Supplementary Table S1.

Characteristics of 97,448 postmenopausal women categorized by

bisphosphonate use at 2008-9 medication inventory and by 5-year hip fracture risk
5-y Hip Fracture Risk 5-y Hip Fracture Risk
< 1.5% (n=43,854) > 1.5% (n=53,594)
Current Bisphosphonate Use Current Bisphosphonate Use
Nonuser User Nonuser User
(n=37,633) (n=6,221) (n=42,730) (n=10,864)
Characteristic No. % or Mean ± SD No. % or Mean ± SD
Age (y) 70.1 ± 3.9 70.0 ± 3.8 79.7 ± 5.1 79.6 ± 5.0
Age > 70 y 17,946 47.7 2,892 46.5 41,538 97.2 10,556 97.2
White race 29,735 79.0 4,933 79.3 40,131 93.9 10,245 94.3
Education
< High school diploma/GED 1,094 2.9 126 2.0 1,587 3.7 266 2.4
High school diploma/GED 5,139 13.7 777 12.5 7,667 17.9 1,793 16.5
School after high school 13,655 36.3 2,005 32.2 16,162 37.8 3,711 34.2
College degree or higher 17,454 46.4 3,274 52.6 17,062 39.9 5,043 46.4
Prior fracture after age 54 y 6,421 17.1 1,388 22.3 19,867 46.5 6,013 55.3
Parental hip fracture 3,035 8.1 637 10.2 6,988 16.4 2,056 18.9
Rheumatoid arthritis diagnosis 3,044 8.1 431 6.9 3,950 9.2 938 8.6
Glucocorticoid use > 3 months 203 0.5 49 0.8 1,453 3.4 484 4.5
Alcohol > 3 servings/day 833 2.2 118 1.9 2,109 4.9 432 4.0
Current smoker 1,039 2.8 171 2.7 1,150 2.7 268 2.5
Hip fracture risk scorea 15.8 ± 2.2 16.2 ± 2.0 23.0 ± 2.9 23.3 ± 2.9
BMI (kg/m2) 29.3 ± 6.2 26.7 ± 5.4 27.5 ± 5.4 25.7 ± 4.8
Physical function score 81.2 ± 20.8 84.7 ± 18.4 65.9 ± 26.8 69.7 ± 25.2
Recreational physical activityb 15.2 ± 14.9 16.5 ± 15.3 12.2 ± 13.5 13.2 ± 13.5
General health rating
Fair or poor 1,360 3.6 142 2.3 6,541 15.3 1,232 11.3
Good 11,009 29.3 1,518 24.4 17,698 41.4 4,318 39.7
Very good or excellent 25,207 67.0 4,546 73.1 18,451 43.2 5,309 48.9
Treated diabetes mellitus 3,188 8.5 295 4.7 3,188 7.5 295 2.7
Severe memory impairment 485 1.3 67 1.1 1,740 4.1 363 3.3
Parkinson’s disease diagnosis 279 0.7 50 0.8 451 1.1 116 1.1
Cancer diagnosis 5,846 15.5 1,036 16.7 8,022 18.8 2,070 19.1
Ever used bisphosphonates 3,988 10.6 6,221 100 8,436 19.7 10,864 100
Ever used SERMs 3,766 10.0 938 15.1 4,938 11.6 1,606 14.8
Ever used calcitonin 514 1.4 238 3.8 1,641 3.8 624 5.7
Ever used estrogens 28,279 75.1 4841 77.8 18,588 43.5 7,332 67.5
Current calcium supplement use 29,116 77.4 5,803 93.3 33,821 79.2 10,155 93.5
Abbreviations: BMI, body mass index; GED, General Education Development; SD, standard deviation.
aRisk score for hip fracture within 5 years calculated from an 11-item algorithm where scores of 15.8,

16.2, and 23 equal probabilities of 0.5%, 0.6%, and 3.5%, respectively; bRecreational physical activity
was categorized in metabolic equivalent-hours per week.