Agents correlation between the emotional makeup of an Inorganic agents used to treat GI individual and the Disorders: incidence of peptic ulcer. 1. Products for altering gastric pH The tenser the person is, Antacids the higher the chances Betaine HCl the person will get the Glutamic acid HCl ulcer. 2. Protectives for intestinal Types of Ulcer (peptic inflammation ulcer) a. Esophageal Ulcer Drugs to reduce inflammation (esophagus) 3. Adsorbents for intestinal toxins Heartburn Protects the stomach - This is due to 4. Cathartics/Laxatives for the gastric acid constipation entering the esophagus Keep in mind: These drugs are mostly either during a OTC (Over the counter). belch or upon lying in bed. Responsibilities of a Pharmacist 1. To help the patient and give more Remedy is to lie information about the drug. down with the head elevated The reason is that the - This is to indications are symptoms of a reduce the flow more serious condition of gastric fluid 2. Advising the patient about the from the utilization of the drug/s. stomach to the esophagus Types of GI Drugs b. Gastric Ulcer I. Antacids (stomach) - Alkaline bases - Neutralizes excess HCl Malignancy and - Inactivates the proteolytic hemorrhage enzyme, pepsin. Remedy: - Hyperacidity anticholinergic Low acid pH is due to the therapy or drugs presence of endogenous c. Duodenal ulcer HCl (duodenum) Gastritis to ulceration Perforation Gastritis – a general Remedy: inflammation of the shortening of the gastric mucosa intestines through Ulcer – a specified surgery. circumscribed erosion
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Distributed to first year students for A. Y. 2014 - 2015. Page 1 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 People who drink dioxide. The result is the a lot get this type sparkling flavor of ulcer often. otherwise have a flat The general remedies of saline taste. ulcer are: b. Aluminum hydroxide USP a. Use a high pillow when 31 lying down - Al(OH)3 b. No stress - Synonym/s: amphogel c. Good diet - Two forms of amphogel: d. Antacids 1. Aluminum e. Anticholinergic diet (to hydroxide gel USP lower the production of 26 HCl) - White viscous f. Surgery (if it gets worse suspension already or it is the - Small amounts of duodenal ulcer) clear liquid may - Criteria for the ideal antacid: separate on a. Not absorbable or cause standing systemic alkalosis - Contains b. Not a laxative or cause aromatics like constipation peppermint oil and c. Exert the effect rapidly and sweetening over a long period of time substances like d. Not cause a large sucrose, glycerin, evolution of gas saccharin, among e. Buffer in the pH 4-6 range others. f. Inhibits pepsin - Not more than 0.5% - Chemical Compounds preservatives are a. Sodium bicarbonate allowed like - Na2HCO3 sodium benzoate, - The qualities that made benzoic acid, this not an ideal antacid: methyl paraben, 1. Water soluble etc. 2. Short duration of - pH: 5.5-8.0 action - Dosage form: 3. Increases gastric pH Suspension at above 7 2. Dried aluminum 4. Large evolution of hydroxide gel USP gas 26 Can cause - White, colorless, belching and tasteless, flatulence. amorphous - Main function is to react powder with an acid (citric, - Soluble in dilute tartaric, etc) with the mineral acids and evolution of carbon
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Distributed to first year students for A. Y. 2014 - 2015. Page 2 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 solutions of fixed - Poorly soluble salts will alkali hydroxide. only go to the solution - Insoluble in water if acid is present to and alcohol. consume the - Dosage form: solubilized salt in the Tablet and Gel solution. - Advantages of using - Raises up the pH to amphogel: nearly 7. 1. Colloidal adsorptive - Tends to be property constipating so it is 2. Amphoteric mixed with magnesium property antacids. 3. Adsorbs pepsin i. Calcium carbonate USP - Disadvantages of 31 amphogel: - CaCO3 1. Loss of antacid - Synonym/s: property in time Precipitated chalk 2. Causes - Fine, white, odorless, constipation tasteless, (astringent property) microcrystalline 3. Causes nausea and powder vomiting. - Stable in air - Uses: gastric antacid - Insoluble in water but (for the treatment of solubility is increased hyperchlorohydria and by nay ammonium peptic ulcer) and an salt or carbon dioxide. intestinal toxemia. - Insoluble in alcohol - Its mechanism of - Dissolves with action is attributed to effervescence in its capability in diluted acetic acid, adsorbing HCl, toxins, diluted HCl and gases and bacteria. diluted nitric acid. - It can also interfere - Causes flatulence with the adsorption of and constipation other drugs and - Uses: antacid caution should be because of its fast exercised in the co- action administration of the - Mixed with gels and other drugs. Magnesium (laxative) c. Calcium-containing ii. Tribasic Calcium antacids phosphate USP 31 - Their action is - 10CaO•3P2O5•H2O dependent upon their - Synonym/s: basic properties and precipitated calcium not on amphoteric phosphate, tertiary effect.
