Module Handbook

M.Sc.
Biomedical Engineering

Medical Faculty Mannheim

Heidelberg University
General Information
Latest revision: December 2015

Module description for full time study.

Regular study duration: 2 years

1 ECTS1 is equivalent to 30 study hours.

Module catalogue

1. Qualification objectives at Heidelberg University

2. General requirements of the study
3. Aims of the MSc. programme in Biomedical Engineering
4. Specializations included in the programme
5. Curriculum
6. Overview of the courses
7. Courses in detail

1. Qualification objectives at Heidelberg University

In accordance with its mission statement and constitution, Heidelberg Universitys degree
courses have subject-related, transdisciplinary and occupational objectives. They aim to
provide a comprehensive academic education equipping graduates for the world of work.

The main points of the competence profile are the following:

developing subject-related skills with a pronounced research orientation

developing the ability to engage in transdisciplinary dialogue
developing practice-related problem-solving skills
developing personal and social skills
promoting the willingness to assume social responsibility on the basis of the skills
acquired

1
European Credit Transfer System
2. General requirements of the study

Students Profile
The Master programme in Biomedical Engineering (MSc: Master of Science) is an
interdisciplinary course open for candidates with undergraduate or higher education in:

Physics (BSc2 or higher)

Engineering (with basic knowledge in physics)
Mathematics

This programme focuses on biomedical research and has a strong bias towards
computational science. This reflects the ever-increasing demand for IT competence in this
field, in conjunction with knowledge of biomedical devices and their usage. Graduates from
this program are well-prepared for positions in hospitals, academia and industry.

Courses Locations

The master courses are located mostly at Mannheim Medical Campus. However some
courses are located at Heidelberg University Campus in Heidelberg and the Institute of
Molecular Biology in Mainz.

Course Material

The learning material of all courses is accessible at the learning platform Moodle of the
Medical Faculty Mannheim. The access to the platform is enabled for the students enrolled in
the MSc. programme. Over this platform all administrative documents for students are
managed as well, including the lecture schedule, the rules and regulations, the course
selection and registration, the grades reports, etc.

moodle.medma.uni-heidelberg.de

2
Bachelor of Science
Master Thesis

The Master in Biomedical Engineering programme is nationally and internationally connected

to leading institutions in research and education for radiotherapy and medical imaging.
The master thesis can be done in any of the internal research groups in the University
Medical Center Mannheim or by any of the cooperation partners in a topic related with
biomedical engineering. The option to perform the master thesis in other external institution
is possible provided that all the requirements stipulated by the Academic Committee are
fulfilled. More information about this topic is found in the guideline available in Moodle.

3. Aims of the MSc. Programme in Biomedical Engineering

The program aims at enabling students to work and/or carry out independent research in the
field of biomedical engineering, notably those aspects related to computer science and
medical physics.

After completing this course, students will have

acquired basic knowledge of anatomy, physiology, genetics

acquired basic knowledge of biophysics and engineering mathematics (numerically
oriented), including programming
found out how to use computational concepts in life sciences related to image
analysis, scientific visualization, inverse problems and simulation systems
acquired detailed knowledge of radiotherapy, nuclear medicine, medical imaging
performed a scientific (life-science related) project
successfully tackled technical issues related to Biomedical Engineering
acquired expert competence in the critical assessment of technical systems in
medicine

Graduates career prospects are best in health-care/life-science sectors, research

organizations and the medical technology industry (producers of biomedical
instruments/imaging systems, health-care-oriented software companies, the pharmaceutical
industry, etc.).
Joint Degree with Shanghai Jiao Tong University, China

The MSc. in Biomedical Engineering offers to students the possibility of a double degree
through the exchange program with Shanghai Jiao Tong University in China. The contents of
the programme cover all aspects of the innovative field of computational bio-photonics, i.e. all
aspects of the diagnostic and therapeutic use of photons in medicine supported by advanced
computing.

The students, who decided to participate in the joint degree, should stay in Mannheim during
the first year of studies. The second year gives two options:
Option 1 is to carry out the 3rd and 4th semester (elective taught modules or Master
thesis, respectively) in Shanghai.
Option 2 is to only perform the 3rd semester (elective taught modules) in Shanghai
and complete the Master Thesis in Mannheim/Heidelberg.
To receive a joint degree diploma, students have to be at least half a year in any of both
institutions.

4. Specializations included in the program

1. Radiotherapy
The specialization in Radiotherapy is focused on basic and advanced knowledge
related to planning and treatment methods (3D, IMRT, VMAT, IORT, IGRT) of cancer
in radiation therapy, to radiotherapy equipment (linear accelerators, computed
tomography, intraoperative system), to give basic insight for clinical tasks as well as
for advanced research work.

2. Imaging
Imaging specialization is focused on oncological radiotherapy treatment planning and
monitoring by using physiological and functional imaging of CT, MRI and PET. The
courses are oriented to provide the student with the fundamental knowledge in
processing, analysis and quantification of medical images. Special attention is laid on
the interdisciplinary approach to radiotherapeutic cancer treatment.
3. Computational Medical Physics

Computational medical physics is focused on the fields of mathematics, computer

engineering, computer science, and physics. The aim of the advanced modules in
this specialization is the knowledge in modern computational physics with application
in life sciences. The courses are focused on inverse problems for image
reconstruction, restoration, analysis, simulation, modeling and instrumentation.
4 Curriculum

General Timetable:

1st Semester 2nd Semester 3rd Semester 4th Semester

Taught Courses/ Workshops: Taught Courses/ Labs/ Seminars: Taught Courses/ Labs/ Seminars:
- Basic courses - Lab rotations - Specialized Lab Project
- Mandatory courses - Seminars - General Science Skills Master Thesis
- Elective courses - Lectures + Exercises - Elective Courses
- Workshops - Workshops
(min. 30 ECT) (min. 30 ECT) (min. 30 ECT) (30 ECT)
Specializations: Specializations: Specializations: Specializations: Specializations: Specializations:
- Neurosciences - Neurosciences
- Radiotherapy - Radiotherapy - Radiotherapy - Radiotherapy
- Imaging/ - Imaging/
- Imaging - Imaging - Imaging - Imaging
Biomedical Optics Biomedical Optics
- Computational Medical Physics - Computational Medical - Computational - Computational
- Computer - Computer
Physics Medical Physics Medical Physics
Engineering Engineering
Venue: Venue: Venue: Venue: Venue: Venue:

Heidelberg University, Germany Heidelberg University, Germany Shanghai Jiao Tong Shanghai Jiao Tong
Heidelberg University, Shanghai, Heidelberg University, Shanghai,
University, Germany China University, Germany China
Courses Overview:
Radiotherapy Imaging Computational Medical Physics
Basic course (7.5 ECTS)
Module 1
1.1 Biophysics (1.0)
1.2 Engineering Mathematics (3.5)
1.3 Genetics (1.0)
1.4 Basic Medical Science (2.0)
Advanced courses (4.0 ECTS)
Module 2
2.1 Radiation Protection (1)
2.2 Radiation Physics and Instrumentation (3)
Module 3
Mandatory courses (13.5 ECTS) Mandatory courses (9.5 ECTS) Mandatory courses (6.5 ECTS)
3.1 Physics of Imaging Systems (2.0)
3.2 Radiotherapy Treatment Planning 3.1 Physics of Imaging Systems (2.0)
Dosimetry/Quality Assurance (4.5) 3.7 Diagnostic Radiology (1.5) 3.1 Physics of Imaging Systems (2.0)
st 3.3 Special Radiotherapy Techniques (3.0) 3.8 Nuclear Medicine (2.0) 3.6 Image Analysis (4.5)
1 Semester 3.4 Image Guided Radiotherapy (1.0) 3.10 Basic Optics (2.0) 3.10 Basic Optics (2.0)
Winter Term 3.5 Radiobiology (1.0) 3.14 Biomedical Engineering (2.0)
3.10 Basic Optics (2.0)
(Mannheim/ Module 4
Heidelberg) Elective courses (4.5 ECTS)* Elective courses (5.0 ECTS)* Elective courses (6.0 ECTS)*
3.2 Radiotherapy Treatment Planning
3.1a Medical Devices and Imaging Systems (4.0)
Dosimetry/Quality Assurance (4.5)
3.1b MRT Basics (2.0)
3.3 Special Radiotherapy Techniques (3.0)
3.1c X-Ray Diagnostics and Sonography (2.0)
3.6 Image Analysis (4.5) 3.4 Image Guided Radiotherapy (1.0)
3.2 Radiotherapy Treatment Planning
3.7 Diagnostic Radiology (1.5) 3.5 Radiobiology (1.0)
Dosimetry/ Quality Assurance (4.5)
3.8 Nuclear Medicine (2.0) 3.7 Diagnostic Radiology (1.5)
3.3 Special Radiotherapy Techniques (3.0)
3.9 Biomedical Optics (1.0) 3.8 Nuclear Medicine (2.0)
3.4 Image Guided Radiotherapy (1.0)
3.14 Biomedical Engineering (2.0) 3.9 Biomedical Optics (1.0)
3.5 Radiobiology (1.0)
3.10 Basic Optics (2.0)
3.6 Image Analysis (4.5)
3.13 Novel Diagnostic Methods in Ophthalmology (1.0)
3.9 Biomedical Optics (1.0)
3.14 Biomedical Engineering (2.0)
3.29 Seminar MR Methods and Technology (2.0)
Module 5
Workshops (4.0 ECTS)* Workshops (5.0 ECTS)* Workshops (6.0 ECTS)*
4.1 Basic Cellular Biology/Radiobiology (1.0) 4.10 Eye Clinics (1.0)
4.2 MR-Radiology (1)4.9Adaptive Optics Lab (1.0) 4.11 Nanoscopy Lab (2.0)
4.3 Radiation Protection and Quality Assurance (1.0) 4.12 Matlab Programming Exercise (4.0)
4.4 Diagnostic Radiology/Image Management (1.0) 4.13 C++ Introductory Course (4.0) 7.0 Shanghai Workshop (1.0)

