Professional Documents
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Your friend down in the emergency department (ED) has a patient arriving in a few minutes who was assaulted in a local prison. After asking for your
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assistance with his potential airway and mumbling something about a knife, he hangs up. You've been working nonstop since yesterday morning, so
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the only thing on your mind involves a pillow and the supine position. Nevertheless, you the make your way down to the ED and arrive just as the
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medics roll in with Reviews their patient. He is awake and yelling as they roll him by you into the trauma bay. The emergency medical technician is
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applying pressure to the side of the patient's neck and there is a large knife sticking out of the middle of the patient's face (Figure 1). Your friend
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takes one look and Asks you to help by managing the airway while he coordinates the rest of the trauma resuscitation.
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Because of the need for urgent and accurate decision making in a dynamic environment, airway
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management in the trauma patient can be particularly subject to challenging. The presence of
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hemodynamic instability, potential for direct airway trauma, and need for cervical spine immobilization
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when confronted with competing surgical priorities requires a rapid evaluation for a Potentially difficult
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airway (DA), the development of an airway management plan (including rescue techniques in the
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event of failure), and a willingness to act quickly intervening, Often with incomplete information.
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Intubation approaches commonly used in the elective setting can be difficult, or impossible to
apply in Patients with oropharyngeal massive hemorrhage, airway traumatic injury, or combative
behavior due to Altered mental status. Nevertheless, sound management principles airway
Figure 1.
Beyond the need for emergent intubation, consideration may need to be given to semi-elective
airway management in the trauma patient who is Likely to require a near-term where early operative
Lateral view of the skull showing a penetrating knife injury.
intervention
example, a patient who has fallen off his roof, sustaining pelvic and femoral fractures with severe decisions can be made following discussions with both the emergency medicine (EM) and
pain and Accompanying agitation may need to be intubated early to Facilitate thorough radiologic operative teams to Ensure that perioperative issues, such as consent, timing, and other patient
As you move to the head of the bed, your friend directs the ED staff to establish IV access, keep pressure on the bleeding, and check vital signs as
he evaluates the patient. The patient will not stay still, requiring Several of the staff to keep him from climbing off the bed. He answers questions with
one or two words interspersed with profanity and threats directed at everyone in the trauma bay. His neck injury is on the right at the level of the
thyroid cartilage and Appears to be oozing with visible Significantly hematoma formation. The knife Appears to have penetrated the medial aspect of
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the left orbit to an unknown depth and is protruding about 5 inches from the skin surface. Your friend looks at you and says, "I'm concerned about his
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airway with a Potentially expanding neck hematoma, and we'll have trouble keeping the hemorrhage is controlled without a lot of sedation. I think we
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General Considerations the acute, severely Injured trauma patient is best done using a team approach Clearly with a
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Victims of trauma present with a wide range of injuries that create unique challenges for the designated leader who controls the decision making, sequencing, and flow of the entire resuscitation
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person providing support and airway management. Although many of Reviews These Patients do not effort Including airway management considerations, all the while consulting with other team
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require intubation outside of the OR, Reviews those requiring intubation in the ED can be some of the members.
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most challenging airway cases due to the limited time for evaluation, immobilization, combativeness,
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direct airway trauma, presence of blood or vomit, or a combination of All These factors.
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In the late 1990s, anesthesiologists performed the majority of trauma airway management in the
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United States, both inside and outside the OR, with EM physicians nontrauma handling the majority of
cases in the ED. 2 More with EM physicians nontrauma handling the majority of cases in the ED. 2 More
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with EM physicians nontrauma handling the majority of cases in the ED. 2 More recently, multiple
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studies examining the effect of Transitioning to a primarily EM-based airway management system for
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Emergency intubations outside the OR are Generally associated with a higher frequency of
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difficult, intubation and an Increased complication rate, 1 and higher frequency of difficult, intubation and effect on success or complication rates. 3-5
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an Increased complication rate, 1 and higher frequency of difficult, intubation and an Increased
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complication rate, 1 and in many cases, the usual paradigms of airway management used in elective
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Currently, in the United States, trauma Patients are intubated primarily by EM physicians,
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Although Patients with direct trauma to the airway may best be managed using a team approach, with
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EM physicians, anesthesiologists, and surgeons working in concert to Achieve the best possible
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results , This includes Determining the Appropriate location to proceed with advanced airway
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techniques in complex cases. Internationally, there is Considerable variation in the primary airway
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intubation performed under controlled conditions. Multiple providers are required to ventilate the
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patient, hold cricoid pressure (CP) if applied, administer medications, and provide manual in-line
In addition, more assistance may be required to control a patient who is combative as a result
of intoxication, traumatic brain injury (TBI), or other causes of Altered mental status associated
Figure 2. with agitation. The immediate presence of a surgeon or other physician who can expeditiously
perform a cricothyroidotomy IS ALSO desirable. Even if a surgical airway is not required, the
Rapid sequence induction and intubation, integrating manual in-line stabilization of the cervical spine,
additional experienced hands may PROVE useful during
application of cricoid pressure, preoxygenation, and administration of induction agents.
