Professional Documents
Culture Documents
Stroke
Intradialytic
Hypotension
Gut ischemia - Translocation
Poor Quality of Life
Limits of conventional dialysis modalities
Dialysis-related pathology
Outline of the presentation
Definition
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
Outline of the presentation
Definition
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
HDF combines diffusive, convective and
adsorptive clearances in the same module
Inlet Blood Flow Outlet D+UF
3 1. Ultrafiltration
1 2. Diffusion
3. Adsorption
2
Ultrafilter
100
Outlet Blood Substitution Inlet D+SF
Fluid (SF)
Flow
Hemodiafiltration enhances clearances of middle
and large molecular weight solutes
Diffusion
Convection
Adsorption
D C
KT = KD + Kc+ KAds
Total Diffusive Convective Adsorptive
5l 15 l 25 l 31 l
Postdilution HDF Lornoy W et al, Nephrol Dial Transplant. 2000: 15: 49-54
Outline of the presentation
Definition
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
Prevalence of HDF in Europe in 2010
Percent of HDF treated patients, %
1.00
HD treated patients : 294400 Online HDF treated : 50800 Bag HDF treated : 3550
0.90
0.80
0.70 0.67
0.60 0.55
0.48
0.50
0.42
0.40 0.33
0.29 0.30
0.30 0.26 0.27 0.28
0.19 0.20
0.20 0.16 0.18 0.18
0.13 0.13 0.14
0.10
0.00
Hemodiafiltration Trends by Country
DOPPS 1-4 Sample Patients* (1996-2010)
% of Patients
40%
SW
30%
BE
UK
20% IT
FR
GE
GE SP
10% ANZ
UK JP
SP
0%
1 2 3 4
(1996-2000) (2002-2004) (2005-2008) (2009-Present)
Study Phase (years)
*Initial prevalent cross-sections who dialyzed 3 times/wk with vintage 3 months; DOPPS 4 data are preliminary; ANZ, BE and
SW did not participate in DOPPS phase 1
Facility % of Patients on HDF, by Phase and Country
Facility % of Patients
100%
90%
80%
70%
60%
50%
40%
30%
20%
10%
0%
2 3 4 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 2 3 4 1 2 3 4 3 4 1 2 3 4
ANZ BE* FR GE IT SP* SW* UK* JP All
Initial prevalent cross-sections who dialyzed 3 times/wk with vintage 3 months
* p-value <0.05 for test for trend for HDF use over time; HDF was not used in Japan during DOPPS phases 1 and 2
Outline of the presentation
Definition
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
Hemodialysis/Patient Interaction
Water treatment system
Water Concentrate
HDF machine
Dialysate
Patient
Water treatment system to produce ultrapure
water
Filter
Dialysis
Station
0.1+ Recirculating Loop
Filter Activated
Charcoal RO RO
Tap Water
Softener Filter
Filter
Pump
0.1+
Ultrapure dialysis fluid is now recognized as a new
standard of contemporary dialysis
2009
International Standard ISO 2009
2009
ISO/FDIS 2009-11663
Non-pyrogenic - Sterile vs Ultrapure
ISO/FDIS 2009-11663
Ultrapure dialysis fluid Substitution fluid
ISO/FDIS 2009-11663
Water and dialysis fluid tend to the same degree of
microbiological purity
Microbial contamination
(CFU/ml) <100 <0.1 <0.1
Sensitized methods
Bacterial endotoxins
(IU/ml) <0.25 <0.03 <0.03
LAL
Water Treatment System, Contamination Levels
High Low
contamination contamination
HDF machine
.
Activated Reverse
Carbon Osmosis
Tap
Water
Patient
Storage
F F Tank
Softener Concentrates
Pump F
Waste UF
Basic concept of online production of
substitution fluid (infusate)
Direct connection
Ultrafilter No dead space
Patient Ultrafilter
Ultrafilter
Frequent disinfection
(Heat, Chemical)
Online HDF, Modalities of substitution
Dialysate outlet
+ Ultrafiltrate
Dialysate outlet
+ Ultrafiltrate
Balancing
Module
Balancing
Fluid Infusion
Module
pump
Fluid
Dialysate inlet
- Infusate Dialysate inlet
- Infusate
Sterilizing Sterilizing
Infusion ultrafilters
pump ultrafilters
Nikkiso DBB-05
FMC 5008
FMC 4008 Gambro Innova
Outline of the presentation
Definition
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
Safety and efficacy on long term use (1994-
1997)
CONTRAST Dutch Convective Transport Study Penne EL et al, Kidney Int. 2009 ; 76: 665-672
Clinical safety is confirmed on a routine
basis and large scale
CONTRAST Dutch Convective Transport Study Penne EL et al, Kidney Int. 2009 ; 76: 665-672
Ultrapurity of dialysis fluid is confirmed in
85 to 98% of samples
10 centers
One year follow-up
11258 HDF sessions
97 patients 3961 samples
CONTRAST Dutch Convective Transport Study Penne EL et al, Kidney Int. 2009 ; 76: 665-672
Ultrapurity of infusate is confirmed in 99 to
100 % of samples
CONTRAST Dutch Convective Transport Study Penne EL et al, Kidney Int. 2009 ; 76: 665-672
Effects of OL-HDF & r-HDF on inflammatory &
nutritional markers
25 HD patients
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
High-Efficiency on-line HDF. What does it means?
