Professional Documents
Culture Documents
degradable stents
ca naturally remodels itself
should leave no trace behind, affect future sugeries
bulk erosion - holes start to form, water diffuses in, degrades holes of polymer,
UNPREDICTABLE, CHAOTIC breaking
over time, holes get bigger and bigger
all of a sudden, breaks into chunks
forms debris
surface erosion - degradation only at the surface, faster than the diffusion of water
preferable
polymer washing away
no chunks
while any degredation products be toxic?
drug release profile**
enough mechanical strength to expand and hold artery open for 3-6 mo.?
different erosions a result of different polymer composition
how can you control deg rate?
polymers made up of monomers
degrade when they stop holding hand
alter it by altering number of crosslinks
trigger degredation by altering pH, catalyst, etc.
slide 14
after sterilization, is chemical comp still okay?
sheer?
draw diag. slide 16
aliphatic - charge?
define stereoisomers*
d-lactic and l-lactic* (l makes crystalline/toxic*?, d would be easier/quicker, more
naturally occuring)
slide 18
slide 23
patients with coronary artery disease
current standard of care - bare metal or drug eluting stent
lower restinosis, overall survival
slide 31
compare against degradable and drug eluting
look at restinosis rates, number of major coronary events
diuretics helpful for congestive heart f, makes patients pee out extra fluid
criteria
we want the right tissue
not scar tissue
no quiero una arrethmia
youngs mod - stress v strength(strain?)
tensile strength
trying to match elasticity of cardiac tissue
in situ - you have a gel, combine in a syringe and inject into affected area
in situ: less invasive BUT less control over what happens with scaffold once implantation
occurs
in vitro: mechanical criteria more easily met, more control over what it looks like BUT
more invasive
cardiomyocytes, fibroblasts, myoblasts, adult stem cells, embryonic stems cells
slide 47
patients with heart failure
ventricular cyst device, current standard of treatment\
overall survival