*number of ECTS are maximum allowed values. All courses which are in each respective specialization not listed as mandatory courses can be chosen as elective courses.
 Radiotherapy Imaging Computational Medical Physics
Module 6
Mandatory courses (24.0 ECTS) Mandatory courses (24.0 ECTS) Mandatory courses (28.0 ECTS)

3.16 Scientific Programming in Physics and Engineering +

Exercises (4.0)
3.20 Radiation Therapy Lab: Quality Assurance & Treatment Planning (8.0)
3.18 Volume Visualization + Exercises (8.0)
3.21 Imaging Lab: MR Technology (8.0)
3.19 Inverse Problems + Exercises (8.0)
3.22 Nuclear Medicine Lab: PET Experiments & Data Analysis (8.0)
3.24 Computational Medical Physics Lab (8.0)

Module7
Elective courses (6.0-8.0 ECTS)* Elective courses (6.0-8.0 ECTS)* Elective courses (8.0 ECTS)*
3.1a Medical Devices and Imaging
sd Systems (4.0)
2 Semester
3.1b MRT Basics (2.0)
Summer Term
3.1c X-Ray Diagnostics and 3.15 Computational Medical Physics and Bioinformatics (1.0)
(Mannheim/
Sonography (2.0) 3.17 Simulators in Games and Medicine + Exercises (8.0)
Heidelberg)
3.20 Radiation Therapy Lab: QA & Treatment Planning (8.0)
3.15 Computational Medical Physics and Bioinformatics (1.0) 3.21 Imaging Lab: MR Technology (8.0)
3.16 Scientific Programming in Physics and Engineering + Exercises (4.0) 3.22 Nuclear Medicine Lab: PET Experiments & Data Analysis
3.17 Simulators in Games and Medicine + Exercises (8.0) (8.0)
3.18 Scientific Visualization + Exercises (8.0) 3.25 Radiobiology Lab: Cell Biology & Modelling (8.0)
3.19 Inverse Problems + Exercises (8.0) 3.26 Seminar Radiation Therapy (2.0)
3.24 Computational Medical Physics Lab (8.0) 3.27 Seminar Nuclear Medicine (2.0)
3.25 Radiobiology Lab: Cell Biology & Modelling (8.0) 3.28 Seminar Radiobiology (2.0)
3.26 Seminar Radiation Therapy (2.0) 3.29 Seminar MR Methods and Technology (2.0)
3.27 Seminar Nuclear Medicine (2.0) 3.31 Seminar Computational Medical Physics (2.0)
3.28 Seminar Radiobiology (2.0)
3.29 Seminar MR Methods and Technology (2.0)
3.31 Seminar Computational Medical Physics (2.0)

*number of ECTS are minimum/maximum allowed values.

All courses which are in each respective specialization not listed as mandatory courses can be chosen as elective courses.
 Radiotherapy Imaging Computational Medical Physics
Mandatory courses (19.0 ECTS)
Module 8

6.6 General Science Skills (3.0)

8.1 Specialized Lab Project (16.0)

Module 3/4
Elective courses (6.0 ECTS)* Elective courses (6.0 ECTS)* Elective courses (6.0 ECTS)

3.1a Medical Devices and Imaging Systems (4.0)

3.2 Radiotherapy Treatment Planning
3.1b MRT Basics (2.0)
Dosimetry/ Quality Assurance (4.5)
3.1c X-Ray Diagnostics and Sonography (2.0)
3.3 Special Radiotherapy Techniques (3.0)
3.6 Image Analysis (4.5) 3.2 Radiotherapy Treatment Planning
3.4 Image Guided Radiotherapy (1.0)
3.7 Diagnostic Radiology (1.5) Dosimetry/ Quality Assurance (4.5)
3.5 Radiobiology (1.0)
3.3 Special Radiotherapy Techniques (3.0)
3.8 Nuclear Medicine (2.0) 3.7 Diagnostic Radiology (1.5)
3.4 Image Guided Radiotherapy (1.0)
3.8 Nuclear Medicine (2.0)
3rd Semester 3.9 Biomedical Optics (1.0) 3.5 Radiobiology (1.0)
3.9 Biomedical Optics (1.0)
Winter Term 3.14 Biomedical Engineering (2.0) 3.6 Image Analysis (4.5)
3.13 Novel Diagnostic Methods in
3.9 Biomedical Optics (1.0)
(Mannheim/ 3.13 Novel Diagnostic Methods in
Opthalmology (1.0)
Heidelberg) 3.14 Biomedical Engineering (2.0)
Opthalmology (1.0)
3.29 Seminar MR Methods and Technology (2.0)

Module 5
Workshops (5.0 ECTS)* Workshops (5.0 ECTS)* Workshops (5.0 ECTS)*

4.1 Basic Cellular Biology/Radiobiology (1.0)

4.2 MR-Radiology (1.0)
4.3 Radiation Protection and Quality Assurance (1.0)
4.4 Diagnostic Radiology/Image Management (1.0)
4.10 Eye Clinics (1.0)
4.11 Nanoscopy Lab (2.0)
4.12 Matlab Programming Exercise: Preparation for Master Thesis (4.0)
4.13 C++ Introductory Course (4.0)
7.0 Shanghai Workshop (1.0)

*number of ECTS are minimum/maximum allowed values.

All courses which are in each respective specialization not listed as mandatory courses can be chosen as elective courses.
 Neurosciences Imaging/ Biomedical Optics
rd
3 Semester Elective courses (max. 30 ECTS) Elective courses (max. 30 ECTS)
(Shanghai)
Physical therapy technology (4.5)
Biomedical ultrasound (4.5)
Medical imaging (3.75)
Nanotechnology (3.0) New Technology in Medical Imaging (3.0)
BioMEMS (3.0) Biomedical Sensors (4.5)
Biomaterials (3.0) Laser medicine & biophotonics (3.0)
Neurobiology (3.0) Frontier problems of optics (4.5)
Structure & Function of Biomacromolecules (4.5) Non-linear optics of optical fibers (4.5)
Theoretical Neurosciences (4.5) Modern optics (4.5)
Experiments of modern lab animal science (1.5) Optoelectronics (3.0)
Bioheat & Mass Transfer (4.5) Semiconductor devices (3.0)
Neuroinformatics (3.0) Processing of optical information (3.0)
Principle & technology of laser (4.5)
Non-linear optics (4.5)
Engineering optics (4.5)
Computer Engineering
Elective courses (max. 30 ECTS)
Application of Computers in Life Sciences (3.0)
Signal processing (4.5)
Digital signal processing (3.0)
Bioinfomatics (3.0)
3D image processing & volume visualization (3.0)
Adaptive filtration (3.0)
Biomedical image processing (4.5)
TMS320 digital signal processor (3.75)
Random signal processing (4.5)
Opt. estimation theory & system identification (4.5)
Computer graphics (4.5)
Wireless communication & sensor networks (3.0)
Mobile & wireless networking (4.5)

Module 9
Radiotherapy Imaging Computational Medical Physics
th
4 Semester
Summer Term Mandatory courses (30.0 ECTS)

(Mannheim/
Heidelberg or
5.0 Master Thesis (30.0)
Shanghai)
5. Overview of the Courses
Module Part Course Nr. Title ECTS
1.1 Biophysics 1
1.2 Engineering Mathematics 3.5
Basics 1.3 Genetics 1
1
courses 1.4 Basic Medical Science 2
Total 7.5

