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Preface 04
Introduction 08
References 61
3
PREFACE
PREFACE
5
I regularly write for some of the biggest magazines in the fitness
industrywith Mens Health, Mens Fitness, Muscle & Fitness,
and Flex among these. I dont want to name names, but one ma-
jor publica tiontrust me, youve heard of itapproached me
to write a feature article on something unique and scientific that
works for the purposes of fat loss and muscle building. When I pro-
posed a piece on the health and performance benefits of nicotine
supplementation, the editor-in-chief himself told me it couldnt, and
wouldnt ever, run in their family-oriented magazine.
Now, Ive heard all the rumors about nicotines hazards, but Im not
entirely sure what, if any, effects a naturally-occurring molecule can
have on our collective family values. Still, Ive found most magazine
editors to be nice, sensible people, so I didnt press the issue and
wrote about something else.
The more research I did on the subject, however, the more nico-
tines benefits nagged at meto the point where I decided to put
together this comprehensive report on its efficacy and use. Thats
the thing, though: Ive done my research, and Ive used nicotine
protocols both on myself and with my clients. With this release, Ive
done my absolute best to piece together a compendium of infor-
mation that will guide you to make both intelligent decisions as to
whether you want to use nicotine or not, and to do it properly if you
decide to try it.
PREFACE 6
The other important thing to note here is that this information isnt
for everyone. This is high-performance stuff thats intended for the
use of serious people only. Nicotine isnt a magic bullet, so before
you consider taking it for the purposes were talking about, you need
to make sure everything elseyour diet, training, and all the other
supplementation youre doingis dialed in and on point.
What youre about to read ventures far outside the box with regard
to whats typically recommended for health purposes. Ive written
this report to help you make sense of it all and decide for yourself.
When used under the correct conditions, nicotine can safely ac-
celerate your progress without the side effects common to other fat
burnersbut again, when youre dealing with a substance thats
been stigmatized so viscerally for so long, theres a great deal to
discuss first.
Kiefer
PREFACE 7
INTRODUCTION
Origin Story
INTRODUCTION
Origin Story
What I found in the physique realm was that virtually all higher-level
competitorspeople who have to get down to insanely low levels of
body fat before getting on stageuse massive amounts of prescrip-
tion medications like clenbuterol and albuterol, among other power-
ful fat burners. The less the coach understands about the human
body, the more fat burners they prescribe.
9
These drugs work essentially the way adrenaline and caffeine do,
by stimulating the sympathetic nervous systemthe flight-or-fight
response coordinatorthrough activation of the beta-adrenergic re-
ceptors. When you take these fat burners, youre piling them on top
of a stress load that already exists if youre attempting to lose body
fat with exercise and calorie restriction. This means youre eventu-
ally going to reach a point of diminishing returns where theyre no
longer effective.
INTRODUCTION 10
Although the right diet can get you very close to where you need
to be (unfortunately, most coaches dont use anything remotely
resembling the right diet), you can definitely give yourself an edge
if youre willing to take these prescription medications. After see-
ing their adverse effects, however, I wanted to give my competitors
a natural edgeand I wanted that edge to be even more effective
than the pharmaceutical one.
From what Ive seen, the diets of the vast majority of competitors
are so bad that massive amounts of prescription drugs become
necessary to fix the damage these athletes nutritionists and coach-
es are inflicting on them.
INTRODUCTION 11
As usual, however, theres a nasty downside to all of this. Whats
happening here is that youre burning out your system. Your body
will try to decrease thyroid hormone because your energy expen-
diture has risen too high, so it will downregulate your metabolism.
When you take more drugs to bring your metabolism back up, your
thyroid shuts off.
When you stop taking the drugs, and start gaining weight back
normally, your metabolism will slow, and all the food you eat will be
channeled into restoring your body fat reserves. Your body does
this very well.
These drugs will also burn out your adrenal glands. These glands
are producing massive amounts of adrenaline and cortisol. As a re-
sult, theyre overstressed and overtaxed. At this point, they go into a
kind of survival mechanism where they dump cortisol, and continue
dumping it.
