JOURNAL

OF HEPATOLOGY
VOLUME 67, ISSUE 3, PAGES 437–658

FROM THE EDITOR’S DESK Visualization of hepatitis E virus RNA and proteins in the
human liver
D. Lenggenhager, J. Gouttenoire, M. Malehmir, M. Bawohl,
From the Editor’s desk H. Honcharova-Biletska, S. Kreutzer, D. Semela, J. Neuweiler,
S. Hürlimann, P. Aepli, M. Fraga, R. Sahli, L. Terracciano, L. Rubbia-Brandt,
R. Moreau, R. Bataller, T. Berg, J. Zucmann-Rossi and R. Jalan 437
B. Müllhaupt, C. Sempoux, D. Moradpour and A. Weber 471

Maturation of secreted HCV particles by incorporation of

secreted ApoE protects from antibodies by enhancing
OBITUARY infectivity
D. Bankwitz, M. Doepke, K. Hueging, R. Weller, J. Bruening, P. Behrendt,
J.-Y. Lee, F.W.R. Vondran, M.P. Manns, R. Bartenschlager and
In Memoriam: The Contributions of Thomas Earl Starzl, T. Pietschmann
480
MD, PhD (1926–2017)
J. Fung and H. Bismuth 441
Intrahepatic CD206+ macrophages contribute to
inflammation in advanced viral-related liver disease
A. Tan-Garcia, L.-E. Wai, D. Zheng, E. Ceccarello, J. Jo, N. Banu,
A. Khakpoor, A. Chia, C.Y.L. Tham, A.T. Tan, M. Hong, C.T. Keng,
EDITORIALS L. Rivino, K.C. Tan, K.H. Lee, S.G. Lim, E.W. Newell, N. Pavelka, J. Chen,
F. Ginhoux, Q. Chen, A. Bertoletti and C.-A. Dutertre 490

Visualizing HEV infection in human liver tissue

U. Protzer 443 Cirrhosis
24-Norursodeoxycholic acid in patients with primary
sclerosing cholangitis: A new ‘‘urso saga’’ on the Selective testing for calreticulin gene mutations in
horizon? patients with splanchnic vein thrombosis: A prospective
O. Chazouillères 446 cohort study
J. Poisson, A. Plessier, J.-J. Kiladjian, F. Turon, B. Cassinat, A. Andreoli,
E. De Raucourt, O. Goria, K. Zekrini, C. Bureau, F. Lorre, F. Cervantes,
Universal screening of acute medical admissions for D. Colomer, F. Durand, J.-C. Garcia-Pagan, N. Casadevall, D.-C. Valla,
excess alcohol consumption: WhatÕs the misuse? P.-E. Rautou, C. Marzac and French national network for vascular liver
S.R. Atkinson, N. Vergis, A. Louvet and M.R. Thursz 448 diseases 501

Pre-natal and post-natal environment monitoring to
prevent non-alcoholic fatty liver disease development
A. Alisi and P. Vajro
Eight millimetre covered TIPS does not compromise
shunt function but reduces hepatic encephalopathy in
451 preventing variceal rebleeding
Q. Wang, Y. Lv, M. Bai, Z. Wang, H. Liu, C. He, J. Niu, W. Guo, B. Luo, Z. Yin,
W. Bai, H. Chen, E. Wang, D. Xia, X. Li, J. Yuan, N. Han, H. Cai, T. Li, H. Xie,
J. Xia, J. Wang, H. Zhang, K. Wu, D. Fan and G. Han 508

RESEARCH ARTICLES
Transplantation

Viral Hepatitis Inequity in organ allocation for patients awaiting liver

Contribution of alcohol use disorders on the burden of
chronic hepatitis C in France, 2008–2013: A nationwide
retrospective cohort study
M. Schwarzinger, S. Baillot, Y. Yazdanpanah, J. Rehm and V. Mallet 454
HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined
with KIR3DL1 associate with spontaneous clearance of
HCV infection in people who inject drugs
C. Thöns, T. Senff, T.J. Hydes, A.R. Manser, F.M. Heinemann, A. Heinold,
M. Heilmann, A.Y. Kim, M. Uhrberg, N. Scherbaum, G.M. Lauer, S.I. Khakoo
and J. Timm 462
transplantation: Rationale for uncapping the model for
end-stage liver disease
M.K. Nadim, J. DiNorcia, L. Ji, S. Groshen, J. Levitsky, R.S. Sung, W.R. Kim,
K. Andreoni, D. Mulligan and Y.S. Genyk 517
Cancer
Preoperative gadoxetic acid–enhanced MRI for
predicting microvascular invasion in patients with single
hepatocellular carcinoma
S. Lee, S.H. Kim, J.E. Lee, D.H. Sinn and C.K. Park 526
Sensitive and non-invasive assessment of hepatocellular SPECIAL SECTIONS
iron using a novel room-temperature susceptometer
J. Mueller, H. Raisi, V. Rausch, T. Peccerella, D. Simons, C.H. Ziener,
H.-P. Schlemmer, H.K. Seitz, N. Waldburger, T. Longerich, B.K. Straub and
S. Mueller 535
Clinical Trial Watch