there has been trauma to the face or neck in order to personally visualize the upper clinically apparent in the majority of cases. In some Patients, however, the potential for rapid loss of
airway if the video is employed during the procedure. an intact Initially airway may drive the decision to intubate. Examples of this include a penetrating
neck injury with an expanding neck hematoma or an inhalational injury with anticipation of progressive
Airway management decisions in the trauma patient are frequently driven by considerations airway edema. The need to proceed with intubation for airway protection, however, may be less clear.
beyond identification of the need for an operative intervention. The decision about when and how to Loss of the ability to protect the airway can occur because of Several mechanisms, Including Altered
control a patient's airway is based on a complex series of considerations related to the patient's mental status secondary to TBI, hemorrhagic shock, or ingestion of drugs or alcohol.
specific injuries and overall condition, the likelihood of clinical deterioration, and the need for transport
to locations in the hospital where airway control is desirable based on Reviews These and other
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One of the most common approaches to Determining the ability of a patient to maintain his or
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her airway is to calculate the patient's Glasgow Coma Scale (GCS) score. A GCS score of 8 or
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While the need for emergent or semiurgent intubation is obvious in many Patients, it is less
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lower in the absence of a rapidly reversible cause has been used as an indicator of the coma and
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intuitive in others. The Eastern Association for the Surgery of Trauma (EAST) has published practice
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general requirement for intubation in the setting of trauma. This cutoff has been promulgated
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guidelines addressing the management of emergency tracheal intubation following traumatic injury,
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through the Advanced Trauma Life Support (ATLS) program, Although Patients with a higher GCS
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score may still require intubation in the setting of an Altered neurologic assessment. 9 In a
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Including indications for intubation, the which are summarized in the Table. The main indications for
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emergent intubation can be addressed by asking the following questions during the initial and
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subsequent evaluations:
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• Is there a failure to maintain or protect the airway? 1,000 Consecutive Patients intubated after injury, Sise et al found that twice as many Patients were
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• Is there a failure of oxygenation or ventilation? intubated for the discretionary indication of Altered mental status (GSC score> 8) as Reviews those with
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• Is there a need for intubation based on the anticipated clinical course? 8 a lower score
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course? 8
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Persistent
(SAO
supplemental
2 ≤ 90%)
hypoxemia
oxygen
despite Persistent
supplemental
(SAO 2 ≤ 90%)
hypoxemia
oxygen
despite Persistent
(SAO
supplemental
2 ≤ 90%)
hypoxemia
oxygen
despite Persistent
supplemental
(SAO 2 ≤ 90%)
hypoxemia
oxygen
despite Persistent combativeness fireproof for pharmacological agents
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Severe cognitive
cognitive
impairmentimpairment
(GCS impairment
score
(GCS
≤ 8)score
(GCS≤score
8) Severe
≤ 8) cognitive
Severe respiratory disorders (without hypoxia or hypoventilation)
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Heart failure spinal cord injury (complete cervical injuries at C5 level or above) with evidence of respiratory
depression
• airway obstruction
• impairment
severe cognitive
cognitive impairment
(GSCimpairment
score
(GSC
≤ 8)score
(GSC≤score
8) severe
≤ 8) cognitive
severe
• 40%
The (≥
fuel main
BSA)
40%fuel
BSA)
(≥ 40%
primary
BSA)fuel
primary
(≥
BSA, body surface area; EAST, Eastern Association for the Surgery of Trauma; GCS, Glasgow Coma Scale; SAO 2 arterial oxygen saturation
The decision to intubate resuscitative is a critical decision and can greatly influence subsequent principles that accounts for the patient's current condition, the likelihood of deterioration, planned
management. Airway management in trauma Patients can be anxiety provoking Because Reviews diagnostic and therapeutic interventions (including transport), and preinjury comorbidity, as well as an
their airway Often difficulty is exaggerated by the need for cervical spine immobility, presence of direct assessment of the resources and expertise that are available in the resuscitation area.
airway trauma, compromise of Reviews their hemodynamic status, and propensity for clinical
As you are getting ready to proceed with the intubation, the ED nurse calls out, "The blood pressure is 80/45 and heart rate is 132." She Asks,
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"What do you want for induction?" You are looking down at an agitated patient being restrained by the staff, firm pressure being applied to the
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neck, and the handle of a knife Appears to Prevent an optimal fit for a face mask.
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physicians, and surgeons, showing only 39% of physicians in Europe and 83% of physicians in the
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trauma patient. 11
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All trauma Patients are Considered to be at high risk for aspiration given intoxication, In contrast, a recent national survey of teaching hospitals in the United States found that 91% of
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participants indicated resources of the continued use of the CP as part of Reviews their RSII modified
trauma-induced reduction or absence of gastrointestinal motility, and unknown time of last food
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technique, 17 Although anecdotally this Appears to be part of Reviews their RSII modified technique, 17 Although
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intake. Additionally, pharyngeal hemorrhage due to maxillofacial trauma, secretions, and foreign anecdotally this Appears to be part of Reviews their RSII modified technique, 17 Although anecdotally this
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bodies may Increase the risk. Reasonable precautions should be taken to Prevent aspiration, Appears to be changing as more EM programs Appear to be favoring the avoidance of CP. In support of
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the CP, the most recent guidelines of the American College of Surgeons' ATLS course and the Difficult
particularly subject of gastric contents, trauma management and overalls during airway procedures.
Airway Society's 2015 guidelines unanticipated difficult, intubation in adults include CP as a component of
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The initial intubation method depends on the constellation of patient injuries, hemodynamic status, RSII. 18,19
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and the equipment and expertise available. Most Patients, however, will undergo rapid sequence difficult, guidelines intubation in adults include CP as a component of RSII. 18,19
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induction and intubation (RSII) with the intent of mitigating the risk for vomiting and aspiration during
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If the decision is made to use the CP, it should be Altered or removed to Facilitate
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Noted to be difficult,. Securing the airway and providing ventilation should take precedence over
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the potential risk for aspiration in the trauma setting, given the current level of evidence for CP
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during RSII.
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controversial component of RSII. The use of CP was Widely accepted dogma in trauma for many
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years based on the belief that it could Prevent aspiration via passive regurgitation through
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compression of the upper esophagus against the anterior cervical vertebral bodies. More recently, Drug Selection
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The most commonly used induction agents in the trauma patient are etomidate, ketamine, and
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this belief has been challenged. 11-13 propofol. Other less commonly used agents Described in the literature include remifentanil,
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Controversy regarding the risk-benefit assessment for the continued use of CP in Patients undergoing
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RSII is reflected in the recent published guidelines from multiple organisasi that have recommended If the patient is not completely obtunded and unresponsive, it is recommended to use an induction
eliminating its use or considering it an optional measure. 14-16 agent to Decrease the likelihood of awareness and recall. Trauma Patients are frequently
considering it an optional measure. 14-16 hypovolemic, even if Reviews their initial mean arterial blood pressure is normal. Drug selection must
go hand in hand with volume resuscitation and other resuscitative measures, such as tube
The use of the CP in the trauma patient was recently addressed in the EAST practice thoracostomy, control of external hemorrhage, and pelvic stabilization.
management guidelines for emergency tracheal intubation Immediately following traumatic injury. 14 Based
on evidence that CP may Immediately following traumatic injury. 14 Based on evidence that CP may
Immediately following traumatic injury. 14 Based on evidence that CP may worsen the laryngoscopic
view, impair bag-valvemask (BVM) ventilation efficiency, and not reduce the incidence of aspiration,
the use of CP was removed as a level 1 recommendation. Recommendations Reviews These are
reflected in recent surveys of anesthesiologists, EM
induction agent should be selected to provide the best possible intubation conditions with little
possibility of adverse hemodynamic consequences. induction agent most commonly used in the
United States
Although a single dose of etomidate associated with adrenocortical suppression while, this The selection of a neuromuscular blocking agents as a component of RSII is not Altered by the
does not seem to be clinically significant when a single dose is used for induction to intubation in presence or absence of trauma. Succinylcholine and rocuronium are reasonable choices for RSII,
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both trauma and mixed medical-surgical patients undergoing RSII. 24-26 Although with
rocuronium areSeveral
reasonable
caveats.
choices
36.37 for RSII, Although with Several caveats. 36.37
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mixed medical-surgical patients undergoing RSII. 24-26 Rocuronium produces slightly inferior than succinylcholine for intubation conditions
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RSII. 36
succinylcholine for RSII. 36
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Etomidate may cause myoclonic jerks during the onset, but the use of neuromuscular blocking
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agents fast-acting, such as succinylcholine, substantially alleviate this effect. It also results in significant prolongation of neuromuscular relaxation. In the setting of an Altered level
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of consciousness and suspected TBI, where the clinical exam may Affect the overall management
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decisions, succinylcholine is the preferred agent. If TBI is not suspected and the patient requires a
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Ketamine is also an induction agent commonly used for trauma patients mediated hypotension CT scan or placement of invasive lines, the prolonged relaxation with rocuronium can Facilitate
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due to the increase concentrated in sympathetic tone and catecholamine release. 27 Use in patients
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Reviews These activities. With the availability of sugammadex, a rapid-onset selective binding agent
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with sympathetic tone and catecholamine release. 27 Use in patients with sympathetic tone and
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catecholamine release. 27 Concurrent use in patients with TBI has been questioned by an older report for rocuronium, RSII with rocuronium Followed by reversal with sugammadex Allows for more rapid
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from the elevation of intracranial pressure related. 28 More recent analysis, however, parents of the
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associated elevation of intracranial pressure. 28 More recent analysis, however, parents of the
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associated elevation of intracranial pressure. 28 More recent analysis, however, suggests that the
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caused by ketamine's potential to increase of cerebral activity and intracranial pressure. 28.29
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During RSII, other pharmacologic agents such as lidocaine and opioids have been proposed to
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be useful in attenuating the negative physiologic responses that may occur during intubation. For a
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number of years, lidocaine was proposed to attenuate elevations in intracranial pressure associated
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Also some investigators have raised concerns that the psychotropic effects associated with
with intubation by blunting the sympathetic response. This practice is controversial, with limited
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ketamine may Increase the risk for acute and post-traumatic stress disorders in trauma Patients, 30,31
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Although this was not a post-traumatic stress disorders in trauma Patients, 30,31 Although this was evidence to support the preinduction administration of lidocaine in the trauma patient with suspected
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not a post-traumatic stress disorders in trauma Patients, 30,31 Although this was not found in a study TBI. 39 Several minutes are required after the trauma patient with suspected TBI. 39 Several minutes are
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are required for it to be effective, the which may not always be possible with a trauma RSII. 40
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Of more concern is the potential for barriers to use based on institutional dispensing, tracking, possible with a trauma RSII. 40
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and documentation procedures Preventing timely access to ketamine. When Reviews These barriers
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exist, limiting its availability, ketamine may not be as readily available in the emergency setting as
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other induction agents. Because of its abuse potential, consideration has been given to reclassifying
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ketamine as a Schedule I drug, placing Potentially further barriers to its availability. 33 Overall, ketamine
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continues to be a very commonly used drug for availability. 33 Overall, ketamine continues to be a very
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commonly used drug for availability. 33 Overall, ketamine continues to be a very commonly used drug
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Short-acting opioids such as fentanyl are frequently used to blunt the hemodynamic response to
for RSII in the ED and trauma resuscitation unit. 21
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intubation. In the trauma patient, this must be done with caution given the possibility of hypovolemia
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RSII in the ED and trauma resuscitation unit. 21 and exaggeration of the blood pressure response to RSII. In addition, rapid administration of opioids
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may induce respiratory depression just prior to induction, the which can hinder Efforts at
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preoxygenation.