So here you are, with high cortisol levels and a very low metabo-
lism. What do you think is going to happen when you start eating
carbohydrates? If youre thinking this is a recipe for disaster, youre
absolutely correct. The carbs plus the cortisol will lead you to mas-
sive and rapid fat regain, and most competitors end up getting far
fatter than they ever were before.
INTRODUCTION 12
Taboo, Yet Terribly Effective
Of course, the people were talking about here are profoundly un-
healthy, but it struck me that, when all the peripheral carcinogens
from smoking are removed from the equation, this could conceivably
mean that nicotine is a viable and possibly safe fat burner. Insane?
Sure, but as it turns out, this may actually be the case.
INTRODUCTION 13
CHAPTER 01
We know all this, but where does this fat come from? Well, its most-
ly from your dietand when your diet cant supply enough, it starts
15
to come from liver reserves, if possible. Weve also just learned that
the entire intestinal tract in the human body has specialized cells
that store fat, too2. In other words, youre getting a fat dump from
places that dont necessarily contain the body fat youre trying to
lose.
For example, a very low-fat, high-carb diet for weight loss will actu-
ally force fat cells to refuse to release body fat3-5. This type of diet
will make them try very, very hard to hold onto body fat. Exercising
too much has the same effect, especially when were talking about
cardio. The misapplication of cardio actually forces fat cells to not
get rid of body fat6.
What this means is that even though youre burning fat in your mus-
cles, youre not mobilizing your body fat reserves. This is why peo-
ple who rely on cardio to get rid of body fat fail. Even though theyre
burning a lot of fat, its only the fat theyre eating and the fat stored
in muscle tissue7. Their fat cells arent releasing it to be burned.
CHAPTER 01 16
Were already in an environment where our bodies are burning fat.
This happens all the time. What we really need is to create an en-
vironment where our fat cells are dumping fat to be burned. Thats
the key distinction: Its easy to burn fat, but theres a huge difference
between fat burning and fat mobilisation.
Theres a simple explanation for what happens when you take the
conventional pharmaceutical fat burner regimen advocated by most
physique coaches. I coined the phrase adrenaline diabetes to de-
scribe why conventional fat burners fail.
CHAPTER 01 17
CHAPTER 02
Fat Mobilisation
Remember that body fat loss requires fat cells to release stored fat.
Most energy deprivation dietsthose which require you to expend
more energy than you absorb, either through food restriction, ex-
ercise or bothcan eventually force fat cells to release some fat
through the beta-adrenergic pathway mentioned above. As the body
becomes stressed from energy restriction, it releases ever increas-
ing amounts of cortisol and catecholamines (like adrenaline and nor-
adrenaline) which will force fat cells to release fatty acids for energy.
19
These stress hormones work to release body fat by activating an
enzyme in fat cells called hormone-sensitive lipase (HSL). HSLs
main role is to release free fatty acids from fat cells for use as en-
ergy13, which decreases the size of adipose tissue. Because HSL
requires activation by these hormones, its no mystery why HSL is
labeled as hormone-sensitive. This is one way to cause fat cells to
mobilize body fat for energy.
CHAPTER 02 20
activity18. This is why, even if youre stuck in the adrenaline diabetes
discussed in the previous chapter, you can still take nicotine to tell
your fat cells to start dumping fat. This is essentially a back door into
fat mobilisation, and its the real power and magic of nicotine.
We can see this power of rapid fat release from adipose tissue in
human studies that show a massive rise in glycerinthe glue that
holds triglycerides together in fat cellsand free fatty acids in the
bloodstream after infusion of nicotine15. Since levels of catechol-
amines were elevated during this protocolan elevation that pre-
vents muscle tissue from releasing triglyceridesits likely this surge
of fat came from the breakdown of tri- and diglycerides within adi-
pose tissue.
