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Summary:
Diagnosis:
Bilateral spontaneous pneumothorax in a patient with miliary pattern tuberculosis
Imaging Findings:
In addition to oxygen therapy, treatment with a combination of isoniazid,
rifampicin, ethambutol, and pyrazinamide was started on the third day of
hospitalization. On the fth day of antituberculous treatment, her fever had not
yet decreased, and methylprednisolone (1 mg/kg) was added to the therapy.
Multiple blood cultures were negative. No pathogens were identied in aerobic
cultures of sputum or urine. Wright and Rose Bengal agglutination tests for
brucellosis were negative. The serum levels of CA-125 and CA-15.3 were high,
but gynecological examination and thyroid and mammary ultrasonography
showed no signs of malignancy. No beroptic bronchoscopy or other invasive
procedures were performed because of respiratory failure. On the 38th day of
hospitalization, she complained of pleuritic chest pain, and chest CT revealed a
left-sided pneumothorax (Figure 2). A tube thoracostomy was placed, but after 1
week she developed a new pneumothorax on the other side (Figure 3). The
patient was managed with bilateral tube thoracostomy, and both lungs were
expanded. Her high temperature, which was occasionally subfebrile, continued
for 2 months in spite of systemic corticotherapy. In the fth month of therapy, the
tumor markers (CA-125, CA-15.3) returned to normal levels. The treatment
(antituberculosis drugs and corticosteroids) was continued for 12 months, but the
miliary shadows did not disappear. Her forced vital capacity (FVC) was 55%, her
forced expiratory volume in 1 second (FEV1) was 58%, and her FEV1/FVC was
93% in pulmonary function tests. Diffusion capacity was 65%, but the patient was
not a candidate for an invasive diagnostic procedure at this time.
Discussion:
Miliary pattern and pneumothorax are rare radiological features in pulmonary
tuberculosis. Their incidences are nearly 1.3% and 1.5%, respectively.1 However,
the coincidence of pneumothorax on miliary tuberculosis is a very rare event. We
found only 9 well-documented cases in the English literature.2-7 The age
distribution of these patients showed adult predominance (Table 1), which
supported the ndings of other studies.8,9 Table 1 also illustrates that the
male/female ratio was 4:6. However, this rate was 3:1 in all causes of secondary
spontaneous pneu-mothorax.10
In this patient, at the end of the twelfth month of antituberculous therapy with
corticotherapy, the miliary pattern was unchanged and her diffusion capacity was
reduced, despite the presence of good performance status. These ndings
clearly suggested an interstitial lung disease, such as histiocytosis X or
Langerhans cell his-tiocytosis. Pulmonary histiocytosis X is an uncommon,
smoking-related, interstitial lung disease that primarily affects young adults.
Spontaneous pneumothorax, which may be recurrent, is a recognized feature of
this disease and likely results from the destruction of lung parenchyma with
associated cysts or nodules (with or without cavitation). Prior to a biopsy
procedure, a high-resolution chest CT can be helpful in the diagnostic evaluation.
The natural history is variable, with some patients experiencing spontaneous
remission of symptoms and others progressing to end-stage brotic lung disease.
There is no clear benet for either corticosteroids or cytotoxic agents.11,12
CONCLUSION