Professional Documents
Culture Documents
Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF.
2
Mass Spectrometry for Trace Detection of
Threat Agents
https://www.nap.edu/read/10996/chapter/4#19 1/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
however, all of these instruments operate at high vacuum, and they need
professional care and trained operators.
Mass spectrometry is not new to the TSA; as a result of a TSA program
focusing on the use of MS technology, researchers concluded that there
are no major technical barriers to its use in the field for trace detection
scenarios, provided effective sampling and introduction procedures for the
specific application are employed.3 Currently, the TSA is testing a
personnel screener utilizing an MS-based system from Syagen Technology
and a portal from Sandia National Laboratories.4 MS has also been
1M.A.Grayson, ed. 2002. Measuring Mass: From Positive Rays to
Proteins. Philadelphia: Chemical Heritage Foundation.
2For a rather extensive listing of portable/mobile mass spectrometers
see http://www.gcms.de/#Time-of-Flight.
3S.A. McLuckey, D.E. Goeringer, and K.G. Asano. 1996. High Explosives
https://www.nap.edu/read/10996/chapter/4#19 2/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
https://www.nap.edu/read/10996/chapter/4#19 3/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
BOX 2-1
Deployed Mass Spectrometry-Based Trace Explosives Detector
https://www.nap.edu/read/10996/chapter/4#19 4/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
https://www.nap.edu/read/10996/chapter/4#19 5/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
The higher chemical specificity of MS means that significantly smaller
quantities of target molecules can be detected in the presence of relatively
Opportunities to Improve Airport Passenger Screening with Ma
large quantities of background molecules. This enables the detection
threshold to be lowered without increasing the false alarm rate.
Identification Strategies
unknown substance from scratch but rather must determine whether it
contains one of these ~200 compounds or organisms. If a mass
Opportunities to Improve Airport Passenger Screening with Ma
spectrometer is used, the spectrum obtained would be compared
electronically against a library of reference spectra, and a software
algorithm would determine if a match occurred. These algorithms and
Protection of the traveling public from terrorist
spectral libraries already exist for electron
threatsionization, though it is goal
notofathe
Buy Paperback | $21.00
foregone conclusion that electron ionization
involving explosives
Transportation Security
will be
is a major
the Administration
ionization (TSA).
method For 20
years, the TSA (and the Federal Aviation
of choice. These libraries may be searched for over
Administration 300,000
before reference
it) have been investing in
MyNAP members save
spectra; typically, two measures of confidence
10% online.
technologies intothe
meetspectral match
that goal. To supportarethat
activity, the TSA has asked the NRC to assess a
given as part of a search
Login report.
or Register to If GC or LC is also used, the
variety of technological opportunities for oering
chromatographicsave!elution time can be used to further
such protection. The increase the this
NRC is approaching
assignment by issuing a series of reports on chosen
confidence of the identification. If MS/MS is used, each molecule of
technology applications. This is the rst of that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 7/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
interest would be identified by two or three masses:
for enhanced trace that of (ETD)
detection the parent
of chemicals
contained in explosives. The report describes
(molecular weight) ion (or parent less some known ion loss), indicative of
limitations of trace detection in general and the
the molecular weight, and the masses of onetechnologies
current or two ions that result
in particular. It then from
presents a
intentional fragmentation of the parentdiscussion
ion, forofconfirmation.
the potential for mass
These spectrometry
ions to
improve EDT including challenges faced by such a
would be determined by running standards.
system, recommendations for starting a program to
With highly energetic molecules such take
asadvantage
explosives of mass
orspectrometry,
with the complexand
recommendations for a phased implementation
macromolecules that are present in microorganisms,
plan.
the process of
preparing, vaporizing, and ionizing the sample often causes the target
molecule (and background molecules as well) to break up into fragments.
This tendency is minimized by the use of soft ionization (see above for two
common methods), but the effect can also be utilized in the collision
(fragmentation) process of MS/MS analysis to confirm the identity of the
material. The pattern of fragments formed is characteristic of the structure
of the parent molecule or organism, and under appropriate conditions this
spectrum and the molecular weight can be used to identify the target
molecule/organism by comparing them to the reference library. This
detection strategy makes MS/MS systems much more flexibe than IMS
systems. If additional threat agents become a concern, the MS/MS
molecular species and reference library can be expanded to accommodate
them.