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Distributed to first year students for A. Y. 2014 - 2015. Page 3 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 calcium phosphate, - Laxative effect, so it is calcium phosphate. usually found in - After ignition at 800 combination of degrees Celsius for aluminum and calcium 30 minutes, it antacids. contains the amount i. Magnesium carbonate of phosphate USP 31 equivalent to n.l.t. 90% - Mg(CO3)4•Mg(OH)2•5 of tribasic calcium H2O phosphate, Ca3(PO4)2. - Synonym/s: - It is found abundantly carbonate of in nature as Magnesia, phosphorite or magnesium phosphate rock and carbonate, heavy apatite, magnesium Ca3(PO4)2•CaF2. carbonate - White, odorless and - White bulky odorless tasteless powder powder - Soluble in diluted HCl - Slightly earthly taste and HNO3. - Occurs in friable - Uses: antacid for the masses treatment of - Insoluble in water hyperacidity. - Insoluble in alcohol - Advantage over but dissolves in Sodium bicarbonate: effervescence in 1. No gas produced dilute acids. 2. Does not - Two kinds: alkalinize the 1. Heavy Variety system - Boiling water 3. Source of calcium - 25 mL d. Magnesium-containing - 30 Minutes to Antacids boil - Poorly soluble salts - Air-dry which only go into 2. Light Variety solution as acid - Cold water consumes the small - 125 mL amount of anion - 15 minutes to already in solution. boil - As pH of the stomach - Not exceeding approaches neutrality, 100 degrees the rate of dissolution Celsius to dry. of the magnesium salt - Uses: antacid slows down and stops - Due to its limited at neutrality. solubility, it only - Anion confers the dissolves only as antacid properties. carbonate and
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Distributed to first year students for A. Y. 2014 - 2015. Page 4 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 hydroxide are being - Compound of consumed. magnesium oxide ii. Magnesium hydroxide and silicon dioxide USP 31 containing various - Mg(OH)2 portions of water. - White bulky powder - 20% is magnesium - Soluble in acids oxide and 45% is - Insoluble in water and silicon dioxide. alcohol. - Fine, white, odorless, - Use: efficient antacid. tasteless powder In high doses, - Free from grittiness laxative. - Insoluble in water and - “salt action” in the alcohol intestinal tract that - Readily decomposed causes a mild by mineral acids. laxative action. - Uses: gastric antacid iii. Milk of Magnesia in peptic ulcer. - Mg(OH)2 suspension vi. Magnesium phosphate - A small amount of - Mg3(PO4)2•5H2O citric acid is added to - Synonym/s: Tertiary minimize interaction Magnesium with glass. Phosphate - Flavoring agents are - White, odorless and added. tasteless powder - Uses: antacid and - Soluble in diluted laxative mineral acids iv. Magnesium oxide - Insoluble in water - MgO - Use: antacid - Synonym/s: II. Protectives and Adsorbents Magnesia - Used for treatment for mild - White, odorless diarrhea powder - Diarrhea - Insoluble in water and Symptom and not a alcohol disease - Soluble in dilute acids Factors may impair - Two types: digestion and/or adsorption 1. Light Variety Increasing the bulk of the - 5 grams can intestinal tract occupy 40-50 Increased bulk stimulated mL peristalsis 2. Heavy Variety Serious condition for very - 5 grams can young and elderly patients occupy 10-20 Loss of fluids and mL electrolytes quickly lead to v. Magnesium trisilicate dehydration and electrolyte - 2MgO•3SiO2•xH2O imbalances.
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Distributed to first year students for A. Y. 2014 - 2015. Page 5 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 Types: administration of Acute Diarrhea bismuth-containing Causes: preparations. - Bacterial toxins i. Bismuth subnitrate - Chemical poisons - Bi(OH)2(NO3)4• - Drugs BiO(OH) - Allergy - Synonym/s: - Disease Basic Bismuth Effects Nitrate, White - Tissue damage Bismuth - Irritation - White, slightly - Causing hygroscopic electrolytes to flow powder from body fluids - Acid reaction to into the intestinal litmus tract - Soluble in HCl Chronic Diarrhea - Insoluble in Causes: water and - Gastrointestinal alcohol surgery - Assayed in - Carcinomas terms of - Chronic bismuth trioxide inflammatory (Bi2O3) conditions - It is - Adsorptive defects incompatible - The new products for the with taraganth treatment of diarrhea will - The difficulty consist of: maybe Adsorptive-protective overcomes by Antidiarrheal agent adding sodium - Chemical Compunds biphosphate or a. Bismuth-containing trisodium products phosphate. - Water insoluble but - Uses: non- but a small amount go irritant intestinal into solution antiseptic, - Soluble bismuth cation treatment for exerts a mild gastric ulcer astringent and and antiseptic action. inflammation, - Intestinal hydrogen and remedy sulfide acts upon the against bismuth salt to form diarrhea. bismuth sulfide - Bismuth salts - Causes black stool lessens gastric resulting from oral
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Distributed to first year students for A. Y. 2014 - 2015. Page 6 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 secretion and bismuth reduce acidity. hydroxide and ii. Bismuth subcarbonate subcarbonate - Uses: antacid - BiO2(CO3)2•H2 and astringent O b. Kaolin - Synonym/s: - Al2O3•2SiO2•2H2O Basic Bismuth - Synonym/s: porcelain Carbonate clay, china clay, bolus - White or pale alba yellowish white, - Native hydrated odorless, aluminum silicate, tasteless powdered and freed powder from gritty particles by - Stable in air elutriation. - Slowly affected - Contains 20.9% by light aluminum formed by - Insoluble in the weathering of water feldspar, which is - Soluble in HCl KalSi3O8 with - Soft, yellowish white effervescence or whitish powder or in - Assayed in lumps terms of its - Insoluble in water and bismuth trioxide in cold dilute acids and content. in solutions of alkali iii. Milk of Bismuth hydroxides - Bismuth - Earthly and clay-like hydroxide and taste bismuth - When moistened with subcarbonate in water, it assumes a suspension with darker color and water. develops a marked - Made by clay-like color converting c. Activated Charcoal bismuth - Adsorbent in the subnitrate to treatment of diarrhea bismuth nitrate - Antidote in certain by the addition types of poisoning of nitric acid. III. Saline Cathartics - Treatment with - Also called purgatives ammonium - Laxatives are mild cathartics carbonate and - Most of these are over the ammonia counter drugs (OTC). solution, it is - But these are widely used, converted to abused, and overpromoted.
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Distributed to first year students for A. Y. 2014 - 2015. Page 7 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 - Cathartics are properly used b. Phosphate when: c. Sulfate 1. To ease defecation d. Tartrate 2. To avoid potentially - Soluble magnesium salts are hazardous rises in blood cathartic because of the pressure poorly absorbed magnesium 3. To relieve acute ion. constipation - Saline cathartics are water 4. To remove solid material soluble from the intestinal tract - Taken with large amount of - Laxatives are used for short- water term therapy because - Prevents excessive loss of prolonged use may lead to body fluids and reduces loss of spontaneous bowel nausea and vomiting if a too rhythm. hypertonic solution should - One can be dependent on reach the stomach. laxatives, and it is called the - Chemical Compounds: “laxative habit”. a. Monobasic Sodium - Four types of laxatives phosphate 1. Stimulant Laxatives - NaH2PO4•H2O Act by local irritation on - Synonym/s: Sodium the intestinal tract Dihydrogen Phosphate, Increases peristaltic Sodium Acid activity Phosphate, Primary 2. Bulk-forming Laxative Sodium Phosphate, Made from cellulose Sodium Biphosphate and other non-digestible - Colorless crystals or polysaccharides white crystalline Swell when wet powder Increased bulk - Odorless and slightly stimulates peristalsis deliquescent 3. Emollient Laxatives - Acid to litmus Neither as lubricants - Effervesce with sodium facilitating the passage carbonate of compacted fecal - Acidic because of acid material or as stool dihydrogen phosphate softeners. anion Example: Mineral Oil - Salt in anhydrous form 4. Saline Cathartics - With one or two moles of hydration. Increases osmotic load - Uses: Urinary acidifier of the gastrointestinal and cathartic tract. - Urine goes acidic in the - Poorly adsorbed anions that case of cystitis with are used as saline cathartics hemamethylenetetrami are: ne (Methenamine) as a. Biphosphate
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Distributed to first year students for A. Y. 2014 - 2015. Page 8 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 this susbstance - Crystals are coated decomposes into with white powder. formaldehyde only in - Soluble in water the presence of acid. - Insoluble in alcohol b. Dibasic sodium phosphate - Uses: cathartic, mild - Na2HPO4•7H2O laxative to hydragogue, - Synonym/s: Dibasic an ingredient to Seidlitz sodium phosphate, powder (Potassium disodium hydrogen Sodium Tartrate as phosphate, secondary cathartic) sodium phosphate - Effervescent - Colorless or white preparation granular salt - Platable product - Effervesces in warm, - One of the components dry air of Fehling’s Solution - Alkaline to litmus (Alkaline Cupric - Phenolphthalein Tartrate) - pH = 9.5 - Chelate complexation - freely soluble in water (concentration of cupric - very soluble in alcohol is very little and not - official with 1, 2, 7 or precipitated by sodium 12 moles water of hydroxide) hydration. d. Magnesium sulfate - Uses: due to its poor - MgSO4•7H2O intestinal permeability, - Synonym/s: Epsom salt, it is used as a saline bitter salt cathartic. - It can be prepared by: - Caution: this should 1. Treating the mineral never be confused with magnesite (MgCO3) commercial tribasic with hot dilute sodium phosphate sulfuric acid (very alkaline and 2. Dissolving the caustic and should be mineral kierserite used in intestinal (MgSO4•H2O) in purposes. water, heating and c. Potassium sodium tartrate then concentrating - KNaC4H4O6•4H2O the solution to - Synonym/s: Rochelle crystallization Salt, Seignette Salt 3. Heating by - Colorless crystals or calcination dolomite white crystalline (MgCO3•CaCO3) powder then treating with - Cooling saline taste HCl and - Effloresces slightly in evaporating to warm dry air dryness. The dried mass is dissolved in
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Distributed to first year students for A. Y. 2014 - 2015. Page 9 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 sulfuric acid, boiled - Examples: and filtered. The 1. Aluminum Hydroxide gel with filtrate containing magnesium hydroxide magnesium sulfate Aludrox is evaporated to WinGel crystallization. Maalox - Small, colorless Cremalin crystals, usually 2. Aluminum Hydroxide gel with needle-like magnesium trisilicate - Cooling saline bitter Gelusil taste Tricremalate - Effloresces in air Triosgel - Neutral to litmus 3. Megaldrate (mixture of - Soluble in boiling water aluminum hydroxide and - Sparingly soluble in magnesium hydroxide) alcohol Riopan - Uses: active cathartic 4. Simethicone - The bitter taste is Di-Gel disagreeable and it can Mylanta be lessened by 5. Alginic acid with sodium administering it with bicarbonate ice-cold solution. Gaviscon - Parenterally – Foamtab anticonvulsant - Locally/Topically – Non-official Saline Cathartics: Anesthetic 1. Sodium sulfate action/Antiphlogistic - Glauber’s Salt - Orally – Cathartic 2. Potassium phosphate e. Magnesium citrate - Dibasic Potassium phosphate - Mg2C5H7O6 - Dipotassium Hydrogen - Synonym/s: Citrate of phosphate Magnesia, Purgative - DKP Lemonade 3. Potassium bitartrate - Platable - Cream of tartar - Carbonated - Potassium Acid Tartrate - Lemon-flavored - Potassium Hydrogen Tartrate solution 4. Calomel - It must be sterilized - Mercurous Chloride and pasteurized. - Mild Mercury Chloride
- It is an attempt to balance the constipative effect (aluminum and Topical Agents calcium) with a laxative effect - “topical” means it is used on body (magnesium) and to balance the surfaces duration of action.
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Distributed to first year students for A. Y. 2014 - 2015. Page 10 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 - Applied on body cavities that open - Foliated talc has a in the inside. These include: plate-like structure and Oral it is used for Nasal pharmaceutical Otic purposes. Vaginal - Odorless, tasteless Colonic powder - Will exert local or surface activity - Insoluble in water, - Route of systemic administration dilute acids and bases. are buccal tablets and suppositories. - Low adsorptive - Two types of Topical Agents: property I. Protectives - Uses: filtering aid, - Substances applied to the lubricating and skin to protect certain areas protective dusting from irritation powder and cosmetic - Mechanical origin purposes. - Desirable properties: b. Zinc oxide 1. Insolubility - ZnO 2. Chemically inert - Synonym/s: Zinc White, - Efficient adsorbents Lana o Algodon - It is maximized with particle Filisoficos, Flores de size Zinc - Smaller particles offer a larger - Preparation: Heating C surface area with Zinc mineral - Chemical Compunds: Calamine – a. Talc Zn2SiO4•H2O - 3MgO•4SiO2•H2O Smithsonite – - Synonym/s: French ZnCO3 Chalk, Soapstone, Willemite – ZnSiO4 Piedra Grassa, Creta Franklinite – ZnO Gallica with Fe and Mn - Native anhydrous oxides magnesium silicate that Zincite – red may have aluminum version of ZnO silicate - Fine, odorless, - Fine white or grayish- amorphous white or white crystalline yellowish white powder powder - Free from gritty - Unctuous particles - Adheres readily on skin - Gradually absorbs - Free from grittiness carbon dioxide from the - Layered silicate air to form basic zinc - Softest mineral known carbonate - Smooth, greasy feeling - Insoluble in water and to touch alcohol - Lump form (steatite)
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Distributed to first year students for A. Y. 2014 - 2015. Page 11 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 - Uses: topical protective, oily layer of stearic and mild astringent, palmitic acid antimicrobial - Uses: mild astringent, compound, protective. antimicrobial, dusting - Zinc Oxide is the powders and ointments primary ingredient of as a protective. Calamine USP. - Advantage of this over c. Calamine other products: - ZnO•xFe2O3 1. Not wetted by - Red moisture characteristic/”Pinkish” 2. Not form crusty (Fe2O3) patches - Uses: Topical e. Titanium dioxide protective, dusting - TiO2 powders, ointments - White, amorphous, and lotion (applied to odorless, tasteless, skin for soothing, infusible powder adsorbent, protective - 1:10 solution is neutral properties). to litmus - Calamine Lotion - Insoluble in HCl, nitric With ZnO, acid and dilute sulfuric Bentonite magma acid and Ca(OH)2 - Soluble in hydrofluoric (solution) acid, and in hot Good drying effect concentrated sulfuric and mild astringent acid. - Phenolated Calamine - Fusion with potassium With 1% liquid bisulfate or with alkali phenol carbonates or As a local hydroxides render it anesthetic and soluble in water. antipuritic - Official identification of d. Zinc stearate this compound is dilute - Fine, white bulky sulfurinc acid (which powder turns the solution to - Free from grittiness orange-red color) - Faint characteristic - Uses: topical protective, odor solar ray protective, - Unctuous to touch white pigment in paints - Readily adheres to skin and cosmetics. - Insoluble in water, f. Silicon polymers alcohol and ether - Silicon oils - Hydrolyzed by heating - Primarily in dilute mineral acids dimethylsilicone ethers to form a soluble zinc - Simethicone/ salt and an insoluble Dimethicone
