FACE MAKE-UP BODY

OPTIM HYAL
TM

Sequence of acetylated glucuronic acids

Function:
Skin smoothing.
Definition:
Obtained by biofermentation,
OPTIM HYAL contains Glycokines,
oligosaccharides of acetylated glucuronic
acids (186 glucuronic acids, acetylation
degree 91%) having a similar structure to
hyaluronic acid fragments.
Properties:
Smoothes out wrinkles.
Moisturises skin surface and depth.
Increases skin suppleness and resistance.
Characteristics:
By stimulating hyaluronic acid neosynthesis
and by sustaining its turnover,
OPTIM HYAL helps deliver optimal
moisturising and viscoelastic properties.
In addition, OPTIM HYAL increases
elastin synthesis.
Points of interest:
Hyaluronic acid half-life is less than one day.
The natural pace of renewal decreases
with age. OPTIM HYAL acts to restore
Sustaining
and maintain an optimal hyaluronic acid a young and optim
optimal
al
renewal.
INCI name:
hyaluronic
hyal uronic acid
Hydrolyzed Yeast Extract renewal
Cetyl Hydroxyethylcellulose
Polyglucuronic Acid Lecithin
Applications:
All skin care products for face,
eye contour and body.
before after 1 month
Formulation:
Water soluble.
Incorporate in the emulsion or gel between
25 and 80C for 2 hours maximum.
Recommended use level:
3%
Patents:
WO 2010/067327 ; FR 2 939 799
US 2011/0250276 ; EP 2 367 852

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E-mail: sederma@sederma.fr
Copyright 2014 Sederma.
Significant decrease in wrinkle quantity
All rights reserved.
Member of Croda International Plc
by 46% up to 96% after just 1 month
 CLAIM SUBSTANTIATION 10-2014

In vitro and ex vivo tests

EXTRACELLULAR MATRIX RENEWAL

Optimal and sustained hyaluronic acid neosynthesis Elastin synthesis
Hyaluronic acid production: Improvement of visco-elastic properties:
On human keratinocytes (OPTIM HYAL eq. 3%) ....................+40%, p<0.01 On human fibroblasts (OPTIM HYAL eq. 3%) ......................+359%, p<0.01
On human keratinocytes (OPTIM HYAL eq. 5%) ....................+85%, p<0.01 On human fibroblasts (OPTIM HYAL eq. 5%) ......................+552%, p<0.01
On human fibroblasts (OPTIM HYAL eq. 5%) ........................+35%, p<0.01
Hyaluronic acid receptor CD44 expression: On skin explants under accelerated ageing conditions
On skin explants under accelerated ageing conditions (OPTIM HYAL 1.5% in a cream)...........................................+18%, p<0.04
(OPTIM HYAL 1.5% in a cream)...........................................+55%, p<0.02
OPTIM HYAL demonstrated a strong stimulating power on the
synthesis of elastin.

CD44 By stimulating CD44, a cell receptor involved in hyaluronic acid

red staining anchoring and turnover, and HAS-2 expression, OPTIM HYAL
Control OPTIM HYAL 1.5% generates an efficient cutaneous water network and sustains the self-
renewal of hyaluronic acid.

Hyaluronan synthase-2 expression:

On human fibroblasts (OPTIM HYAL eq. 3%) .....................+90.5%, p<0.01

In vivo tests - Instrumental evaluation

26 female volunteers, mean age 38, with dry skin and wrinkles, applied twice daily for 2 months a cream containing OPTIM HYAL 3% against placebo.
Single blind studies. Measurements after 1 month and 2 months. The results at 2 months are not presented here and are available on request.

MOISTURE SMOOTHNESS

Superficial hydration (Corneometer).................... +24% vs placebo, p<0.01 Main wrinkles (SILFLO profilometry)
Depth ............................................................. -12.5%, p<0.01 up to -52%
In-depth hydration (MoistureMeter) .................... +12% vs placebo, p<0.01 Density.............................................................. -46%, p<0.01 up to -96%
No significant placebo effect
In just 1 month, OPTIM HYAL moisturises both in depth and on the surface.
With OPTIM HYAL, average density and depth of the main wrinkles are
significantly reduced.
SUPPLENESS

Skin visco-elastic properties (Aeroflexmeter)

Resistance ........................................................ +12% (p<0.05 vs placebo)
Firmness ............................................................. +9% (p<0.05 vs placebo)
Density.............................................................. +14% (p<0.01 vs placebo)

With OPTIM HYAL, the skin becomes supple and resistant.

SELF-EVALUATION (after 3 weeks, n=104) T0 T1 month

SENSORY EVALUATION at Eurofins

Micro-depressionary network (SILFLO profilometry)
Well-being during application agree
Area occupied by wrinkles (50 -100 m) .......... -22.5%, p<0.01 up to -58%
Moisturising effect
Roughness ........................................................ -14%, p<0.01 up to -43%
disagree
Smoothing ....................................................... +22%, p<0.01 up to +64%
Skin more elastic
No significant placebo effect
Skin less dry
Skin more comfortable After just one month, OPTIM HYAL significantly smoothes the
Skin nourishing effect cutaneous micro-depressionary network.
0 20 40 60 80 100

In only one month, OPTIM HYAL smoothes out wrinkles, moisturises, and makes the skin more supple and resistant.

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