Analysis Time
In the airport context, the time required for acquisition and analysis of a
sample is a critical factor in determining where and in what circumstances
the trace detection technique can be used. The current system of IMS
trace detectors for explosive residues on passenger carry-on bags takes on
the order of 1 minute from sample acquisition to final analysis. It is
probable that an MS or MS/MS-based system would take about the same
Opportunities to Improve
amount of time or slightlyAirport
longer,Passenger
because forScreening
explosives, with
the Ma
sample
collection and preparation requirements for IMS and MS are essentially the
same.
Once a sample has been acquired by Protection
wiping or of the traveling public
collecting from terrorist
as with IMS,
the time required toBuy
Paperback
acquire | $21.00 can be made short (on the
threats
a mass spectrum
involving explosives is a major goal of the
Transportation Security Administration (TSA). For 20
order of 1 second), and the electronic analysis of the
years, the TSA resulting
(and the spectrum
Federal Aviation
MyNAP Administration before it) have been investing in
takes about the samemembers
amount save
of time. However, in some cases (e.g.,
technologies to meet that goal. To support that
10% online.
biological analysis), sample collection and preparation,
activity, the TSA has askedas the
well
NRCasto assess a
Login or Register to variety of technological opportunities for oering
preseparation of complex mixtures, might add significantly to the analysis
save! such protection. The NRC is approaching this
time. Gas or liquid chromatography used as a preseparator
assignment by issuing a seriesatofthe MSoninlet
reports chosen
technology applications. This is the rst
might add several seconds to several minutes to the analysis time9;of that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 8/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
however, by using an MS/MS configuration, the chromatographic
for enhanced trace detection (ETD) of chemicals
contained in explosives. The report describes
separation on the front end may be avoided, saving significant analysis
limitations of trace detection in general and the
time. Preparation of complex biologicalcurrent
samples for MS
technologies analysisIt (e.g.,
in particular. lysinga
then presents
discussion
cells and digesting polypeptides) may also add of the potential for time
considerable mass spectrometry
to the to
improve EDT including challenges faced by such a
analysis of potential biological agents. There is
system, recommendations for starting a program to
take advantage of mass spectrometry, and
9A short column transfer line chromatograph wouldforadd 1 second; a 6-
recommendations a phased implementation
foot capillary column would add 30 seconds
plan. to 5 minutes, depending
on how much chemical specificity is required from the
chromatography.
Sampling Strategies
The same dry wiping techniques used with current IMS systems can also
be used with MS-based detection systems. However, as discussed in
Chapter 1, automated sampling (either of hand luggage or in a portal
arrangement) would be better because it would avoid the many
uncertainties of manual sampling. Any automated sampling system would
incorporate a condensation or concentration step to counteract the air
flow dilution (such a step is now included in portal sampling systems).
technology (MS) for another (IMS) on the probability of detection and
the false alarm rate. By fusing data from complementary detection
Opportunities to Improve
technologies, one can Airport Passenger
reduce false Screening
alarm rates with no with Ma
degradation in
the overall system detection probability. However, an analysis of the
costs and benefits of such multimodal detection systems is beyond the
scope of this report. Protection of the traveling public from terrorist
well as on passenger boarding passes, have been detected using the
Opportunities to Improve
portable tandem Airport
MS detector Passenger
described Screening
in Box with Ma
2-1 and shown in Figure 2-1.
Biological Agents
22M.D.
Evans, E.R. Beckley, K.A. Hanold, and J.A. Syage 2003. Chemical
weapons screening of water samples by photoionization MS. 51st
Conference
Opportunities to of the American
Improve AirportSociety for Mass
Passenger Spectrometry,
Screening with Ma Montreal.
June 8-12.
23M.V. Johnston. 2000. Sampling and analysis of individual particles by
24D.T. Suess and K.A. Prather. 1999. Mass
Buy Paperback | $21.00 spectrometry
threats ofisaerosols.
involving explosives a major goal of the
Transportation Security Administration (TSA). For 20
Chem. Review 99:3007-3035.
