OBz O
H
0.5 M HCl, THF
25 º C, 2.5 h O O OPMB
OH H O
H OH
BnO
8
Scheme 4
Anionic domino reaction domino reaction is initiated by the
The primary step of anionic domino Michael addition of a nucleophile to the
reaction is the attack of either an anion α,β-unsaturated ketone (9) to furnish a
(such as a carbanion, an enolate or an reactive enolate (10), which in turn can
alkoxide) or a “pseudo” anion as an easily be trapped in a second anionic
uncharged nucleophile (such as an amine reaction to afford the compound (11)
or an alcohol) onto an electrophilic (Scheme 5).
center.2 An excellent example of anionic
O OM O
RM E
EX
R R
9 10 11
Scheme 5
Radical domino reaction use of protecting groups. In addition to
Radical reactions are ideal for that, radicals are equally feasible to add
sequencing because the product of every to either inactivated multiple bonds or to
radical is radical and thus contributes those bearing polar groups.
many efficient domino reactions with For example, iododiene (12) upon
high grades of chemo, region and treatment with tributyl tin hydride in
stereoselectivity. Domino radical benzene produces the compound (15) via
reactions can form complex, highly the intermediate radicals (13) and (14)
substituted ring systems with minimum (Scheme 6).9
O O O
Bu3SnH, AIBN
C6H6, 80 º C
I
H
12 13 14
O
H H
15
Scheme 6
Transition metal catalyzed domino A wonderful example of palladium
reaction catalyzed domino reaction is the
Recently transition metal catalyzed polycyclization of polyenes (16) to give
transformations are receiving much polyspirane (17) (Scheme 7).11
attention as a part of domino reaction.6b,10
OMe
PhO2S
PhO2S 4
16
MeO
17
Scheme 7
Enzymatic domino reaction This underwent another (intramolecular)
The enzymes play a vital role to nucleophilic attack on the second
initiate domino reactions.2,6a For epoxide to furnish a bistetrahydrofuran
example, the following domino reaction derivative (21). At the end of this
was initiated by enzymatic hydrolysis of cascade, the resulting alkoxide was
an ester (18) to form a nucleophile (19), trapped by forming a hemiacetal
which opened an epoxide to furnish the attached to a tristetrahydrofuran moiety
corresponding lactone together with a (22) (Scheme 8).12
free alkoxy moiety in the δ-position (20).
O O
O O O CHO
MeO CHO Pig Liver Esterase
_
O 18 O 19
_ _
O O O H
CHO C O
O O
O O O
20
21
OH
O
O O O
22
Scheme 8
23
CO2Me
CO2Me
+
CO2Me
CO2Me
MeO2C CO2Me
25 26
24
Scheme 9
Conclusions Burke, M. D.; Schreiber, S. L. Angew.
The development of domino reactions Chem., Int. Ed. 2004, 43, 46. (c) Ramon,
is still in its infancy. The future goal will D. J.; Yus, M. Angew. Chem., Int. Ed.
be the discovery of domino reactions in 2005, 44, 1602.
more environmentally friendly 6. (a) Mayer, S. F.; Kroutil, W.; Faber,
conditions. K. Chem. Soc. Rev. 2001, 30, 332. (b)
Chapman, C. J.; Frost, C. G. Synthesis
References 2007, 1.
1. Nicolaou, K. C.; Vourloumis, D.; 7. (a) Denmark, S. E.; Thorarensen, A.
Winssinger, N.; Baran, P. S. Angew. Chem. Rev. 1996, 96, 137. (b)
Chem., Int. Ed. 2000, 39, 44. Neuschütz, K.; Velker, J.; Neier, R.
2. Tietze, L. F. Chem. Rev. 1996, 96, Synthesis 1998, 227.
115. 8. Koert, U. Synthesis 1995, 115.
3. (a) Corey, E. J.; Russey, W. E.; Ortiz 9. Takahashi, T.; Katouda, W.;
de Montellano, P. R. J. Am. Chem. Soc. Sakamoto, Y.; Tomida, S.; Yamada, H.