CHAPTER 02 21
nicotine can increase resting energy expenditure. Nicotine can also
increase thermogenesis, making the body more inefficient. This is
how mammals regulate body temperature to stay warm, through the
oxidation of fatty acids.
Of additional relevance is the fact that the bodys resting energy out-
put decreases with any type of calorie deprivation, or (my preferred
term for this) energy deficit. Pay close attention to this if youre using
an intermittent fasting (IF) protocol, because its why starving your-
self for fat loss decreases your energy output. Calorie deprivation
CHAPTER 02 22
downregulates UCP125-26. Nicotine re-stimulates it so you can keep
burning fat, even if your diet has you dropping calories, or going for
long periods without food, as happens with IF.
The key to fat loss from smoking is this double whammy effect.
Smokers will increase their metabolism and burn more fat than
normal, while their fat cells have a very difficult time trying to store
fat. This is why they stay so thin. When they stop smoking, however,
this all comes to an abrupt halt. If you turn all these mechanisms off,
then flip the switch back the other way, youll then have a multitude
of empty fat cells saying, Oh, hell yeah! Now we can fill up! And
this is precisely what they do. Quickly.
CHAPTER 02 23
Far from it, as Ill discuss later on. The purpose of this section is to
explain why chronic smokers are thin, and why they gain so much
weight back when they stop smoking. Smoking is a deadly habit
that devastates countless systems within the human body, and my
recommendation is to stay as far away from cigarettes as humanly
possible.
CHAPTER 02 24
CHAPTER 03
This, obviously, is the ideal situation for muscle cells, and its the
reason insulin and glucose help us growbecause theyre direct
stimulators of the TOR pathway. Leucine is also a regulator of the
TOR pathway, which is the reason youll always hear me recom-
mend leucine supplementation with all my programs.
The problem with glucose and leucine, however, is that they can
both cause releases of insulin. This is not an ideal situation when
youre trying to get rid of body fat. In contrast, the amazing thing
26
about nicotine is that its one of the fewif onlynatural, non-
nutritive substances that directly stimulates this TOR pathway of
growth27.
This has two advantageous effects. First, if youre trying to get rid of
as much body fat as possible, nicotine is helping to preserve your
muscle tissue. If youre getting a growth signal, your body wont
destroy this tissueor, at the very least, it will attempt to avoid
destroying it. Next, if youre in a hypertrophy phase where youre
trying to add mass, youll be giving a stronger growth signal to your
muscle tissue.
If you want to increase growth in any cell in your body, you have to
activate the TOR pathway. If its turned off, its very hard for your
body to grow. Rapamycin is an anti-cancer drug that turns off the
TOR pathway, essentially negating any gains you get from resis-
tance training. When this pathway is turned off, you can lift weights
all day, every day, without any benefit to your muscles.
When the TOR pathway shuts off, you cant grow. This is obviously
beneficial for cancer patients, because it means no cells can grow.
Cancer cells are typically highly rampant, and they grow rapidly, but
CHAPTER 03 27
rapamycin has the capability of shutting that growth down, including
skeletal muscle hypertrophy28-29.
Thats why nicotine has major advantages over the synthetic pre-
scription drugs I outlined earlier. It gets your fat cells to release fat,
but it also potentially protects your muscle cells at the same time by
telling them to grow. Nicotine doesnt have enough nutrient resourc-
CHAPTER 03 28
es to actually grow muscle tissue, but its trying, so therefore your
body wont destroy it.
Theres one other thing thats worth noting in this section, especially
with regard to hypertrophy. Nicotine does two additional things here:
It can increase nitrous oxide (NO) production during training, and it
activates the AMP-activated protein kinase (AMPK) pathway30. Free-
radical accumulation during training tends to ignite muscular growth,
but if this stays elevated for too long, its detrimental.