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Distributed to first year students for A. Y. 2014 - 2015. Page 12 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 Gastric protective - Tastes sour antiflatulent - Produces a froth in the - Uses: ointments and mouth creams for application - Pure hydrogen peroxide to the skin was water is colorless, syrupy repellant and liquid with astringent protectives against properties contact irritants - Heated to 100 degrees II. Antimicrobials Celsius can decompose - Three mechanisms of action to water and hydrogen of astringents and - Miscible in water, antimicrobials: alcohol and either 1. Oxidation - How to render it more 2. Halogenation stable: 3. Protein precipitation 1. It should be kept in a - Astringent cool place protected - Control of from light and dust Antimicrobial/Astringent 2. Amber colored Action bottles are used as 1. Making solutions of containders appropriate concentration 3. Preservatives such for the desired use as actenilide is 2. Placing them in a vehicle added which will slow their 4. It may be stabilized release to the site of action with any organic and 3. Complexation of a ligand inorganic acids, 4. Synthesized into insoluble complexing agents form and used in or adsorbents suspensions, ointments - Use: mild oxidizing and creams for their antiseptic antimicrobial action b. Potassium permanganate because of the slow c. Sodium hypochlorite release of the active agent. solution - Chemical Compounds: d. Other Chlorine-containing a. Hydrogen peroxide substances: solution i. Chlorinated Lime - H2O2 ii. Chloramines - Synonym/s: Hydrogen e. Iodine Peroxide, Aqua f. Povidone-Iodine Oxigenada g. Silver Nitrate - Preservatives may be h. Ammoniated Mercury added i. Sublimed sulfur - Clear colorless liquid j. Precipitated Sulfur - Odorless or with odor k. Sulfurated Potash resembling Ozone l. Selenium Sulfide - Acid to litmus
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Distributed to first year students for A. Y. 2014 - 2015. Page 13 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 m. Antimony Potassium darkening, giving a “mottled” Tartrate appearance. III. Astringent - Dental fluorosis happens when the - Protein precipitants drinking water has fluoride - Chemical Compounds: exceeding 2 pp. a. Alum - Lethal dose: 2-5 grams b. Aluminum Chloride - Two hypothesis on how fluoride c. Other Aluminum- works in the teeth: containing Astringents 1. Fluoride decreases solubility of i. Aluminum Sulfate the enamel ii. Aluminum Acetate 2. Enzyme inhibitory property of solution fluoride. d. Zinc Chloride - Routes of administration of fluoride: e. Zinc Sulfate 1. Orally Allows the systemic Chapter VII: Dental Products circulation of fluoride 2. Topically Anticaries Agents - Daily intake: 2.2 mg or six 8-oz - Lactic acid caused the formation of glasses of fluoridated water dental caries. Lactic acid is taken from oral Examples of Anticaries agents: bacterial metabolism of dietary 1. Sodium fluoride carbohydrates. - NaF - The build-up of plaque aids in the - Molecular weight: 41.99 decay process by forming pockets - White odorless powder or crevices on the teeth surface. - Soluble in water - Ways to prevent dental caries: - Insoluble in alcohol 1. Brushing and flossing with - Use: dental prophylactic agent fluoride - Application: 2% applied at ages 3 Taken internally or topically (initially on growing teeth), 7 The fluoride is in solution or in (when the teeth are emerging), rapidly soluble salts 11 and 13. 2. Intake of fluoride 2. Stannous fluoride From fluoridated drinking - SnF2 water - Molecular Weight: 156.69 In fluoridated drinking water, it - Synonym/s: Tin Difluoride contains 1 ppm fluoride. - White crystalline powder - Too much fluoride can cause dental - Bitter salty taste fluorosis (mottled enamel). - Melts at around 213 degrees Celsius The enamel is chalky and soft. - Soluble in water It indicates that the teeth have - Insoluble in alcohol, ether and loosely bound structure. chloroform. The pigments in foods are - Uses: topical fluoride application adsorbed on the modified and dental prophylactic agent enamel causing patches of
