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THESIS PROPOSAL
Title of Research
By
Supervisor
Problem Statement
PEEK has low elastic modulus similar to bone and considered to be the best substitution of
metallic implants. But the non-treated PEEK is biologically inert, so it has less cellular adhesion
to the biological surfaces, which makes it bio inert [5]. The surface modification and
characterization of PEEK has been a major concern in the recent times.
Research objective
To modify the surface of polymer with deposition of diazonium salt and to analyse the
charactertics of polymer.
Literature Survey
Now a days, Diazonium salt are extensively used in many fields, it has many application in inks
and paints, stents in the medical field, and thin layers for microelectronics. Diazonium salt are
commonly used in surface modification of the metal and polymers, which enhance the
charactertics of the surfaces and these polymers and metal are widely used in many fields [6].
The surface modification of cyclic olefin copolymer with aryldiazonium salt has been reported.
Modify surface can be characterized by fluorescence microscopy and contact angle
measurements, infrared spectroscopy, X-ray photoemission spectroscopy and Raman
spectroscopy. With the help of diazonium salt the COC modified its wettability, roughness and
the chemical reactivity, which is normally inert.
This diagrams shows the various diazonium layers can enhance the wettability of COC, the
wettability was measured my contact angle. To increase the wettability of COC, it is useful in
medical field and also aryldiazonium salt can bring benefits such as versatile chemical groups
for post-functionalization, low cost and a fast process. This work give the opportunity to
develop biosensor using carboxylated terminated COC surfaces to attach covalently peptide,
protein or NH2 terminated DNA [7].
The grafting of diazonium salts has been used in the biomedical field for the surface
modification of stents. Stents are endovascular devices for treating vascular diseases such as
stenosis of arteries [8].
Modification of PMMA surface with help of the Diazonium salt has been reported. The film of
salt that is attached to PMMA is in the 1-5 nm range. The modified surface is characterized by
IR, XPY and water contact angle. This surface modification permits to control the
hydrophilicity/phobicity of the surface which could be useful for applications where PMMA is
used as a substitute of glass but also to modify to impart specific properties to microfluidic
channels [4].
PEEK has been modify by hydroxyapatite (HA) to make it biocompatible. PEEK is bio inert and
does not integrate well with the surrounding tissues. To solve this problem, chemical
deposition of HA crystalline particles on PEEK substrate. For confirmation, EDX results the
deposition of HA, and the XRD shows that the treated layer was crystalline HA. Similarly FT-IR
analysis show the chemical bonding between HA and substrate Surfaces. The water contact
angle showed an increase in wettability of the treated sample from 71.6 to 36.4 degrees,
which in turn increased its bioactivity [5].
Experimental Methodology
To perform the experiments there are two basic material are used
I. PEEK
II. Diazonium Salt
Methodology
Selection of Polymer
Preparation of Diazonium Salt
Surface activation of Polymer
Deposition of Salt on Polymer
Characterization of Polymer
Selection of polymer
Polymers are used as alternative material to metals and used in many fields due to its
remarkable charactertics. One of the best polymer is polyetheretherketone, widely used in
many fields but the most prominent in medical field. PEEK is commonly used for spinal
implants and in orthopedic, but due its low biocompatibility, diazonium salt is used to improve
its cellular adhesion [9].
Now a days, diazonium salt are used for the surface modifications of many polymers, specially
it is used to enhance the biocompatibility of many polymers, so select two major materials
PEEK and diazonium salt for the experimentations.
Preparation of Diazonium Salt
The diazonium salt will be prepared by following steps
Take 250 ml of beaker, dissolve 5 ml aniline in 16 ml of concentrated HCl and dilute it
with 20 ml water
Cool the temperature of an ice-bath until the temperature has fallen below 5oC
Take 4g of sodium Nitrite(NaNO3)in another beaker with 20 ml water and cool this
solution in the ice-bath
Diazotize the aniline solution by adding NaNO3 solution, in instalment of 2 ml at a time
while stirring the solution continuously and maintain the temperature [4].
Characterization of polymer
The modified polymeric samples will be analyzed using the following methods
Literature Review
Panel Preparation
Experimentation
Thesis Write-up
Reference
[1] S. M. Kurtz, An Overview of PEEK Biomaterials, p.^pp. 1-6: William Andrew, 2011.
[2] Y.-W. Du, L.-N. Zhang, Z.-T. Hou, X. Ye, H.-S. Gu, G.-P. Yan, P. Shang, Physical
modification of polyetheretherketone for orthopedic implants, Frontiers of Materials
Science, vol. 8, no. 4, pp. 313-324, 2014.
[3] W. Brock, A History Of Chemistry By Bernadette Bensaude-vincent; Isabelle Stengers;
Deborah Van Dam, p.^pp. 185-186, 1998.
[4] M. M. Chehimi, A. Lamouri, M. Picot, J. Pinson, Surface modification of polymers by
reduction of diazonium salts: polymethylmethacrylate as an example, Journal of
Materials Chemistry C, vol. 2, no. 2, pp. 356-363, 2014.
[5] D. Almasi, S. Izman, M. Assadian, M. Ghanbari, A. Kadir, Crystalline ha coating on peek
via chemical deposition, Applied Surface Science, vol. 314, pp. 1034-1040, 2014.
[6] M. M. Chehimi, Aryl Diazonium Salts: New Coupling Agents and Surface Science, p.^pp.
125: John Wiley & Sons, 2012.
[7] F. Brisset, J. Vieillard, B. Berton, S.-M. Grognet, C.-D. Poc, F.-L. Derf, Surface
functionalization of cyclic olefin copolymer with aryldiazonium salts: A covalent
grafting method, Applied Surface Science, vol. 329, pp. 337-346, 2015.
[8] J. A. Belmont, C. Bureau, M. M. Chehimi, S. G. Derouich, J. Pinson, Patents and
industrial applications of aryl diazonium salts and other coupling agents, p.^pp. 5,
2012.
[9] A. H. Poulsson, and R. G. Richards, Surface modification techniques of
polyetheretherketone, including plasma surface treatment, PEEK Biomaterials
Handbook, pp. 145, 2011.
[10] "Introduction to Fourier Transform Infrared Spectrometry," 26th january, 2016;
mmrc.caltech.edu/FTIR/FTIRintro.pdf.
[11] C. R. Anderson. "Thermogravimetric Analysis," 25th january 2016;
http://www.andersonmaterials.com/tga.html.
[12] C. R. Anderson. "Scanning Electron Microscopy," 25th january, 2016;
http://www.andersonmaterials.com/sem.html.
Comments of Supervisor: