Molecular Allergology grass

Suggested profiles for SIT decision

Phleum pratense Timothy components are suitable markers for many
grass due to high degree of similarity between species

ImmunoCAP® arundinoideae Phragmites (Common reed)

Allergen Phl p 1, Phl p 5b Phl p 2, Phl p 4, Phl p 6, Phl p 11 Phl p 7, Phl p 12
Cynodon (Bermuda grass)
Components chloridoideae

Paspalum (Bahia grass)

• Specific components
for grass
• Indication for grass
pollen SIT
• Specific components
for grass
• Data on SIT outcome
are not available in
literature
PANICoidEAE
• Cross-reactive Zea (Maize)
Sorghum (Johnson grass)
allergen components
• Often minor aller- Elymus (Wild rye grass)
Triticum (Culltivated wheat)
gens which may Hordeum (Barley)
not be available in
sufficient amount POACEAE Holcus (Velvet grass)
Arrhenatherum (False oat-grass)
in the SIT extract (Gramineae) Anthoxanthum (Sweet vernal grass)
Avena (Cultivated oat)
• IgE to Phl p 7 and Phalaris (Canary grass)
12 alone indicate Phleum (Timothy)
pooideae
low suitability for Alopecurus (Meadow foxtail)
grass pollen SIT. Agrostis (Redtop)
Keep on looking Distichlis (Salt grass)
for the real cause. Lolium (Rye grass)
Dactylis (Cocksfoot)
Poa (Meadow grass)
Festuca (Meadow fescue)

Secale (Cultivated rye)

Bromus (Brome grass)

Grasses and their botanical relations, adapted from L Yman (24)

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Molecular Allergology grass

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All available grass components
for a complete patient management
ImmunoCAP ®
Complete Phleum g6, Thimoty grass.
Allergens pratense

g205, group 1 grass allergen.

Phl p 1 A specific marker for timothy grass and other grasses.
Major timothy pollen allergen, up to 90 % of pollen allergic patients display IgE to Phl p 1.

g206, group 2 grass allergen.

Phl
A p2 specific marker for timothy grass and other grasses.
Minor timothy pollen allergen.

g208, group 4 grass allergen.

Phl
A p4 specific marker for timothy grass and other grasses.
Major timothy pollen allergen, up to 80 % of pollen allergic patients display IgE to Phl 4. Carries CCD.
ImmunoCAP ®
g215, group 5 grass allergen.
Allergen Phl p 5b A specific marker for timothy grass and other grasses.
Major timothy pollen allergen, 65–85 % of pollen allergic patients display IgE to Phl p 5.
Components
g209, group 6 grass allergen.
High sequence similarity to Phl p 5 and IgE recognition may part represent cross-reactivity to Phl p 5.
Phl p 6 Major timothy pollen allergen restricted to a few grass species and hence not a general marker for grasses.
There is little evidence of IgE antibodies that bind uniquely to Phl p 6.

g210, Polcalcin.
Phl p 7 A cross-reactive allergen present in grass, tree and weed pollen only. High degree of similarity across species.
Minor allergen, about 10 % of grass pollen sensitized individuals show IgE response to Phl p 7.

Phl p 11 g211, group 11 grass allergen.

Minor timothy pollen allergen.

g212, Profilin.
Phl p 12 A cross-reactive allergen present in pollen, plant foods and latex. High degree of similarity across species.
Minor allergen, 15–30 % of pollen-allergic patients are sensitized to profilin.

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