Tugas Kimia Medisinal Pertemuan ke 3

Kelas D

(Desi Mariana Purba 260110150127)

All chemical substances that are not nutrient for body (foreign to body) and which
enter the body through ingestion, inhalation or dermal exposure. This is meaning of
....

a. Patogen
b. Virulen
c. Xenobiotics
d. Xerotoksin
e. Drug

Answer : c.Xenobiotics

(Florencia Irena K 260110160122)

What reaction occurs when pregnancy becomes factor that influence on drug
metabolism?

a. Induction of Enzymes System

b. Decreasing of Metabolism Speed
c. Changes in metabolism in G I epithelium
d. Various Reactions
e. Increasing of Metabolism Speed

Answer : d. Various Reactions

(Rusydina Sabila 260110160123)

On phase I of biotransformation reaction drug metabolite are

a. Active
b. Inactive
c. Large
d. Huge
e. Toxic

Answer : a. Active

(Marcellino 260110160124)

Gases and volatile substances will be eliminated through

a. Lungs
b. Bile
c. Intestine
d. Salivary glands
e. Breast milk

Answer : a. Lungs

(Ega Megawati 260110160125)

Whats active metabolite form from Digitoxin ...

a. Salicylic acid
b. Aloxantin
c. Digoxin
d. Prednisolon
e. Morphine

Answer : c. Digoxin
(Nita Rahmasari 260110160126)

Pharmacological activation is the conversion of an inactive drug to active metabolite

such as the structure of the phenacetin above then become its active metabolite,
which is

a.

b.

c.

d.
 e.

Answer : b (Paracetamol Structure)

(Nabilah 260110160127)

1. Wich one is pancuronium bromide?

a.

b.
 c.

d.

e.

Answer : A

(Hafidz Firnandi 260110160128)

On phase II of biotransformation reaction drug metabolite are

a. Active
b. Inactive
c. Large
d. Huge
e. Toxic
Answer : b.Inactive

(Aslamnur Fikri R 260110160129)

Normal GFR is

a. 90 ml/min
b. 100 ml/min
c. 110 ml/min
d. 120 ml/min
e. 130 ml/min

Answer: d. 120 ml/min

(Sri Indrayani 260110160130)

The active metabolite of Codeine is ...

a. Prednisolon
b. Digoxin
c. Morphine
d. Oxyfenbutazon
e. Nortriptilin

Answer : c. Morphine

(Aurizal Risandy 260110160131)

The wrong statement about glomerular filtration is ..

a. Normal GFR 120 ml/min

b. Glomerular capillaries have pores larger than usual
c. The kidney is responsible for excreting of all lipid soluble substances
 d. All nonprotein bound drugs (lipid soluble or insoluble) presented to the
glomerulus are filtered
e. Glomerular filtration of drugs depends on their plasma protein binding and
renal blood flow

Answer : c. The kidney is responsible for excreting of all lipid soluble substances

(Albert Thengio 260110160132)

What reaction which cause the reaction above and what compound is released during
the reaction?

a. Acetylation,CH2COO
b. Deacetylation,CH3COO
c. Substitution, CH3COO
d. Acetylation,CH3COO
e. Deacetylation,CH2COO

Answer : b.Deacetylation,CH3COO

(Rezkia Azka K 260110160133)

What is the inhibition of CYP-3A4 ?

a. Rifampicin
b. Phenytoin
c. Intraconazole
 d. Phenobarbital
e. Carbmazepine

Answer : c. Intraconazole

(Restu Amelia - 260110160134)

Which of the following is an antiepileptic drug that induces CYP3A4 and is also
metabolized by CYP3A4?

a. Ketoconazole
b. Tamoxifen
c. Carbamazepine
d. Mitomycin C
e. Losartan

Answer: c. Carbamazepine

(Danaparamita Bashirah 260110160135)

In toxicological activation, Sulphonamides will transform into

a. Digoxin
b. Trifluoracetic Acid
c. Acetyl Derivatives
d. Morphine
e. Malaoxon

Answer : c. Acetyl Derivatives

(Dewi Sarah 260110160136)

Conversion of Phenobarbitone to P-Hydroxyphenobarbitone is the biotransformation

function as....
 a. Pharmacological Inactivation.
b. Bioactivation.
c. Toxicological Activation.
d. Lethal Synthesis.
e. Biotransformation.

Answer : a. Pharmacological Inactivation.

(Alda Anjella LCPA - 260110160137)

Below are the examples of Phase I Reduction, except

a. Chloramphenicol
b. Levodopa
c. Halothane
d. Lidocaine
e. Warafin

Answer : d. Lidocaine

(Hazna Putri S - 260110160138)

The right statement about the letal synthesis is...

a. It causes conversion of an active drug to inactive or less active metabolite(s)

b. It causes conversion of an inactive to more active metabolite(s)
c. It causes conversion of an inactive to more active toxic metabolite(s)
d. It causes conversion of an active drug to active metabolite(s)
e. It causes conversion of an active drug to equally active metabolite(s)

Answer : c.It causes conversion of an inactive to more active toxic metabolite(s)

(Umi Azizah - 260110160139)

It causes conversion of an inactive drug ( pro drug ) to active metabolite called as

a. Pharmacological activation
b. Biofarmasi
c. No change activation
d. Ekological activation
e. Substitution activation

Answer : a. Pharmacological activation

(Nicholas Sugianto - 260110160140)

Chemical subtance that are not nutrient for body is ?

a. Metabolism
b. Xenobiotic
c. Bioactivation
d. Bioinactivation
e. Lethal synthesis

Answer : b. Xenobiotic

(Iyan Rifky - 260110160141)