We cant ignore the role of free fatty acids on skeletal muscle pres-
ervation. Elevated free fatty acids can preserve muscle tissue, even
during periods of starvation or energy deprivation31-35. Its hard to
say the exact mechanisms responsible for this preservation, but
it could be related to ketone production. High levels of free fatty
acids is enough to spark ketogenesis36-37, which nicotine causes
through various pathways. Ketones have demonstrated the ability to
preserve muscle tissue, although the mechanisms for this are still
unknown38-39.
Nicotine also has a great advantage for glucose uptake, which can
be particularly useful with Carb Nite, Carb Back-Loading or other
cyclic ketogenic diets. AMPK activation can enhance glucose uptake
in skeletal muscle tissue and can also possibly increase mitochon-
CHAPTER 03 29
drial biogenesis40. Mitochondrial biogenesis relates to the maximum
size a muscle fiber can obtain through training, but this process is
beyond the scope of this book and will be covered in an upcoming
book thatll show you how to achieve metabolic flexibility for high-
intensity, strength-endurance sports.
Finally, recent animal studies have shown that nicotine may stimu-
late a pathway that downregulates myostatinthe protein that pre-
vents muscles from getting big41.
CHAPTER 03 30
CHAPTER 04
Controversial Aspects
CHAPTER 04
Controversial Aspects
32
We run into problems when we extrapolate our facts from this
data. When you get to the protocols section of this report, youll see
Im only recommending much smaller dosages of nicotine per day,
as opposed to smoker-level dosages. What weve extrapolated over
the years, though, is the notion that if megadoses of nicotine are
dangerous, then any amount of nicotine must necessarily be dan-
gerous, too.
Research has shown this logic to be faulty, and that nicotine by itself
isnt necessarily carcinogenic43. This doesnt mean there arent any
downsides to it, but in order to recognize nicotines role in the hierar-
chy, you need to understand what a carcinogen actually is.
This, however, isnt the case with nicotine. It hasnt been shown to
be potently carcinogenic by itself. Problems occur when you already
have cancer, because nicotine will stimulate that growth pathway44-48.
This is why cancer patients cant take growth hormonebecause
GH will cause all the cells in the body to grow, including the cancer-
ous ones. This, obviously, makes cancer worse.
CHAPTER 04 33
If youre young and healthy, theres very little risk of nicotine having
any deleterious effects with regard to cancer, but there are some
other negatives. Its been shown to age arterial tissueyour arteries
and veinsbut thats only when taken in very high dosages over a
long period of time.
CHAPTER 04 34
Why Its Safe
Out in the real world, we see the real causes of cancer with people
who dont care about their health. Theyre sick, theyre malnour-
ished, theyre vitamin deficient, and nicotine makes all of this worse
because its an extra stressor on the body.
CHAPTER 04 35
This is especially dangerous when youre on a carbohydrate-based
diet.
The idea, then, is to avoid mixing nicotine with carb ingestion, be-
cause it can interfere with the absorption of glucose into your mus-
cle cells. This is why people get sick, and research has shown that
smokers can develop diabetes without even being overweight51.
CHAPTER 04 36
CHAPTER 05
Nootropic Effects
Appetite Suppression
38
in appetite because of the increased energy demands placed on the
body by an accelerated metabolism. This, of course, is amplified by
the fact that most mainstream diets used for fat loss cause massive
hunger pangs and making sticking with a diet difficult. The rebound
effect after dieting is also worse because of the increased hunger.
CHAPTER 05 39
CHAPTER 06
The Protocols
CHAPTER 06
The Protocols
To find the correct dosing necessary for the fat mobilizing and burn-
ing effects of nicotine, we first need to investigate nicotine metabo-
lisation and blood concentrations necessary for these benefits. For
this section, Im going to discuss the use of nicotine gum, since
most of the data from human trials looks at peak nicotine levels and
clearance rate using gum. We can therefore make sure our dosing
achieves the blood concentrations needed for results.
In the above cited works17,19, the profound effects seen on fat mo-
41
bilisation and increased fat oxidations were achieved with intrave-
nous infusion of nicotine until levels reached between 7 and 8 ng/ml
(nanograms per milliliter). This would require a piece of gum con-
taining 4 mg of nicotine59.
