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Number of sample in this research is 40, divided into 2 groups contains 20 samples
each with blind randomize. First group was given 10 mg Rivaroxaban per oral 6 - 10 hours post-
operation, on the second group was given placebo. D-Dimer level checked in 1 day pre-
operative, 1 day post-operative and 3 days post-operative. D-Dimer mean result in Rivaroxaban
group, pre-operative 0.54 mg/L, 1 day post-operative 1.17 mg/L, 3 days post-operative 1.03
mg/L. D-Dimer Mean result in placebo group, pre-operative 0.77 mg/L, 1 day post-operative
5.74 mg/L, 3 days post-operative 3.89 mg/L. This research using independent T-Test in 1 day
post operative in both groups with significance 0.002 (p<0.05) and on 3 days post-operative with
significance 0.002 (p<0.05).