Safety data sheet

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BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol
(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013

1. Substance/preparation and company identification

Vitamin A-Palmitate 1.7 Mio IU/G stabilized with

Tocopherol
Use: food additive(s), cosmetic ingredient

Company:
BASF India Ltd
1st Floor, VIBGYOR Towers, Plot No. C 62, G Block,
Bandra Kurla Complex, Mumbai 400051, INDIA
Telephone: +91 22 6661-8000
Telefax number: +91 22 6758-2753

Emergency information:
International emergency number:
Telephone: +49 180 2273-112

2. Composition/information on ingredients
Chemical nature

retinyl palmitate
CAS: 79-81-2 EINECS: 201-228-5

stabilized with: D,L-alpha-tocopherol

Hazardous ingredients

retinyl palmitate
Content (W/W): >= 75 % - <= 100 %
CAS Number: 79-81-2
EC-Number: 201-228-5
Hazard symbol(s): T
 Page: 2/10
BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
R-phrase(s): 53, 38, 61

D,L-alpha-tocopherol
Content (W/W): >= 1 % - < 3 %
CAS Number: 10191-41-0
EC-Number: 233-466-0
Hazard symbol(s): Xi
R-phrase(s): 43

The wording of the hazard symbols and R-phrases is specified in section 16 if dangerous ingredients
are mentioned.

3. Hazard identification

Irritating to skin.
May cause sensitization by skin contact.
May cause long-term adverse effects in the aquatic environment.
May cause harm to the unborn child.
When finely distributed, self-ignition is possible.

4. First-Aid Measures

General advice:
Immediately remove contaminated clothing. If adverse health effects develop seek medical attention.
First aid personnel should pay attention to their own safety.

If inhaled:
Keep patient calm, remove to fresh air, seek medical attention.

On skin contact:
Wash off thoroughly with ample water. Consult a doctor if skin irritation persists.

On contact with eyes:

Wash affected eyes for at least 15 minutes under running water with eyelids held open.

On ingestion:
Rinse mouth immediately and then drink plenty of water, seek medical attention.

Note to physician:
Symptoms: The most important known symptoms and effects are described in the labelling (see
section 2) and/or in section 11., Further important symptoms and effects are so far not known.
Treatment: Symptomatic treatment (decontamination, vital functions).

5. Fire-Fighting Measures

Suitable extinguishing media:

water spray, carbon dioxide, dry powder, foam

Specific hazards:
 Page: 3/10
BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
Evolution of fumes/fog.

Special protective equipment:

Wear self-contained breathing apparatus and chemical-protective clothing.

Further information:
Dispose of fire debris and contaminated extinguishing water in accordance with official regulations.
Cool endangered containers with water-spray.

6. Accidental Release Measures

Personal precautions:
Use personal protective clothing. Information regarding personal protective measures see, section 8.
Ensure adequate ventilation. Do not breathe vapour/spray. Avoid contact with the skin, eyes and
clothing.

Environmental precautions:
Do not discharge into drains/surface waters/groundwater.

Methods for cleaning up or taking up:

For small amounts: Contain with absorbent material (e.g. sand, silica gel, acid binder, general
purpose binder, sawdust). Place into suitable container for disposal. After taking up material in
containers, cover immediately with water layer.
For large amounts: Dike spillage. Vacuum up spilled product.
Dispose of absorbed material in accordance with regulations.

7. Handling and Storage

Handling
Avoid aerosol formation. Ensure that there is no crystallized product in the container before use.
Processing machines must be fitted with local exhaust ventilation. Wear suitable protective clothing
and eye/face protection. Avoid contact with the skin, eyes and clothing. Keep container tightly
sealed.

Protection against fire and explosion:

Risk of self-ignition when a large surface area is produced due to fine dispersion. Take precautionary
measures against static discharges. Avoid all sources of ignition: heat, sparks, open flame.

Storage
Segregate from oxidants.
Further information on storage conditions: Keep container tightly closed and dry; store in a cool
place. Protect from air. Protect from the effects of light. Keep under nitrogen.

Storage stability:
Storage temperature: 8 - 15 C

Damage by exceeding the maximum temperature is not reversible.

 Page: 4/10
BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
8. Exposure controls and personal protection

Components with occupational exposure limits

none

Personal protective equipment

Respiratory protection:
Respiratory protection in case of vapour/aerosol release. Particle filter with medium efficiency for
solid and liquid particles (e.g. EN 143 or 149, Type P2 or FFP2)

Hand protection:
Suitable chemical resistant safety gloves (EN 374) also with prolonged, direct contact
(Recommended: Protective index 6, corresponding > 480 minutes of permeation time according to
EN 374): E.g. nitrile rubber (0.4 mm), chloroprene rubber (0.5 mm), butyl rubber (0.7 mm) and other
Supplementary note: The specifications are based on tests, literature data and information of glove
manufacturers or are derived from similar substances by analogy. Due to many conditions (e.g.
temperature) it must be considered, that the practical usage of a chemical-protective glove in
practice may be much shorter than the permeation time determined through testing.

Eye protection:
Safety glasses with side-shields (frame goggles) (e.g. EN 166)

Body protection:
Body protection must be chosen depending on activity and possible exposure, e.g. apron, protecting
boots, chemical-protection suit (according to EN 14605 in case of splashes or EN ISO 13982 in case
of dust).

General safety and hygiene measures:

Under no circumstances should the product come into contact with the skin of pregnant women or be
inhaled by them. Avoid contact with skin. Wearing of closed work clothing is required additionally to
the stated personal protection equipment. Handle in accordance with good industrial hygiene and
safety practice. No eating, drinking, smoking or tobacco use at the place of work. Hands and/or face
should be washed before breaks and at the end of the shift. Store work clothing separately.

9. Physical and Chemical Properties

Form: liquid, partially crystallized

Colour: light yellow
Odour: mild

pH value: 7

Melting point: approx. 26 C

Boiling point: approx. 100 C (measured)
The substance / product
decomposes.

Flash point: 194 C (DIN EN 22719; ISO 2719,

closed cup)
 Page: 5/10
BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
Flammability: not flammable
Lower explosion limit:
For liquids not relevant for
classification and labelling.
Upper explosion limit:
For liquids not relevant for
classification and labelling.
Ignition temperature: 261 C (DIN EN 14522)
Self ignition: Based on its structural properties the Test type: Spontaneous self-
product is not classified as self- ignition at room-temperature.
igniting.

Self heating ability: It is not a substance capable of

spontaneous heating.

Explosion hazard: Based on the chemical structure

there is no indicating of explosive
properties.
Fire promoting properties: Based on its structural properties
the product is not classified as
oxidizing.

Vapour pressure: < 0.000001 hPa (measured)

(20 C)
Extrapolated value
0.0000882 hPa (measured)
(64 C)

Density: 921.1 kg/m3 (pyknometer)

(20 C)
907.9 kg/m3 (pyknometer)
(40 C)
Relative density: 0.9211 (pyknometer)
(20 C)
0.9079 (pyknometer)
(40 C)
Relative vapour density (air):
not determined

Solubility in water: Study technically not feasible.

Solubility (qualitative) solvent(s): organic solvents
soluble
Partitioning coefficient n-octanol/water (log Pow): 15.51 (calculated)
(25 C)
Surface tension:
Study technically not feasible.

Viscosity, dynamic: 44 mPa.s

(60 C)

Molar mass: 524.87 g/mol

 Page: 6/10
BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
10. Stability and Reactivity
Conditions to avoid:
Temperature: > 60 C
Disregard of the conditions mentioned may result in undesirable decomposition reactions.

Thermal decomposition: 465 C (DTA)

Substances to avoid:
oxidizing agents

Corrosion to metals: No corrosive effect on metal.

Hazardous reactions:
When finely distributed, self-ignition is possible.

Hazardous decomposition products:

No hazardous decomposition products if stored and handled as prescribed/indicated.

11. Toxicological Information

Acute toxicity

Assessment of acute toxicity:

Virtually nontoxic after a single ingestion.

LD50 rat (oral): > 2,000 mg/kg (BASF-Test)

The product has not been tested. The statement has been derived from substances/products of a
similar structure or composition.

Irritation

Assessment of irritating effects:

Skin contact causes irritation. Not irritating to the eyes.

Primary skin irritation rabbit: Irritant. (BASF-Test)

Primary skin irritation rabbit: moderately irritating (OECD Guideline 404)

Primary irritations of the mucous membrane rabbit: non-irritant (OECD Guideline 405)

Assessment other acute effects

Assessment other acute effects:

Based on available Data, the classification criteria are not met.

Sensitization

Assessment of sensitization:
May cause sensitization by skin contact.
 Page: 7/10
BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013

Repeated dose toxicity

Assessment of repeated dose toxicity:

Repeated exposure to large quantities may affect certain organs.

Genetic toxicity

Assessment of mutagenicity:
In the majority of tests performed (bacteria/microorganisms/cell cultures) a mutagenic effect was not
found. A mutagenic effect was also not observed in in-vivo assays. The product has not been fully
tested. The statements have been derived in parts from products of a similar structure or
composition.

Carcinogenicity

Assessment of carcinogenicity:
Results from a number of long-term carcinogenity studies and short-term tests are available. Taking
into account all of the information, there is no indication that the substance itself is carcinogenic.
Literature data.

