Syphilis

Disease description

24

(Syphilis)1
2013 7


46

Mucous patches

(Syphilis)2
2013 7
 37

1,000 10

1020

10 1030

(Syphilis)3
2013 7


Clutton Hutchinson Hutchinson

Infectious agent

Epidemiology

2035

1970 1980

1983 1986

1990 1990 2000 2001

2005

2006

2007 2008 5,808 5,807 6,526 18,141

25.4525.34 28.3820062008

30 49 70

Reservoir

Mode of transmission

(Syphilis)4
2013 7


Incubation period

1090 3

Period of communicability

2 2

2448

Susceptibility and resistance

30

Case definition

1+2 3

RPR+ VDRL+
TPHA=1

320 ( 320)

VDRL

(Syphilis)5
2013 7
Specimens taking and transportation

Measures of control

1 3

2 6

3 1

(Syphilis)6
2013 7


11

Benzathine penicillin, 2.4 m.u. IM in a single dosse.

2
1 Doxycycline, 100 mg bid p.o. 14 days
2 Tetracycline, 500 mg qid p.o. 14 days
3 Mincycline 100 mg po bid x 14 d
4 Azithromycin 2g po qw x 2 w
5 Ceftriaxone 1g im/iv qd x 8-10 d
3

Benzathine penicillin, 2.4 m.u. IM qw 3 weeks

Alternative tx:

Doxycycline 100mg po bid x 28 d

Minocycline 100mg po bid x 28 d

Tetracycline 500mg po big x 28 d

Crystalline penicillin G, 18-24 m.u.IV qd 1014 days

Alternative:

Ceftriaxone 2g im/iv x 10-14 d

6

(Syphilis)7
2013 7


(Syphilis)8
2013 7


Treponema pallidum

39

1
10

(1) Benzathine penicillin, 2.4 m.u. IM in a single dosse

(2)
1 Doxycycline, 100 mg bid p.o. 14 days
2 Tetracycline, 500 mg qid p.o. 14 days

3 Mincycline 100 mg po bid x 14 d

4 Azithromycin 2g po qw x 2 w
5 Ceftriaxone 1g im/iv qd x 8-10 d
(3) Benzathine penicillin, 2.4 m.u. IM qw 3 weeks

Alternative tx:

Doxycycline 100mg po bid x 28 d

Minocycline 100mg po bid x 28 d

Tetracycline 500mg po big x 28 d
(4)

Crystalline penicillin G, 18-24 m.u.IV qd 1014 days

Alternative:
Ceftriaxone 2g im/iv x 10-14 d

(Syphilis)9
2013 7