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Other induction agents, such as propofol, thiopental sodium, and high-dose benzodiazepines,
must be used with caution in the trauma patient since they have a greater tendency to cause
hypotension. While propofol is the most common induction agent in the nonemergent patient Finally, some clinicians advocate the use of alphaadrenergic agents, such as phenylephrine or
presenting to the OR in the United States, it Reduces systemic vascular resistance and induces epinephrine, as a pretreatment prior to RSII in the hemodynamically unstable patient. There are no
myocardial depression, making it less Appropriate in the hypotensive and hypovolemic trauma clinical trials examining the effect of this practice, so this will be a clinical decision for the practitioner
patient. Pharmacokinetic and pharmacodynamic studies in a swine model of hemorrhagic shock based on an assessment of the patient's vital signs, volume status and cardiac function at the
suggest a significant reduction in dosage of propofol bedside. This presumes that Appropriate resuscitation is ongoing at the time of RSII.
Technique characteristics, such as airway trauma, cervical spine immobility, hemodynamic compromise, and
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For the trauma patient, the choice of intubation technique must take into account the injury other Potentially life-threatening injuries, can exacerbate the inherent DA markers, necessitating rapid
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pattern, underlying physiologic state of the patient, potential Difficulties, urgency, and timely decision making without a complete evaluation. Thus, the use of rapidly identified and Easily Obtained
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availability of various devices and surgical backup. RSII remains the preferred method for most factors associated with difficult, intubation in the ED setting would be optimal in identifying the subset
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trauma intubations for a number of reasons, Including Reviews those Discussed above. In addition, of highest-risk Patients.
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the present unrelaxed Patients Significantly more potential for cervical spine motion as a result of
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coughing, bucking, gagging, or other movement during an awake intubation attempt. In a published
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report of 17.583 ED intubations from the National Emergency Airway Registry, Including 5.451 trauma
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intubations, 85% were done with RSII. 21 The modified LEMON criteria have been shown to have a high sensitivity and a reasonable
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negative predictive value in Several studies (Figure 3). 42,43 The and a reasonable negative predictive
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value in Several studies (Figure 3). 42,43 The and a reasonable negative predictive value in Several studies
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were done with RSII. 21 (Figure 3). 42,43 The original criteria included the Mallampati score, but this was dropped due to difficulty in
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Obtaining valid assessments in the emergent airway management settings and poor correlation with a
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Because in an emergency setting Patients are more Likely to present as a difficult, intubation, Although the tool is overly sensitive at the cost of specificity, its application in the trauma setting
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early recognition of the DA is essential. 42 A thorough DA difficult, intubation, early recognition of the
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DA is essential. 42 A thorough DA difficult, intubation, early recognition of the DA is essential. 42 A should alert the provider to the more high-risk patient.
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thorough assessment DA is ideal before RSII in the multitrauma patient, but may not be possible in
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In the setting of a difficult, airway trauma, Several issues should be considered. First, there may
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be limited time for evaluation, as stated above, making it Necessary to proceed without a full airway
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assessment. Even in the setting of a Likely DA, the presence of hemodynamic instability (eg, shock)
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or lack of cooperation (eg, intoxication, TBI, combativeness) will override or limit some of airway
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management options. Second, waking up the patient or canceling the procedure is rarely an option,
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L as the need for emergent airway control Likely Will Werner. Finally, Several conditions associated
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Visible externally:
facial trauma huge incisors
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with trauma (Discussed below in more detail) may further alter the airway management plan.
