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Administering Vaccines:

Dose, Route, Site, and Needle Size


Vaccine Dose Route Injection Site and Needle Size
Diphtheria, Tetanus, Pertussis Subcutaneous (Subcut) injection
0.5 mL. . IM ..
(DTaP, DT, Tdap, Td) Use a 2325 gauge needle. Choose the injection site that is appropriate to
Haemophilus influenzae type b (Hib) 0.5 mL IM the persons age and body mass.
18 yrs: 0.5 mL age Needle injection site
Hepatitis A (HepA) IM length
19 yrs: 1.0 mL
Fatty tissue over anterolateral
Hepatitis B (HepB) 19 yrs: 0.5 mL Infants (112 mos) "
thigh muscle
Persons 1115 yrs may be given Recombivax HB (Merck) IM
1.0 mL adult formulation on a 2-dose schedule. 20 yrs: 1.0 mL Fatty tissue over anterolateral
Children 12 mos or older,
Human papillomavirus (HPV) 0.5 mL IM " thigh muscle or fatty tissue
adolescents, and adults
over triceps
0.2 mL (0.1 mL in Intranasal
Influenza, live attenuated (LAIV) Intramuscular (IM) injection
each nostril) spray
Fluzone: 0.25 mL Use a 2225 gauge needle. Choose the injection site and needle length that
Influenza, inactivated (IIV); for ages is appropriate to the persons age and body mass.
IM
635 months FluLaval: 0.5 mL
age needle injection site
Influenza, inactivated (IIV); recombinant
0.5 mL length
(RIV), for ages 18 years and older
Newborns (1st 28 days) " Anterolateral thigh muscle
Influenza (IIV) Fluzone Intradermal,
0.1 mL ID Infants (112 mos) 1" Anterolateral thigh muscle
for ages 18 through 64 years
Measles, Mumps, Rubella (MMR) 0.5 mL Subcut 11" Anterolateral thigh muscle
Toddlers (12 years)
Meningococcal conjugate 1" Deltoid muscle of arm
0.5 mL IM
(MCV4 [MenACWY]) Children 1"* Deltoid muscle of arm
Meningococcal serogroup B (MenB) 0.5 mL IM (310 years) 11" Anterolateral thigh muscle
Pneumococcal conjugate (PCV) 0.5 mL IM Adolescents and teens 1"* Deltoid muscle of arm
IM or (1118 years) 11" Anterolateral thigh muscle
Pneumococcal polysaccharide (PPSV) 0.5 mL
Subcut
Adults 19 years or older
IM or
Polio, inactivated (IPV) 0.5 mL Female or male <130 lbs 1"* Deltoid muscle of arm
Subcut
Rotarix: 1.0 mL Female or male 130152 lbs 1" Deltoid muscle of arm
Rotavirus (RV) Oral
Rotateq: 2.0 mL Female 153200 lbs
11" Deltoid muscle of arm
Male 153260 lbs
Varicella (Var) 0.5 mL Subcut
Female 200+ lbs
Zoster (Zos) 0.65 mL Subcut 1" Deltoid muscle of arm
Male 260+ lbs
Combination Vaccines
DTaP-HepB-IPV (Pediarix) * A 5/8" needle may be used for patients note: Always refer to the package insert included
DTaP-IPV/Hib (Pentacel) 0.5 mL IM weighing less than 130 lbs (<60 kg) for with each biologic for complete vaccine administration
DTaP-IPV (Kinrix; Quadracel) IM injection in the deltoid muscle only information. CDCs Advisory Committee on Immunization
if the skin stretched tight, the subcuta- Practices (ACIP) recommendations for the particular
MMRV (ProQuad) 12 yrs: 0.5 mL Subcut neous tissue is not bunched, and the
vaccine should be reviewed as well. Access the ACIP
HepA-HepB (Twinrix) 18 yrs: 1.0 mL IM injection is made at a 90-degree angle.
recommendations at www.immunize.org/acip.

Intramuscular (IM) injection Subcutaneous (Subcut) injection Intradermal (ID) administration Intranasal (NAS) administration
of Fluzone ID vaccine of Flumist (LAIV) vaccine

90 angle
90 angle 45 angle
Administer
skin skin in area
subcutaneous tissue of deltoid
subcutaneous tissue

muscle muscle

Technical content reviewed by the Centers for Disease Control and Prevention

Immunization Action Coalition Saint Paul, Minnesota 651- 647- 9009 www.immunize.org www.vaccineinformation.org
www.immunize.org/catg.d/p3085.pdf Item #P3085 (9/17)