SCHIZOPHRENIA SPECTRUM AND OTHER PSYCHOTIC DISORDERS

DISORDER FEATURES DIFFERENTIAL DIAGNOSIS COMORBID ONSET / DURATION EXCLUSION CRITERIA

SCHIZOTYPAL (PERSONALITY) AFFECT: Constricted - Delusional disorder, - Anxiety Early adulthood / pervasive Should not occur during:
DISORDER BEHAVIOR: Eccentric; Unkempt; Unusual mannerisms - Schizophrenia - Depression in variety of contexts - Schizophrenia
(premorbid) If criteria are met prior to the COGNITION: Cognitive / perceptual distortions; Ideas of - Bipolar or depressive disorder with - Bipolar disorder
onset of schizophrenia reference; Odd beliefs / magical thinking; Unusual psychotic features - Depressive disorder with
perceptual experiences; Odd thinking and speech; - Neurodevelopmental disorders: Autism psychotic features
Suspiciousness / paranoid; Negative judgment of self and language communication disorders - Autism
PHYSICAL: - Other personality disorders
SOCIAL: Lack of close friends; Excessive social anxiety; - Medical condition
Inattention to usual social conventions; Attracts teasing - Substance use disorders
DELUSIONAL DISORDER AFFECT: Can occur with mood episodes but should be - OCD - Mood episodes adolescence or early - Criterion A for schizophrenia has
Subtypes: briefer than the total duration of the delusion period; - Body dysmorphic adulthood / 1 month or never been met
Erotomanic Irritable or dysphoric mood; - Delirium, major neurocognitive disorder, longer - Effects of substance or other
Grandiose BEHAVIOR: Should not be bizarre or odd psychotic disorder due to another medical conditions
Jealous COGNITION: False belief; Hallucination (but must be medical condition, and - Not body dysmorphic disorder
Persecutory parallel with the false belief; Factual insight but not true substance/medication-induced - Obsessive-compulsive disorder
Somatic insight psychotic disorder
Mixed PHYSICAL: - Schizophrenia and schizophreniform
With bizarre content SOCIAL: disorder.
- Depressive and bipolar disorders and
Specify if: with bizarre content; schizoaffective disorder.
Specify if (a 1-year duration): - Paranoid personality disorder
First or multiple episode or continuous or - Shared psychotic disorder
unspecified
Acute, partial, or full remission
BRIEF PSYCHOTIC DISORDER AFFECT: Typically experience emotional turmoil or over - Other medical conditions adolescence or early The disturbance is not better
Specify if: whelming confusion - Substance-related disorders adulthood / at least 1 day explained by:
With catatonia BEHAVIOR: Disorganized speech; grossly disorganized - Depressive and bipolar but less than 1 month with - Major depressive or bipolar
current severity of delusions, hallucinations, or catatonic behavior; increased risk of suicidal behavior - Other psychotic disorders eventual full return to disorder with psychotic features or
disorganized speech, abnormal psycho COGNITION: Delusion; Hallucination - Malingering and factitious disorders premorbid level of - Another psychotic disorder such
motor behavior, negative symptoms, PHYSICAL: - Personality disorders functioning as schizophrenia or catatonia
impaired cognition, depression, and mania SOCIAL: - Is not attributable to the
symptoms physiological effects of a
With marked stressor(s) substance (e.g., a drug of abuse,
Without marked stressor(s) a medication) or another medical
With postpartum onset condition.
SCHIZOPHRENIFORM DISORDER AFFECT: - Schizophrenia - Anxiety adolescence or early - No major depressive episodes
With good prognostic features BEHAVIOR: Disorganized speech; grossly disorganized - Brief psychotic disorder - Depression adulthood / at least 1 during active-phase symptoms or
Without good prognostic features behavior; Negative symptoms - Substance- or medication-induced month but less than 6 may be present but only for a
With catatonia COGNITION: Delusions; Hallucinations psychotic disorder months minority of the total duration of the
PHYSICAL: - Bipolar affective disorder active phase and residual period
SOCIAL: Impairment in social and occupational - Depression of the illness
functioning is not necessary - Delirium - Is not attributable to the
- Schizoaffective disorder physiological effects of a
 SCHIZOPHRENIA SPECTRUM AND OTHER PSYCHOTIC DISORDERS

DISORDER FEATURES DIFFERENTIAL DIAGNOSIS COMORBID ONSET / DURATION EXCLUSION CRITERIA

SCHIZOPHRENIA
Specify if (a 1-year duration):
First or multiple episode or continuous or
unspecified
Acute, partial, or full remission
SCHIZOAFFECTIVE DISORDER
Bipolar type
Depressive type
With catatonia
Specify if (a 1-year duration):
First or multiple episode or continuous or
unspecified
Acute, partial, or full remission
- Psychotic disorder due to another substance (e.g., a drug of abuse,
disease or its treatment a medication) or another medical
- Delusional disorder condition.
- Schizotypal, schizoid, or paranoid
personality disorder
- Autism spectrum disorder
- Disorders presenting in childhood with
disorganized speech
- Attention deficit hyperactivity disorder
- Obsessive-compulsive disorder
- Posttraumatic stress disorder
- Traumatic brain injury
AFFECT: Inappropriate affect; a dysphoric mood that can - Schizophrenia - Substance-related Childhood onset / - No major depressive episodes
take the form of depression, anxiety, or anger - Brief psychotic disorder disorder (tabacco adolescence or early during active-phase symptoms or
BEHAVIOR: Disorganized speech; grossly disorganized - Substance- or medication-induced use disorder) adulthood / More than 6 may be present but only for a
behavior; Negative symptoms; Disturbed sleeping psychotic disorder - Anxiety months minority of the total duration of the
pattern; lack of interest in eating foods; Hostility and - Bipolar affective disorder active phase and residual period
- OCD
aggression - Depression of the illness
COGNITION: Delusions; Hallucinations; odd beliefs, - Delirium - Panic disorder Severely ill, chronic - Is not attributable to the
unusual perceptual experiences; Depersonalization, - Schizoaffective disorder - Schizotypal symptoms and poor physiological effects of a
derealization; phobias; Decrements in memory, executive - Psychotic disorder due to another personality and prognosis substance (e.g., a drug of abuse,
functions, slow processing speed; Abnormalities in disease or its treatment paranoid personality a medication) or another medical
sensory processing; lack of insight (anosgia) - Delusional disorder disorders condition.
PHYSICAL: Somatic concerns; Reduced overall brain - Schizotypal, schizoid, or paranoid
volume personality disorder
SOCIAL: Impairment in social and occupational - Autism spectrum disorder
functioning; Social withdrawal; lack of theory of mind; - Disorders presenting in childhood with
disorganized speech
- Attention deficit hyperactivity disorder
- Obsessive-compulsive disorder
- Posttraumatic stress disorder Traumatic
brain injury
AFFECT: Pervasive depressed mood/mania; - Schizophrenia - substance use disorders Early adulthood / 1 to 6 - Exclusion of autism spectrum
BEHAVIOR: Ahnedonia; Difficulties with self-care - Bipolar - anxiety disorders months disorder or other communication
COGNITION: Delusions or hallucination must be present - Brief psychotic disorder disorder of childhood onset
for 2 weeks in the absence of major mood episodes; - Depression - Is not attributable to the
Anosognia (poor insight) physiological effects of a
PHYSICAL: substance (e.g., a drug of abuse,
SOCIAL: Restricted social contact; a medication) or another medical
condition.