2.1 Radiation Protection 1

Advanced 2.2 Radiation Physics and Instrumentation 3
2
courses Total 4

3.1 Physics of Imaging Systems 2

3.1a Medical Devices and Imaging Systems (Advanced)
3.1b MRT Basics (Advanced)
3.1c X-Ray Diagnostic and Sonography (Advanced)
3.2 Radiotherapy Treatment Planning/ Dosimetry/ QA 4.5
Specializati 3.3 Special Radiotherapy Techniques 3
on 3.4 Image Guided Radiotherapy 1
3/4 Winter term 3.5 Radiobiology 1
3.6 Image Analysis 4.5
3.7 Diagnostic Radiology 1.5
3.8 Nuclear Medicine 2
3.9 Biomedical Optics 1
3.10 Basic Optics 2
3.13 Novel Diagnostic Methods in Ophthalmology 1
3.14 Biomedical Engineering 2

3.15 Computational Medical Physics and Bioinformatics 1

Scientific Programming in Physics and Engineering +
3.16
Exercises 4
3.17 Simulators in Games and Medicine + Exercises 8
3.18 Volume Visualization + Exercises 8
3.19 Inverse Problems + Exercises 8
Radiation Therapy Lab: Quality Assurance &
3.20
Treatment Planning (6 weeks) 8
3.21 Imaging Lab: MR Technology (6 weeks) 8
Nuclear Medicine Lab: Experiments & Data Analysis
Specializati 3.22
(6 weeks) 8
on
3.24 Computational Medical Physics Lab (6 weeks) 8
6/7 Summer
Radiobiology Lab: Cell Biology & Modelling (6
term 3.25
weeks) 8
Seminar Radiation Therapy: Journal Club +
3.26
Presentation 2
Seminar Nuclear Medicine: Journal Club +
3.27
Presentation 2
3.28 Seminar Radiobiology: Journal Club + Presentation 2
Seminar MR Methods and Technology: Journal Club
3.29
+ Presentation 2
Seminar Computational Med. Physics: Journal Club
3.31
+ Presentation 2
 4.1 Basic Cellular Biology/Radiobiology 1
4.2 MR Radiology 1
4.3 Radiation Protection and Quality Assurance 1
4.4 Diagnostic Radiology/ Image Management 1
Workshops 4.10 Eye Clinics (Mannheim) 1
5
(elective) 4.11 Nanoscopy Lab (Mainz) 2
Matlab Programming Exercise: Preparation for Master
4.12
Thesis 4
4.13 C++ Introductory Course 4
7.0 Shanghai Workshop 1

Academic
6.6
Skills General Science Skills 3
8
16
8.1
Lab Project Specialized Lab Project
Total 18

Master Masters project and thesis writing; Public presentation

9 5.0
thesis of the thesis and final examination 30
 1

6. Modules in Detail

Module 1. Basic courses (Mandatory)

Course Nr. Module Title

1.1
Biophysics

Credit Points Lecture 25 h Type of Course Turn Language

Self-Study 3 h
1.0 Preparation for Exam 2 h Lecture Yearly English

Contents of Module:
Biophysics of DNA/sequencing, Protein/Protein structure determination and prediction
Biophysical electrophysiology

Learning Objectives:

Students should have the competence to read and understand papers in this field. They should be
able to apply the knowledge to concrete applications. They should further be able to solve typical
questions in this field of biophysical processes. In particular, they are able to develop programs for
sequence alignment, protein structure classification, and prediction, find native conformations using
force-fields, and be able to correctly perform electrophysiological measurements.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/ oral/ exercises/ report): Basics in Physics

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. J. W. Hesser

Recommended Literature:
Will be given at the beginning of the lecture.
 2

Module Title
Course Nr.
1.2 Engineering Mathematics

Credit Points Lecture 30 h Type of Course Turn Language

Self-Study 25 h
3 Preparation for Exam 5 h Lecture Yearly English

Contents of Module:
System modelling and description (numerical methods for solution of linear systems,
approximation/integration, solving differential equations, optimization, Fourier transforms, and
systems theory)
Matlab exercises (basic programming)

Learning Objectives:
Students should be able to solve typical numerical problems in computational physics. They should
also be able to program the solutions and use the pre-existing Matlab functions for this purpose.
Further, they should be select the most appropriate techniques and be able to perform simple
mathematical proofs.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/ oral/ exercises/ report): Basics in Physics

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. J. W. Hesser

Recommended Literature:
Will be given at the beginning of the lecture.
 3

Course Nr. Module Title

1.3
Genetics

Credit Points Lecture 15 h Type of Course Turn Language

Self-Study 10 h
1.0 Preparation for Exam 5 h Lecture Yearly English

Contents of Module:
Genetics
DNA, genome, chromosomes
Physical and chemical properties of DNA
Cell division, cell cycle
Genetic diseases

Learning Objectives:
Knowledge in genetics and the genome.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: Written Exam: Basics in Medicine

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. Veldwijk , PD Dr. P. Maier

Recommended Literature:
Will be given at the beginning of the lecture.
 4

Course Nr. Module Title

1.4
Basic Medical Science

Credit Points Lecture 40 h Type of Course Turn Language

Self-Study 10 h
2.0 Preparation for Exam 10 h Lecture Yearly English

Contents of Module:
Medical terminology
Macroscopic anatomy of the human body as required for physicists (anatomical relations,
organ motion, differences in tissue properties and their consequences)
Focus on anatomical relations of truncus and CNS.
Preparation of slice-imaging techniques (CT, US, MRI, PET) and their interpretation
Physiology of cardiovascular system, CNS and Metabolic organs (Liver, Kidney)
Modelling of physiology
Contouring of structures in radiation planning
Radiation response

Learning Objectives:
Competence in anatomy and physiology.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: Written Exam: Basics in Medicine

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. W. Kriz, Prof. Dr. U. Bcker, Prof. Dr. F. Lohr, Prof. Dr. J. Maurer, Dr. T. Gloe

Recommended Literature:
Netters Anatomy, Thieme Verlag
 5

Module 2. Advanced Courses (Mandatory)

Course Nr. Module Title

2.1
Radiation Protection

Credit Points Lecture 8 h Type of Course Turn Language

Self-Study 14 h
1.0 Preparation for Exam 8 h Lecture Yearly English

Contents of Module:
Basics of biological radiation effects
Estimation of risk of stochastic radiation damage on basis of epidemiological data
Consideration of development of tumors, risk of damage in germline and risk of embryo
damage
Discussion of legal regulations about diagnostic and therapeutic radiation

Learning Objectives:
Risk of radiation, radiation protection, estimate risk of radiation, legal regulations for radiation

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

General Knowledge Nuclear Physics, Radiation Physics

Exam Regulations: Written Exam: Basics in Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. F. Wenz, Mr. V. Steil, PD Dr. C. Herskind

Recommended Literature:
www.icrp.org, especially:
http://www.icrp.org/docs/Summary_B-scan_ICRP_60_Ann_ICRP_1990_Recs.pdf
resp. complete ICRP Report 60
 6

Course Nr. Module Title

2.2
Radiation Physics and Instrumentation

Credit Points Lecture 26 h Type of Course Turn Language

Self-Study 26 h
3.0 Preparation for Exam 12 h Lecture Yearly English

Contents of Module:
Technical and clinical development of radiation therapy
Application of radiation therapy to malicious, benign tumors
Technical foundation of radiation therapy (planning, simulator dose calculation, tele-therapy,
brachytherapy)
Chain of radiation oncology: CT, simulation, virtual simulation
Foundations of radiation physics

Learning Objectives:
Basics of radiation oncology, medical indication, different modalities of treatment, treatment chain, and
physical background.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

General Knowledge Nuclear Physics, Radiation Physics and Radiation Protection

Exam Regulations: Written Exam: Basics in Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. F. Lohr, Mr. V. Steil, PD Dr. H. Wertz, Dr. M. Polednik, Prof. Dr. A. Zakaria

Recommended Literature:
A century in Radiology: http://www.xray.hmc.psu.edu/rci/
Radiotherapy Physics: in Practice, Williams/Thwaites, Oxford University Press, 2000
The Physics of Radiation Therapy, Faiz M. Khan, Lippincott, 2003
Radiation Oncology Management Decisions, Chao, Lippincott, 2002
Practical Radiotherapy Planning, Dobbs/Barrett/Ash, Edwar Arnold, 1999
Radiation Therapy Planning, Bentel, McGraw-Hill, 1995
 7

Module 3 / 4. Mandatory & elective courses in winter term

Course Nr. Module Title

3.1
Physics of Imaging Systems
Credit Points Lecture 24 h Type of Course Turn Language
Self-Study 30 h
2.0 Preparation for Exam 10 h Lecture Yearly English

Contents of Module:
physical basics of imaging systems:
conventional X-ray
Computer Tomography CT
Magnetic Resonance Imaging MRI
Sonography/ Ultrasound
Medical Equipment

Learning Objectives:
Students should learn about the physical basics of different imaging systems: X-ray, CT, MRI and
Sonography.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

General basics in physics.

