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ACTION:
pancreas. Its action on insulin secretion is mainly due to the restoration of the early
In man, apart from having hypoglycemic effect, gliclazide has been shown to reduce
properties. As such, gliclazide scavenges free radicals, and therefore, decreases the
sulfonylureas and related drugs; diabetic precoma; severe liver or kidney disease;
treatment with miconazole. Use cautiously in: Hepatic or renal impairment; hypoglycemia
Total daily dose may vary from 1-4 orally. Adjust dose according to patient’s individual
response in the majority of cases, 2 tabs/day with meals. Elderly diabetic: starting dose is
hepatitis.
NURSING RESPONSIBILITIES:
doctor.
• Do not take a double dose to compensate for the single dose that was not taken.
• Instruct the patient that it should be taken with meals; swallow whole and do not
chew or crush.
• Inform the doctor in the following cases: Surgery, trauma, fever or infection,
insulin.
• Inform the doctor if the patient wishes to become pregnant. If the patient is
pregnant, inform the doctor so that he may prescribe a more suitable treatment.
• If any undesirable effects which have not been mentioned occur, inform the doctor
or pharmacist.
• Certain interactions with other drugs must be avoided as they can cause significant
changes in the blood glucose levels. The patient must not take other drugs on his
own initiative.
• The doctor or pharmacist must be informed if the patient is taking or have recently
taken any other drugs, especially danazol (hormonal drug), corticoids, diuretics,
miconazole or alcohol.