AROSOL CHEMICALS

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A Natural-Herbal methionine
M ethionine (abbreviated as Met or M) is an -aminoacid with the
chemical formula HO2CCH(NH2)CH2CH2SCH3. This essential amino
acid is classified as nonpolar. Together with cystein, methionine is one of
two sulfur-containing proteinogenic amino acids. Its derivative S-
adenosyl methionine (SAM) serves as a methyl donor. Methionine is an
intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithine,
and other phospholipids. Improper conversion of methionine can lead to
atherosclerosis.
Methionine is required for
It assists in the breakdown of fats and thereby prevents the build-up of
fat in the arteries, as well as assisting with the digestive system and
removing heavy metals from the body since it can be converted to
cysteine, which is a precursor to glutathione, which is of prime
importance in detoxifying the liver.
The amino acid methionine is also a great antioxidant as the sulfur it
supplies inactivates free radicals.
It is also one of the three amino acids needed by the body to manufacture
creatine monohydrate, a compound essential for energy production and
muscle building.
Deficiency of methionine
Severe deficiency may manifest in dementia, while lesser deficiencies
may be known by symptoms like fatty liver, slow growth, weakness,
edema and skin lesions.
Methionine is required in the diet and thus is considered an
essential amino acid.
Methionine helps in the biochemical breakdown of fats in the
body; this action prevents the accumulation of fat in the liver.
The availability of methionine in the body may affect the
biochemical synthesis of the amino acids cystein and taurine.
Methionine also aids in the rapid detoxification of harmful
compounds such as lead and any other heavy metals which
may cause toxic side effects due to their presence in the body.
Methionine also actively reduces the onset of muscular
weakness.
Methionine is also believed to be beneficial for proper bone
formation.
Methionine has a powerful antioxidant action against free
radicals produced in the natural metabolic processes of the
body.
The amino acid methionine is also an excellent source for the
essential mineral sulfure, which quickly inactivates free
radicals produced in the body.
The amino acid is also required during the synthesis of nucleic
acids, collagen and different proteins found in almost every
cell- it is a constituent of many enzymes and proteins found in
different parts of the body.
Methionine is not synthesized in the body and is considered
to be an essential amino acid.

It needs to be obtained in the diet from methionine rich food

sources or via dietary supplements of methionine or protein
rich complexes in easily available form.
Methionine is a lipotropic, or a chemical substance that
helps the liver process fats (lipids). Other lipotropics include
choline, inositol, and betaine (trimethylglycine), all of which
help prevent the accumulation of fat in the liver and thus
ensure normal liver function, which is essential for the
elimination of toxins from the body. Methionine also supports
liver function by regulating glutathione supplies..
Methionine is essential for the formation of healthy collagen
used to form skin, feathers, and connective tissue, and helps
reduce the level of inflammatory histamines in the body.
Methionine is an essential vitamin, which means it must be
obtained through dietary sources..
A FATTY LIVER (POULTRY)
Higher level of methionine is required to
meet with the increased tissue demands for
fast growth and high production.
It helps optimize protein synthesis and
improves the tone and pliability of the skin
and strengthens feathers.
Methionine is essential for the absorption
and transportation and bioavailability of
some essential minerals in the body.
It also acts as a methyl donor and prevent
excess fat buildup in the liver.
 Methionine deficiency causes

Slow growth in broilers, layer chicks

and growers.
Poor feed conversion ratio, lowered
egg production.
Liver damage.
Loss of muscle tone and fat.
Skin tone and feather loosening.
Immune depression.
 Natural Methionine
Nature has provided methionine to plants as
dipeptides and oligopeptides along with its
precursors and intermediates to facilitate
optimum biosynthesis of methionine, as per
birds needs.
Herbs also have enzymes required for
conversion of methionine into S-Adenosyl
Methionine (SAM) which is Active Methionine.
Herbal Methionine as researched based
formulation contains bioactive natural
methionine in free as well as conjugated
dipeptide and oligopeptide forms.
Herbal Methionine contains the precursors and
intermediates of methionine, folic acid.
Serine - Serine is an efficient contributor to
methionine formation. Natural serine present
in Herbal Methionine provides significant
contribution to methionine production. Herbal
Methionine contains all of these pre-requisites
for methionine formation from serine.
Aspartic Acid Like serine, natural aspartic
acid present in Herbal Methionine is converted
through homoserine into homocysteine and
then methionine, thereby providing an useful
source of methionine bio-synthesis.
 Folic Acid - Folic acid present in Herbal
Methionine helps in one carbon transfer reactions
and thus spares methionine for protein synthesis
and methylation functions.
Recycler of Methionine S-Adenosyl
Methionine (SAM) obtained from methionine is
used in the synthesis of creatine. The homocystine
further gets reconverted into methionine with the
help of phosphatidyl choline and folic acid
present in Herbal Methionine, for sustained
bioavailability and activity of methionine.
 Andrographis paniculata 350 gms.
Zea mays 250 gms.
Ocimum sanctum 300 gms.
Asparagus racemosus 100 gms.

