2016 AAGP Annual Meeting

neurodegeneration; together with the exposure-clinical effect relationship, these data support the exploration of higher doses of
gantenerumab.

This research was funded by: SCarlet RoAD is an F. Hoffmann-La Roche funded study.

Poster Number: NR 32
Non-Pharmacologic Insomnia Intervention for Older Adults with Mild Cognitive Impairment:
Improvements in Actigraphy-Assessed Sleep Parameters
Erin L. Cassidy-Eagle, PhD1,2; Allison Siebern, PhD1,3; Lisa Unti, MPH2; Jill Glassman, PhD2; Laura B. Dunn, MD1

1
Stanford University School of Medicine, Stanford, CA
2
ETR, Scotts Valley, CA
3
Fayetteville NC VA Medical Center, Fayetteville, NC

Introduction: Sleep problems plague older adults, with negative effects of physical and mental health and quality of life. Sleep
problems are a risk factor for declining health status. Growing evidence links sleep problems to the development of mild
cognitive impairment (MCI). Cognitive-behavioral therapy for insomnia (CBT-I) has been shown to be effective in a broad
range of individuals with sleep problems. However, cognitive therapies such as CBT-I involve cognitive processes that are
frequently impaired in MCI (i.e., executive processes such as planning and problem solving, memory, and language). Therefore,
evaluations of CBT-I for people with MCI should include measures of these cognitive functions. Because CBT-I has not be
implemented in this population, our aim was to adapt commonly used strategies for those with memory impairments and
measure whether or not the intervention resulted in improvements in the sleep parameters measured by actigraphy.
Methods: In the first part of this study, a six-session cognitive behavioral intervention for insomnia (CBT-I) was adapted for
people with MCI and administered by sleep specialists to older adults with MCI (n = 28) in two residential facilities.
Participants were randomly assigned to either the sleep intervention or an active control group focused on nutrition in aging.
Actigraphy was used at baseline, immediately post-intervention and at a four month follow-up to assess sleep latency, wake
after sleep onset, and sleep efficiency. Insomnia severity was measured with the Insomnia Severity Index (ISI). The D-KEF
Color-Word Interference Test was used to assess executive functioning.
Results: Significant (all p values < 0.001) improvements in actigraphy-assessed sleep outcomes (sleep latency, wake after sleep
onset, sleep efficiency) and insomnia severity were found in the intervention group, compared to the control group. The
intervention group also demonstrated a significant, positive change in executive functioning (D-KEFS; p < .02). Anxiety
(p = .08) and physical functioning (p = .06) also showed a trend towards improving, though there was no significant
improvement in depression scores.
Conclusions: Nonpharmacological interventions such as CBT-I may be beneficial for people with MCI. Further study of
CBT-I in people with MCI is warranted. Such research should include pre- and post-intervention measures of cognitive
functions. Targeting of sleep has the potential to have broad public health impact, including in people with MCI.

This research was funded by: This study is supported by Grant #2012-199 from the Retirement Research Foundation.

Poster Number: NR 33
25-Year Physical Activity Trajectories and Brain MRI Measures in Mid-Life: The Coronary Artery Risk
Development in Young Adults (CARDIA) Study
Sophia Wang, MD1,2; Tina D. Hoang, MSPH3; Stephen Sidney, MD, MPH4; David Jacobs, PhD5; Rachel Whitmer, PhD4;
Lenore Launer, PhD6; Kristine S. Yaffe, MD3

1
Indiana University, Indianapolis, IN
2
Richard L. Roudebush VA Medical Center, Indianapolis, IN
3
University of California San Francisco, San Francisco, CA
4
Kaiser Permanente of Northern California, Oakland, CA
5
University of Minnesota, Minneapolis, MN
6
National Institute on Aging, Bethesda, MD

S162 Am J Geriatr Psychiatry 24:3, Supplement 1