years, the TSA (and the Federal Aviation
MyNAP members save Administration before it) have been investing in
technologies to meet that goal. To support that
10% online. activity, the TSA has asked the NRC to assess a
Login or Register to
mass spectrometry has already shown variety
significant capabilities
of technological for biological
opportunities for oering
save! such protection. The NRC is approaching this
identification.25,26 assignment by issuing a series of reports on chosen
technology applications. This is the rst of that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 13/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
A paper by Randolph Long27 of Edgewood Arsenalan
for enhanced Army
trace detection laboratory
(ETD) of chemicals
contained in explosives. The report describes
that has been conducting and funding research on chem/bio detection for
limitations of trace detection in general and the
more than 30 yearscompares the three current
current contenders
technologies forIt then
in particular. the presents a
discussion of the potential for mass spectrometry to
detection of chemical and biological agents and bioactive peptides and
improve EDT including challenges faced by such a
toxins: immunoassays; assays based onsystem,
nucleic acid sequence;
recommendations andamass
for starting program to
take advantage of mass spectrometry,
spectrometry. In contrast to immunoassays, which are specific to a single and
recommendations for a phased implementation
agent and take 15-20 minutes, and assays
plan.based on nucleic acid sequence,
which use polymerase chain reaction (PCR) amplification and detection
with DNA arrays, mass spectrometry was characterized as follows:
spectrometer, Block II (CBMS).28 The CBMS was developed with funds from
the U.S. Armytoand
Opportunities the Department
Improve of EnergyScreening
Airport Passenger for use in chemical
with Maand
biological warfare. It consists of an ion-trap MS/MS mass spectrometer
with chemical ionization source and three specific inlets to handle various
sample types to be analyzed.29 Biodetection
Protection forof bacterial, viral,from
the traveling public andterrorist
toxin
targets was accomplished
Buy Paperback | $21.00
by concentrating
threats particles in a respirable
involving explosives range
is a major goal of the
Transportation Security Administration (TSA). For 20
(2-10 m) into a quartz pyrolysis/thermolysis tube, where, after the
years, the TSA (and the Federal Aviation
addition of a derivatization
MyNAP members reagent,
save theAdministration
sample is before thermolyzed.
it) have beenThe mass
investing in
technologies to meet that goal. To support that
spectra of the10%
liberated
online.chemical biomarkers are then processed to
activity, the TSA has asked the NRC to assess a
Login or Register
determine if targeted to agentsvariety
biological are present in the
of technological sample. for
opportunities Viruses
oering
save! such protection. The NRC
and toxins are typically distinguished on the basis of protein fragments,is approaching this
assignment by issuing a series of reports on chosen
technology applications. This is the rst of that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 14/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
while bacteria are distinguished on thefor
basis of their
enhanced fatty acid
trace detection (ETD)methyl
of chemicals
contained in explosives. The report describes
ester profiles.30 limitations of trace detection in general and the
Another extensive program developing mass
current spectrometry
technologies for
in particular. chemical
It then presents a
discussion of the potential for mass spectrometry to
and especially biological detection is being conducted at the Johns Hopkins
improve EDT including challenges faced by such a
University Applied Physics Laboratory system,
(APL).recommendations
With fundingfor from DARPA
starting as to
a program
take advantage
part of a systems approach to the detection of mass
of threats inspectrometry, and
the environment,
recommendations for a phased implementation
APL has built and is testing an integrated
plan.chemical and biological detection
system based on a miniaturized
25M.P.
McLoughlin, W.R. Allman, C.W. Anderson, A.A. Carlson, J.J.
DeCicco, and N.H. Evancich. 1999. Development of a field-portable
time-of-flight mass spectrometer system. Johns Hopkins APL
Technical Digest 20(3): 326-334.
26W.H. Griest, M.B. Wise, K.J. Hart, S.A. Lammert, C.V. Thompson, and
30S.A. Lammert, W.H. Griest, M.B. Wise, K.J. Hart, A.A. Vass, D.A. Wolf,
TOF mass spectrometer utilizing electron impact ionization for vapors and
laser desorption-ionization for higher molecular weight threats
(bioregulators, toxins, and microbes; see Figure 2-2).31,32
Recent reports from Purdue University suggest that the identification of
whole proteins from complex mixtures can be accomplished with lysated
cells (E. coli) and mass spectrometry alone, using no chromatography or
other preparation step.33 For targeted biomolecules, this raises the
possibility of significant reductions in sample preparation time.
CHALLENGES FOR MASS SPECTROMETRY-
Opportunities to Improve Airport Passenger Screening with Ma
BASED TRACE DETECTION SYSTEMS
MS-based systems face a number of challenges before they can be
deployed in airports as trace detectors,Protection
discussed of the traveling public from terrorist
further below.
