The Gulf Journal of Dermatology and Venereology MCQ’s Mohammed Mohy El-Din Selim, MD. Mark the follo F for False: 1. Some drugsused to treat DM and hyperten- ( sion may induce lichen planus of the s and mucous membranes, 2 String of pearls is the phenomenon of annu- ( lar fluorescence of basal cells produced by indirect immunofluorescence using the se- rum of patients with drug induced lichenoid reaction because their serum has circulat- ng IgG to the causative drug. 3 Association of oral erosive lichen planus, ( DM and hypertension is known as Grinspan’s syndrome. 4. There is strong evidence that DHT is the ( active metabolite responsible for androge- netic alopecia. 5. Theenzyme 5-alpha-reductase has 2 isoen- ( zymes. 6 S-alpha-reductase isoenzyme one is located ( in the inner root sheath of the hair follicle. J- 5-alpha-reductase isoenzyme one isin the ( sebaceous gland, 8 S-alpha-reductase Isoenzyme’one is respon ( sible for changing testosterone into DHT. 9% S-alpha-reductase isoenzyme two is located ( inthe inner layer of the outer hair root sheath, 10-5-alpha-reductase isoenzyme 2 is also lo- ( cated in the inner root sheath in some parts of the hair follicle. L1- Minoxidil hasan antiandrogeniceffectin hair ( regrowth in androgenetic alopecia 12- Minoxidil isa vasodilator ( 13- Minoxidil opens potassium channels ¢ I Minoxidil increases growth phase of hair ( cycle. 15- Finasteride isa specific inhibitor of S-alpha- ( reductase isoenzyme one 16- Finasteride is a specific reductase isoenzyme 2 17- Tinea capitis is caused by Epidermophyton ( dermatophyte bitor of S-alpha ( Consultant Dermatologist Dermatology & Venereology Department Hamad Medical Corporation, PO, Box: 3050, Doha Qa Fax No. 10974 4303088 g statements T for True and 18-M. Distortum is geophilic 19- M. Distortum is zoophilic 20- M. gypseum is geophilic 21-T, Yaoundei is Zoophilic 22. Penetration of hyphae to the hair in Tinea capitis cannot proceed deeper than the up- per limit of the keratogenous zone 23- Small spore ectothrix infection in Tinea capitis can fluoresce under Wood’s light 24- Large spore ectothrix do not fluoresce un- der Wood's Light 25- Endothrix infection Tinea Capitis can con- tinue in anagen and Telogen hair growth 26- Griseofulvin is an antifungal antibiotic and itinhibits fungal DNA, RNA, microtubular assembly and cell wall synthesis 27- Azoles antifungals mechanism of action in- volves inhibition of p450 dependant en acting in biosynthesis of ergosterol is an essential component of fungal cell membrane 28- Ketoconazole and itraconazole reach the skin via sebaceous secretion and eccrine sweat glands 29- Dose of itraconazole inTinea capitisis Smg/ kg/day for 4-weeks 30- The dose of micronized griseofulvin in Tinea, Capitis is 20mg/kg/day for 6-12. weeks 31- The dose of ultramicronized griseofulvin is I5mg/kg/day for 6-12 weeks 32. The dose of Fluconazole is 3 for2-4 weeks 33- The dose of Fluconazole is 8mg/kg once per week for 4-8 weeks 34 Small spore ectothrix Tinea capitis is caused by'T. verrucosum and'T. mentagrophytes 35- Large spore ectothrix Tinea capitis is caused by m. audouinii and m. canis S mg/kg/day HRRER ERE RARRARRARAR FREER REE 22 RRRER LEER mamynon ssoMsUY Volume 11, No. 1, April 2004