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BIOCHEMICAL ASPECTS OF
FLAVIN-CONTAINING MONOOXYGENASES
(FMOs)
IDepartment of Toxicology
North Carolina State University
Raleigh, North Carolina 27695-7633
2National Institute for Environmental Health Sciences
Research Triangle Park, North Carolina 27709
1. INTRODUCTION
1.1. Historical
55
E. Arin et al. (eds.), Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes
Kluwer Academic / Plenum Publishers, New York 1999
56
y
E. Hodgson et al.
FMO - FAD
NADP+
HO
2
~ .,-NADPH
\ +W
xo~
FMO - FADHOOH
(NADP+)
amine oxidize and other names, including "Ziegler's enzyme", was purified from hog liver
and shown to contain flavin-adenine dinucleotide (FAD).8
It was subsequently determined that this "amine oxidase" had a wider range of sub-
strates, and a more appropriate name, the flavin-containing monooxygenase (usually abbre-
viated to FMO)(EC 1.14.13.8), was adopted. Among organic compounds metabolized by
FMO are those containing nitrogen, sulfur or phosphorus heteroatoms. 9- 13 More recently,
boron and selenium containing compounds have been identified as FMO substrates. 14 . IS