Exam Regulations: Written Exam: Physics of Imaging Systems

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. L. Schad

Recommended Literature:
Medical Imaging Physics, Hendee/Ritenour, Wiley-Liss, 2002
Bildgebende Systeme fr die medizinische Diagnostik, Morneburg, 1995
Computertomographie. Grundlagen, Gertetechnologie, Bildqualitt,
Anwendungen, Kalender, 2006
Magnetic Resonance Imaging Theory and Practice, Vlaardingerbroek/den
Boer, 2003
 8

Course Nr. Module Title

3.1a
Medical Devices and Imaging Systems (Advanced)

Credit Points Lecture 56 h Type of Course Turn

4 Self-Study 30 h Lecture Yearly
Preparation for Exam 10 h

Contents of Module:
Technical basics to the following imaging systems:
Conventional X-ray
Computer Tomography CT
Magnetic Resonance Imaging MRI

Learning Objectives:
Students should learn about the physical basics of different imaging systems

Requirements of Participation/ Required Previous Knowledge:

successful attendance in module 3.1

Useful Previous Knowledge:

General basics in physics.

Exam Regulations: Written Exam: Physics of Imaging Systems

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Lecturers:
Prof. Dr. L. Schad

Recommended Literature:
Medical Physics and Biomedical Engineering, Brown et al., 1999
 9

Course Nr. Module Title

3.1b
MRT Basics (Advanced)

Credit Points Lecture 24 h Type of Course Turn

2 Self-Study 30 h Lecture Yearly
Preparation for Exam 10 h

Contents of Module:
Advanced techniques of Imaging in MRI

Learning Objectives:
Students should learn about the physical basics of the MRI techniques

Requirements of Participation/ Required Previous Knowledge:

successful attendance in module 3.1

Useful Previous Knowledge:

General basics in physics.

Exam Regulations: Written Exam: Physics of Imaging Systems

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Lecturers:
Prof. Dr. L. Schad

Recommended Literature:
Magnetic Resonance Imaging Theory and Practice, Vlaardingerbroek/ den Boer, 2003
 10

Course Nr. Module Title

3.1c
X-Ray Diagnostic and Sonography (Advanced)

Credit Points Lecture 24 h Type of Course Turn

2 Self-Study 30 h Lecture Yearly
Preparation for Exam 10 h

Contents of Module:
Advanced techniques of Imaging Systems/ Diagnostics
Conventional X-ray
Sonography/ Ultrasound

Learning Objectives:
Students should learn about the physical basics of Conventional X-ray and Sonography

Requirements of Participation/ Required Previous Knowledge:

successful attendance in module 3.1

Useful Previous Knowledge:

General basics in physics.

Exam Regulations: Written Exam: Physics of Imaging Systems

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Lecturers:
Prof. Dr. L. Schad

Recommended Literature:
Medical Imaging Physics, Hendee/Ritenour, Wiley-Liss, 2002
Bildgebende Systeme fr die medizinische Diagnostik, Morneburg, 1995
 11

Course Nr. Module Title

3.2
Radiotherapy Treatment Planning/ Dosimetry/ Quality Assurance

Lecture 26 h
Credit Points Lecture 26 h Type of Course Turn Language
Practical Course 6h
4.5 Self-Study 69 h Lecture/ Practical Yearly English
Preparation for Exam 14 h Course

Contents of Module:
Basics of treatment planning and computation of monitor units for radiation oncology with
linear accelerators
Methods for dose measurement (Ionization chambers, semi-conductor detectors, TLDs, film
dosimetry)
Algorithms for dose computation: Pencil Beam, Collapsed Cone, Monte Carlo
Quality assurance of treatment planning/workflow in radio-oncology (imaging systems,
computers, simulator, accelerator) focusing on geometric and dosimetric parameters

Learning Objectives:
Basic and detailed knowledge of relevant techniques in treatment planning, dosimetry, and quality
assurance, current workflow and theoretical basis for measurement and experiments with radiation
systems

Requirements of Participation/ Required Previous Knowledge:

Successful Participation in Modules 1.1, 1.2, 2.1 and 2.2

Useful Previous Knowledge:

Modules 3.7 & 2.2 (Diagnostic Radiology & Radiation Oncology/ Radiation Physics)

Exam Regulations: Written Exam: Advanced Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
PD Dr. H. Wertz, Dr. M. Polednik, Prof. Dr. J. Hesser

Recommended Literature:
A century in Radiology: http://www.xray.hmc.psu.edu/rci/
Radiotherapy Physics: in Practice, Williams/Thwaites, Oxford University Press, 2000
The Physics of Radiation Therapy, Faiz M. Khan, Lippincott, 2003
Practical Radiotherapy Planning, Dobbs/Barrett/Ash, Edwar Arnold, 1999
Radiation Therapy Planning, Bentel, McGraw-Hill, 1995
ESTRO Publications:
1. Monitor Unit Calculation for High Energy Photon Beams
2. Recommendations for a Quality Assurance Programme in External Radiotherapy
3. Practical Guidelines for the Implementation of a Quality System in Radiotherapy
AAPM Radiation Therapy Committee Task Group 53: Quality assurance for clinical
radiotherapy treatment planning, Fraas et al., Med Phys Vol. 25, No. 10, October 1998
 12

Course Nr. Module Title

3.3
Special Radiotherapy Techniques

Credit Points Lecture 16 h Type of Course Turn Language

Self-Study 38 h
3.0 Preparation for Exam 16 h Lecture Yearly English

Contents of Module:
Foundations of brachytherapy
1. used dose rates:
Low dose rate, Intermediate dose rate, High dose rate, Pulsed Dose Rate)
2. dosimetry systems (Paris System, Manchester System), principles of brachytherapeutic
applications
3. computer based and image based treatment planning
Stereotactic-based precision radiation therapy
Intensity modulated radiotherapy (IMRT): special technical foundations/ quality assurance
Particle therapy.

Learning Objectives:
Innovative radio-oncologic methods and how they are practically used.

Requirements of Participation/ Required Previous Knowledge:

Successful Participation in Modules 1.1, 1.2, 2.1, 2.2 and 3.2

Useful Previous Knowledge:

General Knowledge Nuclear Physics, Radiation Physics, radiation planning, Dosimetry and quality
assurance in radiology and radiotherapy

Exam Regulations: Written Exam: Advanced Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Dr. F. Stieler, tbd

Recommended Literature:
The GEC/ESTRO Handbook of Brachytherapy, Gerbaulet, ESTRO Publishing, 2002
Intensity-Modulated Radiation Therapy, Webb, Institute of Physics Publishing, 2001
Inverse planning algorithms for external beam radiation therapy, Chui, Med. Dosim, 2001
AAPM Report on IMRT, Ezzell et al., Med. Phys. 30, 2003
 13

Course Nr. Module Title

3.4
Image Guided Radiotherapy

Credit Points Lecture 8 h Type of Course Turn Language

Self-Study 12 h
1.0 Preparation for Exam 10 h Lecture Yearly English

Contents of Module:
Techniques of patient positioning and target location in radiation therapy (simulation, portal
imaging, positioning support systems/mask systems), inaccuracies herein concerning
positioning accuracy and dosimetry
Localization by ultrasound
Localization by 2D X-ray (portal imaging, Fiducial markers)
3D-CT (Cone Beam CT, Gantry Mounted Volume Imaging)
Adaptive radiation therapy

Learning Objectives:
Medical foundations of image guided radiotherapy and their physical principles.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in Modules 1.1, 1.2, 2.1, 2.2 and 3.2

Useful Previous Knowledge:

General Knowledge Nuclear Physics, Radiation Physics, imaging systems, radiation therapy

Exam Regulations: Written Exam: Advanced Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
PD Dr. H. Wertz

Recommended Literature:
will be given at the beginning of the lecture.
 14

Course Nr. Module Title

3.5
Radiobiology

Lecture/ Workshop 10 h
Credit Points Preparation for Type of Course Turn Language
Presentation 6h
1.0 Self-Study 10 h Lecture/ Yearly English
Preparation for Exam 4 h Workshop

Contents of Module:
Basics of biological radiation effect (physical interaction of different radiation qualities with
matter, chemical reactions following, biological consequences)
Cell cycle, proliferation, signal chain gene-protein
DNA-defects and their consequences, DNA repair
Different radiation sensitivity on cellular and tissue level
Biological consequences of different fractionation protocols

Learning Objectives:
Describe the biological basis of radiation effects.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in Modules 1.1, 1.3 and 1.4

