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Pharmacology Test 2 Drug List
Categorized
Sulfinpyrazone Anti-Inflammatory; Anti- Promotes the excretion of uric acid in the proximal
Gout tubule. Do not use when urinary uric acid levels are
already high, asurate calculi may result. Adverse
Uricosuric Effects: Allergic dermatitis, GI disturbances.
Probenecid Anti-Inflammatory; Anti- Promotes the excretion of uric acid in the proximal
Gout tubule. Do not use when urinary uric acid levels are
already high, asurate calculi may result. Adverse
Uricosuric Agent Effects: Allergic dermatitis, GI disturbances.
Adjunct
Auranofin Anti-Inflammatory; Anti- 29% gold, PO. Mech: Macrophages uptake the drug ------
RA > suppress phagocytic and lysosomal activity. Gold
accumulates in multiple tissues.
Gold Salts
Aurothioglucose Anti-Inflammatory; Anti- 50% gold, IM. Mech: Macrophages uptake the drug ------
RA > suppress phagocytic and lysosomal activity. Gold
accumulates in multiple tissues.
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Gold Salts
Aurothiomalate Anti-Inflammatory; Anti- 50% gold, IM. Mech: Macrophages uptake the drug ------
RA > suppress phagocytic and lysosomal activity. Gold
accumulates in multiple tissues.
Gold Salts
Sulindac Anti-Inflammatory; NSAID Pro-Drug must first be metabolized before it inhibits COX.
Tolmetin Anti-Inflammatory; NSAID Does not displace drugs from plasma binding proteins as
much as others. Preferred drug for use with Warfarin.
Indomethacin Anti-Inflammatory; NSAID Stronger and more toxic than other NSAID's.Indications:
Osteoarthritis of the hip, acute gouty arthritis,
Anti-Gout ankylosing sponylitis, patent ductus arteriosus.
Phenylbutazone Anti-Inflammatory; NSAID Potent anti-inflammatory, but weak analgesic and anti-
pyretic. Indications: Acute gouty arthritis, RAthat is
Anti-Gout refractory to treatment with other NSAID's.
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Adverse Effects: GI distress, peptic ulcer; can be worse
than aspirin. Also soar throat, agranulocytosis.
Nabumetone Anti-Inflammatory; NSAID Can be given only once a day to treat RA.
(Relafen) Long-acting
Oxaprozin Anti-Inflammatory; NSAID Can be given only once a day to treat RA.
(Daypro) Long-acting
Piroxicam Anti-Inflammatory; NSAID Can be given only once a day to treat RA. Causes GI
disturbances in 20% of patients.
Long-acting
Fenoprofen Anti-Inflammatory; NSAID Short-acting. Must be given 4 times a day for RA.
Ibuprofen Anti-Inflammatory; NSAID Short-acting. Must be given 4 times a day for RA. Does
not displace drugs from plasma binding proteins as much
(Motrin) Propionic Acid Derivative as others. Preferred drug for use with Warfarin.
Ketoprofen Anti-Inflammatory; NSAID Short-acting. Must be given 4 times a day for RA. Unique
in that it inhibitsboth cyclooxygenase and
(Orudis) Propionic Acid Derivative lipoxygenase.Does not displace drugs from plasma
binding proteins as much as others. Preferred drug for
use with Warfarin.
Naproxen Anti-Inflammatory; NSAID Longer acting than the other propionic-acid derivatives.
Half-life of about 13 hours. Can be given twice a day for
Propionic Acid Derivative RA.
Folinic Acid Anti-Microbial; Anti- Given withTrimethoprim, it is the reduced form of THF.
Bacterial It prevents the anti-folate side-effects of trimethoprim:
Megaloblastic anemia, granulocytopenia, leukopenia.
Adjunct
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Pyridoxine (Vit. Anti-Microbial; Anti- Given withIsoniazid, it prevents the peripheral neuritis
B6) Bacterial side-effect that can be seen with this drug. The
peripheral neuritis results from an anti-pyridoxine effect.
Adjunct
Adjunct
Dapsone Anti-Microbial; Anti- Indicated for treating Leprosy. Resistance is on the rise.
Bacterial
Adverse Effects: Hemolytic anemia in people with G6PD
Anti-Mycobacterial deficiency, Erythema Nodosum, Methemoglobinemia.