Treatment schedule
3 sessions of 4 hours weekly (minimum)
Longer or more frequent (possible)
Highly permeable synthetic membrane
Large surface area > 1.8 m2
Ultrapure bicarbonate dialysis fluid
High blood flow (effective QB: 350 - 400 ml/min)
High dialysate flow (500-700 ml/min) diffusive dose
Large volume of substitution convective dose
Post-dilution (Qsub : 100 ml/min, 24 l / session)
Pre-dilution (Qsub : 200 ml/min, 48 l / session)
Mixed dilution (Qsub : 150ml/min, 36 l/session)
Distribution of Mean Replacement Fluid Volume for Patients on
HDF, by Country
Volume of replacement fluid (Liters)
50 Percentile
45 95th
75th
40
50th
35 25th
30 5th
25
20
15
10
0
ANZ BE FR GE IT JP SP SW UK All
50 86 184 142 270 73 56 129 69 1059
Country across phase 1 - 3
40
24,5
20
4,3
Urea Monitoring, BioStat 1000 Canaud B et al, Am J Kidney Dis 1998; 31:74-80
HDF vs HFHD: modest increase of urea Kt/V
but significant reduction of circulating 2M
ol-HDF
LFHD
HD HD
70 HD pats 24wks 24wks
4hrs x 3wk
HF80 - QD800
Direct dialysate quantification
HD HD
22 HD pats
HDF HDF Lornoy W et al, J Ren Nut 2006; 16: 47-53
Hemodynamic tolerance is improved in HDF
mean
Intracorporeal Convective
resistance dose
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
Outcomes of HDF versus HD
Author, Year HDF vs Comparator Type of study Grading
Jirka et al, 2006 HDF vs LFHD vs HFHD Historical prospective cohort IIa
7% ns
35% hs
French Trial
Dutch Trial Italian Trial Turkish Trial
HFHD vs HDF Catalonian Trial
CONTRAST LFHD vs HF/HDF HFHD vs HDF
> 65yo HFHD vs HDF
LFHD vs HDF 150/75/75 300/300
300/300 300/300
350/350 Tolerance CV events
Tolerance CV events
CV events Morbidity Mortality
CV events Mortality
Mortality Mortality 24 months
Mortality 24 months
36 months 24 months
24 months
Future Epidemio
of HDF
Outcomes Regulatory
Efficacy Safety
Focusing on middle moleculesConvective
dialysis dose
Small water soluble solutes Protein-bound solutes Middle molecules
Asymmetric dimethylarginine 3-Deoxyglucosone Adrenomedullin
Benzylalcohol CMPF* Atrial natriuretic peptide
-Guanidinopropionic acid Fructoselysine 2-Microglobulin
-Lipotropin Glyoxal -Endorphin
Creatinine Hippuric acid Cholecystokinin
Cytidine Homocysteine Clara cell protein
Guanidine Hydroquinone Complement factor D
Guanidinoacetic acid Indole-3-acetic acid Cystatin C
Guanidinosuccinic acid Indoxyl sulfate Middle
Degranulationmolecules
inhibiting protein I
Hypoxanthine Kinurenine Delta-sleep-inducing peptide
Malondialdehyde Kynurenic acid 2Endothelin
- Microglobulin
Methylguanidine Methylglyoxal Hyaluronic acid
Myoinositol N-carboxymethyllysine Interleukin 1
Orotic acid P-cresol Interleukin 6
Orotidine Pentosidine Kappa-Ig light chain
Oxalate Phenol Lambda-Ig light chain
Pseudouridine P-OHhippuric acid Leptin
Symmetric dimethylarginine Quinolinic acid Methionine-enkepahlin
Urea Spermidine Neuropeptide Y
Uric acid Spermine Parathyroid hormone
Xanthine Retinol binding protein
*CMPF is carboxy-methyl-propyl-furanpropionic acid Tumor necrosis factor alpha
Vanholder R. et al New insights in uremic toxins. Kidney Int, 2003, 63; 84: S6S10
HDF vs Daily HDF, 2-M Kinetic
Cleansing
Manual
Priming
infusion
Rinsing
Biofeedback
system
Suppressing
saline
Internal HDF requirement
Reducing
manual
handling
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