1966, 88, 4750. (b) Corey, E. J.; Virgil, Tetrahedron Lett. 1995, 36, 2273.
S. C. J. Am. Chem. Soc. 1991, 113, 10. Ajamian, A.; Gleason, J. L. Angew.
4025. (c) Corey, E. J.; Virgil, S. C.; Chem. Int. Ed. 2004, 43, 3754.
Sarshar, S. J. Am. Chem. Soc. 1991, 113, 11. Dauben, W. G.; Dinges, J.; Smith, T.
8171. C. J. Org. Chem. 1993, 58, 7635.
4. (a) Robinson, R. J. Chem. Soc. 1917, 12. Russel, S. T.; Robinson, J. A.;
111, 762. (b) Robinson, R. J. Chem. Soc. Williams, D. J. Chem. Commun. 1987,
1917, 111, 876. 351.
5. (a) Armstrong, R. W.; Combs, A. P.; 13. (a) Paquette, L. A.; Wyvratt, M. J.;
Tempest, P. A.; Brown, S. D.; Keating, Berk, H. C.; Moerck, R. E. J. Am. Chem.
T. A. Acc. Chem. Res. 1996, 29, 123. (b) Soc. 1978, 100, 5845.
TRAITS NEEDED TO BE the time to see the big picture will help
SUCCESSFUL us stay focused and keep us motivated.
consistent in his job by his own drive Remember, excellence is a habit not an
and when situations are bad he act. It takes practice and perseverance.
continues to work with the same vigour 9) Self management: If success
or may be more. There is no need to depends on effective action, effective
search for means of motivation; the action depends on the ability to focus
work itself is a cause to enjoy it. The our attention where it is needed most,
crux is-if we don’t love what we do, no when it is needed most. Strong
one else will either. organizational skills, effective
6) Learn, Unlearn and Relearn: We productivity habits, and a strong sense of
need not know everything about the job discipline are needed to keep our self on
that we do. But we constantly need to track.
learn new things, grasp new ways and
imbibe new perspectives that best suit 10) Networking: Networking is not
our present work. We need to keep a only for finding jobs or clients. In an
economy dominated by ideas and
tab on the latest news, trends and buzz
innovation, networking creates the
related to our field of work. channel through which ideas flow and in
Nobody wants a robot, whose which new ideas are created. A large
breadth of knowledge is limited to network, carefully cultivated, ties one
his/her task at work alone, but someone into not just a body of people but a
who is well informed and updated about body of relationships, and those
the latest trends, news and happenings relationships are more than just the sum
in the field of work, around the world. of their parts. The interactions those
This will keep us in the good books of relationships make possible give rise to
our superiors and will also make us a innovation and creativity – and provide
good company at official gatherings so the support to nurture new ideas until
that we get a fresh perspective always they can be realized.
to anything related to our work. ---
7) Public speaking: The ability to Achieving the Goal
speak clearly, persuasively, and Barak Obama: childhood to present –
forcefully in front of an audience –
whether an audience of one or of
thousands – is one of the most
important skills anyone can develop.
People who are effective speakers come
across as more comfortable with
themselves, more confident, and more Child Obama at Obama a basket
attractive to be around. Being able to Hawaii beach ball player
speak effectively means we can sell
Barack Obama was born in Honolulu to a
anything – products, of course, but also Kenyan father and an American mother,
ideas, ideologies, etc. Hawaii on August 4, 1961. Graduated from
8) Chase Excellence: That’s the theme Columbia University and Harvard Law School,
behind the success of the biggest worked as a community organizer, university
lecturer, and civil rights lawyer before entering
blockbuster of 2009, “3 Idiots” – Chase
politics. According to childhood fellows: ‘he
Excellence, Success will follow. To be used to be a naughty boy particularly among
successful at anything, we need to be an his female seniors. Once he destroyed the
expert first in that particular thing. school’s fence which made from bamboos.’ ‘In
Unless we know the product we are a creative writing lesson, other students said
that they wanted to be a doctor or pilot, but
selling, its make, its parts, the
Barry claimed that he wanted to be a
chemicals, used, and its functions, we president.’
will not be able to market it or sell it. --------------
Acknowledgement: The editor is highly indebted to Dr. Manab Sharma for his kind
help in making this issue in this readable form. The help from Dr. Arindam Adhikari,
Dr. Ashim J Thakur and Dr. Pankaj Bharali are also sincerely acknowledged.