Isoniazid Anti-Microbial; Anti- First line drug, and used for chemoprophylaxis. Mech: it
Bacterial blocksmycolic acid synthesis. Gets into CNS.
Anti-Mycobacterial; 1st-line
Rifampin Anti-Microbial; Anti- First line drug. Mech: It inhibits RNA synthesis by binding
Bacterial to the beta-subunit of bacterial RNA-Polymerase. Gets
into CNS. Adverse Effects: Hepatotoxicity.
Anti-Mycobacterial; 1st-line
Anti-Mycobacterial; 2nd-
line
Ethionamide Anti-Microbial; Anti- Second-line drug. Mech: Analog of Isioniazid that also
Bacterial inhibits mycolic acid synthesis.
ICWS
Nalidixic Acid Anti-Microbial; Anti- Quinolone that blocks Topoisomerase II. Effective against
Bacterial gram-negatives.
ICWS; Carbopenem
ICWS; Cephalosporin
1st generation
Cefazolin Anti-Microbial; Anti- IV. Excreted mainly by glomerular filtration (rather than
Bacterial active tubular secretion), thus it has a longer half-life.
ICWS; Cephalosporin
1st generation
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Cephalexin Anti-Microbial; Anti- PO administration.
Bacterial
ICWS; Cephalosporin
1st generation
ICWS; Cephalosporin
1st generation
ICWS; Cephalosporin
2ndgeneration
Cefamandole Anti-Microbial; Anti- May show Disulfarim-like reaction; don't take with EtOH.
Bacterial
Cephalosporinase-resistant.
ICWS; Cephalosporin
2ndgeneration
ICWS; Cephalosporin
2ndgeneration
ICWS; Cephalosporin
2ndgeneration
ICWS; Cephalosporin
2ndgeneration
ICWS; Cephalosporin
2ndgeneration
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Cefixime Anti-Microbial; Anti- PO administration. Can penetrate into the CNS.
Bacterial
ICWS; Cephalosporin
3rd generation
3rd generation May show Disulfarim-like reaction; don't take with EtOH
3rd generation
ICWS; Cephalosporin
3rd generation
ICWS; Cephalosporin
3rd generation
ICWS; Cephalosporin
3rd generation
ICWS; Cephalosporin
3rd generation
4th generation
ICWS; Penicillins
Broad-Spectrum
Extended-Spectrum
Extended-Spectrum
Extended-Spectrum
Penicillinase-Resistant
Penicillinase-Resistant
Metabolic Inhibitor;
Sulfonamide
Metabolic Inhibitor;
Sulfonamide
Metabolic Inhibitor;
Sulfonamide
Metabolic Inhibitor;
Sulfonamide
Anti-Parasitic
Synthesis Inhibitor;
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Tetracycline
Synthesis Inhibitor;
Tetracycline
Kanamycin Anti-Microbial; Anti-Bacterial Older drug. Now only used as topical agent,
due to severity of adverse effects.
Synthesis Inhitor;
Aminoglycoside
Anti-Mycobacterial; 1st-line
Adverse Effects:
Hepatotoxicity,gynecomastia,
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thrombophlebitis.
Imidazole (Topical)
Mebendazole Anti-Microbial; Anti-Parasitic Given PO, but only about 10% is absorbed
(poorly absorbed). It
Anti-Helminthitic inhibitsmicrotubule
synthesis innematodes.Indicated
forpinworms, hookworms, ascariasis.
Anti-Malarial
Mefloquine Anti-Microbial; Anti-Parasitic Only PO. Primarily used for prophylaxis and
treatment of Chloroquine-resistant P.
Anti-Malarial Falciparum strains. Adverse Effects: Can
have bad CNS and psychological effects.
Anti-Malarial
Chloroquine Anti-Microbial; Anti-Parasitic Usually PO, also IV, IM. Most popular blood
schizonticide. Extensive tissue binding
Anti-Malarial requires large loading dose. Resistance is
common and occurs by P.
Falciparummaking phosphoglycoprotein
Anti-Inflammatory; Anti- pumps to pump out the drug. Adverse
Arthritis Effects: generally well-tolerated; long-term
retinopathyy, myopathy, ototoxicity.
Anti-Protozoal
Slow-acting, and resistance can be a
problem.
Diloxanide Furoate Anti-Microbial; Anti-Parasitic Given orally, Diloxinide is the active drug,
released by gut bacteria. Mild drug used to
Anti-Protozoal combat intestinal amebiasis. Well-tolerated.