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Distributed to first year students for A. Y. 2014 - 2015. Page 14 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 - Application: 8% solution at 6 to - Synonym/s: Aire Vital, 12 months intervals. Only Dehlogisticated Aire, Fire Air, requires one application per Aire Puro treatment and it is the advantage - Odorless, colorless gas over Sodium fluoride. - Preparation - Applied to cleaned, dry teeth. 1. Fractional distillation of liquid aire Dentifrices 2. Electrolysis of water - A powder, paste or liquid for 3. Thermolysis of KClO3 cleaning the teeth. - Supports combustion - Use: Inhalant Example of Dentifrices: - Stored in green container 1. Pumice - Prolonged use can cause - Synonym/s: pumice stone, piedra edema in the lungs pomez 2. Carbon dioxide - Volcanic origin - CO2 - Made of complex silicates of - Synonym/s: carbonic acid gas, aluminum (Al+2), potassium (K+) carbonic anhydride and sodium (Na+). - Odorless, colorless gas - Very light - Acid to litmus - Hard rough porous gray masses - Stored in gray metallic or gritty gray powder containcer - Grades of fineness: - 7% oxygen is added 1. Pumice Flour/Superfine (respiratory stimulant) and Pumice stored in gray/green cylinders 2. Fine Pumice - Gaseous, liquid or solid state 3. Coarse Pumice - Dry ice - Odorless Caustic to remove - Tasteless unwanted tissues - Stable in air (angiomas, eczema, - Insoluble in water moles, psoriasis, warts, - Not attacked by acids corn and calluses) - Use: dental abrasive - Soft drink industry uses sodium bicarbonate mixed Chapter VIII: Miscellaneous with citric acid Inorganic Pharmaceutical - Air displacement in parenteral Agents and topical preparation. 3. Helium - He Inhalants - Colorless, odorless, tasteless - That of which it is inhaled, either gas from the atmosphere or as a - Does not support combustion medicine. - Stored in brown cylinders - Examples: - 20% or 40% oxygen mixed 1. Oxygen and it is stored in brown/green - O2 cylinders
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Distributed to first year students for A. Y. 2014 - 2015. Page 15 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 - Uses: treatment for Expectorants and Emetics respiratory diseases, to - Administration: Orally overcome difficulty in - Expectorants stimulate the flow of respiration respiratory tract secretions - Helium-oxygen mixture can - Examples: prevent bend (bubbles in the 1. Ammonium Chloride USP 31 blood). 2. Potassium Iodide 4. Nitrous oxide - N2O Antidotes - Synonym/s: Laughing gas, - It is an agent that counteracts nitrogen monoxide, dinitrogen poison. monoxide - Examples: - Coercible (condensable) gas, 1. Sodium nitrate colorless 2. Sodium thiosulfate - Slightly agreeable odor 3. Activated Charcoal - Sweetish taste 4. Cupric sulfate - Soluble in water at low 5. Calcium sulfate temperatures 6. Colloidal silicon dioxide - Maintains and revives combustion Lubricants - Decomposes easily - It makes the tablet eject cleanly - Nitrous oxide will not have from the mold. any reaction with nitric oxide - These are mostly insoluble soaps – - In small doses, it causes heavy metals of fatty acids. inebriation (that is why it is - Examples: named “laughing gas”) 1. Calcium Stearate - 2. Magnesium Stearate 5. Nitrogen - N2 Suspending Agent - Synonym/s: Azote - It acts by altering the surface - Colorless, odorless, tasteless character of the solvents gas (surfactants) and others are - Non-flammable thickening agents. - Does not support combustion - Example: - Stored in black cylinders 1. Bentonite NF 26 - Uses: air displacement, - Al2O3•4SiO2•H2O increases shelf life of a - Synonym/s: Soap clay, product Mineral Soap, Wilkinite - Displaces air in parenteral - Native, colloidal, hydrated and topical preparations. aluminum silicate. - Very fine, odorless, pale buff Respiratory Stimulants or cream colored powder - Examples: - Free from grittiness 1. Aromatic Ammonia Spirit - Lightly earthly taste 2. Ammonium Carbonate NF 26 - Hygroscopic