Buy Paperback | $21.00
threats involving explosives is a major goal of the
Transportation Security Administration (TSA). For 20
years, the TSA (and the Federal Aviation
Reduce Cost and Complexity, Increase Ruggedness
Administration before it) have been investing in
MyNAP members save
technologies to meet that goal. To support that
10%
As noted above, online.
the U.S. Army and DARPA have conducted proof-of-
activity, the TSA has asked the NRC to assess a
Login and
principle research or Register to
development, testing,
variety of and evaluation
technological for both
opportunities for oering
save! such protection. The NRC is approaching this
chemical and biological threat analysis using fieldable, rugged, specialized
assignment by issuing a series of reports on chosen
mass spectrometer systems. It is likely technology
that much of the This
applications. work these
is the rst ofand
that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 16/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
other agencies have done to develop equipment
for enhanced concepts could
trace detection (ETD) ofbechemicals
used
contained in explosives. The report describes
directly or modified for TSA threat scenarios, but TSA needs to focus on its
limitations of trace detection in general and the
unique needs for a rugged, backbone mass
currentspectrometer that would
technologies in particular. be
It then presents a
discussion of the potential for mass spectrometry to
useful for many threat detection scenarios.
improve EDT including challenges faced by such a
system,
31R.J. Cotter, R.D. English, B. Warscheid, recommendations
A. Hardy, and B.D. for Gardner.
starting a program to
take advantage of mass spectrometry, and
Miniaturized time-of-flight mass spectrometers
recommendations for
for abioagent
phased implementation
detection and identification. Submitted
plan. for publishing.
32See a series of articles in the Johns Hopkins APL Technical Digest, Vol.
20, No. 3 (1999).
33G.E. Reid, H. Shang, J.M. Hogan, G.U. Lee, and S.A. McLuckey 2002.
run around the clock, with several mass spectrometers overseen in their
automatic operations
Opportunities to Improve by technicians.
Airport Passenger Screening with Ma
The costs of laboratory instruments depend on their complexity and the
volume produced. GC/MS instruments that sell in the thousands of units
per year are offered at about $50,000. LC-ion trap machines and TOF
Protection of the traveling public from terrorist
machines cost fromBuy
$100,000 to $250,000
Paperback | $21.00
threatsand are sold
involving in quantities
explosives is a major goalof
Transportation Security Administration (TSA). For 20
of the
hundreds per year. The annual maintenance contracts typically cost about
years, the TSA (and the Federal Aviation
10 percent of the purchase
MyNAP membersprice
saveper year in a laboratory
Administration setting.
before it) have been investing in
Once an analyzer technologies
configuration is selected, theto operational,
meet that goal. To support that
10% online.
activity, the TSA has asked the NRC to assess a
cost/benefit, Login or Register requirements
and functional to varietycan be specified,
of technological test protocols
opportunities for oering
save! such protection. The
issued, and bids solicited from companies with MS product history toNRC is approaching this
assignment by issuing a series of reports on chosen
supply a rugged and cost-effective product or design.
technology Cost
applications. This goals must
is the rst be
of that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 17/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
given, but there are limits of design andforpricing
enhancedthat
trace depend on volume.
detection (ETD) of chemicalsTo
contained in explosives. The report describes
keep costs as low as possible, it would be desirable to involve multiple
limitations of trace detection in general and the
vendors in the design and production of an MS-based
current ETD
technologies in system.
particular. It then presents a
discussion of the potential for mass spectrometry to
improve EDT including challenges faced by such a
Resolve Sampling Issues system, recommendations for starting a program to
take advantage of mass spectrometry, and
The configuration of the sample inlet (chromatograph,
recommendations for aifphased
needed) and the
implementation
plan.
ionization, mass analysis, and ion detection methods will depend on the
problem to be solved. It is not reasonable to expect that one inlet and
ionization method will serve all threat materials or all threat scenarios. It is
moreover possible to have more than one inlet or ion source in or attached
to the MS. Ion trap analyzers, in particular, can perform several different
types of mass spectrometer scans (MS/MS/MS...) and change the polarity
of detected ions, all based on information from the previous scan. As can
be seen from the examples so far, several different configurations have
been chosen for solutions to chem/bio problems: systems utilizing gas or
liquid chromatography, chemical vs. electrospray ionization, ion trap or
TOF, MS/MS or MS alone, and positive/negative ion detection, among
others. Choosing the most appropriate configurations will take time,
expertise, in-depth knowledge of the manufacture of mass spectrometers,
and perhaps additional research. A significant attempt should be made to
select configurations that are extendable to as many threat scenarios and
substances as possible.
Several groups and companies are working on related problems, and
these efforts must be considered. For example, R.G. Cooks at Purdue
University is leading an initiative on multiplexing and miniaturizing ion
trap mass spectrometers.35 These devices (Figure 2-3)36 are ion traps and
hence have MS/MS capability. They are miniaturized and have a single
vacuum system; they are, however, the only devices having separate mass
spectrometers
Opportunities to and separate
Improve ion inlets,
Airport allowing
Passenger differentwith
Screening ionization
Ma and
sample handling techniques.