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Modifications to the American Society of Anesthesiology (ASA) Difficult Airway Algorithm for
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trauma has been proposed by the ASA Committee on Trauma and Emergency Preparedness. 45 It
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Mallampati score: trauma patients (Figure 4) with additional recommendations for certain trauma conditions, including
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N neck mobility: downhill Besides RSII with direct laryngoscopy (DL), the use of video laryngoscopy (VL) for airway
management in trauma patients provides additional functionality. Although prone to lens
contamination of secretions and blood, glottis visualization is almost always better. There has
Each listed item is worth 1 point. The maximum number of airway assessment
been significant interest in the use of VL in the ED for both trauma and nontrauma population. 46.47 As
score = 9 a result, it is now for both trauma and nontrauma population. 46.47 As a result, it is now for both
trauma and nontrauma population. 46.47 As a result, now
While VL Appears to be playing a role in an Increased airway trauma management, the In summary, when dealing with the difficult, airway trauma, a team approach is the best solution
importance of other adjuncts should not be forgotten. It can not be overemphasized that the "bougie" in any scenario. The most experienced operator airway should be present to increase is the
intubating stylet is arguably the most important adjunct DA during DL. The combination of DL and first-attempt success rate, as the first attempt is always the best. In managing the severely
bougie may be the optimal approach to successful first-pass success in the trauma of the airway with traumatized patient, it is important to have a clear definition of airway failure and a prepared action
anything less than a grade 1 Cormack-Lehane plan, such as the one shown in Figure 4.
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Based on the reference 45. Reprinted with permission from the American Society of Anesthesiologists.
Conclusion realization that you will rarely have the opportunity to wake the patient and start over.
The airway trauma is a subset of the difficult airway. The need to integrate airway management
into a dynamic environment with ongoing evaluation and resuscitation Potentially complicated by The foundation for success is an orderly approach, Including prioritization of resuscitation
hemodynamic instability, cervical spine immobilization, and / or direct airway trauma can be very steps, evaluation of the specific characteristics of the difficult airway, careful selection of
challenging. At the same time, the fundamental principles of difficult airway management must be pharmacologic agents, early use of video or optically enhanced airway tools, and coordination with
applied to the trauma patient, with the other members of the resuscitation team ,
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References
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1. Martin LD, Mhyre JM, Shanks AM, et al. 3.423 emergency tracheal intubations at a university hospital: airway outcomes and 15. Jensen AG, Callesen T, Hagemo JS, et al; Clinical Practice Committee of the Scandinavian Society of Anesthesiology and Intensive
complications. Anesthesiology. 2011; 114 (1): 42-48. hospital: airway outcomes and complications. Anesthesiology. 2011; 114
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(1): 42-48. hospital: airway outcomes and complications. Anesthesiology. 2011; 114 (1): 42-48. Care Medicine. Scandinavian Clinical practice guidelines in general anesthesia for emergency situations. Acta Anaesthesiol
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Scand. 2010; 54 (8): 922-950. general anesthesia for emergency situations. Acta Anaesthesiol Scand. 2010; 54 (8): 922-950.
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2. Nayyar P, Lisbon A. Non-operating room emergency airway management practices and endotracheal intubation: a survey of anesthesiology
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85 (1): 62-68. intubation practices: a survey of anesthesiology program directors. Anesth analg. 1997; 85 (1): 62-68.
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16. Field JM, Hazinski MF, Sayre MR, et al. Part 1: executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary
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3. Bushra JS, McNeil B, Wald DA, et al. A comparison of trauma intubations managed by anesthesiologists and emergency
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11 (1): 66-70. anesthesiologists and emergency physicians. Acad Emerg Med. 2004; 11 (1): 66-70.
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17. Ehrenfeld JM, Cassedy EA, Forbes VE, et al. Modified rapid sequence induction and intubation: US survey of current practice. Analg
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anesthesia. 2012; 115 (1): 95-101. Intubation: US survey of current practice. Analg anesthesia. 2012; 115 (1): 95-101.
4. Levitan RM, Rosenblatt B, meiner EM, et al. Alternating day emergency medicine and anesthesia resident responsibility for Intubation: US survey of current practice. Analg anesthesia. 2012; 115 (1): 95-101.
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management of the airway trauma: a study of performance laryngoscopy and intubation success. Ann Emerg Med.
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18. ATLS for Student Doctor manual. 9th ed. Chicago, IL: American
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5. Varga S, Shupp JW, Maher D, et al. Trauma Airway management: transition from anesthesia to emergency medicine. J Emerg Med. 19. Frerk C, Mitchell VS, McNarry AF, et al. Difficult Airway Society guidelines intubation working groups: difficult airway management
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guidelines in 2015 Public unexpected difficult intubation in adults. Br J Anaesth. 2015; 115 (6): 827-848. adults. Br J Anaesth. 2015;
emergency medicine. J Emerg Med. 115 (6): 827-848. adults. Br J Anaesth. 2015; 115 (6): 827-848.
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