In the process of drug metabolism, exttrahepatic microsomal enzymes exist in what

organs? except

a. liver
b. stomach
c. intestines
d. colon
e. lungs
Answer : b. stomach

(Rahadianti Khofiisuwanditya - 260110160142)

Functions of biotransformation that causes conversion of an inactive drug (pro-

dug) to active metabolite is

a. Pharmacological activation
b. Lethal synthesis
c. Toxicological activation
d. Pharmacological inactivation
e. Bioactivation

Answer: a. Pharmacological activation

(Bunga Dacilia - 260110160143)

The conversion of an active drug to more active metabolite(s) is called as

a. Lethal Synthesis
b. Pharmacological Activation
c. Pharmacological Inactivation
d. No change pharmacological activity
e. Toxicological Activation

Answer : e. Toxicological Activation

(Izzatul Khairunnisa 260110160144)

These are the examples of biactivation which causes conversion of an active to more
active metabolite(s), except ...

a. Procaine p-Aminobenzoic acid

b. Codeine Morphine
 c. Malathion Malaoxon
d. Sulphonamides Acetyl derivatives
e. Paracetamol Imidoquinone of N-hydroxylate metabolite

Jawaban : a. Procaine p-Aminobenzoic acid

(Nida Istiazah - 260110160145)

Pro drug is the drug that active

a. Before metabolism
b. After metabolism
c. Should be with inhibitor
d. Directly after consumed
e. Before being consumed

Answer : b. After metabolism

(Mochamad Rizky F - 260110160146)

Between the main biotransformation paths below, which are included in the phase 1
biotransformation path.

a. Conjugation with sulfat

b. Acethylation
c. Methylation
d. Hydrolysis
e. Conjugation with glucuronic acid

Answer : d. Hydrolysis

(Astiningsih Diah - 260110160147)

Why metabolism is essensial in pharmacokinetics process?

 a. it renders lipid soluble and non-polar compounds to water soluble and polar
compound
b. It causes conversion of an active drug to inactive or less active metabolites
c. It causes conversion of an active to more active metabolites
d. It causes conversion of an active drug to active metabolites having entirely
different pharmacological activity
e. It causes conversion of an active drug to equally avtive metabolites

(Nurike Susendi - 260110160148)

As influence of consuming alcohol too often on drug metabolism is ...

a. Induces the enzyme system

b. Increasing drug metabolism
c. decreasing drug metabolism
d. Improve bioavailability
e. Circade changes in drug metabolism

Answer : a.Induces the enzyme system

(Luluk Luqyana - 260110160150)

The active metabolite form from the structure above is:

a. Amitriptyline
 b. Aloxantine
c. Allopurinol
d. Nortriptyline
e. Oxyfenbutazon

Answer: d. Nortriptyline

(Sinthya Eka W - 260110160151)

From the statement below, which is a factor that influence the metabolic processes of
drugs

a. Age, when a person grows older then the speed of his metabolism is greatly
increased
b. Pregnancy, in pregnant women then accelerate metabolism becomes
unbalanced
c. Pregnancy, in pregnant women then the speed of metabolism decreases
d. Environment, at the time of contact with insecticide chlorine then the
metabolism will increase
e. Smoking, When taking drugs then speed up metabolism will increase

Answer : d. Environment, at the time of contact with chlorine insecticides then

the metabolism will increase

(Putri Kholilah - 260110160153)

Here are the active drugs and its metabolite to inactive metabolites on results of

biotransformation, except

a. Ibuprofen
b. Paracetamol
c. Chlormphenicol
 d. Tramadol
e. Levodopa

Answer : d. Tramadol

(Nurul Fitri R 260110160155)

Biotransformation of the drug becomes active (or more active) metabolites are
divided into two

thats initial drugs and active metabolit. Below, is a compound belonging to the initial
drugs.

Which one a compound that is not an initial group compound

a. Digitoxin
b. Diazepam
c. Methyldopa
d. Codein
e. Prednisolon

Answer : E. prednisolone

(Alvin Al Baihaqi - 260110160156)

Active metabolite form of Codein is called .

a. Digoxin
b. Morphine
c. Prednisolon
d. Oxyfenbutazon
e. N-oxypropranolol

Answer : b. Morphine
(Adrian 260110160157)

Which is the factor influenced in drug metabolism that giving reaction by increase
metabolism speed ?

a. GI pathology
b. Genetic factor
c. Age
d. Pregnancy
e. Nutrition character

Answer : d. Pregnancy

(Fanny Seftiani DS - 260110160158)

Biotransformation Codein Morphine is the example of?

a. Pharmacological inactivation
b. Lethal synthesis
c. Bioactivation or toxicological activation
d. Pharmacological activation

Answer : c. Bioactivation or toxicological activation

(Ulfa Rahmatul F - 260110160159)

It causes conversion of an inactive to more active toxic metabolite(s) called as:

a. Pharmacological activation
b. Bioactivation
c. Lethal synthesis
d. Pharmacological inactivation
e. Toxicological activation
Answer: c. Lethal synthesis

(Bima Kinayan - 260110160160)

There are several organs that play a role in the process of drug metabolism. Below
which is organs that involved, except ?

a. Muscullar tissue
b. Lungs
c. Skin
d. Blood
e. Hair

Answer : e. Hair

(Anggun Nurlatifah - 260110160161)

Which is the right statement about prodrug and active drug?

a. Active drug is inactive before metabolism

b. Pro drug take effect directly
c. Pro drug is inactive before metabolism
d. Active drug take effect after metabolism
e. There are no difference between pro drug and active drug

Answer : c. Pro drug is inactive before metabolism