EFFECTIVENESS OF

TREATMENT OPTIONS FOR

Open-Angle
GLAUCOMA
Despite several clinical trials on the
effectiveness of medical treatment on the
management of glaucoma, additional
research is needed to determine the
effectiveness of each treatment.

The RiGOR study compared the effectiveness of medications,

laser surgery, and incisional and/or other surgery in patients
with open-angle glaucoma who were seen at follow-up periods
of 3, 6 and 12 months after treatment.

To assess the effectiveness, the primary study end-point was

the reduction in IOP of 15% or more at the 12-month mark,
which is considered an indicator of success...

A TOTAL OF 2597 ELIGIBLE PATIENTS WERE ENROLLED:

1377 436
(53%) (17%)
With With incisional or
medication other surgical
therapy procedures

784
(30%)
Of whom were
planned to be treated
with laser surgery

Based on the study, a higher proportion of patients receiving

incisional or other surgical procedures achieved the target of
15% 15% reduction in IOP at the 12 month follow-up, compared with
patients in the medication group. Small or no differences were
seen between the laser surgery and medication groups.

PERCENTAGE OF PATIENTS ACHIEVING REDUCTION IN

INTRAOCULAR PRESSURE

Laser surgery Other surgical procedures Additional medications

15% reduction in IOP 25% reduction in IOP

ALL PATIENTS

56.6% 81.6% 57.0%

35.7% 71.5% 40.2%

BLACK PATIENTS

51.1% 79.4% 57.3%

35.1% 69.1% 40.5%

HISPANIC PATIENTS

39.5% 73.7% 49.0%

28.9% 63.2% 33.3%

REDUCTION IN IOP REDUCTION IN IOP

OF 15% OR MORE OF 25% OR MORE
FROM BASELINE FROM BASELINE

Laser
surgery 56.6% 35.7%
(n=784)

Incisional/other
surgical
procedures 81.6% 71.5%
(n=436)

Additional
Medication 61.4% 44.5%
(n=1377)

American Academy of Ophthalmology

aao.org
FUNDED BY THE AGENCY FOR HEALTHCARE RESEARCH AND QUALITY
ROCKVILLE, MD
GRANT NUMBER: 1418HS022006-01

Source:
Anne L. Coleman, Flora C. Lum, Priscilla Velentgas, Zhaohui Su, and Richard E. Gliklich. "Impact of
Treatment Strategies for Open Angle Glaucoma on Intraocular Pressure: The RiGOR Study." Journal of
Comparative Effectiveness Research 5.1 (2016): 87-98.