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Cancer may affect people at all ages, even fetuses, but the risk for
most varieties increases with age. Cancer causes about 13% of all human
deaths.] According to the American Cancer Society, 7.6 million people died
from cancer in the world during 2007. Cancers can affect all animals. Nearly
all cancers are caused by abnormalities in the genetic material of the
transformed cells. These abnormalities may be due to the effects of
carcinogens, such as tobacco smoke, radiation, chemicals, or infectious
agents. Other cancer-promoting genetic abnormalities may be randomly
acquired through errors in DNA replication, or are inherited, and thus
present in all cells from birth. The heritability of cancers is usually affected
by complex interactions between carcinogens and the host's genome. New
aspects of the genetics of cancer pathogenesis, such as DNA methylation,
and microRNAs are increasingly recognized as important.
Causes
Cancer is a diverse class of diseases which differ widely in their causes and
biology. Any organism, even plants, can acquire cancer. Nearly all known
cancers arise gradually, as errors build up in the cancer cell and its progeny
(see mechanisms section for common types of errors). Anything which
replicates (our cells) will probabilistically suffer from errors (mutations).
Unless error correction and prevention is properly carried out, the errors will
survive, and might be passed along to daughter cells. Normally, the body
safeguards against cancer via numerous methods, such as: apoptosis, helper
molecules (some DNA polymerases), possibly senescence, etc. However
these error-correction methods often fail in small ways, especially in
environments that make errors more likely to arise and propagate. For
example, such environments can include the presence of disruptive
substances called carcinogens, or periodic injury (physical, heat, etc.), or
environments that cells did not evolve to withstand, such as hypoxia (see
subsections). Cancer is thus a progressive disease, and these progressive
errors slowly accumulate until a cell begins to act contrary to its function in
the animal.
Research about cancer causes often falls into the following categories:
Diagnosis
People with suspected cancer are investigated with medical tests. These
commonly include blood tests, X-rays, CT scans and endoscopy.
Biopsy
Vaccination