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Organic chemistry
Lab Report
To
Patraphorn Sanguansat
By
Prame Ruangkana
1106
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INTRODUCTION
Have you ever wonder why bother learning chemistry? Well, almost every product that we used in
our daily life were started from lab experiment such as soap, shampoo, lotion drug, plastic, paper, paint,
vitamin, etc. Chemistry demonstrates a basic knowledge of how these consumable products were made.
In this report, you will know the structure of the organic compound called Nalorphine and the structure of
it.
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OBJECTIVE
The purpose of this project is to inform a readers to be able to identify the functional group called Nalorphine
in our daily life.
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NALORPHINE FUNCTIONAL GROUP

Consisting of
- Alcohol: HO
- Amine: O
- Ether: N
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PURPOSE OF THE COMPOUND

It is used for treatment with people who overdose with narcotic drugs[1][2]. It can help by
reverberate sing respiratory depression which can also be combine with either morphine or meperidine to
reduce rate of depression during parturition[4]. It can help reduce or annihilate neuroleptic activities of
narcotic substance such as morphine, codeine, hydromorphone, etc[5][6]. However, it does not work with
non narcotic substance or barbiturates[6].
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CHEMICAL PROPERTIES[3]
Name Value

Molecular Weight 311.381 g/mol

Hydrogen Bond Donor Count 2

Hydrogen Bond Acceptor Count 4

Molecular Rotatable Bond Count 2

Complexity 549

CACTVS Substructure Key Fingerprint
AAADceB6MAAAAAAAAAAAAAAAAAAAASAAA
AA8YIEAAAAWAEjBAAAAHgAACAAADzzhmAYw
BoMABgCAAiBCAACCCAAgIAAIiAAOiIgNNiKGsR
uGeCOkwBGLuAew8PcPoAABAAAYQADQAAaAAD
SAAAAAAAAA

Topological Polar Surface Area 52.9 A^2

Monoisotopic Mass 311.152 g/mol

Exact Mass 311.152 g/mol

XLogP3 1.9

Compound Is Canonicalized TRUE

Formal Charge 0

Heavy Atom Count 23

Defined Atom Stereocenter Count 5

Undefined Atom Stereocenter Count 0

Defined Bond Stereocenter Count 0

Undefined Bond Stereocenter Count 0

Isotope Atom Count 0

Covalently-Bonded Unit Count 1

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PHYSICAL PROPERTIES[3]

Color Crystals

Melting Point 208 deg C

- Slightly soluble in water; soluble in alkali, acetone,

ethanol
Solubility - Sparingly soluble in ether; soluble in chloroform,
dilute alkalies

Vapor Density 1.5X10-10 mm Hg at 25 deg C (est)

LogP log Kow = 1.86

When heated to decomposition it emits very toxic fumes

Decomposition of /nitrogen oxides/.

Dissociation Constants pKa = 7.64

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MARVINSKETCH
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CITATION
1. Thefreedictionary, n.d. http://www.thefreedictionary.com/nalorphine.
2. Nalorphine. Pubchem, n.d. https://pubchem.ncbi.nlm.nih.gov/compound/Nalorphine#section=Top.
3. Chemical and Physical Properties. Pubchem, n.d. https://pubchem.ncbi.nlm.nih.gov/compound/
Nalorphine#section=Chemical-and-Physical-Properties.
4. Briggs, G.G, R.K. Freeman, S.J. Yaffe. A Reference Guide to Fetal and Neonatal Risk. Drugs in
Pregnancy and Lactation. 4th ed. Baltimore, MD: Williams & Wilkins 1994., p. 610
5. Pain Medications - Narcotics. Medlineplus, n.d. https://medlineplus.gov/ency/article/007489.htm.
6. Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The
Pharmaceutical Press, 1982., p. 1032
7. Lasagna, Louis. NALORPHINE (N-ALLYLNORMORPHINE) Practical and Theoretical
Considerations, October 1954. http://jamanetwork.com/journals/jamainternalmedicine/article-abstract/
559749?resultClick=1.