Reproductive toxicity

Assessment of reproduction toxicity:

No reliable data are available concerning reproduction toxicity.

Developmental toxicity

Assessment of teratogenicity:
May cause harm to the unborn child.

Other relevant toxicity information

The product has not been tested. The statements on toxicology have been derived from the
properties of the individual components.

12. Ecological Information

Ecotoxicity

Assessment of aquatic toxicity:

There is a high probability that the product is not acutely harmful to aquatic organisms. The inhibition
of the degradation activity of activated sludge is not anticipated when introduced to biological
treatment plants in appropriate low concentrations.

Toxicity to fish:
LC50 (96 h) > 10,000 mg/l, Leuciscus idus (DIN 38412 Part 15, static)
The details of the toxic effect relate to the nominal concentration. The product has not been tested.
The statement has been derived from substances/products of a similar structure or composition.

Aquatic invertebrates:
EC50 (48 h) > 100 mg/l, Daphnia magna (Screening test, static)
 Page: 8/10
BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
The details of the toxic effect relate to the nominal concentration. The product has not been tested.
The statement has been derived from substances/products of a similar structure or composition.

Aquatic plants:
EC50 (72 h) 152.94 mg/l (growth rate), Scenedesmus subspicatus (DIN 38412 Part 9, static)
The product has low solubility in the test medium. An aqueous solution prepared with solubilizers has
been tested.

Microorganisms/Effect on activated sludge:

EC20 (30 min) > 1,000 mg/l, activated sludge, domestic (DIN EN ISO 8192-OECD 209-
88/302/EEC,P. C, aerobic)

Mobility

Assessment transport between environmental compartments:

Adsorption to solid soil phase is expected.

Persistence and degradability

Assessment biodegradation and elimination (H2O):

Not readily biodegradable (by OECD criteria). Moderately/partially biodegradable.

Elimination information:
40 - 50 % BOD of the ThOD (28 d) (OECD 301F; ISO 9408; 92/69/EEC, C.4-D) (aerobic, activated
sludge, domestic)

Assessment of stability in water:

In contact with water the substance will hydrolyse slowly.

Bioaccumulation potential

Assessment bioaccumulation potential:

Does not significantly accumulate in organisms. Because of the product's consistency and low water
solubility, bioavailability is improbable.

Additional information

Other ecotoxicological advice:

The product has not been tested. The statements on ecotoxicology have been derived from the
properties of the individual components.

13. Disposal Considerations

Observe national and local legal requirements.

14. Transport Information

Domestic transport:
Not classified as a dangerous good under transport regulations

Sea transport
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BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
IMDG
Not classified as a dangerous good under transport regulations

Air transport
IATA/ICAO
Not classified as a dangerous good under transport regulations

15. Regulatory Information

Regulations of the European union (Labelling)

Directive 1999/45/EC ('Preparation Directive'):

Hazard symbol(s)
T Toxic.

R-phrase(s)
R38 Irritating to skin.
R43 May cause sensitization by skin contact.
R53 May cause long-term adverse effects in the aquatic environment.
R61 May cause harm to the unborn child.

S-phrase(s)
S36/37 Wear suitable protective clothing and gloves.
S45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S51 Use only in well-ventilated areas.
S53 Avoid exposure - obtain special instructions before use.
S61 Avoid release to the environment. Refer to special instructions/safety
data sheets.

Only for the professional user. Care - avoid exposure - obtain special instructions before use.

Hazard determining component(s) for labelling: VITAMIN-A-PALMITATE, D,L-alpha-tocopherol

Other regulations

If other regulatory information applies that is not already provided elsewhere in this safety data
sheet, then it is described in this subsection.
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BASF India Ltd Safety data sheet
Date / Revised: 06.02.2013 Version: 4.0
Product: Vitamin A-Palmitate 1.7 Mio IU/G stabilized with Tocopherol

(30041031/SDS_GEN_IN/EN)
Date of print 08.02.2013
16. Other Information

Any other intended applications should be discussed with the manufacturer. Corresponding
occupational protection measurements must be followed.

Full text of hazard symbols and R-phrases if mentioned as hazardous components in section 2:
T Toxic.
Xi Irritant.
53 May cause long-term adverse effects in the aquatic environment.
38 Irritating to skin.
61 May cause harm to the unborn child.
43 May cause sensitization by skin contact.

Vertical lines in the left hand margin indicate an amendment from the previous version.

The data contained in this safety data sheet are based on our current knowledge and experience and
describe the product only with regard to safety requirements. The data do not describe the product's
properties (product specification). Neither should any agreed property nor the suitability of the product for
any specific purpose be deduced from the data contained in the safety data sheet. It is the responsibility
of the recipient of the product to ensure any proprietary rights and existing laws and legislation are
observed.