Dr. Zerrudo: BREAST/MALE c.

Colloidcarcinoma
d. Tubular carcinoma
1. Fibrocystic change usually occurs at 10. This lesion is characterized by neoplastic cells
a. Before 30 years of age arranged in single files
b. 20-40 years of age a. Invasive lobular carcinoma
c. After 40 years b. Mucinous carcinoma
d. 6th decade c. Tubular carcinoma
2. Most common benign tumor of the female d. Medullary carcninoma
breast 11. This breast lesion is characterized by marked
lymphocytic infiltration
a. Fibroadenoma a. Medullary carcinoma
b. Benign phylloides tumor b. Tubular carcinoma
c. Galactocele c. Invasive lobular carcinoma
d. Tubular adenoma d. Mucinous carcinoma
3. Most common congenital anomaly 12. This lesion is characterized by islands of
a. Supernumerary nipples neoplastic cells floating in lakes of mucin
b. Accessory axillary breast tissue a. Tubular carcinoma
c. Congenital inversion of nipples b. Invasive lobular carcinoma
d. Mammary duct ectasia c. Mucinous carcinoma
4. All of the following are inflammatory d. Medullary carcinoma
conditions, except 13. This lesion is characterized by well-formed
a. Acute mastitis tubules lined by single layer of cells with
b. Supernumerary nipples apocrine snouts
c. Galactocele a. Invasive lobular carcinoma
d. Silicone breast implants b. Mucinous carcinoma
5. Mimics carcinoma clinically and on c. Medullary carcinoma
mammogram d. Tubular carcinoma
a. Fat necrosis 14. Most important prognostic factor in breast
b. Mammary duct ectasia carcinoma
c. Galactocele a. Axillary lymph node status
d. A and B b. Histologic subtype
6. Which of the following is the most common c. Tumor size
type of breast carcninoma d. Tumor histologic grade
a. Invasive ductal carcinoma 15. The stage where there is an invasive CA 2 cm or
b. Mucinous carcninoma less in size including microinvasion with
c. Medullary carcinoma negative nodes and no distant metastases.
d. Invasive lobular carcinoma a. Stage I
7. Genetic factors usually involved in Breast b. Stage II
Carcinoma, except c. Stage III
a. Li-Fraumeni syndrome d. Stage IV
b. BRCA-1, BRCA-2 mutations 16. Cryptorchidism/testicular atrophy-
c. Chromosome 11q mutation UNDESCENDED TESTES
d. Heterozygous ATM gene mutation 17. Epididymis- much more affected than testes
8. This lesion is characterized by solid sheets of proper
high-grade malignant cells with central necrosis 18. TESTICULAR NEOPLASMS- MALIGNANT!!!, most
a. Pagets disease important cause of painless testicular
b. Cribriform variant enlargement.
c. Medullary carcninoma 19. 95% of ALL TESTICULAR NEOPLASMS- from
d. Comedocarcinoma GERM CELLS; 5%- from SUPPORT CELLS
9. Well circumscribed mass lacking desmoplastic 20. SEMINOMA- ~dysgerminoma IN OVARY, NO
response HEMORRHAGE/NECROSIS
a. Pagets disease a. Large cells with clear cytoplasm
b. Medullary carcinoma b. Fibrous septae
 c. Mild lymphocytic infiltrate
d. (-) A-fetoprotein/ HCG
e. (+) placental alkaline phosphatase
21. EMBRYONAL CARCINOMA- INVASIVE masses
with HEMORRHAGE and NECROSIS ; neoplastic
cells are ANGRY LOOKING, hyperchromatic
nuclei, prominent nucleoli
a. May be positive for hcg/afp
22. YOLK SAC TUMOR- most COMMON PRIMARY
TESTICULAR NEOPLASM in children <3 years of
age- GOOD PROGNOSIS
a. CHILDREN- pure
b. ADULTS- mixed with EC.
c. (+) AFP
23. CHORIOCARCINOMA- trophoblastic
differentiation from TOTIPOTENTIAL GERM
CELLS
a. (+) HCG
24. TERATOMA- MORE THAN ONE germ layer type.
a. ADULT- ALL MALIGNANT
b. OVARY- BENIGN
25. MIXED GERM CELL TUMORS- 50-60%
a. Teratocarcinoma- most common
b.
Dr. Layda: FEMALE REPRODUCTIVE SYSTEM
1. CANDIDA- white curdly material
2. HPV- Condyloma Acuminata (venereal
Warts)
3. MOSSCUM CONTAGIOSUM Pox virus,
producing a characteristic lesion
4. HSV 2- HERPETIC Ulcer development: macules,
papules, vesicles, very painful but do not
actually leave any serious sequelae
5. BARTHOLINS DUCT CYST- lined by
TRANSITIONAL CELLS which sometimes become
METAPLASTIC, hence sometimes it becomes
STRATIFIED SQUAMOUS EPITHELIAL LINING
6. LICHEN SCLEROSIS (CHRONIC VULVITIS)- elderly
females, THINNED OUT SKIN with underlying
SUBEPITHELIAL FIBROSIS
7. CONDYLOMA LATUM/LATA- T. pallidum:
SYPHILLIS (CHANCRE).
