EFFECT OF GREEN TEA LEAF EXTRACT (Camelia Sinensis) ON SGPT LEVELS AND

HISTOPATHOLOGY EXAMINATION OF WHITE RAT LIVER (Rattus Novergicus)

INDUCED BY CHOLESTEROL

Nadia Alaydrus, Agus Suharto

Medical Faculty
Universitas Muhammadiyah Yogyakarta
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ABSTRACT

Background: Diseases correlated with lifestyle tends to increase recently. High fat diet may
cause adverse effect to many organs. Liver is one of the major organ regulating fat metabolism in
human body. Liver produces a variety enzyme when it damage. These enzymes include: alkali
phospatase (ALP), lactic dehidrogenase (LDH), aspartat aminotransferase (AST), alanine
aminotransferase (ALT), dan gamma glutamyltransferase (GT). SGPT stands for dari serum
glutamic pyruvic transaminase, often also referred to ALT, is an enzymes found in liver cells and
is effective to diagnose liver cells destruction. SGPT is considered more specific to assess liver
damage than SGOT.
The use of traditional medicine for prevention and treatment of various diseases widely use
recently. One of traditional medicine most studied is green tea. Previous research has shown that
green tea can protect liver from substance which may damage liver cell and other hepatotoxic
drugs.
This study aims to assess the hepatoprotector effect of green tea on SGPT levels and liver
histopathology examination of white rat induced by cholesterol.

Study design: Experimental

Location: Pathology anatomy laboratorium of Medical Faculty, Universitas Muhamadiyah

Yogyakarta.

Result: This study population included 24 white rats divided randomly in to four groups:
negative control group (K-), treatment group 1 (P1), treatment group 2 (P2), positive control
group (K+). The results showed that there are differences on SGPT levels in K- compared to K+,
P1 compared to K+, P2 compared to K+ (sig 0,002, 0,014, 0,023 respectively). SGPT levels
between K- compared to P1, K- compared to P2, and P1 compared to P2 showed no significance
difference (sig 0,795, 0,655, 0,955 respectively). This study result on histopathology examination
showed differences in K- compared to K+, P1 compared to K+, P2 compared to K+ (sig 0,004,
0,002, 0,033 respectively). Histopathology examination between K- compared to P1, K-
compared to P2, P1 compared to P2 showed no significant differences (sig 0,167, 0,751, 0,553
respectively).

Conclusion: Green tea affect SGPT level and histopathology examination of liver rat induced by
cholesterol. Green tea does not affect SGPT levels and histopathology examination in rat which
is not induced by cholesterol. Further research is needed to make recommendation for clinical
setting.
Keyword: green tea, SGPT, liver hystopathology.