fe TTT IE | MANIPAL UNIVERSITY BDS PHASE-I YEAR-2 DEGREE EXAMINATION — SEPTEMBER 2013 SUBJECT: MICROBIOLOGY - I (ESSAY) Thursday, September 12, 2013 1:30 His. @© Describe the steps involved in viral replication. L (5 marks) 2. Write short notes on: 2A. Contributions of Robert Koch > 2B. Mechanism of type I hypersensitivity (2+3 = 5 marks) 3. 4 year old Michael was found to have a dry, irritant cough that evolved into bouts of coughing spells. At the end of the spell he would gasp with a characteristic sound. The doctar noticed coryza, sneezing and low grade fever. Post nasal swab sent to the laboratory for investigation revealed gram negative bacilli 3A. What is the most probable etiology? 3B. Discuss the pathogenesis of the above clinical condition. 3 3C. With regards to prophylaxis, comment on the probable reason for Michael to acquire this infection. (13H = 5 marks) 4. A 20 year old college student from a densely populated city, developed fever, headache, conjunctival injection along with severe pain in his back and limbs since 7 days, On examination he was found to have thrombocytopenia, enlarged lymph nodes and maculopapular rashes on the skin. IgM ELISA was reported positive for a flavivirus having four serotypes. Name the vector-bome infection in the above mentioned case and explain the pathogenesis. (144 4G)marks) 5. List two helminths causing central nervous system infections and describe the pathogenesis of neuroeysticercosis, (243 {5 )narks) 6. Describe the clinical course of HIV infection.Clinical features of Creutzfeldt-Fakob disease 7B. Ridley and Jopling classification of leprosy @4Q)=5 marks) | 7. Write short notes on: 8. Discuss the etiopathogenesis of: 8A. Cancrum oris | @®) Periodontitis | QQ)» = 5 marks) Denes Page 2 of 2Reg. No. | MANIPAL UNIVERSITY BDS PHASE-I YEAR-2 DEGREE EXAMINATION - SEPTEMBER 2013 SUBJECT: MICROBIOLOGY - II (MCQs) Thursday, September 12, 2013 ‘Time: 12:00 - 12:30 Hrs. Max. Marks: 60 INSTRUCTIONS 1. Foreach statement, select T (True) or F (False) as your choice. 2. Indicate your choice by darkening the appropriate circle itr the answer sheet provided. 3. Use only HB or 2B pencils to darken the circle. 4, Leave blank for Don’t Know response. 5. Scoring systems is as follows: For every Correct response imark is awarded For every Wrong response 0.5 mark is deducted For every Don’t Know response No mark is deducted Indicate your roll number (Registration Number) clearly and correctly. Do not write anything in the question paper. The true/false statements are numbered 101 to 160 (Total 60 statements). This question paper contains 02 pages. Please make sure that the question paper provided to ‘you has all the pages. were Following pairs correctly match the phases of — 115. Fixes the complement bacterial growth curve with the associated 116. Is an opsonin features. 117, Crosses the placenta 101. Lag phase: Cell division Following pairs correctly match 102, Log phase: Susceptibility to antibiotics immunodeficiency conditions with their 103. Stationary phase: Spore formation appropriate causes JWI. Phase of decline: Release of autolytic enzymes 118. Chronic granulomatous disease: T cell deficiency Transduction in bacteria 119. Bruton’s disease: B cell deficiency 120. Chronic mucocutaneous "candidiasis: @ Is proved by Griffith experiment Phagocytic deficiency 106. 1s mediated by a bacteriophage 107. Requires the participation of sex pilus Leptospirosis 108. Leads to antibiotic resistance 121. Causing agent is demonstrated by negative Bacterial endotoxin is staining 122, Is transmitted by human body louse 109. Heat stable 123, Complicates to Weil’s disease 1@. Made up of protein 1g. enzymatic in nature ‘Human papilloma virus 112. Present in all bacteria 113. Toxoidable 124, Is an enveloped DNA virus 125. Infection is characterized by the formation of Immunoglobulin M koilocytes, 126. Causes condylomata acuminata RG) Isadimer 127, Is associated with cervical carcinoma Page 1 of 2Neisseria gonorrhoeae 128. Is a gram positive diplococcus 129. Produces IgA protease 130. Is isolated using Thayer Martin’s medium An adventurer who was out in bat caves; after 2 weeks was admitted with diagnosis of hydrophobia and excessive salivation. With regards to the above: 131. Infective agent belongs to Rhabdoviridae family 132, ‘The organism is cultivated in duck eges 133. Condition involves demyelination of neurons 134. The causative agent produces intranuclear inclusion bodies 135. Is prevented by Salk vaccine Hydatido: 136. Is caused by Hymenolepis nana 137, Is seen as brood capsules in the brain 138. Is diagnosed by delayed type hypersensitivity skin test 139. Causing organism is a hermaphrodite 140. ‘Causing organism has man. as the intermediate host Mycobacterium tuberculosis 141. Is called Hansen’s bacillus 142. Is grown on Bordet-Gengou medium 143., Causes caseating granulomas in the lung tissue 144, Is an acid fast bacterium 145. Infection leading to tuberculin reactivity is mediated by cellular arm of immune response Parasites infecting skin include: Trichinella spiralis ‘Trichiuris trichiura 8. Ascaris lumbricoides 449. Leishmania donovani 738. ‘Trypanosoma cruzi Gas gangrene 151. Is eaused by Clostridium perfringens 152, Causing organism produces lecithinase 153. Is known as necrotizing myositis 154, Is characterized by crepitus formation 155. Isatoxemia Hepatitis B virus 156, Is transmitted feco-orally 157, Surface antigen indicates transmissibility 158, Exhibits latency in B lymphocytes 159, Complicates to hepatocellular carcinoma 160, is prevented by @ live attenuated Page 2 of 2