8. KOILOCYTES- squamous cells with NUCLEAR
ATYPIA and PERINUCLEAR CLEARING/halo by a
dense rim of cytoplasm; NUCLEUS is raisinoid
9. PAGETS DISEASE- large anaplastic tumor cells
with perinuclear clearing or halo, confined to
the basal layer up to the middle.
10. SQUAMOUS CELL CARCINOMA- 95% of tumors,
chronic inflammatory cell dermal infiltrate
11. MALIGNANT
MELANOMA/MELANOCARCINOMA- 2nd most
common malignant tumor
12. CLUE CELLS- G. vaginalis, cytoplasm covered
by organisms.
13. BOTRYOID RHABDOMYOSARCOMA
(Sarcoma botryoides)- BUNCH OF GRAPES;
Cambium Layer: subepithelial dense zone
14. Hallmark of HPV-
KOILOCYTOSIS/KOILOCYTOTIC ATYPIA
15. CERVICAL INTRAEPITHELIAL NEOPLASIA
(CIN) 1- Including Condyloma, the
superficial cell layers (koilocytes), with
preservation of epithelial maturation.
16. ASCUS- Atypical squamous cell of
undetermined significance: nuclear
enlargement 2.5-3x nucleus, variation in nuclear
size, shape, and nucleation, mild
hyperchromasia
17. HYDATID CYST OF MORGANI- Paratubal cyst, 1-
2 cm, SEROUS FLUID, PAPER-THIN WALL,
columnar to cuboida.
18. POLYCYSTIC OVARY- Stein- Levinthal Syndrome,
polycystic ovary associated with AMENORRHEA,
ANOVULATION, OBESITY 40%, HIRSUTISM 50%,
VIRILISM
19. ENDOMETRIOSIS in OVARY- blood lakes in
TRANSPLANTATION AREA: CHOCOLATE CYSTS
20. ENDOMETRIOTIC CYSTS:
a. Endometrial glands
b. Endometrial stroma
c. Hemosiderin laden macrophages/
histiocytes
21. Serous: MALIGNANT SURFACE EPITHELIAL
TUMORS- SEROUS CYSTADENOCARCINOMA: (+)
PSAMMOMA BODIES, you are sure that you are
dealing with SEROUS TYPE
22. BRENNER TUMORS- uncommon
adenofibromas in which the epithelial
component consists of NESTS OF
TRANSITIONAL CELL resembling URINARY
BLADDER.
23. GRANULOSA CELL TUMORS- Adult type: CALL
EXNER-BODIES/ Juvenile type: no nuclear
grooving, teratomas (immature/mature), yolk
sac tumors
24. FIBROMA- Meigs syndrome: fibroma, ascites,
pleural effusion
25. GERMINOMAS/DYSGERMINOMA- Most
radiosensitive of ovarian tumors, separated by
 delicate bands of FIBROUS TISSUE WITH b. MALIGNANT:
LYMPHOCYTES (-sensitive to radiation),
ADENOSQUAMOUS CA
monotonous population of germ cells with
prominent nucleoli. 44.GRADE III: solid tumor cells
26. DERMOID CYSTS/ CYSTIC TERATOMAS- from predominate over the glandular areas
3 GERM LAYERS!!! (poorly differentiated).
27. STRUMA OVARI- composed of ENTIRELY
MATURE THYROID TISSUE
28. METASTATIC OVARIAN TUMORS-
KRUKENBERG TUMOR: Bilateral metastasis
composed of mucin producing SIGNET RING
CANCER.
29. COMPLETE HYDATIDIFORM MOLE- Grossly
swollen chorionic villi, BUNCH OF GRAPES,
Haploid 23X duplicates to 46XX.
30. CHORIOCARCINOMA- mass with CENTRAL
NECROSIS and HEMORRHAGE, from
TROPHOBLAST, high serum HCG
31. BATTLEDOR PLACENTA- True marginal
insertion of placenta, cord inserted marginally
32. PROLIFERATIVE PHASE- ESTROGEN
33. SECRETORY PHASE- saw-toothed appearance
34. PREGNANCY- Arias Stella Reaction
35. PILL ENDOMETRIUM- Asynchronous or
discordant pattern
36. CHRONIC ENDOMETRITIS- (+) PLASMA CELLS
37. ADENOMYOSIS/ ENDOMETRIOSIS
INTERNA- whorls and trabeculated appearance
38. SIMPLE HYPERPLASIA- without atypia, aka
CYSTIC HYPERPLASIA or SWISS CHEESE
HYPERPLASIA
39. LEIOMYOMA- aka UTERINE FIBROIDS, MOST
COMMON TUMOR of the UTERUS, smooth
muscle tumor
40. MALIGNANT MIXED MULLERIAN TUMORS
(MMT)- ALL COMPONENTS derived from
MESODERM, also called CARSINOSARCOMA
41. Type 1 endometrial CA: present
unopposed estrogen and hyperplasia, pre
and PERIMENOPAUSAL status
42.ADENOCARCINOMA- also called
ADENOCARCINOMA with SQUAMOUS
METAPLASIA, with nests of benign
squamous cells
43.ADENOSQUAMOUS CA- BOTH glands and
squamous cells are MALIGNANT, often
with CLEAR and SQUAMOUS CELLS
a. BENIGN: ADENOACANTHOMA