ISONIAZID -intense Gi irritation (alleviated B6) FOR A T Y P I C A L T B

-paired with pyridoxine 1.MAC

-inactivatrd by KatG, mycobacterial catalase- 2. CAPREOMYCIN- I/PPS - u need third agent
peroxidase 3.CYCLOSERINE- I/CWS CLARI/AZI + ETHAN& RIFABUTIN + CIPRO
-most impt drug for TB *peripheral neuropathy and liver dysfunxn
-Latent inf "prophylaxis"
=enzyme inhibitor siya...iniincrease ang level ng 4.P-AMINOSALICYCLIC ACID-----Ag/FS
lahat ng icombine sa kanya na drug. -similar to PABA but rarely
-hemolysis in g6pd used bc of resistance
Rifamycin
RIFAMPICIN___ I/DNA-RNA polymerase -Rifampin 5. AMIKACIN- strep
-Against M.tuberculosis -Rifabutin resistant
*orange Rifampin Kanamycin is rendered
*proteinuria -Rifapentine obsolete
-for leprosy
-enhances elimination of drugs
-Rifaximin 6. FLUOROQUINOLONES-
-more toxic than INH esp in chidren used if resistant sa first line
- if given LT 2x/week, u can have anemia& flu like drugs
syndrome Gati& Moxi…….Levofloxacin……Cipro

ETHAMBUTOL___I/AT 7.LINEZOLID-
-Always given with INH and RIFAM - last resosrt
-inhibits arabinoyl transferase -combination sa second and third line to treat MDR
-remains unchanged in urine strains
*toxic===red-green color blindness
*retinal damage, optic neuritis 8. RIFABUTIN
-derived from rifamycin, related from rifampin
PYRAZINAMIDE -less potent inducer of TB with HIV
-unknown ang target na drug, but pyrazinoic acid and
nagwowork 9. RIFAPENTINE-----I/BacterialRNA
-shortens the regimen when u combine with first 3 -not used in TB HIV
-Parent molecule and metabolite are excreted in urine
-INCREASE t1/2 in hepatic renal failure 10. RIFAXIMIN
*maculopopular rash - TRAVELER’s diarrhea
*myalgia
*porphyria L E P R O S Y D R U G S
1.SULFONES
STREPTOMYCIN____I/PS 1.1 DAPSONES- I/FAS
-life-threatening TB cases - should be combined with Clofa/Rifam as initial
-kills extracellular tuberculae bacilli therapy

---ALTERNATIVE DRUGS— 2. ACEDAPSONE

-mas toxic, doesnt mean more effective -for pjirovecii

1.ETHIONAMIDE 3. CLOFAZIMINE---- red-brown coloration

- blocks synthesis of mycolic acid - Phenazine dye