mitoq.

com

Breathe easy and

get on the move again
with MitoQ + GLME

edition v
 Contents

03 Lung and Airway Health

04 Joint Health

05 What is GLME?

07 What is MitoQ?

08 Mitochondrial dysfunction and

LOX-5/COX-2 activity

09 Breathe easy and get on the move again

with MitoQ + GLME

10 Product Information
Lung and Airway Health

Our lungs serve the vital role of by the immune system. These can
absorbing oxygen from the air cause constriction of the airways
we breathe and releasing carbon and overproduction of mucus in the
dioxide from our blood back into the lungs. Such conditions can be quite
atmosphere. Our lungs also serve as debilitating or even life threatening.
a barrier to infection, help to maintain
MitoQ can improve mitochondrial
blood pressure and pH and move the
function in the lungs and the resulting
air that allows us to speak. Air enters
oxidative stress while GLME supports
the lungs through the respiratory tract
minimum healthy levels of leukotrienes.
which starts at the trachea and then
Through these actions, MitoQ + GLME
branches out into the two bronchii
provides support for normal airway
and then smaller bronchioles. These
function and respiratory health,
continue to divide until they reach the
enabling you to breathe a little easier.
microscopic pockets called alveoli
Clinical research has also shown that
where the gas exchange occurs.
GLME supports optimal breathing
Together, the lungs contain 1,500
during exercise.
miles of airways and up to 500 million
alveoli, providing a huge surface area
for the absorption of oxygen and
release of CO2.
There are a number of conditions
which can affect the lungs and airways,
most of which involve a reduction in
lung function or a restriction of the
airways. Although smoking is still
the leading cause of lung conditions,
many others exist which can be
caused by allergies, infections or
chemical imbalances within the body.
Mitochondrial dysfunction is known to
be a significant cause or consequence
of many of these conditions. In addition,
as part of the bodys natural allergic
response, messenger chemicals
such as leukotrienes can be released

03
Joint Health
A joint is the connection between
bones in the body. There are many
different types of joints which can
provide a wide and varied range of
motion such as the fingers, or can
simply keep a body part in a fixed
place such as the ribs. There are over
250 joints in the human body and these
allow us to perform all of our everyday
movements from chewing to typing to
running. As such, our joints
can be subject to a lot of wear and tear
so it is important to look after them
wherever possible.
There are many conditions which
can affect our joints, and these
can significantly affect our
mobility and comfort.
Injuries, wear and
tear from physical
activity, certain
health conditions and
aging can result in the
cartilage and even bone
at the joints becoming
damaged or destroyed.
Many such conditions are now
known to be related to mitochondrial
dysfunction. High activity of the
LOX-5 enzyme and the subsequent
elevated levels of immune mediators
has also been shown to be a
significant contributor to many
of these conditions associated
with aggravation and overactive
immune and allergic responses.
MitoQ + GLME can reduce the
free radical damage from poorly
functioning mitochondria while
simultaneously minimizing the
impact of leukotriene
overproduction often seen in
joint conditions.In addition, studies
have shown that GLME supports
muscle and joint recovery
following exercise.
04
What is GLME?

The Green Lipped Mussel (Perna GLME is a highly purified product

Canaliculus) is a species of shellfish which is extracted from the whole
found only in the pristine coastal mussel using a solvent-free technique
waters of New Zealand. The mussel is called supercritical CO2 extraction.
clearly distinguishable by the green This gentle, non-toxic process does
colouration of the shell near the lip, not expose the mussel to any heat
which gives the mussel its name. or leave any chemical residue, and
Green Lipped Mussels feed exclusively is the same process used to extract
on marine phytoplankton and delicate essential oils. Only the lipid
zooplankton, and are one of the portion of the mussel is extracted,
largest species of mussels, reaching leaving behind the proteins and
up to 9 inches in length. carbohydrate molecules. It is certain
protein components of shellfish (and
The native Maori people of New
other foods) which are known to be
Zealand have utilized this mollusc as
responsible for causing allergic reactions
a substantial portion of their diet, and
in people. So in addition to being much
have used its shells for tools, containers
more concentrated, the complete
and decorations since ancient times.
removal of these proteins makes GLME
In the 1970s, commercial farming of
a much safer product than powdered
Green Lipped Mussels began. Wild
or whole mussel extracts.
mussel seed clings to seaweed which
is collected from New Zealand beaches.
This seeded seaweed is then attached
to ropes on which the mussels are
grown in sheltered bays
along the coast.