So, if we want the maximum benefit of fat burning and fat mobilisa-
tion, well need to chew 4 mg pieces of nicotine gum. With this, peak
levels of nicotine will be achieved within 30 minutes of chewing and
maintained for roughly two hours or more59.
CHAPTER 06 42
Next, nicotine will elevate your body temperature, and its also a
stimulant. Both of these factors can and will affect the quality of
your sleep. So, at least until you figure out how your body reacts to
it, limit your nicotine intake to the first part of the day, so its at least
partially cleared out of your system before you go to sleep.
CHAPTER 06 43
time to take nicotine is early in the morning, this is an especially ef-
fective protocol for people who train in the early AM hours.
When you train later in the evening, the key to using nicotine effec-
tively is keeping it as far away from your carbohydrate loads as pos-
sible. In this case, the protocol remains the same, at least in terms
of restricting your nicotine ingestion to the morning hours.
CHAPTER 06 44
DENSITY BULKING PROTOCOL: Take 4 mg upon waking, then
train in the evening. Do not take nicotine before or after training.
The timing of your ingestion doesnt matter quite as much with Carb
Nite as it does with Carb Back-Loading, because you wont be eat-
ing carbs for the majority of the week, and you wont be touching
any nicotine on your actual carb niteor the day after. If you can tol-
erate taking nicotine at night without any adverse effect on the qual-
ity of your sleep, feel free to use it then. If youre resistance training
while on Carb Nite, cycle it around your workouts as outlined for
Carb Back-Loading.
CHAPTER 06 45
CARB NITE PROTOCOL (ON CARB NITE): Again, its crucial
that you avoid carbs when taking nicotine, so in order to make sure
youre staying highly sensitized, take two full days without ingesting
any nicotine: Your actual carb nite, and the following day.
CHAPTER 06 46
INTERMITTENT FASTING (IF) PROTOCOL: Take 1 mg every 2
hours during your morning fast.
Taking nicotine and caffeine together will give you a nice little one-
two punch, especially before you train, but I wouldnt recommend
doing this if youre just coming off some form of contest prep, or if
youve just concluded a period of particularly intense training, i.e.,
CrossFit.
CHAPTER 06 47
Cycling
The idea, then, is to cycle your nicotine intake on and off. A good
rule of thumb is to try the protocols for four weeks, then take a break
of at least two weeks where youre not using any nicotine at all. This
cycling, as far as research can tell, should mitigate any of nicotines
downsides. When combined with the low doses youll be taking, this
wont have any adverse effects on your health.
CHAPTER 06 48
CHAPTER 07
T E D _]
R E D A C
[ _
CHAPTER 08
57
much theoretical. To be perfectly honest, you wont notice much of
a difference in your actual performance. Youll experience a greater
effect in that department simply by making the switch to Carb Back-
Loading or The Carb Nite Solution as your primary diet.
With that said, there are definitely some interesting dynamics be-
tween nicotine and creatine that could take place on the cellular
level. Since nicotine has such a profound effect on metabolism, you
theoretically may need more creatine than normal, or you may need
to start taking creatine if you dont already use it.
Is nicotine Paleo?
CHAPTER 08 58
Can I use nicotine with cardio?
Nicotine will make short-burst cardio more effective, and it can also
mitigate some of the adverse effects of long-duration cardio, as well.
Too much long-duration cardio can prevent fat cells from releasing
fat as effectively as theyd normally be able to, and nicotine can help
attenuate that response.
From the research thats out there, and from the experience Ive had
with clientswhich includes working with medical doctors and their
patientsweve seen no downside whatsoever to these protocols.
This isnt to say no downsides exist, because we dont have the
CHAPTER 08 59
long-term data to make definitive statements yet, but what Im try-
ing to do here is give you cutting-edge information to increase your
performance and your fat loss results over the short-term. There are
always risks to being radical.
CHAPTER 08 60
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