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Distributed to first year students for A. Y. 2014 - 2015. Page 16 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 - Insoluble in water, but swells - Uses: Diagnostic aid in the study up to 12 times its size when of the function of the thyroid added to water. gland for scanning the thyroid - Its adsorbing large amounts of gland (size, position and tumor water makes it form highly location). viscous suspensions and gels - Uses for I-131: to determine the - Insoluble and does not swell blood and plasma volumes and in inorganic solvents. the cardiac output. - Uses: suspending agent, 4. Sodium Rose Bengal I-131 stabilizer in many industrial Injection (Robengatope I-131) emulsions, soaps and - Uses: radioactive tracer in the cleansers (detergent effects) determination of liver function. and clarifying agent 5. Sodium Iodohippurate I-131 (adsorptive powers for dyes Injection (Hippuran -131) and other coloring matters) - Uses: diagnostic agent to determine kidney function. Chapter IX: 6. Chlormerodin Hg 197 Injection and Radiopharmaceuticals and Hg 203 Injection - Uses: Scintillation scanning of Contrast Media the kidneys and brain. 7. Sodium phosphate P 32 Solution Element (phosphotope) - Every atom composes of a nucleus, - Uses: Treatment of polycythemia protons and electrons. vera (increase in RBC), - The number of protons is equal to localization of intraocular tumors. the number of neutrons (in an 8. Technetium Tc 99m Injection electronically neutral atom). (Sodium Pertechnetate) - The number of protons in the - Uses: brain scanning to nucleus is the atomic number. determine the presence and location of neoplastic lesions. Radiopharmaceutical preparations: 9. Cyanobalamin Co-57 and Co-60 1. Sodium Chromate Cr 51 Injection Capsules and Solutions (Chromitope Sodium Rachromate - - Uses: diagnostic agent for 51) pernicious anemia. - Uses: Diagnostic determination of red blood cell mass, volume Radiopague Contrast Media and survival time, and scanning - Chemical compounds containing of the spleen. elements of high atomic number 2. Gold Au 198 Injection (Aurcoloid - which will stop the passage of X- 198, Aureotope, Auroscan) rays. - Use: Diagnostic preparation for - Example: scintillation scanning of the liver. 1. Barium sulfate USP 31 3. Sodium Iodide I 123 Solution - BaSO4 (Iodotope I 125) and Sodium Iodide - Synonym/s:Barium Meal, I 131 Capsules and Solution Sulfato de Bario, Esophotrast (Iodotope I-131)
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Distributed to first year students for A. Y. 2014 - 2015. Page 17 of 18 Pharmaceutical Chemistry 1 Comprehensive Notes for Chapter 5 – 9 - Caution: title should always be written in full To avoid confusion with barium sulfide and barium sulfide (both are poisonous) - Fine white odorless and bulky powder - Free from grittiness - Insoluble in water, organic solvents and aqueous solutions of acids and alkalis - Uses: opaque contrast medium in the roetgenographic examination of the intestinal tract and the stomach.
References:
Dean Manansala’s lectures
Mims.com
Merriam-Webster Dictionary
Lecture Notes in Phar. Chem 1 by Dean
Manansala
Laboratory Manual in Phar. Chem. 1 by
Dean Manansala
PharCare notes
Made by 1FPH Student (AY 2013-2014).
Distributed to first year students for A. Y. 2014 - 2015. Page 18 of 18