Useful Previous Knowledge:

General Knowledge Nuclear Physics, Radiation Physics, knowledge of cell biology

Exam Regulations: Presentation/ Written Exam/ Report: Advanced Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
PD Dr. C. Herskind, Prof. Dr. M. Veldwijk

Recommended Literature:
Hall, E. J. and Giaccia, A. J. "Radiobiology for the Radiologist" 7th Edition. Lippincott Williams
& Wilkins (Philadelphia) 2012. ISBN-13: 978-1-60831-193-4
Joiner, M. and van der Kogel A. (Eds) "Basic Clinical Radiobiology" 4th Edition. Hodder Arnold
(London) 2009. ISBN: 978 0 340 929 667
 15

Course Nr. Module Title

3.6
Image Analysis

Lecture 20 h
Credit Points Exercise 50 h Type of Course Turn Language
Self-Study 50 h
4 Preparation for Exam 10 h Lecture/ Exercise Yearly English

Contents of Module:
Digitalization of image information/ relevant data formats
Mathematical methods of image transformation, digital filtering (linear, non-linear), Fourier-
transform, segmentation, registration and pattern recognition

Learning Objectives:
Students should be able to perform all steps of the image processing workflow. They should have the
competence to select the most appropriate methods, program them and evaluate the achieved results.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in modules 1.2 and 3.7

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/oral/exercises/report)

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. J. W. Hesser

Recommended Literature:
Medical Image Processing, Gonzalez/Woods/Eddin, Pearson, 2004
 16

Course Nr. Module Title

3.7
Diagnostic Radiology

Credit Points Lecture 12 h Type of Course Turn Language

Self-Study 24 h
1.5 Preparation for Exam 9 h Lecture Yearly English

Contents of Module:
Physical foundations of imaging systems:
a) X-ray (fluoroscopy, angiography, mammography)
b) CT
c) MRI, MRS
d) US
especially: radiation quality, imaging parameters, future developments
Properties of imaging systems for therapy planning
Image transfer, image storage, typical data formats

Learning Objectives:
Physical basis of different radio-diagnostic systems and the main aspects of their clinical usage.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 1.4

Useful Previous Knowledge:

General Knowledge Nuclear Physics, Radiation Physics

Exam Regulations: Written Exam: Advanced Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
PD Dr. G. Weisser, Prof. Dr. K. Bsing, Dr. S. Haneder

Recommended Literature:
Medical Imaging Physics, Hendee/Ritenour, Wiley-Liss, 2002
 17

Course Nr. Module Title

3.8
Nuclear Medicine (advanced)

Credit Points Lecture 20 h Type of Course Turn Language

Self-Study 28 h
2.0 Preparation for Exam 12 h Lecture Yearly English

Contents of Module:
Basic physics of imaging with radioactive substances
Nuclear Medicine instrumentation (e.g. gamma camera/SPECT/PET)
Radionuclide production
Evaluation of diagnostic systems
Modelling in nuclear medicine
Radiochemistry / radiopharmacy
Clinical nuclear medicine (scintigraphy / immunoscintigraphy / PET)
Molecular radiotherapy (radioiodine therapy, radioimmunotherapy, peptide receptor
radionuclide therapy)
Combination of nuclear medical methods with other imaging techniques
(Fusion PET/CT, SPECT/CT)

Learning Objectives:
Main nuclear medical imaging and therapy techniques, their physical basics and usage in the clinic.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

m2.1: Radiation Protection
m2.2: Basic Radiation Oncology/Radiation Physics
m3.7: Diagnostic Radiology

Exam Regulations: Written Exam: Advanced Radiotherapy

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. G. Glatting, Prof. Dr. D. Dinter, Prof. Dr. B. Wngler, Prof. Dr. K. Bsing

Recommended Literature:
Physics in Nuclear Medicine. SR Cherry, JA Sorenson, ME Phelps. 4 ed. Philadelphia,
th

Pennsylvania: Saunders/Elsevier 2012.

Medical Imaging Physics, Hendee/Ritenour, Wiley-Liss, 2002
 18

Course Nr. Module Title

3.9
Biomedical Optics (Basic Optics and Lasers)

Credit Points Lecture 12 h Type of Course Turn Language

Self-Study 10 h
1.0 Preparation for Exam 8 h Lecture Yearly English

Contents of Module:
physical basics of biomedical optics
basics of geometrical optics: reflection- and refraction law, dispersion, polarization
physical basics of optics: particle/wave dualism, Maxwell laws
basics of laser physics: principals, interaction with matter, laser-properties and systems
biomedical applications: lasers in medicine, microscopy, etc.

Learning Objectives:
students should learn about the physical basics in optics and lasers

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 3.10

Useful Previous Knowledge:

general basics in physics and optics

Exam Regulations: Written Exam: Basics in Optics and Laser Physics

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. L. Schad

Recommended Literature:
E. Hecht and A. Zajac, Optics, Addison Wesley, International 4 ed., 2003
th

M. Born and E. Wolf, Principles of optics: Electromagnetic theory of propagation, Cambridge

University Press, 2002
M.H. Niemz, Laser-Tissue Interactions: Fundamentals and Applications (Biomedical and
rd
Medical Physics, Biomedical Engineering), Springer, 3 enlarged ed., 2003
L.O. Bjrn, Photobiology, Springer, 2008
 19

Course Nr. Module Title

3.10
Basic Optics

Credit Points Lecture 16 h Type of Course Turn Language

Self-Study 32 h
2.0 Preparation for Exam 12 h Lecture Yearly English

Contents of Module:
Geometric optics: reflection, refraction, dispersion, polarization
Optical aberration
Gauss-optics
Diffraction optics
Interferometry
Optical resolution, human eye, optical instruments

Learning Objectives:
Geometric optics, lens equations for optical systems, diffraction theory and interfereometrical
measurement methods.

Requirements of Participation/ Required Previous Knowledge:

Successful Participation in Introductory Courses 1.1 1.4

Useful Previous Knowledge:

General knowledge in optics

Exam Regulations: Written Exam: Basic Optics

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. J. Bille

Recommended Literature:
E. Hecht, Physics, Brooks/Cole Publishing Company,1994
P. Tipler, Physics, Worth Publishers Inc., 1982
M. Born and E. Wolf, Principles of optics: Electromagnetic theory of propagation, Cambridge
University Press, 2002
 20

Course Nr. Module Title

3.13
Novel Diagnostic Methods in Ophthalmology

Credit Points Lecture 12 h Type of Course Turn Language

Self-Study 24h
1.0 Lecture Yearly English

Contents of Module:
Light scatter in cornea, measurement of thickness of cornea
Concepts of laser scanning tomography, three-dimensional pailla analysis, nerve fiber layer
measurements
Principles of angiography

Learning Objectives:
Recent diagnostic methods in ophthalmology.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 3.10

Useful Previous Knowledge:

None

Exam Regulations: no

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. H. Krastel, Prof. Dr. S. Beutelsbacher, Prof. Dr. F. Schlichtenbrede

Recommended Literature:
will be given at the beginning of the lecture.
 21

Course Nr. Module Title

3.14
Biomedical Engineering

Credit Points Lecture 24 h Type of Course Turn Language

Self-Study 30 h
2.0 Preparation for Exam 10 h Lecture Yearly English

Contents of Module:
Basic Physics of biomedical engineering:
Blood Pressure
Blood Flow
ECG
EEG
MEG
MRS

Learning Objectives:
Basic knowledge in biomedical engineering.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 1.4

Useful Previous Knowledge:

Basics in Physics

Exam Regulations: Written Exam: Basics in Biomedical Engineering

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Coordinator:
Prof. Dr. L. Schad

Recommended Literature:
Medical Physics and Biomedical Engineering, Brown et al., 1999
 22

Module 6 / 7. Mandatory & Elective course in summer term

Course Nr. Module Title

3.16
Scientific Programming in Physics and Engineering + Exercises
(advanced)

Lecture 15 h
Credit Points: 4
Exercise 70 h Type of Course Turn Language
1.5 (Lecture)
Self-Study 30 h Lecture and
2.5 (Exercises)
Preparation for Exam 5 Exercises Yearly English
h

Contents of Module:
Introduction and Exercises to basic techniques of software development on basis of C++/Phyton.
Programming environment
Test strategies
Documentation
Software architecture
Software libraries
Efficient programming, parallel programming
Generic and object oriented programming

Learning Objectives:
Basic knowledge in software engineering for developing programs in science disciplines like physics
and engineering.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 4.13 or previously gained background in C++

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/oral/exercises/report)

Formalities Required: Registration to this lecture, C++ introduction course required