05
Scientific analysis of the mussel extract
has revealed intriguing nutritional and
chemical properties. Green Lipped
Mussel Extract (GLME) contains a
unique blend of over 90 different lipids,
many of which are not found in fish or
other marine oils. GLME is a mixture
of saturated, monounsaturated and
polyunsaturated fatty acids and is rich
in omega-3 fatty acids such as EPA,
DHA, ETA and OTA.
GLME also contains a mixture of other
biologically important molecules such
as fatty acid esters and sterols. GLME
has been shown to possess antioxidant
properties, and to support normal
LOX-5/COX-2 activity and minimum
healthy levels of immune mediators
such as leukotrienes, prostaglandins
and thromboxanes.
The result of the pristine growing
environment, sustainable farming
practices and delicate extraction
techniques is a unique, potent and
pure product with numerous health
benefits. GLME has a superior lipid
profile and omega-3 content to fish oils,
increased efficacy over common joint
supplements such as glucosamine/
chondroitin, and the rare property
of being a clinically proven effective
ingredient in supporting normal lung
function and healthy airways.

06
What is MitoQ?
MitoQ is a mitochondria-
targeted antioxidant; a new
type of antioxidant able to deliver
a payload of free radical defense
directly into your cells energy-
producing mitochondria. Discovered
and developed at The University of
Otago (Dunedin, New Zealand), it is
considered to be a significant advance
in antioxidant technology.
Until this discovery, no-one had been
able to restore the mitochondrial
antioxidant defense system in a
meaningful way. This is because the
mitochondrial membrane is particularly
impermeable to most substances. Many
antioxidant supplements are simply not
able to get to where they need to be
inside the mitochondria in your cells.
When the researchers at Otago
University identified a way to target
mitochondria with antioxidants, they
looked carefully to identify the most
important antioxidant within the
mitochondria. That antioxidant was
CoQ10. MitoQ is a mitochondria-targeted
form of this very popular supplement.
MitoQ accumulates inside the
mitochondria hundreds of times more
effectively than all other forms of CoQ10
supplements. And when you increase
levels of CoQ10 in the mitochondria it
is like tuning up your cellular engine,
making more energy available to your
cells and reducing oxidative stress from
free radical damage.
Over the last decade, MitoQ has been
studied by researchers all around
the world as they look to understand
what happens when you improve
mitochondrial function and reduce
oxidative stress in a large number of
models of human disease and aging,
including many common airway and
joint disorders.
Recently, MitoQ was selected for a
world-leading independent research
program run by the USA National
Institute on Aging to evaluate its effect
on slowing and potentially reversing the
aging process.
To date, more than $50 million has
been spent on research, and over 180
scientific papers have been published,
investigating MitoQs effect in over 70
disease conditions.
By restoring the mitochondrial free
radical defense system, we achieve
the double benefit of both restoring
mitochondrial function and reducing
free radical leakage into the cell. This
supports optimal mitochondrial health
and function and results in improved
energy production for the cell. Our cells
get an energy boost, and that helps
them operate like they did when they
were younger and healthier.
07
Mitochondrial dysfunction and
LOX-5/COX-2 activity
Mitochondria are tiny
organelles found in almost
all of our cells, and theyre
responsible for generating
the energy our cells need
to function.
Mitochondria are like tiny power plants
that combine the food we eat with the
air we breathe to make the energy our
cells need to operate. Mitochondria are
also crucial to proper cell growth and
play many other important roles within
the cell. When mitochondria produce
this energy, they produce free radicals
as a byproduct. A small amount of
these free radicals are used by the
cell as signaling molecules, however
most of them are neutralized by our
cells antioxidant defense system. This
is because excess free radicals can
damage the mitochondrial membrane
causing the mitochondria to not
function properly any more. This can
also allow more free radicals to leak out
into the cell and damage other cellular
components, including DNA.
Over the last decade, scientists have
begun to recognize the link between
mitochondrial function (or decline of
function) and our health and many
common diseases. It is becoming
increasingly apparent that our overall
health, and even how fast we age,
is closely related to how well our
mitochondria are functioning.
LOX-5 (5-lipoxygenase) and COX-
2 (cyclooxygenase-2) are enzymes
responsible for turning certain
essential fatty acids into a number of
biologically important molecules. These
include a family of chemicals such as
leukotrienes, prostaglandins and
thromboxanes which are important
mediators of the bodys natural
immune and allergic responses. When
LOX-5/COX-2 activity is too high, the
large number of these biochemicals
produced can contribute to a number
of health conditions, including common
debilitating disorders of the airways and
joints. Maintaining normal LOX-5/COX-
2 activity is therefore important to our
overall wellbeing and our respiratory
and joint health.
New MitoQ + GLME contains
ingredients which support normal
mitochondrial function and 5-LOX/
COX-2 activity which, in turn, have
been shown to support joint health and
mobility and healthy airways.
08
Breathe easy and get on the move again
with MitoQ + GLME