Nifurtimox
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(Stavudine) Anti-AIDS; Nucleoside
Analog
Anti-AIDS; Nucleoside
Analog
Azidothymidine Anti-Microbial; Anti-Viral Half-life of 1-3 hrs. Gets into CNS
(AZT) (60%). Mech: It is phosphorylates to
Anti-AIDS; Nucleoside the triphosphate form, which is the
(Zidovudine) Analog active form. Then, (1) It
competitively inhibits HIV Reverse
Transcriptase, and (2) It is
Immunosuppressant a chain-terminator of HIV viral
DNA synthesis. Resistance is
common, due mutations in viral
Reverse Transcriptase.
Anti-AIDS; Protease
Inhibitor
Ritonavir Anti-Microbial; Anti-Viral
Anti-AIDS; Protease
Inhibitor
Saquinavir Anti-Microbial; Anti-Viral Well tolerated, but low oral
bioavilability (5%).
Anti-AIDS; Protease
Inhibitor
Interferon -alpha Anti-Microbial; Anti-Viral Enhances host-cell resistance to viral
(IFN-alpha) infections, and possibly some
Endogenous Factor tumors. Adverse effects: fever,
malaise, headaches, anemia, GI
distress.
Acyclovir Anti-Microbial; Anti-Viral Indicated for HSV-1, HSV-2, VZV.
Used topically for skin lesions, or IV
Nucleoside Analog for encephalitis or neonatal disease.
It is activated by HSV
viralThymidine Kinase ------> (1)
it binds andinhibits viral DNA
polymerase, and (2) it is
incorporated into viral DNA, where it
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acts as a chain-terminator.
Aziridine
Procarbazine Chemotherapy; Hydrazine. Part of the MOPP group of
Alkylating Agent drugs, to fight Hodgkin's Disease.
Adverse Effects: Has especially high
Hydrazine incidence ofsecondary
malignancies, particularly
leukemias.
Chlorambucil Chemotherapy; Nitrogen Mustard, Oral. Indicated
Alkylating Agent forlymphomas, CLL.
Nitrogen Mustard
Mechlore thamine Chemotherapy; Nitrogen Mustard, IV. Directly toxic.
Alkylating Agent It has the shortest half-life (a few
minutes) and is the least stable of all
Nitrogen Mustard alkylating agents. Is often infused
directly into artery supplying the
tumor, due to its short half-life. Part
of the MOPP group of drugs, to
fightHodgkin's Disease.
Melphalan Chemotherapy; Nitrogen Mustard, Oral. Indicated
Alkylating Agent for Multiple Myeloma.
Nitrogen Mustard
Cyclopho sphamide Chemotherapy; Pro-drug, oral. It is converted to its
Alkylating Agent active form by Cytochrome-P450
enzyme.
Nitrogen Mustard
Broad-spectrum agent Useful at
Immunosuppressant fighting solid tumors, leukemias,
ovarian carcinoma.
Nitrosurea
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Carboplatin Chemotherapy; Platinum complex, similar to Cis-
Alkylating Agent Platin.
Platinum Complex
Cis-Platin Chemotherapy; Forms Platinum complex, a unique
Alkylating Agent platinum-bond with DNA causes both
damage and cross-linkage of DNA
Platinum Complex strands. Broad-spectrum agent.
Useful at fighting solid
tumors: breast, ovarian,
testicular, lung, bladder cancers.
Indications: Broad-
spectrum agent, used in combo
chemotherapy to treat many tumors.
Mitoxantrone Chemotherapy; The only synthetic anti-cancer
Antibiotic antibiotic, with properties similar to
the other Anthracyclines. They
Anthracycline; Synthetic areintercalating agents,blocking
both replication and transcription by
non-covalent interactions.
Cumulativecardiotoxicity, which
can be potentially fatal.
Hydroxyurea Chemotherapy;
Miscellaneous
Iron- Deficiency
Anemia
Iron-Deficiency
Anemia
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Iron Dextran Hemopoeitic; Parenteral iron administration, IM or
Anemia IV. IM can be painful.
No adverse effects.
Given prophylactically
before gallbladder surgery.
Toxicity
Indicated for tPA,
streptokinasetoxicity.
Indications: Kidney
transplantation.