Max. Number of Participants: 40

Other Comments: -

Lecturers:
Prof. Dr. J. Hesser

Recommended Literature:
tba
 23

Course Nr. Module Title

3.17
Simulators in Games and Medicine + Exercises (advanced)

Credit Points: Lecture 42 h

Type of
8.0 Exercise 100 h Turn Language
Course
3 (Lecture) Self-Study 63 h
Lecture and
5 (Exercises) Preparation for Exam Yearly English
Exercise
15 h

Contents of Module:
Basic components of simulation engine (games)
Architecture of games engines
Introduction of OGRE as an open-source game engine
Overview: graphics and computer games
Collision engine
Animation and physics engine (open-source library Bullet)
Path planning engine
AI (artificial intelligence) engine

Learning Objectives:
Basic knowledge of concept of computer games and its challenges. Introduction to development of
architecture engines and how to deal with typical problems in graphics, collision, animation, physics,
path planning, artificial intelligence. Exercises, how to develop games and realize game engines.
Basic knowledge in basics of medical simulation systems.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 4.13 or previously gained background in C++
Successful attendance in module 3.16

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/oral/exercises/report)

Formalities Required: Registration to this lecture, C++ introduction course required, attendance in
module 3.16

Max. Number of Participants: 40

Other Comments: -

Lecturers:
Prof. Dr. J. Hesser

Recommended Literature:
Gregory et al: Game Engine Architecture
Ericson: Real-Time Collision Detection
Eberly: Game Physics
Millington: Artificial Intelligence for Games
 24

Course Nr. Module Title

3.18
Volume Visualization + Exercises (advanced)

Lecture 28 h
Credit Points: 8.0 Type of Course Turn Language
Exercise 42 h
2 (Lecture) Lecture and
Self-Study 155 h
6 (Exercises) Exercise Yearly English
Preparation for Exam 15
h

Contents of Module:
Computer Graphics basics
Conversion into surface and volume grids
Sampling and approximation theory
Volume rendering
Vector and information visualization
Programming technique: GPU- programming

Learning Objectives:
Basic knowledge in the fundamental methods of representing complex scientific information.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 4.13 or previously gained background in C++

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/oral/exercises/report)

Formalities Required: Registration to this lecture, C++ introduction course required

Max. Number of Participants: 40

Other Comments: -

Lecturers:
Prof. Dr. J. Hesser

Recommended Literature:
Engel et al: Real-Time Volume Graphics: www.real-time-volume-graphics.org,
Schroeder et al: VTK Textbook: http://www.kitware.com/products/books/vtkbook.html
 25

Course Nr. Module Title

3.19
Inverse Problems + Exercises (advanced)

Credit Points: 8.0 Lecture 28 h

Type of Course Turn Language
2 (Lecture) Exercise 42 h
Lecture and
6 (Exercises) Self-Study 155 h
Exercise Yearly English
Preparation for Exam 15
h

Contents of Module:
Examples of inverse problems, especially tomography and deblurring
Deterministic approaches, Tikhonov regularization
Stochastic methods (Bayesian techniques)
Estimating the regularization parameter
Compressed sensing

Learning Objectives:
Basic knowledge in solving inverse problems.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/oral/exercises/report)

Formalities Required: Registration to this lecture

Max. Number of Participants: 40

Other Comments: -

Lecturers:
Prof. Dr. J. Hesser

Recommended Literature:
Vogel: Computational Methods for Inverse Problems
http://www.math.montana.edu/~vogel/Book/
 26

Course Nr. Module Title

3.20
Radiation Therapy Lab: Quality Assurance & Treatment Planning
(advanced)
Lab 40 h Turn Language
Credit Points: Type of Course
Self-Study 176 h
8.0 Lab
Written Report 24 h Yearly English

Contents of Module:
Practical exercises for quality assurance of workflow and treatment planning system (system
geometry, dosimetry) end-to-end-test.
Dosimetry with different detector systems (ionization chamber, solid state detector, film
dosimeter) in different measurement systems (water phantom, water equivalent solid phantom
etc.)
Patient Treatment planning (different tumor sites).

Learning Objectives:
Practical application of theoretical knowledge by measuring in phantoms for dosimetry and quality
assurance as well as basic knowledge in treatment planning.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in module 2.1, 2.2, 3.2 and 3.4

Useful Previous Knowledge:

Basic Knowledge in Radiation Physics

Exam Regulations: Presentation/Short Report/Exercises/Exam

Formalities Required: no

Max. Number of Participants: 12

Other Comments: Block Lab

Lecturers:
Mr. V. Steil, PD Dr. H. Wertz, Dr. M. Polednik

Recommended Literature:
tba
 27

Course Nr. Module Title

3.21
Imaging Lab: MR Technology (advanced)

Lab 40 h Turn Language

Credit Points Type of Course
Self-Study 176 h
8.0 Lab
Written Report 24 h Yearly English

Contents of Module:
Practical exercises for image acquisition with MR (phantom experiments)
Characteristics of conventional image sequences regarding tissue contrast, artefacts
Characteristics of fast image sequences
Application of special sequences (angiography, diffusion tensor imaging, functional MRI)
Exercises for MR- spectroscopy

Learning Objectives:
In-depth exercises in MRI following the theoretical knowledge of module 3.1. The students learn the
important applications of MR in medicine. They learn to handle imaging sequences and gain
knowledge in MR- spectroscopy.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in courses 3.1 and 4.2

Useful Previous Knowledge:

Basic Knowledge in Physics

Exam Regulations: Presentation/ Short Report/ Exercises/ Exam

Formalities Required: no

Max. Number of Participants: 12

Other Comments: Block Lab

Lecturers:
Prof. Dr. L. Schad

Recommended Literature:
tba
 28

Course Nr. Module Title

3.22
Nuclear Medicine Lab: Experiments & Data Analysis (advanced)

Lab 40 h Turn Language

Credit Points Type of Course
Self-Study 176 h
8.0 Lab
Written Report 24 h Yearly English

Contents of Module:
Radioactivity
Calibration Factor
Positron-Emission-Tomography
Emphasis:
Image reconstruction and/or
Evaluation of dynamic PET-studies and/or
Solution of optimization problem in radionuclide- therapy

Learning Objectives:
The students repeat and deepen their knowledge in nuclear medicine, e.g. radioactivity and PET.
Additionally, they get to know and apply easy examples of image reconstruction and evaluation of
dynamic PET data with compartmental models. The students understand how experimental data are
obtained in nuclear medicine and how to interpret these. An optimization problem in radionuclide
therapy will be evaluated and solved. They learn how to work scientifically, including literature
research, protocol writing of experiments.
At the end, the students will write a short report about their results.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance of module 3.8

Useful Previous Knowledge:

Basics in Mathematical Modelling and MATLAB

Exam Regulations: Presentation/Short Report/Exercises/Exam

Formalities Required: no

Max. Number of Participants: 12

Other Comments: Block Lab

Lecturers:
Prof. Dr. G. Glatting, PD Dr. K.-A. Bsing, Prof. Dr. B. Wngler

Recommended Literature:
tba
 29

Course Nr. Module Title

3.24
Computational Medical Physics Lab (advanced)

Lecture: 4 h
Lab 180 h Type of Turn Language
Credit Points
Self-Study 40 h (for report) Course
8.0
Preparation for Presentation Lab Yearly English
16 h

Contents of Module:
Methods of non-linear numerical analysis eLearning-course
GPU programming hands-on-course with examples
Mathematical models in medical physics and biomedical optics such as eLearning course

Learning Objectives:
The students learn to deal with research topics related to computational medical physics. They learn
special techniques to prepare themselves for the master thesis. They will work on a small lab project,
write a short report about the workflow and the results and give a short presentation in the seminar
(elective, module 3.30). They gain experience in scientific work and evaluation.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: Presentation/Short Report/Exercises/Exam

Formalities Required: no

Max. Number of Participants: 12

Other Comments: Block Lab

Lecturers:
Prof. Dr. J. Hesser

Recommended Literature:
tba
 30

Course Nr. Module Title

3.25
Radiobiology Lab (advanced)

Lab 40 h Turn Language

Credit Points Type of Course
Self-Study 176 h
8.0 Lab
Written Report 24 h Yearly English

Contents of Module:
Basics of cell culture
Techniques in micro biology
Basics of molecular biology techniques (Flowcytometry, PCR, Genetransfer, gene expression
analysis)

Learning Objectives:
In depth theoretical and practical knowledge about cell culture, sterile working, molecular biology
methods.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

Basics in Biology and Chemistry

Exam Regulations: Presentation/Short Report/Exercises/Exam

Formalities Required: no

Max. Number of Participants: 4

Other Comments: Block Lab

Lecturers:
PD Dr. C. Herskind, Prof. Dr. M. Veldwijk

Recommended Literature:
tba
 31

Course Nr. Module Title

3.26
Seminar Radiation Therapy: Journal Club + Presentation
(advanced)

Journal Club: 15 h
Turn Language
Credit Points Preparation for Type of Course
2.0 Presentation and report: Seminar
Yearly English
30 h