MitoQ is the only available antioxidant MitoQ + GLME is the only product in
that rapidly and significantly targets the world to include both the powerful
CoQ10 directly to the energy factories 3rd generation CoQ10 antioxidant
of your cells, your mitochondria. MitoQs MitoQ and the unique natural health
antioxidant potency has been shown benefits of pure New Zealand Green
to be hundreds of times higher than Lipped Mussel Extract. These
that of standard CoQ10 or ubiquinol. exceptional ingredients combine
Once inside your mitochondria, MitoQ to create a safe and potent super
immediately goes to work to neutralize supplement recommended for anyone
free radicals and restore mitochondrial seeking joint or airway support or
function which promotes optimal anyone looking to experience the many
cellular energy and supports normal benefits from this unique combination
cellular and organ function. of ingredients.
GLME is a unique blend of dozens of
fatty acids (including a full spectrum
of omega-3s) and marine sterols which
has been clinically shown to be superior
to fish oil in supporting healthy airways
and normal joint function and mobility.
GLMEs complex lipid profile has many
beneficial mechanisms of action,
making GLME a superior joint support
product to single-ingredient products
such as glucosamine or chondroitin.
GLME is a highly concentrated extract
which eliminates the need for the large
capsules required for powdered mussel
products. In addition, the exclusive
combination of lipids in GLME can
support healthy cholesterol levels and
cardiovascular function.

09
Product Information
MitoQ + GLME is recommended for daily use. While great
care has been taken to exclude the allergy-inducing proteins
of shellfish, we recommend you consult your physician before
taking MitoQ + GLME if you are pregnant, breastfeeding or
have a strong shellfish allergy.
Active Ingredients per dose:
Mitoquinol mesylate equiv. Mitoquinol: 10mg
New Zealand Green Lipped Mussel Oil: 100mg
MitoQ + GLME also contains:
Vitamin E 2.6 IU (as an antioxidant), organic New Zealand
flax seed oil, gelatin, glycerol, beeswax, purified water and
color. MitoQ + GLME contains no dairy products or gluten.
Contains shellfish (Perna canaliculus).
Adult dose:
2 softgel capsules each morning, on an empty stomach
with plenty of water.
Made in New Zealand

These statements have not been evaluated by the Food

and Drug Administration. This product is not intended
to diagnose, treat, cure or prevent any disease.

Always read the label and use as directed.

If symptoms persist see your healthcare professional.
MitoQ Limited, PO Box 1671, Shortland Street, Auckland, NZ
Email: customerservice@mitoq.com

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