Bolin Chetia
………………
Bolin Chetia has completed his college
education from Science College Jorhat and
M.Sc from Dibrugarh University. He
secured 1st class 1st position in M.Sc
The Life Science Zurich Graduate School houses several Ph.D. programs that cover distinct areas of
the life sciences. Each program offers research and education opportunities in a stimulating
international environment for ambitious students who wish to work towards a Ph.D. degree. Accepted
students perform their research project in one of the participating research groups of their favorite
program, according to their scientific interest. Advanced teaching and training courses are offered
throughout the curriculum. The program language is English throughout. Ph.D. studies usually last 3-4
years. Applicants must hold or anticipate receiving a Master’s degree or equivalent from a university
in a relevant field before starting the Ph.D. program. Applicants accepted for the program will have to
register with either the University of Zurich or ETH Zurich, depending on the affiliation of their future
research group.
At the Medical University of Vienna, CCHD, a PhD Program in biomolecular Medicine supported by
the Austrian Science Fund (FWF), has been established. The program offers cutting-edge education in
the fields of Neurobiology, Vascular Biology, Immunology, and Inflammation Research and
integrates basic, applied, and clinical sciences, as well as a huge spectrum of experimental techniques.
Admitted PhD students will receive funding for at least three years including support to visit
international conferences and specialized workshops. Applicants must hold a final degree in the
diploma studies of Medicine, Dentistry, or in ny scientific/technical subject-related diploma studies
(such as Cell or Molecular Biology) by the commencing term of the program. Further information on
research topics and courses, as well as application forms are available at:
www.phd-cchd.at
REESEARCH COOPERATION
South Africa : This call is s open to all working researchers residing in South Africa
and affiliated with a recognised higher education or research institution such as a
university, university of technology or science council. An application must designate
two principal investigators, one in South Africa and the other in India, who will bear the
main responsibility for the project, including its technical and administrative
coordination as well as scientific and financial reporting. The South h African applicant
must be in possession of at least a master’s degree (preferably a PhD). Commercial
institutions and private education institutions are not eligible to apply under this
programme.
India : The Principal Investigator (PI) and other investigators in n India should be
Scientists/ faculty members working in regular capacity in UUGC recognized
Universities/ Deemed Universities, Academic Institutes and National Research &
Development Laboratories// Institutes. The Indian PI should not be retiring or leaving
the parent institute during the proposed duration of the project.
How do I apply?
South Africa: Application forms for South African applicants may be downloaded
electronically from the NRF F website (www.nrf.ac.za). A compulsory soft copy and
scanned signature page off the South African application must be submitted to: Mr
Raven Jimmy (raven@nrf..ac.za)
No hard copies of the app plication will be accepted.
Only applications endorse ed by the research office or its equivalent at higher education
or research institutions will be accepted.
India : Application forms for Indian applicants may be down loaded from the
websites www.dst.gov.inor r www.stic-dst.org.
Government of India
Ministry of Science & Technology
Department of Science & Technology
Moderators
1. Arindam Adhikari, Ph.D. 2. Ashim J. Thakur, Ph.D.
Institute of Surface Chemistry, Royal Chemical Science Dept
Institute of Technology, Stockholm, Sweden Tezpur University, Tezpur, Assam
Email: arindam_tsk@yahoo.com Email: ajtthax@yahoo.com
http://tech.groups.yahoo.com/group/northeast_india_research/
http://www.neindiaresearch.org/