Contents of Module:
The topic depends on the current state of the art and the supervising lab (module 3.20).
Workflow:
Attendance in the Journal Club Radiation Therapy (min. 5 times)
Presentation in Journal Club (1 time)
Report submission

Learning Objectives:
The students learn to take part in scientific discussions, formulate a topic related to current state of the
art and present it. They learn to work on and present scientific problems, including i.e. literature
research.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in courses 2.1, 2.2, 3.2

Useful Previous Knowledge:

None

Exam Regulations: Presentation, min. 5 times presence in seminar

Formalities Required: no

Max. Number of Participants: 12

Other Comments: Seminar, every Tuesday

Lecturers:
PD Dr. H. Wertz

Recommended Literature:
tba
 32

Course Nr. Module Title

3.27
Seminar Nuclear Medicine: Journal Club + Presentation
(advanced)

Journal Club: 15 h
Turn Language
Credit Points Preparation for Type of Course
2.0 Presentation and report: Seminar
Yearly English
30 h

Contents of Module:
The topic depends on the current state of the art .
Workflow:
Attendance in the Journal Club Radiation Therapy (min. 5 times)
Presentation in Journal Club (1 time)
Report submission

Learning Objectives:
The students learn to take part in scientific discussions, formulate a topic related to current state of the
art and present it. They learn to work on and present scientific problems, including literature research.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in courses 3.8

Useful Previous Knowledge:

None

Exam Regulations: Presentation, min. 5 times presence in seminar

Formalities Required: no

Max. Number of Participants: 12

Other Comments: Seminar, every Tuesday

Lecturers:
Prof. Dr. G. Glatting

Recommended Literature:
tba
 33

Course Nr. Module Title

3.28
Seminar Radiobiology: Journal Club + Presentation (advanced)

Journal Club: 15 h
Turn Language
Credit Points Preparation for Type of Course
2.0 Presentation and report: Seminar
Yearly English
30 h

Contents of Module:
The topic depends on the current state of the art.
Workflow:
Attendance in the Journal Club Radiobiology (min. 5times)
Presentation in Journal Club (1 time)
Report submission

Learning Objectives:
The students learn to take part in scientific discussions, formulate a topic related to current state of the
art and present it. They learn to work on and present scientific problems, including i.e. literature
research.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in courses 3.5

Useful Previous Knowledge:

None

Exam Regulations: Presentation, min. 5 times presence in seminar / protocol

Formalities Required: no

Max. Number of Participants: 4

Other Comments: Seminar, every second Wednesday

Lecturers:
PD Dr. C. Herskind, Prof. Dr. M. Veldwijk

Recommended Literature:
tba
 34

Course Nr. Module Title

3.29
Seminar MR Methods and Technology: Journal Club + Presentation
(advanced)

Journal Club: 15 h
Credit Points Preparation for Presentation Type of Turn Language
2.0 and report: 30 h Course
(whole year seminar: total 96 Seminar Yearly English
h)

Contents of Module:
The topic depends on the current state of the art and the supervising lab (module 3.21).
Physical basics of imaging and/or diagnostic techniques:
MRI
CT
Workflow:
Attendance in the Journal Club Imaging (min. 5 times)
Presentation in Journal Club (1 time)
Report submission.

Learning Objectives:
The students learn to take part in scientific discussions, formulate a topic related to current state of the
art and present it. They learn to work on and present scientific problems, including i.e. literature
research.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in courses 3.1 and 3.21

Useful Previous Knowledge:

None

Exam Regulations: Presentation, min. 5 times presence in seminar

Formalities Required: no

Max. Number of Participants: 6

Other Comments: Seminar, every Wednesday

Lecturers:
Prof. Dr. L. Schad

Recommended Literature:
Medical Imaging Physics, Hendee/Ritenour, Wiley-Liss, 2002.0
Bildgebende Systeme fr die medizinische Diagnostik, Morneburg, 1995
Computertomographie. Grundlagen, Gertetechnologie, Bildqualitt,
Anwendungen, Kalender, 2006
Magnetic Resonance Imaging Theory and Practice, Vlaardingerbroek/den
Boer, 2003
 35

Course Nr. Module Title

3.31
Seminar Computational Medical Physics: Journal Club +
Presentation (advanced)

Journal Club: 15 h
Turn Language
Credit Points Preparation for Type of Course
2.0 Presentation and report: 30 Seminar
Yearly English
h

Contents of Module:
The topic depends on the current state of the art and the supervising lab (module 3.21).
Workflow:
Attendance in the Journal Club Image Analysis (min. 5 times)
Presentation in Journal Club (1 time)
Report submission

Learning Objectives:
The students learn to take part in scientific discussions, formulate a topic related to current state of the
art and present it. They learn to work on and present scientific problems, including i.e. literature
research.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in courses 3.24

Useful Previous Knowledge:

None

Exam Regulations: Presentation, min. 5 times presence in seminar

Formalities Required: no

Max. Number of Participants: 6

Other Comments: Seminar, every Thursday

Lecturers:
Prof. Dr. J. Hesser

Recommended Literature:
tba
 36

Module 4. Workshops

Course Nr. Module Title

4.1
Basic Cellular Biology/ Radiobiology

Credit Points Type of Course Turn Language

Practical Course 16 h
1.0 Practical Course/
Self-Study 14 h
Lab Yearly English

Contents of Module:
Basics of cell culture
Techniques in micro biology
Basics of molecular biology techniques (Flowcytometry, PCR, Genetransfer, gene expression
analysis)

Learning Objectives:
Theoretical and practical basics about cell culture, sterile working, molecular biology methods.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

Basics in Biology and Chemistry

Exam Regulations: data evaluation / presentation / report

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Practical Course

Lecturers:
PD Dr. C. Herskind, Prof. Dr. M. Veldwijk, PD Dr. P. Maier

Recommended Literature:
Hall, E. J. and Giaccia, A. J. "Radiobiology for the Radiologist" 7th Edition. Lippincott Williams
& Wilkins (Philadelphia) 2012. ISBN-13: 978-1-60831-193-4
Joiner, M. and van der Kogel A. (Eds) "Basic Clinical Radiobiology" 4th Edition. Hodder Arnold
(London) 2009. ISBN: 978 0 340 929 667
 37

Course Nr. Module Title

4.2
MR-Radiology

Credit Points Type of Course Turn Language

Practical Course 16 h
1.0 Practical Course/
Self-Study 14 h
Lab Yearly English

Contents of Module:
Practical training in image acquisition with MRI (phantom experiments)
Characteristics of conventional imaging sequences regarding tissue contrast, artefacts
(T1, T2)
Characteristics of fast imaging sequences
Application of special sequences (angiography, diffusion tensor imaging, functional MRI)
Practical training in MR- spectroscopy

Learning Objectives:
In-depth exercises in MRI following the theoretical knowledge of module 3.1. The students learn the
important applications of MR in medicine. They learn to handle imaging techniques and different
contrast modalities as well as gain knowledge in MR- spectroscopy.

Requirements of Participation/ Required Previous Knowledge:

successful attendance in module 3.1

Useful Previous Knowledge:

general basics in physics and MRI

Exam Regulations: presentation and data evaluation

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Practical Course

Lecturers:
Prof. Dr. L. Schad

Recommended Literature:
Medical Imaging Physics, Hendee/Ritenour, Wiley-Liss, 2002
 38

Course Nr. Module Title

4.3
Radiation Protection and Quality Assurance

Credit Points Type of Course Turn Language

Practical Course 16 h
1.0 Practical Course/
Self-Study 14 h
Lab Yearly English

Contents of Module:
Person dosimetry, radiation protection from architectural side
Practical exercises for quality assurance of workflow and treatment planning system (system
geometry, dosimetry)
Dosimetry with different detector systems (ionization chamber, solid state detector, film
dosimeter) in different measurement systems (water phantom, water equivalent solid phantom
etc.)

Learning Objectives:
Practical application of theoretical knowledge by measuring in phantoms for dosimetry and quality
assurance.

