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Alternative name:
thromboangiitis obliterans
Definition:
Is a recurring progressive inflammation and thrombosis (clotting) of small and
medium arteries and veins of the hands and feet. It is strongly associated with
use of tobacco products, [1] primarily from smoking, but also from smokeless
tobacco.
History
King George VI and Buerger’s Disease
- As reported by Alan Michie in God Save the Queen, published in 1952 (see
pages 194 and following), King George VI was diagnosed with the disease in
late 1948 and early 1949. Both legs were affected, the right more seriously than the
left. The King's doctors prescribed complete rest and electric treatment to stimulate
circulation, but either unaware of the connection between the disease or smoking
(the King was a heavy smoker) or unable to persuade the King to stop smoking, the
disease failed to respond to their treatment. On March 12, 1949, the King underwent
a lumbar sympathectomy, performed at Buckingham Palace by Dr. James R.
Learmonth. The operation, as such, was successful, but the King was warned that it
was a palliative, not a cure, and that there could be no assurance that the disease
would not grow worse. From all accounts, the King continued to smoke.
Causes:
Tobacco smoking
Prognosis
Feature:
Diagnosis:
M.Buerger
1. Typically between 20–40 years old and male, although recently females
have been diagnosed.
2. Current (or recent) history of tobacco use
3. Presence of distal extremity ischemia (indicated by claudicating, pain at
rest, ischemic ulcers or gangrene) documented by noninvasive vascular testing
such as ultrasound
4. Exclusion of other autoimmune diseases, hypercoagulable states, and
diabetes mellitus by laboratory tests.
5. Exclusion of a proximal source of emboli by echocardiography and
arteriography
6. Consistent arteriographic findings in the clinically involved and
noninvolved limbs.
Buerger’s disease can be mimicked by a wide variety of other diseases that cause
diminished blood flow to the extremities. These other disorders must be ruled out with an
aggressive evaluation, because their treatments differ substantially from that of
Buerger’s disease. For Buerger’s there is no treatment known to be effective.
Diseases with which Buerger’s disease may be confused include atherosclerosis (build-
up of cholesterol plaques in the arteries), endocarditis (an infection of the lining of the
heart), other types of vasculitis, severe Raynaud’s phenomenon associated with
connective tissue disorders (e.g., lupus or scleroderma), clotting disorders of the blood,
and others.
Angiograms of the upper and lower extremities can be helpful in making the diagnosis of
Buerger’s disease. In the proper clinical setting, certain angiographic findings are
diagnostic of Buerger’s. These findings include a “corkscrew” appearance of arteries that
result from vascular damage, particularly the arteries in the region of the wrists and
ankles. Angiograms may also show occlusions (blockages) or stenosis (narrowing) in
multiple areas of both the arms and legs. The changes are particularly apparent in the
blood vessels in the lower right hand portion of the picture (the ulnar artery distribution).
To rule out other forms of vasculitis (by excluding involvement of vascular regions
atypical for Buerger’s), it is sometimes necessary to perform angiograms of other body
regions (e.g., a mesenteric angiogram).
There is no test can confirm whether you have BD. Instead your doctor will likely order
tests to rule out more common conditions including:
Blood test
- Blood tests to look for certain substances can rule out other conditions that
may cause similar signs
and symptoms. For instance, blood tests can help rule out scleroderma, lupus, blood
clotting disorders
and diabetes, along with other diseases and conditions.
Allen’s Test
- Your doctor may conduct a simple test called the Allen's test to check blood
flow through the arteries carrying blood to your hands. In the Allen's test, you make a
tight fist, which forces the blood out of your hand. Your doctor presses on the arteries
at each side of your wrist to slow the flow of blood back into your hand, making your
hand lose its normal color. Next, you open your hand and your doctor releases the
pressure on one artery then the other. How quickly the color returns to your hand
may give a general indication about the health of your arteries. Slow blood flow into
your hand may indicate a problem, such as Buerger's disease.
Angiogram
- An angiogram, also called an arteriogram, helps doctors see the condition of
your arteries. Doctors
inject dye into an artery and then take X-rays or other types of images. Images show
any blockages in
the artery. Your doctor may order arteriogram be performed on both of your arms
and your legs —
even if you don't have signs and symptoms of Buerger's disease in all of your limbs.
Buerger's disease
almost always affects more than one limb, so even though you may not have signs
and symptoms in
your other limbs, this test may detect early signs of vessel damage.
Symptoms:
Pain
Foot cramps
Cold sensitivity in some cases
Rubor of the foot
Absence of pedal pulse
Redness of cyanotic discoloration upon progression of disease
Gangrene
Intermittent Claudication (Pain even at rest)
Paresthesia
Poikilothermia
Anatomy and Physiology
The disease is typically encountered in heavy smokers, often before the age of
35 years.
Thromboangiitis obliterans is marked by segmental thrombosing, acute, and
chronic inflammation of intermediate and small arteries and veins in the extremities.
It begins with nodular phlebitis, followed by Raynaud's-like cold sensitivity and leg
claudication.
Acute lesions consist of neutrophilic infiltration of the arterial wall, with mural or
occlusive thrombi
Containing microabscesses, often with giant cell formation and secondary
involvement of the adjacent vein and nerve.
Late lesions show organization and recanalization.
The cause is unknown.
The vascular insufficiency can lead to excruciating pain and ultimately gangrene
of the extremities
Three layers of the arteries and veins
Tunica Intima
Tunica Media
Tunica Adventitia
Neutrophil polymorphs
Buerger’s Disease
Prosthesis
Management:
A. Surgical Intervention
Sympathectomy
- is a surgical procedure that destroys nerves in the sympathetic nervous
system. The procedure is done to increase blood flow and decrease long-
term pain in certain diseases that cause narrowed blood vessels. It can also be used
to decrease excessive sweating. This surgical procedure cuts or destroys the
sympathetic ganglia, collections of nerve cell bodies in clusters along the thoracic or
lumbar spinal cord.
Amputations for gangrenous tissue
- An amputation usually refers to the surgical removal of the whole or part of
an arm/hand or a leg/foot. Amputation of a toe or leg is one of the oldest surgical
procedures.
Ganglionectomy to remove ganglions
- ganglionectomy, also called a gangliectomy, is the surgical removal of
a ganglion. The removal of a ganglion cyst usually requires a ganglionectomy.
Such cysts usually form on the hand, foot or wrist and may cause pain or impair
body function. Aspiration of the cyst andsteroid injections are typically performed
first. If they fail, the cyst is excised under local, regional or even
general anesthetic. Ganglionectomies are also performed for other reasons, such
as the treatment of chronic pain.
Discharge Planning
Medication
-As prescribed by the physician
-Vasodilator
Exercise
-Ambulate as tolerated
Treatment
- Gradual cessation of smoking
- Amputation
- Ganglionectomy
- Sympathectomy
Health teaching
-Discuss the etiology of the condition
-Ways to avoid injury
-Proper footcare including nail trimming.
Outpatient Care
-Follow up checkups as indicated by the physician.
Diet
-High in protein. Low in cholesterol diet.
Spiritual
-Continue Religious practices