drtajdararosol@yahoo.com
Causes of Poor Feathering
The absence of feathers on birds can result from any of several causes
and can be separated into two groups: 1) those birds that cannot grow
feathers and 2) those birds that pull or break them off. Either situation
can be reversed by correcting the problem's cause.
The most common reason that feathers do not develop is a deficiency of
a critical protein constituent (amino acid) from the diet of the birds. The
feathers of birds contain high levels of a subunit of proteins called
"methionine." Methionine is one of only a few amino acids that contain
sulfur, and sulfur is a major constituent of feathers. If bird diets are
deficient in any single amino acid, it will most likely be methionine. An
adequate level of methionine is required in the diet and a deficiency
results in reduced growth and feather development. A methionine
deficient bird will tend to eat feathers in an attempt to satisfy a craving
for this amino acid. A bird may even pull them from its own body.
Few ingredients used in making poultry diets contain adequate amounts
of methionine, so manufactured methionine must be added to the dietary
mixture to ensure that the birds receive an adequate amount. All quality
poultry feeds are designed to contain adequate methionine and prevent
reduced body growth and feather development. However, if additional
grains (such as corn) are fed with the complete feed, then the amount of
methionine consumed by the bird can be inadequate for providing
growth and feather development. Feeding of additional grains with
complete poultry feeds is not recommended.
 Pyruvate + SO4 NH3 -Ketobutyrate Propionyl
5 CoA

Cysteine Cystathionine
4
Cystathionase
Cystathionine -synthase (requires pyridoxal phosphate)
CH
CH33 group adenosine
donation 3

CH3 S-Adenosylmethionine Homocysteine-SH CH33-B12 THF

1
Methionine
adenosyltransferase 2a Methionine synthase 2b

CH3 3
Methionine-S-CH
ATP
Hydroxy B12 N5-CH
CH3 THF
Figure 4. Metabolism of methionine and cysteine. THF is tetrahydrofolate.
 In a study published in British Journal of
Nutrition (1985), Linda Saunderson reported
that l-methionine incorporates better into
different tissues like breast, leg, skin and brain
of broiler chicks as compared to dl-
methionine.
Linda Saunderson also reported that l-
methionine excretes significantly lesser (less
than 5 times) as compared to dl-methionine,
providing sustained bio-actibity
14C incorporation (per min per gm tissue)

dl-methionine l-methionine

Breast 2851 4249

Leg 2821 4169

Skin 2431 4540

Brain 1797 3468

14C in excreta extract

Excreta 9.59 1.88

ADVANTAGES :
Provides 100% Methionine to the animal/bird for
optimum growth.
Controls fat metabolism hence prevents fatty liver
syndrome
Provides energy so that the animal/bird remain in healthy
& lively state
Keep the Liver in its vibrant state of performance hence
there is production of optimum bile secretion and
prevention from aflatoxicosis
Methonine is helpful in optimum cell synthesis hence it
provides basic building blocks for newer cells.
Optimizes hatchability
INDICATIONS :
Improves skeletal & muscular growth
Improves FCR & Anabolic effect
Optimum production
Enhanced Convalescence
Healthy Digestion
Early recovery from skin diseases and feather loss
Recovers Leg Weakness
DOSAGE FORM : Powder Oral
PRESENTATION: -
1 Kg Pack 20 Kg Pack
Effect of supplementing Herbal Methionine on
performance and immune response of broilers
Abstract
A study was conducted with broilers to find out the effect of addition of
herbal methionine (1 g/kg) to a basal diet containing crude protein, 223
g/kg, ME, 1225 MJ/kg, Supplemental levels of methionine was found
to be highly effective in improving the growth, food consumption, food
conversion ratio and immunity of broilers. A higher value for leucocyte
migration inhibition was observed in chicks fed on the diet containing
1.5 g/kg methionine which indicated a significant improvement in
cellular immune response. Hamagutination test and ELISA indicated
enhanced antibody titres in chicks receiving 2.5 g/kg of herbal
methionine, showing a significantly better humoral immune response.
Hence it is advocated to supplement Herbal Methionine for efficient
FCR, growth and enhanced immunity of boilers.
Growth and Carcass Quality of Slow Growing Chicks on diets containing Different
Levels of Herbal Methionine
The responses of slow growing chicks to different dietary levels of
herbal methionine and its interaction were investigated during the starter-
grower period from 1 to 56 d of age. Therefore, a basal marginally herbal
methionine deficient all-mash corn-soybean meal diet was formulated to
contain 0.32% herbal methionine, 0.65% total sulphur amino acid
(TSAA) and adequate level of choline (NRC, 1994). This diet was
supplemented with 0, 0.05 and 0.10% of herbal methionine. Thus, there
were nine experimental diets; each diet was fed to 40 chicks divided
equally among 5 replicates of eight chicks each. Herbal Methionine level
at 0.37 and 0.42% significantly improved BWG by 2.1 and 8.1% and
FCR by 4.5 and 8.6% compared to the basal diet, respectively. Moreover,
herbal methionine at 0.37 and 0.42% significantly decreased serum AST
and ALT, and abdominal fat compared to the basal diet. There were
significant interaction between methionine level. In conclusion, slow
growing chicks (14.6 g/d) during 1-56 d of age could be fed diet
containing 0.42% methionine.