Requirements of Participation/ Required Previous Knowledge:

Participation in courses 2.1, 2.2 and 3.2

Useful Previous Knowledge:

Basics in radiation protection / treatment planning / dosimetry / quality assurance

Exam Regulations: data evaluation /report

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Practical Course

Lecturers:
Mr. V. Steil, Dr. M. Polednik, Dr. S. Clausen

Recommended Literature:
A century in Radiology: http://www.xray.hmc.psu.edu/rci/
Radiotherapy Physics in Practice, Williams/Thwaites, Oxford University Press, 2000
The Physics of Radiation Therapy, Faiz M. Khan, Lippincott, 2003
Practical Radiotherapy Planning, Dobbs/Barrett/Ash, Edwar Arnold, 1999
Radiation Therapy Planning, Bentel, McGraw-Hill, 1995
ESTRO Publications:
1. Monitor Unit Calculation for High Energy Photon Beams
2. Recommendations for a Quality Assurance Programme in External Radiotherapy
3. Practical Guidelines for the Implementation of a Quality System in Radiotherapy
AAPM Radiation Therapy Committee Task Group 53: Quality assurance for clinical
radiotherapy treatment planning, Fraas et al., Med Phys Vol. 25, No. 10, October 1998
 39

Course Nr. Module Title

4.4
Diagnostic Radiology / Image Management

Type of Course Turn Language

Credit Points Practical Course 16 h
Practical Course/
1.0 Self-Study 14 h
Lab Yearly English

Contents of Module:
Workflow in radiology department
Working with different imaging systems (x-ray and non-x-ray devices)
Practical exercises for a system architecture of image storage and handling
Image transfer techniques, networking, tele-radiology

Learning Objectives:
Working with imaging systems (CT, MRI), data storage/ management and transfer.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

module 3.7 (Diagnostic Radiology)

Exam Regulations: no

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Practical Course

Lecturers:
PD Dr. G. Weisser, Prof. Dr. C. Groden

Recommended Literature:
Medical Imaging Physics, Hendee/Ritenour, Wiley-Liss, 2002
 40

Course Nr. Module Title

4.10
Eye Clinics (Mannheim)

Type of Course Turn Language

Credit Points Practical Course 16 h
Practical Course/
1.0 Self-Study 14 h
Lab Yearly English

Contents of Module:
Practical exercises in SLO, OCT and cornea angiography

Learning Objectives:
Application of ophthalmologic systems and practical experience in ophthalmologic diagnostic systems.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: written protocol

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Lecturers:
Prof. Dr. H. Krastel, Prof. Dr. S. Beutelsbacher, Prof. Dr. F. Schlichtenbrede

Recommended Literature:
will be given at the beginning of the lab.
 41

Course Nr. Module Title

4.11
Nanoscopy Lab (Mainz)

Credit Points Practical Course 24 h Type of Course Turn Language

2.0 Self-Study 36 h Practical Course/
Lab Yearly English

Contents of Module:
Confocal laser scanning microscopy
Spectral precision microscopy
Wavefield microscopy
Signal processing and biological application

Learning Objectives:
Knowledge about different light-optical microscopes for structure imaging beyond conventional optical
resolution.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: written protocol

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Lecturers:
Prof. Dr. C. Cremer, Dr. U. Birk (IMB, University Mainz)

Recommended Literature:
will be given at the beginning of the lab.
 42

Course Nr. Module Title

4.12
Matlab Programming Exercise: Preparation for Master Thesis

Credit Points Lecture 10 h Type of Course

Turn Language
4.0 Self-Study 90 h Lecture /
Preparation for Exam Practical Course
Yearly English
20 h

Contents of Module:
User interfaces
Advanced Matlab programming skills
Typical applications where Matlab is applied in the master thesis

Learning Objectives:
Advanced programming concepts, should obtain the required programming knowledge required to
realize a programming-oriented master thesis.

Requirements of Participation/ Required Previous Knowledge:

Basic knowledge of programming in Matlab

Useful Previous Knowledge:

None

Exam Regulations: yes Exam (written/oral/exercises/report)

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Instructor:
Supervisor or co-supervisor for master topic

Recommended Literature:
http://www.lmsc.ethz.ch/Teaching/ipss_2010/advancedProgramming.pdf
http://jagger.berkeley.edu/~pack/e177/
http://www.mathworks.cn/programs/downloads/presentations/MasterClassA_AdvancedProgra
mming.pdf
 43

Course Nr. Module Title

4.13
C++ Introductory Course

Credit Points Lecture 10 h Type of Course Turn Language

4.0 Self-Study 90 h Lecture /
Preparation for Exam 20 h Practical Course Yearly English

Contents of Module:
Simple programming tools (editor, compiler, shell)
Types, variables, operators, combined types
Flow control
Pointer, references, dynamic variables
Classes, methods, attributes, inheritage
IO
STL

Learning Objectives:
Programming concepts, competence to write simple programs.

Requirements of Participation/ Required Previous Knowledge:

Basic knowledge of programming in Matlab

Useful Previous Knowledge:

C or Java knowledge

Exam Regulations: yes Exam (written/oral/exercises/report)

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Block Course

Instructor:
tbd

Recommended Literature:
http://wiki.kip.uni-heidelberg.de/ti/Informatik-Vorkurs/index.php/Main_Page
 44

Course Nr. Module Title

7
Shanghai Workshop

Workshop 16 h Turn Language

Credit Points Type of Course
Self-Study 14 h
1.0 Workshop
Yearly English

Contents of Module:
The schedule of the workshop in Shanghai covers one week. Both Shanghai Jiao Tong University and
Mannheim Faculty, University of Heidelberg, provide about 8-hour lectures.
The lectures cover the topics:
Radiotherapy, Nuclear Medicine:
Modern Radiation Oncology (Shanghai Jiao Tong University)
Image Guided Radiotherapy (University of Heidelberg)
Hyperthermia (University of Heidelberg)
Biomedical Optics (Shanghai Jiao Tong University)
Additionally, the students join the Annual Sino-German Radiation Oncology Symposium.

Learning Objectives:
Inter-institutional interaction on the recent developments and current research activities in
Radiotherapy and Biomedical Optics.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: presentation / oral exam

Formalities Required: no

Max. Number of Participants: 20

Other Comments: Block Course

Lecturers:
Prof. Dr. F. Wenz, Prof. Dr. J. Bille, Prof. Dr. J. Hesser, Prof. Dr. L. Schad, Prof. Dr. G. Glatting

Recommended Literature:
will be given at the beginning of the workshop.

Module 8.
 45

Course Nr. Module Title

6.6
General Science Skills

Credit Points Workshop 4 h Turn Language

Type of Course
3.0 Self-Study 86 h
Workshop
Yearly English

Contents of Module:
The students receive a topic/theme (i.e. future master thesis topic).
Following the theme, the students work on the state of the art, write a short report and present
it.
The students learn how to get new ideas through special techniques like brainstorming. They
have to structure these ideas and develop a research plan/proposal. A report has to be
written.
A tutor will introduce the students to each task and will guide them through their work.

Learning Objectives:
The students learn how to plan a scientific work, how to gain information about the state of the art,
how to write and review grant proposals and how to gain new ideas in a research field.

Requirements of Participation/ Required Previous Knowledge:

None

Useful Previous Knowledge:

None

Exam Regulations: Presentation / report /protocol

Formalities Required: no

Max. Number of Participants: 15

Other Comments: Block Workshop

Lecturers:
Prof. Dr. G. Glatting, Prof. Dr. J. Sleeman

Recommended Literature:
Will be given at the beginning of the workshop.
 46

Module Number Module Title

8.1
Specialized Lab Project

Type of Course Turn Language

Credit Points
Lab 480h Scientific Lab
16.0
Project Yearly English

Contents of Module
The topic depends on the supervising department.

Learning Objectives
The students learn to work on a scientific project, including e.g. the scientific approach, protocol
writing of experiments. Thereafter, they have the knowledge and experience to perform a
scientifically oriented master thesis.

Requirements of Participation/Required Previous Knowledge

Successful attendance in General Science Skills (module 6.1/2/3 or 6.5) as well as, if possible,
another specialized seminar in order to know the basics of planning and control of scientific lab
projects.

Useful Previous Knowledge

None

Exam Regulations: protocol to Practical Course

Formalities Required None

Max. Number of Participants: 20

Other Comments independent scientific lab project (supervised)

Recommended Literature:
Depending on the theme of the project.
 47

Module 9.

Course Nr. Module Title

5
Master Thesis

Turn Language
Credit Points Type of Course
4 months (daily)
30.0 Thesis
Yearly English

Contents of Module:
The topic and contents depend on the supervising department.

Learning Objectives:
The students can work independently on a scientific topic, guided by a tutor. They can search and
analyse literature as well as formulate/ organize and perform an experiment.

Requirements of Participation/ Required Previous Knowledge:

Successful attendance in all courses 1, 2 and specialized courses from 3 (related to the individual
specialization of the student)

Useful Previous Knowledge:

None

Exam Regulations: Written Thesis, colloquium (public oral presentation with discussion), final oral
examination about thesis and whole content of the attended lectures

Formalities Required: no

Max. Number of Participants: 40

Other Comments: Independent scientific work (supervised)

Recommended Literature:
Topic-related.