34Since the configuration of fielded instruments is not known at this
time, the extent of technical support and operator
Protection training
of the traveling are terrorist
public from not
Buy Paperback
known and not addressed in this | $21.00
threats
report.
involving explosives is a major goal of the
Transportation Security Administration (TSA). For 20
35L.S. Riter, R.J. Noll, Y. Peng, G.E. Patterson, A. Guyman,
years, the TSA andAviation
(and the Federal R.G. Cooks.
Administration before it) have been investing in
2002. MSn MyNAP members
capability save
of a miniature cylindrical ion trap mass
technologies to meet that goal. To support that
10% Proceedings
spectrometer. online. of the 50th ASMS
activity, Conference
the TSA on to
has asked the NRC Mass
assess a
Login or Register to variety of technological opportunities for oering
Spectrometry and Allied Topics, Orlando, Fla. June 2-6.
save! such protection. The NRC is approaching this
36Personal correspondence includingassignment
presentation materials
by issuing by Amy
a series of reports on chosen
Tabert and Professor Cooks, 2002. technology applications. This is the rst of that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 18/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
for enhanced trace detection (ETD) of chemicals
contained in explosives. The report describes
limitations of trace detection in general and the
current technologies in particular. It then presents a
discussion of the potential for mass spectrometry to
improve EDT including challenges faced by such a
system, recommendations for starting a program to
take advantage of mass spectrometry, and
recommendations for a phased implementation
plan.
Automated Sampling
actual capabilities and understanding of these approaches need further
Opportunities to Improve Airport
funding and optimization, Passengeronce
with deployment Screening withbeen
they have Mashown to
be justified.
To identify a target molecule using a mass spectrometer, the spectrum
Opportunities
obtained wouldto Improve Airport
be compared Passenger
against a libraryScreening
of reference with Ma and a
spectra,
software algorithm would determine if there is a match. Such algorithms,
formats, and spectra libraries already exist and will form the basis for those
used in this application. Once the methods of analysis
Protection arepublic
of the traveling chosen,
from terrorist
corresponding libraries
Buy will
Paperback | $21.00
need to be threats
agumented. All commercialgoal
involving explosives is a major
MSof data
Transportation Security Administration (TSA). For 20
the
specific list of explosives and cannot easily be reconfigured to
detect an
Opportunities to expanded list of explosive,
Improve Airport Passenger chemical, andwith
Screening biological
Ma threat
substances.
deployment of mass spectrometry-based systems for residue threat
Opportunities
scenarios thattoinvolve
Improve theAirport
expandedPassenger
threat list. Screening
Rugged, with Ma MS-
miniaturized
based trace detection systems should be developed for use in an airport
environment in order to achieve lower alarm thresholds without increasing
false alarm rates and to provide versatility for threat
Protection substances
of the traveling public from not now
terrorist
detected.
Buy Paperback | $21.00
threats involving explosives is a major goal of the
Transportation Security Administration (TSA). For 20
A good way to bootstrap this entire process would
years, the TSA beFederal
(and the to purchase
Aviation the
best field-deployed
MyNAPinstrument
members save to gainAdministration
experiencebefore andit)tohave
testbeen investing in
system
technologies to meet that goal. To support that
10% option
applications. One online. would be for TSA tothe
activity, purchase
TSA has askedanthe
instrument
NRC to assesswitha
Login or Register to
the capabilities of the Scentinel instrument described
variety of technologicalinopportunities
Box 2-1 and for oering
save! such protection. The NRC is approaching this
evaluate its effectiveness in an airport setting.
assignment by issuing a series of reports on chosen
technology applications. This is the rst of that series
Download Free PDF and presents an assessment of mass spectrometry
https://www.nap.edu/read/10996/chapter/4#19 22/23
21/10/2016 2MassSpectrometryforTraceDetectionofThreatAgents|OpportunitiestoImproveAirportPassengerScreeningwithMassSpectrometry|The
Download Free PDF and presents an assessment of mass spectrometry
In Chapter 3, the committee suggestsforone possible
enhanced example
trace detection ofofan
(ETD) orderly
chemicals
program for development, testing, and contained
deploymentin explosives. The report describes
of mass-spectrometry-
limitations of trace detection in general and the
based systems. current technologies in particular. It then presents a
discussion of the potential for mass spectrometry to
improve EDT including challenges faced by such a
system, recommendations for starting a program to
The National Academies of Sciences, Engineering, and Medicine
take advantage of mass spectrometry, and
500 Fifth St., NW | Washington, DC 20001 recommendations for a phased implementation
2016 National Academy of Sciences. All rights reserved.
plan.