1. A. Bound drug is filtered freely and find in tubule. A.B.

B. Active tubular secretion of drug usually occurs in the proximal

tubule. A.B.
2. A. Passive tubular reabsorption usually occurs in the proximal
tubule. A.B.
B. Tubular reabsorption requires ionized drug. A.B.
3. A. Aminoglycoside antibiotics are poorly absorbed from the GIT.
A.B.
B. The Vd of aminoglycoside antibiotics is smaller because of
distribution to the extracellular fluid (20-25% of BW). A.B.
4. A. A 55 yo female patient has a stable SCr data at 4mg/dL
(50kg/150cm). Calculate CrCl. A. 12.54, B. 10.54, C.8,54, D.
12.54mL/min, E. 10.54mL/min.
B. A 65 yo male patient has a stable SCr data at 3.5mg/dL
(60kg/165cm). Calculate CrCl. A. 17.86, B. 10.86, C.
17.86mL/min, D. 7.86mL/min, E. 8.86mL/min.
5. A. Uremic patients may exhibit pharmacokinetic changes in: 1.
Decreasing in GFR, 2. Vd, 3.Cl, 4.BA. A.B.C.D.E.
B. RI could be caused by: 1. DM, 2.Metals, 3. Allergens, 4. Drugs.
A.B.C.D.E.
6. A. t1/2el will be longer in RI patients BECAUSE 0f decreasing in
renal drug excretion. A.B.C.D.E.
B. Scr will accumulate BECAUSE of loss of glomerular filtration
in kidney. A.B.C.D.E.
7. A. CrCl usually used in estimation of renal function BECAUSE a
rapid and convenient. A.B.C.D.E.
B. Hypertension can cause RI BECAUSE Chronic overloading of
kidney with food. A.B.C.D.E.
8. A. A liver failure patient is treated using drug (70% metabolized by
the liver). Albumin 3mg/dL, Bilirubine 12mg/dL, Prothrombine
time 8seconds, and severe acites & mild encephalohepatic.
Calculate the score (CPS) of drug & decereasing of dose (%). A.
12/50%, B. 10/25%, C. 13/25%, D. 13/50%, E. 9/25%.
B. Cl 45L/h, Vd 75L. Cpss 10g/mL. IV LD. A.10mg, B. 10g,
C.450mg, D. 0.1g, E.750mg
9. A. Cl =30 L/h, Vd=100 L. Cpss 10 mg/L. MD. A.3.0mg/h, B.
3.0g/h, C. 30.0mg/h, D. 300mg/h E.3000mg/h
B. A drug is injected IV-ly bolus into patient BW of 50kg. Vd is
20L/kg. Cpss needed is 100 ng/mL. LD of the drug is: A. 0.01mg,
B. 0.1 mg, C. 1mg, D. 10 mg, E. 100mg.
10. A.The kidney is an important organ in regulating: 1. Body
fluids, 2. Electrolyte balance, 3. Removal of metabolic waste, 4.
Drug excretion from the body. A.B.C.D.E.
B.A patient was given an intravenous LD of luminal 600 mg over a
period of about an hour. One day & four days after luminal dosing,
Cp were 12.6 & 7.5 mg/L, respectively. The elimination rate
constant of luminal: A. 0.173h-1 B. 0.173 h-1 C. 0.173 d-1 D. 0.0173
d-1 E. 0.173 d-1.