Molecular and Cell Biology Emerging molecular therapeutic targets for

cholangiocarcinoma
S. Rizvi and G.J. Gores 632
Effector CD8+ T cell-derived interleukin-10 enhances
acute liver immunopathology
J. Fioravanti, P. Di Lucia, D. Magini, F. Moalli, C. Boni, A.P. Benechet,
V. Fumagalli, D. Inverso, A. Vecchi, A. Fiocchi, S. Wieland, R. Purcell,
C. Ferrari, F.V. Chisari, L.G. Guidotti and M. Iannacone 543 Hepatology Snapshot

Gallstone disease: Optimal timing of treatment

Cholestasis and Autoimmune Diseases P.-R. Scherber, F. Lammert and M. Glanemann 645

norUrsodeoxycholic acid improves cholestasis in

primary sclerosing cholangitis
P. Fickert, G.M. Hirschfield, G. Denk, H.-U. Marschall, I. Altorjay, M. Färkkilä, LETTERS TO THE EDITOR
C. Schramm, U. Spengler, R. Chapman, A. Bergquist, E. Schrumpf,
F. Nevens, P. Trivedi, F.P. Reiter, I. Tornai, E. Halilbasic, R. Greinwald,
M. Pröls, M.P. Manns, M. Trauner and European PSC norUDCA Study Group Hepatocellular carcinoma diagnosis and surveillance:
549
Socioeconomic factors donÕt seem to matter, unless you
are an immigrant
A.A. Ashhab, H. Rodin, J. Powell and J.D. Debes 648
Genetic and Metabolic Diseases
Cartilage oligomeric matrix protein associates with
Universal screening for alcohol misuse in acute medical hepatic inflammation and fibrosis in hepatitis C virus
admissions is feasible and identifies patients at high risk infection
K. Andréasson, J. Waldenström, J. Westin, H. Norrgren, G. Jönsson,
of liver disease K. Nyström and M. Lagging 649
G. Westwood, P. Meredith, S. Atkins, P. Greengross, P.E. Schmidt and
R.J. Aspinall 559
Doublecortin domain containing protein 2 (DCDC2)
Infant nutrition and maternal obesity influence the risk of genetic variants in primary sclerosing cholangitis
A.C. Cheung, B.D. Juran, R.M. Moore, N.F. LaRusso and K.N. Lazaridis
non-alcoholic fatty liver disease in adolescents 651
O.T. Ayonrinde, W.H. Oddy, L.A. Adams, T.A. Mori, L.J. Beilin, N. de Klerk and
J.K. Olynyk 568
Reply to: ‘‘Doublecortin domain containing protein 2
Validity criteria for the diagnosis of fatty liver by M probe- (DCDC2) genetic variants in primary sclerosing
based controlled attenuation parameter cholangitis’’
T. Grammatikopoulos and R.J. Thompson 652
V.W.-S. Wong, S. Petta, J.-B. Hiriart, C. Cammà, G.L.-H. Wong, F. Marra,
J. Vergniol, A.W.-H. Chan, A. Tuttolomondo, W. Merrouche, H.L.-Y. Chan,
B. Le Bail, U. Arena, A. Craxı̀ and V. de Lédinghen 577 The IRGM rs10065172 variant increases the risk for
steatosis but not for liver damage progression in Italian
obese children
G. Bellini, E. Miraglia del Giudice, V. Nobili and F. Rossi 653
REVIEWS
Reply to: ‘‘The IRGM rs10065172 variant increases the
ELITA consensus statements on the use of DAAs in liver risk for steatosis but not for liver damage progression in
transplant candidates and recipients Italian obese children’’
L.S. Belli, C. Duvoux, M. Berenguer, T. Berg, A. Coilly, I. Colle, S. Fagiuoli, Y.-C. Lin and Y.-H. Ni 655
S. Khoo, G.P. Pageaux, M. Puoti, D. Samuel and M. Strazzabosco 585
Pressure volume curves in cirrhosis: More than meets
Non-coding RNA in hepatocellular carcinoma: the eye
Mechanisms, biomarkers and therapeutic targets C. Ripoll, R. Yotti, R. Bañares and J. Bermejo 656
M. Klingenberg, A. Matsuda, S. Diederichs and T. Patel 603
Reply to: ‘‘Pressure volume curves in cirrhosis: More
Biliary bile acids in hepatobiliary injury – What is the link? than meets the eye’’
P. Fickert and M. Wagner 619 W.-J. Shin and G.-S. Hwang 657
Registration of Clinical Trials

The Journal of Hepatology endorses the policy of the WHO and the International Committee of Medical Journal Editors (ICMJE) on the
registration of clinical trials. Therefore, any trial that starts recruiting on or after July 1, 2005 should be registered in a publicly owned, publicly
accessible registry and should satisfy a minimal standard dataset. Trials that started recruiting before that date will be considered for publication
if registered before September 13, 2005.
More detailed information regarding clinical trials and registration can be found in New Engl J Med 2004;351:1250–1251 and New Engl J Med
2005;352:2437–2438.

Cover image: In Memoriam: The Contributions of Thomas Earl Starzl (1926–2017). J. Fung and H. Bismuth in this issue (pages 441–442).
We are plunged into the universe of liver transplantation through the lens of a surgical scene in honor of Thomas Earl Starzl. Cover design by
Caitlin Monney.