Predisposing Factors: Precipitating Factors:

:
Age Present of stagnant water
Race Poor sanitation
Climate

Geographical location

Aedes Aegypti( Dengue virus carrier) 8-12 days of

viral replication on mosquitoes salivary glands

Redness and
Arbovirus penetrates into the disrupted itchiness in
epidermis( Incubation period: 3 to 14 days) the area

Virus attaches to the cell surface Positive tourniquet test

Flaviradae virus enters to the cell

Forms Dengue Virus Antibody complex Penetration of viral DNA is injected to the cell
Attack the bone marrow Replication of Nucleic Acid

Thrombopoesis Synthesis new protein coats are synthesized within

the mast cell

Assembly of mature virions within the cells to

Release of platelets
be release

Decrease platelet
Virus leakage
Dengue- virus antibody destroy count
the platelets

Virus leaks outside the cell Replicate into other cells

Increase release of platelets from
the bone marrow causing to be
destroyed
Activation of interleukin-1 and Activation of spleen
tumor necrosing factor
Destroyed platelets circulate in S/sx:
the liver to be filtered out Hyperthermia
Activation of cytokines Release of monocytes

Overcompensation of the liver Anti-pyretic Drugs

Promote B cell growth and maturation Dengue virus attach to monocytes

S/sx:

HEPATOMAEGALY -Vomiting Dx Test:

-RUQ pain Increase WBC activity Monocytes will be infected
Hematology:
Increase WBC count
Decrease function of the liver Antibody attaches themselves to mast Dengue virus infected monocytes attach
cells and infected cells to splenocytes

Degraded to act as maintaining Release of histamine,kinin, serotonin and Spleen become inflamed
oncotic pressure in the body prostaglandin
Decrease BP
Hypertonic IV fluid Vasodilation SPLENOMEGALY
S/sx:
-LUQ pain
Increase capillary permeability
Loss of albumin

If treated If not treated

Third space Fluid shifting

-Antibiotics Wall of the

spleen burst
-splenectomy
Increase ICP Compression of
Pleural effusion Ascites
surrounding tissue

Life threatening
-Cerebral swelling Edema -rapid breathing -abdominal pain Bleeding inside the
FAIR
-vomiting abdomen
-chestpain -constipation PROGNOSIS
-headaches
-cough -sense of fulness
-Impaired
thinking and
changes in
consciousness. S/sx:
-bruises
-hematuria
May leak out from the vessel -hematemesis
-epistaxis
-melena
Complete rupture of the blood vessel
 Hypotension

Lack of blood flow to the different organs of the body

With treatment: If not treated

Diagnostic tests S/sx:

-Cold clammy skin
-CBC
SHOCK -Rapid weak pulse
-Chest x-ray
-Prothrombin time
-Urinalysis
DEATH
Medical Management
-IVF (hypertonic solution)
-transfusion of platelet ffffffffffffconcentrate
-antihistamine (Cetirizine) BAD PROGNOSIS
-antipyretic (Paracetamol)
-on DAT with no dark colored foods

GOOD PROGNOSIS